Incidental Mutation 'R5413:Wnt3a'
ID 427605
Institutional Source Beutler Lab
Gene Symbol Wnt3a
Ensembl Gene ENSMUSG00000009900
Gene Name wingless-type MMTV integration site family, member 3A
Synonyms Wnt-3a
MMRRC Submission 042982-MU
Accession Numbers
Essential gene? Essential (E-score: 1.000) question?
Stock # R5413 (G1)
Quality Score 225
Status Not validated
Chromosome 11
Chromosomal Location 59138859-59181578 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 59166182 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Serine to Proline at position 33 (S33P)
Ref Sequence ENSEMBL: ENSMUSP00000010044 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000010044]
AlphaFold P27467
Predicted Effect probably benign
Transcript: ENSMUST00000010044
AA Change: S33P

PolyPhen 2 Score 0.041 (Sensitivity: 0.94; Specificity: 0.83)
SMART Domains Protein: ENSMUSP00000010044
Gene: ENSMUSG00000009900
AA Change: S33P

DomainStartEndE-ValueType
signal peptide 1 18 N/A INTRINSIC
WNT1 44 352 9.57e-218 SMART
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.6%
  • 10x: 97.2%
  • 20x: 95.2%
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family. It encodes a protein which shows 96% amino acid identity to mouse Wnt3A protein, and 84% to human WNT3 protein, another WNT gene product. This gene is clustered with WNT14 gene, another family member, in chromosome 1q42 region. [provided by RefSeq, Jul 2008]
PHENOTYPE: Homozygous null mutants die at embryonic day 10.5-12.5 with failed development of caudal somites, notochord and structures rostral to hindlimbs. Homozygotes for a hypomorphic allele have vertebral defects and a short tail due to loss of caudal vertebrae. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 42 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
9930111J21Rik2 T A 11: 48,911,204 (GRCm39) T410S possibly damaging Het
Adamts3 A G 5: 89,856,626 (GRCm39) S316P probably damaging Het
Angptl3 A T 4: 98,919,259 (GRCm39) L6F probably benign Het
Clint1 T C 11: 45,777,307 (GRCm39) V98A probably damaging Het
Clk2 A G 3: 89,080,785 (GRCm39) N258S probably benign Het
Col18a1 T C 10: 76,905,310 (GRCm39) D723G probably damaging Het
Csmd3 A T 15: 47,701,831 (GRCm39) W1751R probably damaging Het
Daam1 C A 12: 71,993,066 (GRCm39) L352M unknown Het
Dennd2a A T 6: 39,441,227 (GRCm39) F964I probably damaging Het
Dock5 A G 14: 68,002,104 (GRCm39) L1622P probably damaging Het
Dpy19l4 A G 4: 11,289,700 (GRCm39) L195P probably damaging Het
Esp24 A C 17: 39,350,893 (GRCm39) E31A possibly damaging Het
Fars2 T A 13: 36,388,545 (GRCm39) Y11* probably null Het
Fbxl16 C A 17: 26,035,817 (GRCm39) T138K possibly damaging Het
Frmpd1 A G 4: 45,249,196 (GRCm39) I129V probably benign Het
Gria1 A G 11: 57,108,620 (GRCm39) N241S probably benign Het
Homer1 A G 13: 93,528,287 (GRCm39) E274G probably benign Het
Igdcc3 T C 9: 65,084,797 (GRCm39) V189A possibly damaging Het
Igkv12-98 A G 6: 68,548,078 (GRCm39) Y68C possibly damaging Het
Igkv3-3 G C 6: 70,664,414 (GRCm39) R85S probably damaging Het
Ldha A G 7: 46,500,320 (GRCm39) T144A possibly damaging Het
Lrp1 A G 10: 127,423,936 (GRCm39) probably null Het
Myh9 A T 15: 77,692,186 (GRCm39) Y124* probably null Het
Or14c44 A G 7: 86,061,675 (GRCm39) Y35C probably benign Het
Or2n1d G T 17: 38,646,515 (GRCm39) A156S probably benign Het
Or2y1b A T 11: 49,209,240 (GRCm39) Y289F probably damaging Het
Or6b13 A T 7: 139,782,635 (GRCm39) V16E possibly damaging Het
Osbp T C 19: 11,961,855 (GRCm39) Y551H probably damaging Het
Paf1 T C 7: 28,096,040 (GRCm39) M249T possibly damaging Het
Pcsk2 T C 2: 143,538,620 (GRCm39) probably null Het
Piwil1 G A 5: 128,820,944 (GRCm39) V290I possibly damaging Het
Prmt9 A T 8: 78,298,638 (GRCm39) D444V possibly damaging Het
Rapgef2 T C 3: 78,995,173 (GRCm39) D677G probably damaging Het
Tmem59 A G 4: 107,057,659 (GRCm39) E237G probably benign Het
Trpm5 A T 7: 142,634,705 (GRCm39) I664N probably damaging Het
Unc13b G A 4: 43,257,936 (GRCm39) probably null Het
Usp17lc C A 7: 103,067,763 (GRCm39) Q353K probably benign Het
Uvssa G A 5: 33,568,252 (GRCm39) V547M probably damaging Het
Vdac1 G T 11: 52,265,794 (GRCm39) L52F probably null Het
Vmn2r14 T A 5: 109,369,154 (GRCm39) I140L probably benign Het
Wwp2 T A 8: 108,281,710 (GRCm39) Y300N probably damaging Het
Zwilch T A 9: 64,075,892 (GRCm39) probably null Het
Other mutations in Wnt3a
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01108:Wnt3a APN 11 59,147,135 (GRCm39) missense probably benign 0.03
R0334:Wnt3a UTSW 11 59,147,144 (GRCm39) missense probably damaging 0.97
R3912:Wnt3a UTSW 11 59,140,828 (GRCm39) missense possibly damaging 0.91
R4041:Wnt3a UTSW 11 59,140,470 (GRCm39) missense probably damaging 1.00
R4980:Wnt3a UTSW 11 59,140,626 (GRCm39) missense probably damaging 1.00
R5528:Wnt3a UTSW 11 59,166,106 (GRCm39) missense probably damaging 0.99
R5626:Wnt3a UTSW 11 59,181,409 (GRCm39) missense probably benign 0.17
R6355:Wnt3a UTSW 11 59,166,058 (GRCm39) missense probably damaging 1.00
R6700:Wnt3a UTSW 11 59,140,587 (GRCm39) missense probably damaging 0.96
R8552:Wnt3a UTSW 11 59,166,043 (GRCm39) missense probably damaging 0.96
Predicted Primers PCR Primer
(F):5'- AAAGATGGCCAGGCTGTTG -3'
(R):5'- TAGAGGACATTTGCTTCTCCC -3'

Sequencing Primer
(F):5'- CAGGCTGTTGCTGACGG -3'
(R):5'- TAGTGCCCCACTCCACTGAG -3'
Posted On 2016-09-01