Incidental Mutation 'R5445:Ifi207'
ID 427376
Institutional Source Beutler Lab
Gene Symbol Ifi207
Ensembl Gene ENSMUSG00000073490
Gene Name interferon activated gene 207
Synonyms AI607873, Pyhin-A
MMRRC Submission 043010-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.086) question?
Stock # R5445 (G1)
Quality Score 225
Status Not validated
Chromosome 1
Chromosomal Location 173550993-173569313 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 173555363 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Glutamic Acid to Glycine at position 773 (E773G)
Ref Sequence ENSEMBL: ENSMUSP00000119350 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000042610] [ENSMUST00000127730]
AlphaFold E9Q3L4
Predicted Effect probably damaging
Transcript: ENSMUST00000042610
AA Change: E780G

PolyPhen 2 Score 0.987 (Sensitivity: 0.73; Specificity: 0.96)
SMART Domains Protein: ENSMUSP00000048129
Gene: ENSMUSG00000073490
AA Change: E780G

DomainStartEndE-ValueType
PYRIN 6 84 3.2e-15 SMART
low complexity region 121 133 N/A INTRINSIC
low complexity region 136 162 N/A INTRINSIC
low complexity region 207 215 N/A INTRINSIC
internal_repeat_1 286 472 4.17e-7 PROSPERO
low complexity region 476 496 N/A INTRINSIC
internal_repeat_1 565 782 4.17e-7 PROSPERO
Pfam:HIN 788 954 4.9e-76 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000127730
AA Change: E773G

PolyPhen 2 Score 0.987 (Sensitivity: 0.73; Specificity: 0.96)
SMART Domains Protein: ENSMUSP00000119350
Gene: ENSMUSG00000073490
AA Change: E773G

DomainStartEndE-ValueType
PYRIN 6 84 3.2e-15 SMART
low complexity region 121 133 N/A INTRINSIC
low complexity region 136 155 N/A INTRINSIC
low complexity region 200 208 N/A INTRINSIC
internal_repeat_1 279 465 6.41e-7 PROSPERO
low complexity region 469 489 N/A INTRINSIC
internal_repeat_1 558 775 6.41e-7 PROSPERO
Pfam:HIN 781 948 1.8e-78 PFAM
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.5%
  • 10x: 96.9%
  • 20x: 94.3%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 64 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abcg5 A T 17: 84,978,557 (GRCm39) D300E probably damaging Het
Apbb1ip T C 2: 22,725,960 (GRCm39) V244A possibly damaging Het
Arhgap32 T C 9: 32,159,678 (GRCm39) S232P probably benign Het
Atf7ip G A 6: 136,564,255 (GRCm39) V833M probably damaging Het
Casp7 A G 19: 56,421,770 (GRCm39) probably null Het
Ccdc9b T C 2: 118,590,067 (GRCm39) D259G probably damaging Het
Celsr2 T A 3: 108,299,974 (GRCm39) E2911D probably benign Het
Cep350 T C 1: 155,770,469 (GRCm39) D1807G probably benign Het
Cfap251 C T 5: 123,425,240 (GRCm39) T294M probably damaging Het
Chrd A G 16: 20,557,660 (GRCm39) T753A possibly damaging Het
Clasp2 A G 9: 113,733,014 (GRCm39) D971G probably damaging Het
Cnnm2 A G 19: 46,865,727 (GRCm39) T772A possibly damaging Het
Cntn1 A T 15: 92,192,958 (GRCm39) N687Y probably damaging Het
Col6a3 G A 1: 90,709,761 (GRCm39) R1812* probably null Het
Dsc2 T C 18: 20,168,360 (GRCm39) I700V possibly damaging Het
