Incidental Mutation 'R5412:Grk4'
ID 427526
Institutional Source Beutler Lab
Gene Symbol Grk4
Ensembl Gene ENSMUSG00000052783
Gene Name G protein-coupled receptor kinase 4
Synonyms Gprk2l, A830025H08Rik
MMRRC Submission 042981-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.148) question?
Stock # R5412 (G1)
Quality Score 225
Status Not validated
Chromosome 5
Chromosomal Location 34817723-34912649 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to T at 34902612 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Tyrosine to Phenylalanine at position 388 (Y388F)
Ref Sequence ENSEMBL: ENSMUSP00000001112 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000001112]
AlphaFold O70291
Predicted Effect probably benign
Transcript: ENSMUST00000001112
AA Change: Y388F

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
SMART Domains Protein: ENSMUSP00000001112
Gene: ENSMUSG00000052783
AA Change: Y388F

DomainStartEndE-ValueType
RGS 51 171 1.61e-31 SMART
S_TKc 186 448 7.78e-85 SMART
S_TK_X 449 528 2.98e-3 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000134217
Predicted Effect noncoding transcript
Transcript: ENSMUST00000153323
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.5%
  • 10x: 97.0%
  • 20x: 94.5%
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the guanine nucleotide-binding protein (G protein)-coupled receptor kinase subfamily of the Ser/Thr protein kinase family. The protein phosphorylates the activated forms of G protein-coupled receptors thus initiating its deactivation. This gene has been linked to both genetic and acquired hypertension. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2013]
PHENOTYPE: Mice heterozygous for a knock-out allele are viable, fertile and overtly normal. [provided by MGI curators]
Allele List at MGI

All alleles(4) : Targeted, knock-out(1) Targeted, other(1) Gene trapped(2)

