Incidental Mutation 'R5442:Vmn1r70'
ID 427225
Institutional Source Beutler Lab
Gene Symbol Vmn1r70
Ensembl Gene ENSMUSG00000045340
Gene Name vomeronasal 1 receptor 70
Synonyms V1rl1
MMRRC Submission 043007-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.066) question?
Stock # R5442 (G1)
Quality Score 225
Status Not validated
Chromosome 7
Chromosomal Location 10367514-10368410 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) G to T at 10367877 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Alanine to Serine at position 122 (A122S)
Ref Sequence ENSEMBL: ENSMUSP00000154041 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000055847] [ENSMUST00000226255] [ENSMUST00000228090]
AlphaFold Q8R254
Predicted Effect possibly damaging
Transcript: ENSMUST00000055847
AA Change: A122S

PolyPhen 2 Score 0.687 (Sensitivity: 0.86; Specificity: 0.92)
SMART Domains Protein: ENSMUSP00000054445
Gene: ENSMUSG00000045340
AA Change: A122S

DomainStartEndE-ValueType
Pfam:TAS2R 1 292 2.6e-9 PFAM
Pfam:V1R 33 295 3.1e-31 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000226182
Predicted Effect possibly damaging
Transcript: ENSMUST00000226255
AA Change: A122S

PolyPhen 2 Score 0.687 (Sensitivity: 0.86; Specificity: 0.92)
Predicted Effect possibly damaging
Transcript: ENSMUST00000228090
AA Change: A103S

PolyPhen 2 Score 0.675 (Sensitivity: 0.86; Specificity: 0.92)
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.5%
  • 10x: 96.9%
  • 20x: 94.3%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 37 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Aatk A G 11: 119,909,594 (GRCm39) M114T probably benign Het
Ablim3 A T 18: 61,990,296 (GRCm39) probably null Het
Adcy10 A G 1: 165,340,709 (GRCm39) D238G probably benign Het
Astn2 G T 4: 65,500,023 (GRCm39) S955R possibly damaging Het
Casc3 A G 11: 98,712,297 (GRCm39) E112G probably damaging Het
Cetn4 C T 3: 37,364,094 (GRCm39) V39I probably benign Het
Commd4 A G 9: 57,064,090 (GRCm39) V37A possibly damaging Het
Dyrk2 T C 10: 118,696,643 (GRCm39) Q205R possibly damaging Het
Gal3st4 A G 5: 138,264,042 (GRCm39) V319A possibly damaging Het
Inpp5d G A 1: 87,645,788 (GRCm39) A1058T probably benign Het
Lpin3 A G 2: 160,746,936 (GRCm39) Y781C probably damaging Het
Lrat C T 3: 82,810,527 (GRCm39) V165M probably damaging Het
Ltbr G A 6: 125,289,757 (GRCm39) R146W probably damaging Het
Nlrp6 T C 7: 140,502,103 (GRCm39) S142P probably benign Het
Oas1a T C 5: 121,035,269 (GRCm39) T349A probably benign Het
Or52e8 A T 7: 104,624,435 (GRCm39) F252L possibly damaging Het
Or5m3b T C 2: 85,872,295 (GRCm39) V212A probably benign Het
Or5v1 A T 17: 37,810,330 (GRCm39) I263F probably damaging Het
Or8c20 T A 9: 38,261,158 (GRCm39) S260T probably benign Het
Pakap C A 4: 57,637,876 (GRCm39) P18Q probably null Het
Pcdha2 T C 18: 37,072,915 (GRCm39) V182A probably benign Het
Phactr3 A G 2: 177,784,254 (GRCm39) D26G probably benign Het
Phrf1 G A 7: 140,820,850 (GRCm39) R159H probably damaging Het
R3hdm4 C T 10: 79,748,292 (GRCm39) E162K possibly damaging Het
Rab3ip T C 10: 116,754,753 (GRCm39) T268A probably benign Het
Rapgef3 T C 15: 97,656,742 (GRCm39) D299G probably damaging Het
Rem1 A G 2: 152,469,977 (GRCm39) probably null Het
Slc28a2b A G 2: 122,317,350 (GRCm39) N36S probably benign Het
Syne1 A G 10: 5,293,473 (GRCm39) M1286T probably benign Het
Thsd7a T C 6: 12,748,799 (GRCm39) T52A probably benign Het
Tmem135 A T 7: 88,793,872 (GRCm39) F390Y probably damaging Het
Trio T C 15: 27,856,280 (GRCm39) D696G probably benign Het
Ttll11 T C 2: 35,793,135 (GRCm39) *191W probably null Het
Ubr4 A G 4: 139,135,083 (GRCm39) D805G probably damaging Het
Usp9y A G Y: 1,336,467 (GRCm39) I1469T possibly damaging Het
Vmn2r78 G T 7: 86,569,330 (GRCm39) L74F possibly damaging Het
Wdfy3 T C 5: 102,044,425 (GRCm39) E1860G probably benign Het
Other mutations in Vmn1r70
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL03092:Vmn1r70 APN 7 10,368,186 (GRCm39) missense probably benign 0.23
IGL03250:Vmn1r70 APN 7 10,368,208 (GRCm39) missense probably damaging 1.00
R0375:Vmn1r70 UTSW 7 10,367,987 (GRCm39) missense probably damaging 1.00
R0482:Vmn1r70 UTSW 7 10,368,204 (GRCm39) missense probably damaging 1.00
R0497:Vmn1r70 UTSW 7 10,367,953 (GRCm39) missense probably benign 0.19
R1964:Vmn1r70 UTSW 7 10,367,737 (GRCm39) missense possibly damaging 0.88
R2067:Vmn1r70 UTSW 7 10,368,264 (GRCm39) missense possibly damaging 0.61
R3807:Vmn1r70 UTSW 7 10,367,715 (GRCm39) missense probably benign 0.01
R4573:Vmn1r70 UTSW 7 10,367,556 (GRCm39) splice site probably null
R5070:Vmn1r70 UTSW 7 10,368,325 (GRCm39) missense probably benign 0.04
R5558:Vmn1r70 UTSW 7 10,368,402 (GRCm39) missense probably benign 0.01
R6036:Vmn1r70 UTSW 7 10,367,830 (GRCm39) missense probably damaging 1.00
R6036:Vmn1r70 UTSW 7 10,367,830 (GRCm39) missense probably damaging 1.00
R6189:Vmn1r70 UTSW 7 10,367,598 (GRCm39) missense probably benign 0.04
R6976:Vmn1r70 UTSW 7 10,367,971 (GRCm39) missense probably benign 0.02
R7571:Vmn1r70 UTSW 7 10,367,871 (GRCm39) missense probably benign 0.00
R9236:Vmn1r70 UTSW 7 10,368,016 (GRCm39) missense probably damaging 1.00
R9568:Vmn1r70 UTSW 7 10,368,292 (GRCm39) missense probably benign 0.03
R9673:Vmn1r70 UTSW 7 10,368,364 (GRCm39) missense probably damaging 1.00
X0020:Vmn1r70 UTSW 7 10,367,517 (GRCm39) missense probably benign
Predicted Primers PCR Primer
(F):5'- CTCTGCAAAGGAATCCCTCAG -3'
(R):5'- ACATATAGCATCACTGAAGGCC -3'

Sequencing Primer
(F):5'- CCTCAGACAATGACTGCATTTGG -3'
(R):5'- CACTGAAGGCCAATATGATTGC -3'
Posted On 2016-09-01