Flt3 G A 5: 147,291,905 (GRCm39) Q540* probably null Het
Fmo4 T A 1: 162,632,842 (GRCm39) I170F probably benign Het
Fra10ac1 T A 19: 38,207,910 (GRCm39) D72V possibly damaging Het
Garin2 G A 12: 78,761,890 (GRCm39) E185K probably damaging Het
Gemin6 T G 17: 80,535,178 (GRCm39) V46G probably damaging Het
Gm2381 T G 7: 42,469,425 (GRCm39) H233P probably damaging Het
Gm5148 T A 3: 37,768,995 (GRCm39) Q75L probably damaging Het
Gm8369 T C 19: 11,482,170 (GRCm39) V27A possibly damaging Het
Gpr157 T C 4: 150,186,825 (GRCm39) S318P probably benign Het
Hectd4 G A 5: 121,404,337 (GRCm39) V405M probably benign Het
Hemgn T C 4: 46,400,738 (GRCm39) R41G probably benign Het
Hhipl1 T A 12: 108,294,467 (GRCm39) L791Q probably damaging Het
Hjurp T G 1: 88,194,038 (GRCm39) K290T probably benign Het
Kcnh6 T C 11: 105,914,685 (GRCm39) Y697H probably damaging Het
Lonrf2 T C 1: 38,846,234 (GRCm39) T313A probably benign Het
Lrba G T 3: 86,275,902 (GRCm39) V1757L probably benign Het
Lrrc24 T C 15: 76,600,306 (GRCm39) T278A probably benign Het
Ltbp2 T C 12: 84,856,428 (GRCm39) I679V probably null Het
Mapk4 G T 18: 74,064,073 (GRCm39) T383K probably benign Het
Mdn1 C T 4: 32,723,690 (GRCm39) P2542L probably damaging Het
Mia3 A G 1: 183,117,471 (GRCm39) V208A probably benign Het
Myo15a C A 11: 60,411,603 (GRCm39) C3234* probably null Het
Nlrp1b G T 11: 71,108,701 (GRCm39) Q267K probably benign Het
Nphp3 A G 9: 103,881,922 (GRCm39) K37E probably damaging Het
Nwd2 T C 5: 63,962,681 (GRCm39) M755T probably damaging Het
Or10u4 T A 10: 129,802,158 (GRCm39) H137L probably benign Het
Or52ac1 A G 7: 104,246,028 (GRCm39) F120S probably damaging Het
Or5p58 A G 7: 107,693,949 (GRCm39) V276A possibly damaging Het
Pdlim5 C T 3: 142,058,495 (GRCm39) R83K probably null Het
Plekha5 A T 6: 140,498,459 (GRCm39) R173* probably null Het
Pramel25 T A 4: 143,521,707 (GRCm39) V441E possibly damaging Het
Rbms3 T A 9: 117,080,853 (GRCm39) D6V possibly damaging Het
Rhoq A T 17: 87,271,755 (GRCm39) Y57F probably benign Het
Rrm1 A T 7: 102,100,230 (GRCm39) T204S possibly damaging Het
Slf1 A T 13: 77,239,323 (GRCm39) I447N probably benign Het
Smarcc2 T A 10: 128,323,943 (GRCm39) probably benign Het
Spdye4c C T 2: 128,438,484 (GRCm39) Q281* probably null Het
Tert T A 13: 73,792,403 (GRCm39) M890K probably benign Het
Tln1 C A 4: 43,543,905 (GRCm39) R1198L probably benign Het
Tmco4 A G 4: 138,748,178 (GRCm39) M253V probably damaging Het
Usp19 G T 9: 108,375,119 (GRCm39) V782F possibly damaging Het
Usp33 T A 3: 152,080,260 (GRCm39) S464T probably damaging Het
Usp47 A T 7: 111,673,928 (GRCm39) Y397F probably damaging Het
Vmn1r12 A G 6: 57,136,466 (GRCm39) T144A probably benign Het
Vmn2r90 A T 17: 17,954,386 (GRCm39) H850L probably benign Het
Zfhx3 A T 8: 109,682,842 (GRCm39) Q3427L unknown Het
Zfp236 G T 18: 82,700,281 (GRCm39) Q63K probably benign Het
Zfp7 T A 15: 76,775,054 (GRCm39) C365* probably null Het
Zfp786 T C 6: 47,796,619 (GRCm39) E773G probably damaging Het
Other mutations in Ifi207
