Incidental Mutation 'R5415:Vmn1r60'
ID 427682
Institutional Source Beutler Lab
Gene Symbol Vmn1r60
Ensembl Gene ENSMUSG00000090794
Gene Name vomeronasal 1 receptor 60
Synonyms Gm7184
MMRRC Submission 042984-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.055) question?
Stock # R5415 (G1)
Quality Score 225
Status Not validated
Chromosome 7
Chromosomal Location 5547196-5548098 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 5547416 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Histidine to Arginine at position 228 (H228R)
Ref Sequence ENSEMBL: ENSMUSP00000133943 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000173782]
AlphaFold no structure available at present
Predicted Effect probably benign
Transcript: ENSMUST00000172111
AA Change: H228R

PolyPhen 2 Score 0.247 (Sensitivity: 0.91; Specificity: 0.88)
SMART Domains Protein: ENSMUSP00000133113
Gene: ENSMUSG00000090794
AA Change: H228R

DomainStartEndE-ValueType
Pfam:TAS2R 1 294 1.1e-10 PFAM
Pfam:7tm_1 20 280 7.3e-12 PFAM
Pfam:V1R 31 299 1.3e-18 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000173782
AA Change: H228R

PolyPhen 2 Score 0.384 (Sensitivity: 0.90; Specificity: 0.89)
SMART Domains Protein: ENSMUSP00000133943
Gene: ENSMUSG00000090794
AA Change: H228R

