Incidental Mutation 'R5444:Or10ak11'
ID 427323
Institutional Source Beutler Lab
Gene Symbol Or10ak11
Ensembl Gene ENSMUSG00000110947
Gene Name olfactory receptor family 10 subfamily AK member 11
Synonyms Olfr1333, MOR259-6, MOR259-11, GA_x6K02T2QD9B-18703033-18703986
MMRRC Submission 043009-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.089) question?
Stock # R5444 (G1)
Quality Score 225
Status Validated
Chromosome 4
Chromosomal Location 118827659-118836279 bp(-) (GRCm38)
Type of Mutation missense
DNA Base Change (assembly) T to A at 118830111 bp (GRCm38)
Zygosity Heterozygous
Amino Acid Change Isoleucine to Leucine at position 109 (I109L)
Ref Sequence ENSEMBL: ENSMUSP00000154759 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000076019] [ENSMUST00000106361] [ENSMUST00000214477]
AlphaFold Q7TQV7
Predicted Effect probably benign
Transcript: ENSMUST00000076019
AA Change: I110L

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
SMART Domains Protein: ENSMUSP00000075398
Gene: ENSMUSG00000110947
AA Change: I110L

DomainStartEndE-ValueType
Pfam:7tm_1 42 291 4.1e-31 PFAM
Pfam:7tm_4 140 284 2.9e-46 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000106361
AA Change: I111L

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
SMART Domains Protein: ENSMUSP00000101968
Gene: ENSMUSG00000073768
AA Change: I111L

DomainStartEndE-ValueType
Pfam:7tm_4 33 309 6.1e-56 PFAM
Pfam:7tm_1 43 292 3.9e-25 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000214477
AA Change: I109L

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
Predicted Effect probably benign
Transcript: ENSMUST00000214477
AA Change: I109L