Other mutations in this stock
Total: 55 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4930563M21Rik T A 9: 55,886,036 (GRCm39) N36Y probably damaging Het
Ankfn1 T A 11: 89,396,007 (GRCm39) E246D probably benign Het
Arid1a T C 4: 133,446,913 (GRCm39) probably benign Het
Bbs7 A T 3: 36,653,522 (GRCm39) D300E probably benign Het
C3 T C 17: 57,527,187 (GRCm39) D754G probably benign Het
Ccpg1 A T 9: 72,917,588 (GRCm39) Q240L probably damaging Het
Cdk13 G A 13: 17,941,115 (GRCm39) P650S probably damaging Het
Celsr2 G T 3: 108,307,311 (GRCm39) S1933Y probably damaging Het
Cep135 T A 5: 76,764,709 (GRCm39) H562Q probably benign Het
Cyp26a1 G T 19: 37,689,630 (GRCm39) C442F probably damaging Het
Dnah7a T C 1: 53,674,503 (GRCm39) S425G probably benign Het
Espn C T 4: 152,212,582 (GRCm39) V752M probably damaging Het
Glyr1 A G 16: 4,854,297 (GRCm39) S113P possibly damaging Het
H2-T15 C T 17: 36,366,936 (GRCm39) C369Y probably benign Het
Heca C A 10: 17,778,044 (GRCm39) V518F probably damaging Het
Hmcn2 C T 2: 31,236,629 (GRCm39) P391S possibly damaging Het
Hnrnpl A G 7: 28,510,529 (GRCm39) probably benign Het
Hsd3b2 A G 3: 98,619,208 (GRCm39) S246P possibly damaging Het
Ifna11 C T 4: 88,738,380 (GRCm39) P62L probably damaging Het
Katnal2 A T 18: 77,090,131 (GRCm39) V292D probably damaging Het
Krt16 T A 11: 100,137,593 (GRCm39) I371F probably damaging Het
Ly6g2 A T 15: 75,089,669 (GRCm39) E59V probably damaging Het
Map10 A T 8: 126,397,724 (GRCm39) L372F probably damaging Het
Megf10 A T 18: 57,324,219 (GRCm39) M87L probably damaging Het
Ncoa6 T C 2: 155,249,701 (GRCm39) H1201R possibly damaging Het
Ndc80 C A 17: 71,821,226 (GRCm39) D241Y probably damaging Het
Ndufs1 T C 1: 63,205,508 (GRCm39) M94V possibly damaging Het
Nkx2-6 G T 14: 69,412,195 (GRCm39) R121L probably damaging Het
Nos1ap T A 1: 170,176,968 (GRCm39) K145M probably damaging Het
Or6a2 A G 7: 106,600,842 (GRCm39) V75A probably damaging Het
Otop1 A G 5: 38,455,328 (GRCm39) I241V probably benign Het
Panx2 C A 15: 88,953,135 (GRCm39) P542H possibly damaging Het
Pcdha5 C A 18: 37,095,510 (GRCm39) P673Q probably benign Het
Pon1 A G 6: 5,185,314 (GRCm39) L62P probably damaging Het
Prdx6 A T 1: 161,071,860 (GRCm39) I102N probably damaging Het
Prkd3 T A 17: 79,262,140 (GRCm39) I725F possibly damaging Het
Selenon T C 4: 134,269,749 (GRCm39) N395S probably benign Het
Serpinb8 G A 1: 107,533,616 (GRCm39) E224K probably benign Het
Serpinb9b A G 13: 33,213,496 (GRCm39) M18V probably benign Het
Smc6 A G 12: 11,335,400 (GRCm39) E318G possibly damaging Het
Srrt A T 5: 137,294,549 (GRCm39) Y786N probably damaging Het
Stk36 G T 1: 74,644,615 (GRCm39) probably null Het
Stpg1 T A 4: 135,252,786 (GRCm39) L179Q possibly damaging Het
Stra8 G A 6: 34,907,885 (GRCm39) M1I probably null Het
Tiam1 G T 16: 89,681,753 (GRCm39) H408Q possibly damaging Het
Tm2d1 G A 4: 98,253,855 (GRCm39) T106I probably damaging Het
Tmem150b A C 7: 4,719,368 (GRCm39) I184S probably null Het
Vmn1r216 A G 13: 23,284,081 (GRCm39) I255V probably benign Het
Vps13b G A 15: 35,533,531 (GRCm39) A868T probably damaging Het
Wdr81 C T 11: 75,341,620 (GRCm39) D1216N probably null Het
Zfp26 T C 9: 20,349,535 (GRCm39) Y343C possibly damaging Het
Zfp276 A T 8: 123,982,520 (GRCm39) I95F probably damaging Het
Zfp330 T C 8: 83,490,865 (GRCm39) E315G probably benign Het
Zfp683 C A 4: 133,781,862 (GRCm39) P56Q probably damaging Het
Zpld1 T A 16: 55,052,646 (GRCm39) S323C possibly damaging Het
Other mutations in Grk4
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00509:Grk4 APN 5 34,873,634 (GRCm39) missense probably damaging 0.99
IGL00574:Grk4 APN 5 34,852,162 (GRCm39) missense probably benign 0.00
IGL02127:Grk4 APN 5 34,867,530 (GRCm39) missense probably benign 0.00
IGL02191:Grk4 APN 5 34,912,533 (GRCm39) missense probably benign 0.27
IGL02227:Grk4 APN 5 34,852,126 (GRCm39) missense probably benign 0.06
IGL03152:Grk4 APN 5 34,902,701 (GRCm39) missense probably damaging 1.00
IGL03214:Grk4 APN 5 34,909,553 (GRCm39) missense probably benign
F5426:Grk4 UTSW 5 34,902,503 (GRCm39) splice site probably benign
R0110:Grk4 UTSW 5 34,873,557 (GRCm39) missense probably damaging 0.97
R0469:Grk4 UTSW 5 34,873,557 (GRCm39) missense probably damaging 0.97
R0671:Grk4 UTSW 5 34,905,611 (GRCm39) missense probably benign 0.04
R1466:Grk4 UTSW 5 34,852,094 (GRCm39) missense probably benign 0.02
R1466:Grk4 UTSW 5 34,852,094 (GRCm39) missense probably benign 0.02
R1584:Grk4 UTSW 5 34,852,094 (GRCm39) missense probably benign 0.02
R1605:Grk4 UTSW 5 34,831,901 (GRCm39) missense probably damaging 0.98
R1607:Grk4 UTSW 5 34,888,882 (GRCm39) missense probably benign 0.01
R1903:Grk4 UTSW 5 34,833,531 (GRCm39) splice site probably null
R2352:Grk4 UTSW 5 34,826,520 (GRCm39) missense probably benign 0.04
R4561:Grk4 UTSW 5 34,852,157 (GRCm39) missense probably benign 0.00
R4580:Grk4 UTSW 5 34,818,325 (GRCm39) missense probably damaging 1.00
R4807:Grk4 UTSW 5 34,909,552 (GRCm39) missense probably benign
R5905:Grk4 UTSW 5 34,869,074 (GRCm39) missense probably damaging 1.00
R6360:Grk4 UTSW 5 34,831,881 (GRCm39) missense probably damaging 1.00
R6604:Grk4 UTSW 5 34,877,208 (GRCm39) missense probably damaging 1.00
R6865:Grk4 UTSW 5 34,888,894 (GRCm39) missense probably damaging 1.00
R7265:Grk4 UTSW 5 34,873,608 (GRCm39) missense probably damaging 0.96
R7394:Grk4 UTSW 5 34,908,962 (GRCm39) missense probably benign
R7718:Grk4 UTSW 5 34,852,160 (GRCm39) missense probably benign
R7821:Grk4 UTSW 5 34,867,553 (GRCm39) missense probably damaging 1.00
R8074:Grk4 UTSW 5 34,833,482 (GRCm39) missense probably benign 0.30
R8218:Grk4 UTSW 5 34,826,540 (GRCm39) missense probably benign 0.01
R8499:Grk4 UTSW 5 34,902,690 (GRCm39) missense possibly damaging 0.90
R9026:Grk4 UTSW 5 34,877,084 (GRCm39) missense probably damaging 1.00
R9068:Grk4 UTSW 5 34,905,653 (GRCm39) missense
X0064:Grk4 UTSW 5 34,877,228 (GRCm39) missense possibly damaging 0.76
Predicted Primers PCR Primer
(F):5'- TGCATCATTACTGCCTGGCTG -3'
(R):5'- CTTCTGAACCATCAAAAGAGAGG -3'

Sequencing Primer
(F):5'- CTGCCTGGCTGTGATTTTTAAAAAC -3'
(R):5'- GAGGTGAATTAAATGCTTCCCTGCC -3'
Posted On 2016-09-01