DomainStartEndE-ValueType
Pfam:TAS2R 8 304 4.7e-10 PFAM
Pfam:7tm_1 30 289 7.2e-6 PFAM
Pfam:V1R 41 309 1.8e-17 PFAM
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.5%
  • 10x: 96.9%
  • 20x: 94.2%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 39 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Arhgef18 G A 8: 3,438,075 (GRCm39) R303H probably damaging Het
Ark2c C A 18: 77,554,435 (GRCm39) V60L probably damaging Het
Asb15 A T 6: 24,570,690 (GRCm39) Q556L probably benign Het
Ccr1 G T 9: 123,764,413 (GRCm39) P39H probably damaging Het
Cd177 A T 7: 24,451,816 (GRCm39) L400Q probably damaging Het
Cfap298 G T 16: 90,722,953 (GRCm39) D260E probably benign Het
Cideb T C 14: 55,995,312 (GRCm39) E58G probably damaging Het
Drd2 A G 9: 49,313,553 (GRCm39) K241E possibly damaging Het
Ect2 C T 3: 27,201,002 (GRCm39) C126Y probably damaging Het
Eef1d T C 15: 75,775,030 (GRCm39) T210A probably benign Het
Enpp2 G A 15: 54,745,552 (GRCm39) H315Y probably damaging Het
Ero1b A T 13: 12,616,656 (GRCm39) M362L probably benign Het
Exosc2 A G 2: 31,562,578 (GRCm39) K73E possibly damaging Het
Gm9637 T A 14: 19,402,143 (GRCm38) noncoding transcript Het
Gstm5 A G 3: 107,804,811 (GRCm39) D101G probably damaging Het
Igkv4-80 A C 6: 68,993,649 (GRCm39) S81A probably benign Het
Kmt2c T C 5: 25,519,699 (GRCm39) D2137G probably benign Het
Mecom T C 3: 30,011,675 (GRCm39) D619G possibly damaging Het
Met A G 6: 17,527,084 (GRCm39) I512V probably benign Het
Myh15 A G 16: 48,937,658 (GRCm39) K753R probably null Het
Nfatc4 A G 14: 56,070,091 (GRCm39) D753G probably benign Het
Or2l5 T A 16: 19,333,996 (GRCm39) H130L possibly damaging Het
Or4c113 T A 2: 88,885,240 (GRCm39) T177S probably benign Het
Or4c12 T A 2: 89,773,731 (GRCm39) T243S probably benign Het
Otx1 C A 11: 21,947,037 (GRCm39) A91S probably damaging Het
Parp9 C T 16: 35,763,752 (GRCm39) A10V probably damaging Het
Pcdh8 C A 14: 80,007,688 (GRCm39) E292* probably null Het
Pdpn A T 4: 142,995,788 (GRCm39) V161D probably damaging Het
Peg3 A G 7: 6,711,628 (GRCm39) V1198A probably benign Het
Phykpl T C 11: 51,476,342 (GRCm39) S21P probably benign Het
Plcb1 G T 2: 135,189,322 (GRCm39) V817F possibly damaging Het
Polk T C 13: 96,620,463 (GRCm39) Y579C probably benign Het
Ppp1r18 A G 17: 36,178,511 (GRCm39) N129D probably benign Het
Psg29 C A 7: 16,945,561 (GRCm39) probably null Het
Rims4 C T 2: 163,760,596 (GRCm39) R3H probably benign Het
Rps6kl1 A T 12: 85,186,155 (GRCm39) C292S probably benign Het
Uaca G T 9: 60,777,421 (GRCm39) G603C possibly damaging Het
Vmn2r7 T C 3: 64,623,658 (GRCm39) T221A probably benign Het
Zfp647 C A 15: 76,795,593 (GRCm39) V356L possibly damaging Het
Other mutations in Vmn1r60
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01869:Vmn1r60 APN 7 5,547,228 (GRCm39) missense probably benign 0.05
IGL01892:Vmn1r60 APN 7 5,547,309 (GRCm39) missense probably benign 0.02
IGL02427:Vmn1r60 APN 7 5,547,780 (GRCm39) missense probably damaging 1.00
IGL03071:Vmn1r60 APN 7 5,547,368 (GRCm39) missense probably damaging 0.97
R0200:Vmn1r60 UTSW 7 5,547,379 (GRCm39) missense probably benign
R0457:Vmn1r60 UTSW 7 5,548,118 (GRCm39) start gained probably benign
R1175:Vmn1r60 UTSW 7 5,547,621 (GRCm39) missense probably benign 0.01
R1199:Vmn1r60 UTSW 7 5,547,971 (GRCm39) missense probably damaging 0.99
R1529:Vmn1r60 UTSW 7 5,547,902 (GRCm39) missense probably benign 0.00
R1859:Vmn1r60 UTSW 7 5,547,549 (GRCm39) missense possibly damaging 0.64
R2033:Vmn1r60 UTSW 7 5,547,819 (GRCm39) missense probably benign
R2405:Vmn1r60 UTSW 7 5,547,912 (GRCm39) missense probably benign
R3408:Vmn1r60 UTSW 7 5,548,148 (GRCm39) splice site probably null
R3771:Vmn1r60 UTSW 7 5,547,710 (GRCm39) missense possibly damaging 0.76
R3773:Vmn1r60 UTSW 7 5,547,710 (GRCm39) missense possibly damaging 0.76
R3852:Vmn1r60 UTSW 7 5,548,026 (GRCm39) missense possibly damaging 0.79
R4236:Vmn1r60 UTSW 7 5,547,803 (GRCm39) missense probably benign 0.06
R4331:Vmn1r60 UTSW 7 5,547,364 (GRCm39) nonsense probably null
R4439:Vmn1r60 UTSW 7 5,547,488 (GRCm39) missense probably damaging 1.00
R5099:Vmn1r60 UTSW 7 5,547,816 (GRCm39) missense probably damaging 0.98
R5325:Vmn1r60 UTSW 7 5,547,201 (GRCm39) missense probably benign
R5818:Vmn1r60 UTSW 7 5,548,098 (GRCm39) start codon destroyed probably benign 0.04
R6375:Vmn1r60 UTSW 7 5,548,017 (GRCm39) missense probably damaging 0.96
R6378:Vmn1r60 UTSW 7 5,547,782 (GRCm39) missense probably damaging 0.99
R6478:Vmn1r60 UTSW 7 5,547,864 (GRCm39) missense probably damaging 1.00
R6572:Vmn1r60 UTSW 7 5,547,599 (GRCm39) missense probably benign 0.40
R6586:Vmn1r60 UTSW 7 5,547,446 (GRCm39) missense probably benign 0.00
R7061:Vmn1r60 UTSW 7 5,547,310 (GRCm39) nonsense probably null
R7506:Vmn1r60 UTSW 7 5,547,861 (GRCm39) missense
R7589:Vmn1r60 UTSW 7 5,547,688 (GRCm39) missense
R8182:Vmn1r60 UTSW 7 5,547,876 (GRCm39) missense
R9295:Vmn1r60 UTSW 7 5,547,218 (GRCm39) missense probably null
R9408:Vmn1r60 UTSW 7 5,547,918 (GRCm39) missense
Predicted Primers PCR Primer
(F):5'- TGATGTGCACAGAACAATGAC -3'
(R):5'- AAAGGCAATTCGATATGCTCCATC -3'

Sequencing Primer
(F):5'- GATGTGCACAGAACAATGACCCTTAC -3'
(R):5'- AATTCGATATGCTCCATCTCTGGG -3'
Posted On 2016-09-01