Incidental Mutation 'R5442:Vmn1r70'
ID427225
Institutional Source Beutler Lab
Gene Symbol Vmn1r70
Ensembl Gene ENSMUSG00000045340
Gene Namevomeronasal 1 receptor 70
SynonymsV1rl1
MMRRC Submission 043007-MU
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.072) question?
Stock #R5442 (G1)
Quality Score225
Status Not validated
Chromosome7
Chromosomal Location10631532-10636530 bp(+) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) G to T at 10633950 bp
ZygosityHeterozygous
Amino Acid Change Alanine to Serine at position 122 (A122S)
Ref Sequence ENSEMBL: ENSMUSP00000154041 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000055847] [ENSMUST00000226255] [ENSMUST00000228090]
Predicted Effect possibly damaging
Transcript: ENSMUST00000055847
AA Change: A122S

PolyPhen 2 Score 0.687 (Sensitivity: 0.86; Specificity: 0.92)
SMART Domains Protein: ENSMUSP00000054445
Gene: ENSMUSG00000045340
AA Change: A122S

DomainStartEndE-ValueType
Pfam:TAS2R 1 292 2.6e-9 PFAM
Pfam:V1R 33 295 3.1e-31 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000226182
Predicted Effect possibly damaging
Transcript: ENSMUST00000226255
AA Change: A122S

PolyPhen 2 Score 0.687 (Sensitivity: 0.86; Specificity: 0.92)
Predicted Effect possibly damaging
Transcript: ENSMUST00000228090
AA Change: A103S

PolyPhen 2 Score 0.675 (Sensitivity: 0.86; Specificity: 0.92)
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.5%
  • 10x: 96.9%
  • 20x: 94.3%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 37 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Aatk A G 11: 120,018,768 M114T probably benign Het
Ablim3 A T 18: 61,857,225 probably null Het
Adcy10 A G 1: 165,513,140 D238G probably benign Het
Astn2 G T 4: 65,581,786 S955R possibly damaging Het
Casc3 A G 11: 98,821,471 E112G probably damaging Het
Cetn4 C T 3: 37,309,945 V39I probably benign Het
Commd4 A G 9: 57,156,806 V37A possibly damaging Het
Dyrk2 T C 10: 118,860,738 Q205R possibly damaging Het
Gal3st4 A G 5: 138,265,780 V319A possibly damaging Het
Gm14085 A G 2: 122,486,869 N36S probably benign Het
Inpp5d G A 1: 87,718,066 A1058T probably benign Het
Lpin3 A G 2: 160,905,016 Y781C probably damaging Het
Lrat C T 3: 82,903,220 V165M probably damaging Het
Ltbr G A 6: 125,312,794 R146W probably damaging Het
Nlrp6 T C 7: 140,922,190 S142P probably benign Het
Oas1a T C 5: 120,897,206 T349A probably benign Het
Olfr1033 T C 2: 86,041,951 V212A probably benign Het
Olfr110 A T 17: 37,499,439 I263F probably damaging Het
Olfr671 A T 7: 104,975,228 F252L possibly damaging Het
Olfr898 T A 9: 38,349,862 S260T probably benign Het
Pakap C A 4: 57,637,876 P18Q probably null Het
Pcdha2 T C 18: 36,939,862 V182A probably benign Het
Phactr3 A G 2: 178,142,461 D26G probably benign Het
Phrf1 G A 7: 141,240,937 R159H probably damaging Het
R3hdm4 C T 10: 79,912,458 E162K possibly damaging Het
Rab3ip T C 10: 116,918,848 T268A probably benign Het
Rapgef3 T C 15: 97,758,861 D299G probably damaging Het
Rem1 A G 2: 152,628,057 probably null Het
Syne1 A G 10: 5,343,473 M1286T probably benign Het
Thsd7a T C 6: 12,748,800 T52A probably benign Het
Tmem135 A T 7: 89,144,664 F390Y probably damaging Het
Trio T C 15: 27,856,194 D696G probably benign Het
Ttll11 T C 2: 35,903,123 *191W probably null Het
Ubr4 A G 4: 139,407,772 D805G probably damaging Het
Usp9y A G Y: 1,336,467 I1469T possibly damaging Het
Vmn2r78 G T 7: 86,920,122 L74F possibly damaging Het
Wdfy3 T C 5: 101,896,559 E1860G probably benign Het
Other mutations in Vmn1r70
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL03092:Vmn1r70 APN 7 10634259 missense probably benign 0.23
IGL03250:Vmn1r70 APN 7 10634281 missense probably damaging 1.00
R0375:Vmn1r70 UTSW 7 10634060 missense probably damaging 1.00
R0482:Vmn1r70 UTSW 7 10634277 missense probably damaging 1.00
R0497:Vmn1r70 UTSW 7 10634026 missense probably benign 0.19
R1964:Vmn1r70 UTSW 7 10633810 missense possibly damaging 0.88
R2067:Vmn1r70 UTSW 7 10634337 missense possibly damaging 0.61
R3807:Vmn1r70 UTSW 7 10633788 missense probably benign 0.01
R4573:Vmn1r70 UTSW 7 10633629 splice site probably null
R5070:Vmn1r70 UTSW 7 10634398 missense probably benign 0.04
R5558:Vmn1r70 UTSW 7 10634475 missense probably benign 0.01
R6036:Vmn1r70 UTSW 7 10633903 missense probably damaging 1.00
R6036:Vmn1r70 UTSW 7 10633903 missense probably damaging 1.00
R6189:Vmn1r70 UTSW 7 10633671 missense probably benign 0.04
R6976:Vmn1r70 UTSW 7 10634044 missense probably benign 0.02
R7571:Vmn1r70 UTSW 7 10633944 missense probably benign 0.00
X0020:Vmn1r70 UTSW 7 10633590 missense probably benign
Predicted Primers PCR Primer
(F):5'- CTCTGCAAAGGAATCCCTCAG -3'
(R):5'- ACATATAGCATCACTGAAGGCC -3'

Sequencing Primer
(F):5'- CCTCAGACAATGACTGCATTTGG -3'
(R):5'- CACTGAAGGCCAATATGATTGC -3'
Posted On2016-09-01