Mutagenetix > Incidental Mutations

Incidental Mutation 'R5441:Lysmd2'

427186

Institutional Source

Beutler Lab

Gene Symbol

Lysmd2

Ensembl Gene

ENSMUSG00000032184

Gene Name

LysM, putative peptidoglycan-binding, domain containing 2

Synonyms

MMRRC Submission

043006-MU

Accession Numbers

Is this an essential gene?

Probably non essential (E-score: 0.134) question?

Stock #

R5441 (G1)

Quality Score

Status

Validated

Chromosome

Chromosomal Location

75625741-75637771 bp(+) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

C to T at 75625972 bp

Zygosity

Heterozygous

Amino Acid Change

Histidine to Tyrosine at position 70 (H70Y)

Ref Sequence

ENSEMBL: ENSMUSP00000149065 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000034702] [ENSMUST00000214961]

Predicted Effect

probably benign
Transcript: ENSMUST00000034702
AA Change: H70Y

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)

SMART Domains

Protein: ENSMUSP00000034702
Gene: ENSMUSG00000032184
AA Change: H70Y

Domain	Start	End	E-Value	Type
low complexity region	15	44	N/A	INTRINSIC
LysM	72	116	1.91e-10	SMART
low complexity region	146	173	N/A	INTRINSIC

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000213292

Predicted Effect

possibly damaging
Transcript: ENSMUST00000214961
AA Change: H70Y

PolyPhen 2 Score 0.777 (Sensitivity: 0.85; Specificity: 0.92)

Meta Mutation Damage Score

0.0618

Coding Region Coverage

1x: 99.2%
3x: 98.6%
10x: 97.1%
20x: 95.1%

Validation Efficiency

98% (56/57)

Allele List at MGI

Other mutations in this stock

Total: 55 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
9530053A07Rik	C	T	7: 28,156,914	T2042M	probably damaging	Het
Abca12	A	G	1: 71,295,056	Y1096H	probably damaging	Het
Aspa	A	T	11: 73,305,594	F261I	probably damaging	Het
Atm	C	A	9: 53,516,467	G448*	probably null	Het
Atmin	T	A	8: 116,957,957	D785E	probably damaging	Het
C87414	A	T	5: 93,636,597	M139K	possibly damaging	Het
Car1	G	C	3: 14,776,304	R90G	probably damaging	Het
Cdh11	T	C	8: 102,647,546	D520G	probably benign	Het
Cers5	T	A	15: 99,751,238	K50*	probably null	Het
Chad	A	T	11: 94,568,292	D340V	probably benign	Het
Cspg5	T	C	9: 110,246,643	I68T	probably benign	Het
Fcrla	T	A	1: 170,925,422		probably benign	Het
Fer1l4	T	A	2: 156,023,257	D1608V	probably benign	Het
Fzd5	T	A	1: 64,735,417	Q395L	probably benign	Het
Gm7664	T	A	13: 62,528,650		probably benign	Het
Hk3	T	C	13: 55,015,056	E2G	probably damaging	Het
Hmcn2	G	A	2: 31,406,416	E2677K	possibly damaging	Het
Hydin	T	C	8: 110,565,109	L3411P	possibly damaging	Het
Ltbr	G	A	6: 125,312,794	R146W	probably damaging	Het
Msi2	A	G	11: 88,479,992		probably benign	Het
Msi2	G	A	11: 88,718,095		probably benign	Het
Napsa	T	A	7: 44,581,393		probably benign	Het
Nlrp4a	T	A	7: 26,454,153	L710M	probably damaging	Het
Olfr1025-ps1	T	A	2: 85,918,590	F222I	probably benign	Het
Olfr103	T	C	17: 37,336,268		probably null	Het
Olfr1510	T	A	14: 52,409,957	K305M	probably benign	Het
Olfr459	C	T	6: 41,771,848	M150I	probably benign	Het
Olfr522	T	C	7: 140,162,651	T100A	probably benign	Het
Plbd2	T	A	5: 120,499,082	Y105F	probably benign	Het
Plppr5	A	T	3: 117,662,471	I214F	possibly damaging	Het
Ptcd3	A	G	6: 71,881,521	V655A	possibly damaging	Het
Ptpn14	T	C	1: 189,798,570	L78P	probably damaging	Het
Ralgapa1	A	C	12: 55,719,623	D1295E	probably damaging	Het
Rnf213	G	A	11: 119,409,020	D192N	probably damaging	Het
Ropn1	A	G	16: 34,666,797	I34M	probably damaging	Het
Rpe65	G	T	3: 159,604,401	G104C	probably damaging	Het
Scgb2b27	T	C	7: 34,013,157		probably benign	Het
Sh3bgr	T	C	16: 96,205,917	I29T	possibly damaging	Het
Smg1	T	C	7: 118,195,081		probably benign	Het
Stim2	T	A	5: 54,075,370	C68*	probably null	Het
Syne2	G	A	12: 75,989,143	V3736I	possibly damaging	Het
Tbx19	T	C	1: 165,153,680	N82D	probably damaging	Het
Tdp1	T	A	12: 99,910,285	V353D	probably damaging	Het
Tg	T	A	15: 66,696,520	I1352K	possibly damaging	Het
Thsd4	T	C	9: 59,979,783	T919A	probably damaging	Het
Tmprss11f	A	T	5: 86,528,203	M373K	probably damaging	Het
Tmprss15	T	A	16: 79,071,447		probably null	Het
Tpd52	A	T	3: 9,003,406	Y16*	probably null	Het
Ube2o	G	A	11: 116,544,442	R507C	probably damaging	Het
Unc93b1	T	C	19: 3,943,703	F382L	probably benign	Het
Vav2	A	T	2: 27,270,110		probably benign	Het
Vmn1r207-ps	T	C	13: 22,726,516		noncoding transcript	Het
Zan	T	A	5: 137,436,751	I2127F	unknown	Het
Zfp748	C	A	13: 67,540,618	C841F	probably damaging	Het
Zic4	C	A	9: 91,384,200	P299Q	probably damaging	Het

Other mutations in Lysmd2

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL03337:Lysmd2	APN	9	75635663	missense	probably damaging	1.00
R4946:Lysmd2	UTSW	9	75635446	missense	probably damaging	0.99
R5786:Lysmd2	UTSW	9	75635603	missense	probably benign	0.27
R6493:Lysmd2	UTSW	9	75635702	missense	probably damaging	1.00
R6562:Lysmd2	UTSW	9	75635409	missense	unknown
R7549:Lysmd2	UTSW	9	75637237	missense	probably damaging	1.00

Predicted Primers

PCR Primer
(F):5'- GACCCATGGCGGATCTCTC -3'
(R):5'- GCCATGCACTAGCTGGTCG -3'

Sequencing Primer
(F):5'- CGGATCTCTCGCCTGCG -3'
(R):5'- TAGGCGCCCACTGCAGTTG -3'

Posted On

2016-09-01