Incidental Mutation 'R5418:Vmn1r232'
ID 427891
Institutional Source Beutler Lab
Gene Symbol Vmn1r232
Ensembl Gene ENSMUSG00000062165
Gene Name vomeronasal 1 receptor 232
Synonyms V1re4
MMRRC Submission 042986-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.056) question?
Stock # R5418 (G1)
Quality Score 225
Status Validated
Chromosome 17
Chromosomal Location 21133467-21134625 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to A at 21134378 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Tyrosine to Phenylalanine at position 74 (Y74F)
Ref Sequence ENSEMBL: ENSMUSP00000076261 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000077001]
AlphaFold A2RTT5
Predicted Effect possibly damaging
Transcript: ENSMUST00000077001
AA Change: Y74F

PolyPhen 2 Score 0.749 (Sensitivity: 0.85; Specificity: 0.92)
SMART Domains Protein: ENSMUSP00000076261
Gene: ENSMUSG00000062165
AA Change: Y74F

DomainStartEndE-ValueType
Pfam:TAS2R 46 331 6.9e-7 PFAM
Pfam:7tm_1 70 324 1e-6 PFAM
Pfam:V1R 78 338 1.9e-29 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000232004
Meta Mutation Damage Score 0.1795 question?
Coding Region Coverage
  • 1x: 99.3%
  • 3x: 98.6%
  • 10x: 97.3%
  • 20x: 95.4%
Validation Efficiency 99% (81/82)
Allele List at MGI
Other mutations in this stock
Total: 75 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4930568D16Rik A G 2: 35,244,738 (GRCm39) S205P probably damaging Het
Abcc1 T C 16: 14,278,996 (GRCm39) V1102A probably benign Het
Acad8 A T 9: 26,896,853 (GRCm39) M202K probably damaging Het
Acoxl T A 2: 127,719,722 (GRCm39) M161K probably benign Het
Adamts4 T A 1: 171,080,143 (GRCm39) V35E probably damaging Het
Add2 A G 6: 86,087,894 (GRCm39) S614G probably benign Het
Adgrv1 T A 13: 81,567,427 (GRCm39) I5249L probably benign Het
Agps A G 2: 75,689,248 (GRCm39) T252A probably damaging Het
Alms1-ps1 G A 6: 85,732,584 (GRCm39) noncoding transcript Het
Ankrd24 T A 10: 81,480,776 (GRCm39) probably benign Het
Bcl9l A G 9: 44,416,733 (GRCm39) Q218R possibly damaging Het
Bin2 T C 15: 100,547,027 (GRCm39) Y232C probably damaging Het
Bptf A G 11: 107,002,120 (GRCm39) Y331H probably damaging Het
Ccr10 C T 11: 101,064,904 (GRCm39) V209M probably benign Het
Cflar A T 1: 58,791,810 (GRCm39) D371V possibly damaging Het
Col1a2 A G 6: 4,516,931 (GRCm39) probably benign Het
Crlf2 A G 5: 109,704,899 (GRCm39) V104A probably benign Het
Dennd1c CCGCCCCTCGCTGACAGC CC 17: 57,373,755 (GRCm39) probably null Het
Dmxl2 A G 9: 54,281,935 (GRCm39) probably null Het
Dnah17 C A 11: 117,985,810 (GRCm39) E1422D probably benign Het
Dnase1l1 C T X: 73,320,644 (GRCm39) probably null Het
Efcab11 A G 12: 99,821,877 (GRCm39) L80S possibly damaging Het
Emc8 G A 8: 121,385,342 (GRCm39) T130M probably damaging Het
Epha6 C A 16: 60,245,198 (GRCm39) A334S possibly damaging Het
Erc2 A G 14: 27,688,467 (GRCm39) M196V probably benign Het
Etnk2 T C 1: 133,300,995 (GRCm39) I254T probably damaging Het
Fam120b C T 17: 15,622,061 (GRCm39) T13M probably damaging Het
Fam234b A G 6: 135,203,966 (GRCm39) K423E probably benign Het
Fcgbp G A 7: 27,784,738 (GRCm39) G266D probably damaging Het
Fndc4 A T 5: 31,451,978 (GRCm39) S146R probably benign Het
Frmd3 G A 4: 74,079,935 (GRCm39) probably null Het
Glrx2 C A 1: 143,615,446 (GRCm39) S16R possibly damaging Het
Gm26526 T G 7: 39,238,358 (GRCm39) noncoding transcript Het
Hc C T 2: 34,898,195 (GRCm39) probably null Het
Herc2 T C 7: 55,787,313 (GRCm39) C1695R probably damaging Het
Hic1 A G 11: 75,057,425 (GRCm39) probably null Het
Igkv4-92 A T 6: 68,732,564 (GRCm39) V5E possibly damaging Het
Irs1 G A 1: 82,266,491 (GRCm39) T575I probably damaging Het
Kcp A T 6: 29,504,283 (GRCm39) Y143* probably null Het
Klb A G 5: 65,540,813 (GRCm39) N969D probably benign Het
Klra6 T A 6: 129,990,393 (GRCm39) L239F probably damaging Het
Lhx6 A G 2: 35,977,378 (GRCm39) probably null Het
Lrrc34 G A 3: 30,696,923 (GRCm39) P116S possibly damaging Het
Map3k9 T A 12: 81,790,591 (GRCm39) K321* probably null Het