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
Meta Mutation Damage Score 0.0898 question?
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.6%
  • 10x: 97.1%
  • 20x: 95.1%
Validation Efficiency 99% (66/67)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 60 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4930584F24Rik A G 5: 26,479,737 (GRCm38) noncoding transcript Het
Adam11 A G 11: 102,772,848 (GRCm38) Q284R probably damaging Het
Adamts17 T A 7: 67,041,899 (GRCm38) H610Q probably benign Het
Alg6 A G 4: 99,741,579 (GRCm38) Y131C probably benign Het
Apol9b T C 15: 77,735,763 (GRCm38) I253T probably damaging Het
Asb4 T A 6: 5,431,040 (GRCm38) I425N probably damaging Het
Atic T C 1: 71,576,717 (GRCm38) L474P probably damaging Het
B3glct C T 5: 149,746,520 (GRCm38) T318I probably damaging Het
Bbs7 T C 3: 36,612,050 (GRCm38) K22E possibly damaging Het
BC037034 A T 5: 138,260,998 (GRCm38) probably null Het
Cdk17 T G 10: 93,217,961 (GRCm38) probably null Het
Cemip T A 7: 83,982,291 (GRCm38) T438S probably damaging Het
Chd2 T C 7: 73,473,085 (GRCm38) E967G probably damaging Het
Cyp2d26 G T 15: 82,792,538 (GRCm38) D202E probably benign Het
Dhdds G A 4: 133,971,136 (GRCm38) R295* probably null Het
Eef2kmt G A 16: 5,249,095 (GRCm38) probably benign Het
Fn3krp G A 11: 121,421,604 (GRCm38) probably null Het
Gjc3 G A 5: 137,957,547 (GRCm38) L159F probably damaging Het
Gm28434 T C 5: 87,979,288 (GRCm38) probably benign Het
Gp2 G A 7: 119,454,598 (GRCm38) P47S possibly damaging Het
Irf7 C T 7: 141,264,819 (GRCm38) probably benign Het
Itgb8 T C 12: 119,237,838 (GRCm38) probably benign Het
Kcnb2 A T 1: 15,711,492 (GRCm38) I863F probably benign Het
Lamb1 T C 12: 31,298,909 (GRCm38) F647L possibly damaging Het
Mccc1 T A 3: 35,976,742 (GRCm38) M392L probably benign Het
Mtmr10 T C 7: 64,288,401 (GRCm38) probably null Het
Ncstn A C 1: 172,072,839 (GRCm38) V223G possibly damaging Het
Neurl3 G T 1: 36,269,490 (GRCm38) F80L probably damaging Het
Nf1 T C 11: 79,443,959 (GRCm38) M869T possibly damaging Het
Nfatc2 A G 2: 168,534,890 (GRCm38) probably benign Het
Nnat T C 2: 157,561,217 (GRCm38) F26S possibly damaging Het
Nos1ap T C 1: 170,375,251 (GRCm38) Y109C probably damaging Het
Nup205 T A 6: 35,189,189 (GRCm38) D194E probably damaging Het
Or3a4 T C 11: 74,053,977 (GRCm38) S261G probably benign Het
Or52k2 C T 7: 102,604,869 (GRCm38) R172* probably null Het
Or5b109 A T 19: 13,234,958 (GRCm38) Q236L probably benign Het
Or9g3 A T 2: 85,759,919 (GRCm38) F152L probably benign Het
Ostf1 A G 19: 18,581,313 (GRCm38) L202S probably benign Het
Pdzrn4 T A 15: 92,770,925 (GRCm38) M747K probably damaging Het
Plxnb1 A G 9: 109,106,453 (GRCm38) D1019G probably benign Het
Pnlip A G 19: 58,673,163 (GRCm38) I95V probably benign Het
Polr3a T C 14: 24,454,941 (GRCm38) I1084V possibly damaging Het
Ppp1r13b T A 12: 111,838,688 (GRCm38) T197S probably benign Het
Rasgrp3 A T 17: 75,503,375 (GRCm38) I357F probably damaging Het
Rbmxl2 G C 7: 107,209,837 (GRCm38) G110R probably damaging Het
Relch C T 1: 105,726,384 (GRCm38) T826I possibly damaging Het
Rgs22 T C 15: 36,015,627 (GRCm38) D1037G possibly damaging Het
Rnf215 A G 11: 4,135,843 (GRCm38) I107M probably benign Het
Rybp A T 6: 100,287,270 (GRCm38) M3K probably damaging Het
Sgo2b T C 8: 63,926,556 (GRCm38) S1081G possibly damaging Het
Slfn10-ps C T 11: 83,035,287 (GRCm38) noncoding transcript Het
Spag17 T C 3: 100,056,152 (GRCm38) V1062A probably benign Het
Sult2a1 A T 7: 13,836,019 (GRCm38) I96K possibly damaging Het
Tbc1d5 A G 17: 50,735,967 (GRCm38) I831T probably damaging Het
Thbs3 T C 3: 89,223,385 (GRCm38) probably benign Het
Tmub2 T C 11: 102,288,240 (GRCm38) L255S possibly damaging Het
Trank1 T A 9: 111,392,958 (GRCm38) L2921Q probably benign Het
Tuba8 A T 6: 121,226,101 (GRCm38) probably benign Het
Vmn2r25 T C 6: 123,828,492 (GRCm38) I469V probably benign Het
Zfp1007 A T 5: 109,675,636 (GRCm38) Y649* probably null Het
Other mutations in Or10ak11
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01088:Or10ak11 APN 4 118,829,792 (GRCm38) missense probably benign 0.30
IGL03023:Or10ak11 APN 4 118,830,252 (GRCm38) missense probably damaging 0.99
IGL03387:Or10ak11 APN 4 118,830,041 (GRCm38) missense probably damaging 1.00
R0326:Or10ak11 UTSW 4 118,829,825 (GRCm38) missense possibly damaging 0.90
R0532:Or10ak11 UTSW 4 118,829,700 (GRCm38) missense probably damaging 1.00
R1775:Or10ak11 UTSW 4 118,829,868 (GRCm38) missense probably benign 0.00
R1906:Or10ak11 UTSW 4 118,830,270 (GRCm38) missense probably damaging 1.00
R1946:Or10ak11 UTSW 4 118,830,026 (GRCm38) missense probably benign 0.00
R2260:Or10ak11 UTSW 4 118,830,162 (GRCm38) missense probably damaging 1.00
R5084:Or10ak11 UTSW 4 118,829,570 (GRCm38) missense probably damaging 1.00
R5337:Or10ak11 UTSW 4 118,829,666 (GRCm38) missense probably benign 0.44
R5817:Or10ak11 UTSW 4 118,830,099 (GRCm38) missense probably damaging 0.96
R5973:Or10ak11 UTSW 4 118,830,216 (GRCm38) missense probably benign 0.22
R5987:Or10ak11 UTSW 4 118,830,281 (GRCm38) missense probably damaging 0.96
R6031:Or10ak11 UTSW 4 118,830,391 (GRCm38) splice site probably null
R6031:Or10ak11 UTSW 4 118,830,391 (GRCm38) splice site probably null
R7255:Or10ak11 UTSW 4 118,829,952 (GRCm38) missense probably benign 0.17
R7483:Or10ak11 UTSW 4 118,830,320 (GRCm38) missense probably damaging 0.98
R8214:Or10ak11 UTSW 4 118,830,091 (GRCm38) missense probably benign
R8479:Or10ak11 UTSW 4 118,830,015 (GRCm38) missense probably damaging 1.00
R8847:Or10ak11 UTSW 4 118,829,624 (GRCm38) missense probably damaging 0.97
R9661:Or10ak11 UTSW 4 118,830,329 (GRCm38) missense probably benign 0.45
Z1176:Or10ak11 UTSW 4 118,830,050 (GRCm38) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- CAAGTAGTGGTTGACCCTGTTG -3'
(R):5'- ATCATCATGCTGGTCTGCCTG -3'

Sequencing Primer
(F):5'- CCACAATATGGCAGACTCATGGTG -3'
(R):5'- TGGTCTGCCTGGACACACAG -3'
Posted On 2016-09-01