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01776:Ifi207 APN 1 173,552,610 (GRCm39) missense probably damaging 1.00
IGL01864:Ifi207 APN 1 173,564,007 (GRCm39) missense possibly damaging 0.72
IGL02293:Ifi207 APN 1 173,551,314 (GRCm39) missense probably damaging 1.00
IGL02402:Ifi207 APN 1 173,555,159 (GRCm39) missense probably damaging 1.00
IGL03160:Ifi207 APN 1 173,562,670 (GRCm39) splice site probably benign
PIT4458001:Ifi207 UTSW 1 173,562,738 (GRCm39) missense unknown
R0043:Ifi207 UTSW 1 173,556,678 (GRCm39) missense possibly damaging 0.48
R0212:Ifi207 UTSW 1 173,563,964 (GRCm39) missense possibly damaging 0.85
R0395:Ifi207 UTSW 1 173,557,431 (GRCm39) missense possibly damaging 0.85
R0506:Ifi207 UTSW 1 173,563,878 (GRCm39) missense possibly damaging 0.52
R0843:Ifi207 UTSW 1 173,555,143 (GRCm39) missense probably damaging 1.00
R1302:Ifi207 UTSW 1 173,562,861 (GRCm39) missense possibly damaging 0.96
R1373:Ifi207 UTSW 1 173,557,913 (GRCm39) missense unknown
R1462:Ifi207 UTSW 1 173,552,513 (GRCm39) missense probably damaging 1.00
R1462:Ifi207 UTSW 1 173,552,513 (GRCm39) missense probably damaging 1.00
R1471:Ifi207 UTSW 1 173,557,629 (GRCm39) missense unknown
R1502:Ifi207 UTSW 1 173,556,872 (GRCm39) missense possibly damaging 0.56
R1533:Ifi207 UTSW 1 173,555,306 (GRCm39) missense probably benign 0.30
R1831:Ifi207 UTSW 1 173,559,992 (GRCm39) missense unknown
R1928:Ifi207 UTSW 1 173,557,211 (GRCm39) missense possibly damaging 0.68
R1982:Ifi207 UTSW 1 173,562,805 (GRCm39) missense probably benign 0.01
R2132:Ifi207 UTSW 1 173,557,337 (GRCm39) missense possibly damaging 0.84
R2248:Ifi207 UTSW 1 173,564,036 (GRCm39) splice site probably benign
R3703:Ifi207 UTSW 1 173,555,029 (GRCm39) nonsense probably null
R3741:Ifi207 UTSW 1 173,555,128 (GRCm39) missense probably damaging 1.00
R3846:Ifi207 UTSW 1 173,562,869 (GRCm39) missense probably benign 0.33
R4747:Ifi207 UTSW 1 173,556,633 (GRCm39) missense probably benign 0.00
R4772:Ifi207 UTSW 1 173,555,253 (GRCm39) missense probably damaging 1.00
R4776:Ifi207 UTSW 1 173,557,622 (GRCm39) missense unknown
R4855:Ifi207 UTSW 1 173,557,381 (GRCm39) missense probably damaging 0.96
R5170:Ifi207 UTSW 1 173,558,064 (GRCm39) missense unknown
R5244:Ifi207 UTSW 1 173,557,503 (GRCm39) missense probably benign 0.04
R5280:Ifi207 UTSW 1 173,557,870 (GRCm39) missense unknown
R5301:Ifi207 UTSW 1 173,556,977 (GRCm39) missense possibly damaging 0.83
R5334:Ifi207 UTSW 1 173,555,097 (GRCm39) missense probably benign 0.21
R5691:Ifi207 UTSW 1 173,559,992 (GRCm39) missense unknown
R5838:Ifi207 UTSW 1 173,559,953 (GRCm39) missense unknown
R6060:Ifi207 UTSW 1 173,558,093 (GRCm39) missense unknown
R6220:Ifi207 UTSW 1 173,557,112 (GRCm39) missense probably damaging 0.99
R6264:Ifi207 UTSW 1 173,555,111 (GRCm39) missense probably damaging 1.00
R6307:Ifi207 UTSW 1 173,552,619 (GRCm39) missense probably damaging 1.00
R6326:Ifi207 UTSW 1 173,557,532 (GRCm39) missense probably benign 0.01
R6394:Ifi207 UTSW 1 173,556,581 (GRCm39) missense probably benign 0.43