Mapk14 T C 17: 28,960,817 (GRCm39) V196A possibly damaging Het
Matcap2 G T 9: 22,343,066 (GRCm39) R187L probably damaging Het
Mmp1b T C 9: 7,384,897 (GRCm39) I251V possibly damaging Het
Mtmr12 T C 15: 12,270,045 (GRCm39) L711P probably damaging Het
Mylk T C 16: 34,732,600 (GRCm39) S627P probably benign Het
Nbea A T 3: 55,553,410 (GRCm39) Y2631N possibly damaging Het
Ncoa7 A G 10: 30,524,035 (GRCm39) V153A probably damaging Het
Or4a79 T C 2: 89,552,343 (GRCm39) I37M probably benign Het
Pax6 A T 2: 105,521,910 (GRCm39) D175V probably benign Het
Piezo1 A G 8: 123,213,519 (GRCm39) L1793P probably damaging Het
Pkp4 T C 2: 59,140,506 (GRCm39) V404A probably benign Het
Plxnb2 A G 15: 89,050,694 (GRCm39) Y421H probably benign Het
Prkdc T G 16: 15,612,961 (GRCm39) V3173G probably benign Het
Prss40 A T 1: 34,599,840 (GRCm39) I49N probably benign Het
Prx T A 7: 27,216,699 (GRCm39) V400E probably damaging Het
Rbm11 A C 16: 75,393,423 (GRCm39) T40P probably damaging Het
Resf1 T C 6: 149,227,634 (GRCm39) Y227H probably damaging Het
Scara5 CG C 14: 65,997,111 (GRCm39) probably null Het
Sema3f A G 9: 107,569,820 (GRCm39) Y70H probably damaging Het
Senp6 G A 9: 80,029,151 (GRCm39) E505K possibly damaging Het
Slc25a3 T C 10: 90,955,398 (GRCm39) I147M probably benign Het
Slc4a7 T A 14: 14,760,280 (GRCm38) S572T probably benign Het
Smarcal1 C T 1: 72,638,068 (GRCm39) P501S probably benign Het
Sox7 C T 14: 64,185,396 (GRCm39) T144M probably benign Het
Taar1 T C 10: 23,797,214 (GRCm39) F304S possibly damaging Het
Tcf3 A G 10: 80,263,517 (GRCm39) F46L probably damaging Het
Tmem184c A G 8: 78,324,449 (GRCm39) V347A probably damaging Het
Tpcn2 C T 7: 144,832,518 (GRCm39) E113K probably damaging Het
Vmn2r102 C T 17: 19,914,415 (GRCm39) T660I probably damaging Het
Zdhhc3 A G 9: 122,909,456 (GRCm39) M234T probably damaging Het
Zfp960 T A 17: 17,307,805 (GRCm39) L173H probably damaging Het
Other mutations in Vmn1r232
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00900:Vmn1r232 APN 17 21,134,394 (GRCm39) missense probably benign 0.07
IGL02576:Vmn1r232 APN 17 21,134,175 (GRCm39) missense probably benign 0.30
H8562:Vmn1r232 UTSW 17 21,133,656 (GRCm39) missense probably benign 0.29
R1182:Vmn1r232 UTSW 17 21,133,705 (GRCm39) missense possibly damaging 0.95
R2010:Vmn1r232 UTSW 17 21,133,601 (GRCm39) missense probably benign 0.00
R2088:Vmn1r232 UTSW 17 21,133,999 (GRCm39) missense possibly damaging 0.63
R2206:Vmn1r232 UTSW 17 21,134,465 (GRCm39) missense probably benign 0.29
R2207:Vmn1r232 UTSW 17 21,134,465 (GRCm39) missense probably benign 0.29
R2273:Vmn1r232 UTSW 17 21,134,465 (GRCm39) missense probably benign 0.29
R2274:Vmn1r232 UTSW 17 21,134,465 (GRCm39) missense probably benign 0.29
R2275:Vmn1r232 UTSW 17 21,134,465 (GRCm39) missense probably benign 0.29
R2443:Vmn1r232 UTSW 17 21,133,646 (GRCm39) missense probably damaging 1.00
R2516:Vmn1r232 UTSW 17 21,134,288 (GRCm39) missense possibly damaging 0.65
R3700:Vmn1r232 UTSW 17 21,134,465 (GRCm39) missense probably benign 0.29
R5256:Vmn1r232 UTSW 17 21,133,846 (GRCm39) missense probably damaging 1.00
R5726:Vmn1r232 UTSW 17 21,133,601 (GRCm39) missense probably benign 0.00
R5833:Vmn1r232 UTSW 17 21,133,913 (GRCm39) missense probably damaging 1.00
R6528:Vmn1r232 UTSW 17 21,134,309 (GRCm39) missense probably benign 0.12
R7019:Vmn1r232 UTSW 17 21,133,547 (GRCm39) missense possibly damaging 0.76
R7600:Vmn1r232 UTSW 17 21,133,999 (GRCm39) missense possibly damaging 0.63
R8377:Vmn1r232 UTSW 17 21,134,239 (GRCm39) missense probably benign 0.00
R8695:Vmn1r232 UTSW 17 21,134,109 (GRCm39) missense probably benign
R9000:Vmn1r232 UTSW 17 21,134,111 (GRCm39) missense probably damaging 1.00
R9512:Vmn1r232 UTSW 17 21,134,416 (GRCm39) missense probably damaging 0.99
Z1088:Vmn1r232 UTSW 17 21,134,100 (GRCm39) missense probably benign 0.38
Predicted Primers PCR Primer
(F):5'- ACAAGTGGTGATAATGGACATGTTC -3'
(R):5'- TCTTGCACATACATGTCCCAAC -3'

Sequencing Primer
(F):5'- ATGGACATGTTCCTGCTAAGTC -3'
(R):5'- TGTCCCAACTTAGAAAACTTACTTC -3'
Posted On 2016-09-01