R6532:Ifi207 UTSW 1 173,557,211 (GRCm39) missense possibly damaging 0.68
R6660:Ifi207 UTSW 1 173,556,972 (GRCm39) missense probably benign 0.01
R6893:Ifi207 UTSW 1 173,555,208 (GRCm39) missense possibly damaging 0.95
R7190:Ifi207 UTSW 1 173,557,818 (GRCm39) missense unknown
R7192:Ifi207 UTSW 1 173,556,584 (GRCm39) missense not run
R7194:Ifi207 UTSW 1 173,557,490 (GRCm39) missense possibly damaging 0.84
R7327:Ifi207 UTSW 1 173,556,581 (GRCm39) missense probably benign 0.43
R7348:Ifi207 UTSW 1 173,556,762 (GRCm39) small deletion probably benign
R7404:Ifi207 UTSW 1 173,556,494 (GRCm39) missense possibly damaging 0.92
R7442:Ifi207 UTSW 1 173,554,997 (GRCm39) missense probably benign 0.03
R7784:Ifi207 UTSW 1 173,557,698 (GRCm39) missense unknown
R8041:Ifi207 UTSW 1 173,555,268 (GRCm39) missense possibly damaging 0.78
R8116:Ifi207 UTSW 1 173,557,746 (GRCm39) missense unknown
R8166:Ifi207 UTSW 1 173,557,504 (GRCm39) missense probably benign 0.10
R8166:Ifi207 UTSW 1 173,557,166 (GRCm39) missense possibly damaging 0.95
R8168:Ifi207 UTSW 1 173,557,504 (GRCm39) missense probably benign 0.10
R8383:Ifi207 UTSW 1 173,556,770 (GRCm39) small deletion probably benign
R8388:Ifi207 UTSW 1 173,557,016 (GRCm39) frame shift probably null
R8389:Ifi207 UTSW 1 173,557,016 (GRCm39) frame shift probably null
R8390:Ifi207 UTSW 1 173,557,016 (GRCm39) frame shift probably null
R8399:Ifi207 UTSW 1 173,557,844 (GRCm39) missense unknown
R8431:Ifi207 UTSW 1 173,558,070 (GRCm39) missense unknown
R8474:Ifi207 UTSW 1 173,556,605 (GRCm39) missense possibly damaging 0.63
R8505:Ifi207 UTSW 1 173,557,016 (GRCm39) frame shift probably null
R9009:Ifi207 UTSW 1 173,555,382 (GRCm39) missense probably damaging 0.97
R9061:Ifi207 UTSW 1 173,564,153 (GRCm39) intron probably benign
R9071:Ifi207 UTSW 1 173,557,764 (GRCm39) missense unknown
R9090:Ifi207 UTSW 1 173,556,762 (GRCm39) small deletion probably benign
R9323:Ifi207 UTSW 1 173,555,143 (GRCm39) missense probably damaging 1.00
R9407:Ifi207 UTSW 1 173,555,234 (GRCm39) missense probably damaging 1.00
R9493:Ifi207 UTSW 1 173,556,522 (GRCm39) missense probably benign 0.00
R9629:Ifi207 UTSW 1 173,556,561 (GRCm39) small deletion probably benign
RF009:Ifi207 UTSW 1 173,556,558 (GRCm39) missense probably benign 0.00
RF011:Ifi207 UTSW 1 173,556,687 (GRCm39) missense not run
RF032:Ifi207 UTSW 1 173,562,723 (GRCm39) small deletion probably benign
X0003:Ifi207 UTSW 1 173,556,548 (GRCm39) missense probably damaging 0.98
X0004:Ifi207 UTSW 1 173,556,548 (GRCm39) missense probably damaging 0.98
X0005:Ifi207 UTSW 1 173,556,548 (GRCm39) missense probably damaging 0.98
X0009:Ifi207 UTSW 1 173,556,548 (GRCm39) missense probably damaging 0.98
X0010:Ifi207 UTSW 1 173,556,548 (GRCm39) missense probably damaging 0.98
X0011:Ifi207 UTSW 1 173,556,548 (GRCm39) missense probably damaging 0.98
X0012:Ifi207 UTSW 1 173,556,548 (GRCm39) missense probably damaging 0.98
X0013:Ifi207 UTSW 1 173,556,548 (GRCm39) missense probably damaging 0.98
X0014:Ifi207 UTSW 1 173,556,548 (GRCm39) missense probably damaging 0.98
X0017:Ifi207 UTSW 1 173,556,548 (GRCm39) missense probably damaging 0.98
X0018:Ifi207 UTSW 1 173,556,548 (GRCm39) missense probably damaging 0.98
X0019:Ifi207 UTSW 1 173,556,548 (GRCm39) missense probably damaging 0.98
X0020:Ifi207 UTSW 1 173,556,548 (GRCm39) missense probably damaging 0.98
X0021:Ifi207 UTSW 1 173,556,548 (GRCm39) missense probably damaging 0.98
X0022:Ifi207 UTSW 1 173,556,548 (GRCm39) missense probably damaging 0.98
X0023:Ifi207 UTSW 1 173,556,548 (GRCm39) missense probably damaging 0.98
X0024:Ifi207 UTSW 1 173,556,548 (GRCm39) missense probably damaging 0.98
X0025:Ifi207 UTSW 1 173,556,548 (GRCm39) missense probably damaging 0.98
X0026:Ifi207 UTSW 1 173,556,548 (GRCm39) missense probably damaging 0.98
X0027:Ifi207 UTSW 1 173,556,548 (GRCm39) missense probably damaging 0.98
X0028:Ifi207 UTSW 1 173,556,548 (GRCm39) missense probably damaging 0.98
X0033:Ifi207 UTSW 1 173,556,548 (GRCm39) missense probably damaging 0.98
X0034:Ifi207 UTSW 1 173,556,548 (GRCm39) missense probably damaging 0.98
X0035:Ifi207 UTSW 1 173,556,548 (GRCm39) missense probably damaging 0.98
X0036:Ifi207 UTSW 1 173,556,548 (GRCm39) missense probably damaging 0.98
X0037:Ifi207 UTSW 1 173,556,548 (GRCm39) missense probably damaging 0.98
X0038:Ifi207 UTSW 1 173,556,548 (GRCm39) missense probably damaging 0.98
X0039:Ifi207 UTSW 1 173,556,548 (GRCm39) missense probably damaging 0.98
X0040:Ifi207 UTSW 1 173,556,548 (GRCm39) missense probably damaging 0.98
X0050:Ifi207 UTSW 1 173,556,548 (GRCm39) missense probably damaging 0.98
X0052:Ifi207 UTSW 1 173,556,548 (GRCm39) missense probably damaging 0.98
X0053:Ifi207 UTSW 1 173,556,548 (GRCm39) missense probably damaging 0.98
X0054:Ifi207 UTSW 1 173,556,548 (GRCm39) missense probably damaging 0.98
X0057:Ifi207 UTSW 1 173,556,548 (GRCm39) missense probably damaging 0.98
X0058:Ifi207 UTSW 1 173,556,548 (GRCm39) missense probably damaging 0.98
X0060:Ifi207 UTSW 1 173,556,548 (GRCm39) missense probably damaging 0.98
X0061:Ifi207 UTSW 1 173,556,548 (GRCm39) missense probably damaging 0.98
X0062:Ifi207 UTSW 1 173,556,548 (GRCm39) missense probably damaging 0.98
X0063:Ifi207 UTSW 1 173,556,548 (GRCm39) missense probably damaging 0.98
X0064:Ifi207 UTSW 1 173,556,548 (GRCm39) missense probably damaging 0.98
X0065:Ifi207 UTSW 1 173,556,548 (GRCm39) missense probably damaging 0.98
X0066:Ifi207 UTSW 1 173,556,548 (GRCm39) missense probably damaging 0.98
X0067:Ifi207 UTSW 1 173,556,548 (GRCm39) missense probably damaging 0.98
Z1177:Ifi207 UTSW 1 173,557,145 (GRCm39) missense probably damaging 1.00
Z1187:Ifi207 UTSW 1 173,558,093 (GRCm39) missense unknown
Z1192:Ifi207 UTSW 1 173,558,093 (GRCm39) missense unknown
Predicted Primers PCR Primer
(F):5'- CTTGGGATGAACTTGCTTATTAGAGC -3'
(R):5'- TAACTGGAATCACTAGGATGTGTTC -3'

Sequencing Primer
(F):5'- GAGCTGTGTCAAAAACCTTCACTCTG -3'
(R):5'- GCTTTTAGTATGGCAACCA -3'
Posted On 2016-09-01