Incidental Mutation 'R5419:Grm3'
ID 427914
Institutional Source Beutler Lab
Gene Symbol Grm3
Ensembl Gene ENSMUSG00000003974
Gene Name glutamate receptor, metabotropic 3
Synonyms mGluR3, mGlu3, 0710001G23Rik, Gprc1c
MMRRC Submission 042987-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R5419 (G1)
Quality Score 225
Status Not validated
Chromosome 5
Chromosomal Location 9535541-9775170 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 9620233 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Phenylalanine to Serine at position 337 (F337S)
Ref Sequence ENSEMBL: ENSMUSP00000004076 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000004076]
AlphaFold Q9QYS2
Predicted Effect probably damaging
Transcript: ENSMUST00000004076
AA Change: F337S

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000004076
Gene: ENSMUSG00000003974
AA Change: F337S

DomainStartEndE-ValueType
signal peptide 1 18 N/A INTRINSIC
Pfam:ANF_receptor 67 473 4.8e-102 PFAM
Pfam:NCD3G 505 555 2.4e-14 PFAM
Pfam:7tm_3 588 825 4.7e-62 PFAM
low complexity region 849 861 N/A INTRINSIC
Coding Region Coverage
  • 1x: 99.3%
  • 3x: 98.6%
  • 10x: 97.3%
  • 20x: 95.4%
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors, that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5 and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3 while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities. [provided by RefSeq, Jul 2008]
PHENOTYPE: Mice homozygous for a targeted mutation display normal morphology, clinical chemistry, hematology, and behavior. Mice homozygous for a knock-out allele exhibit altered neuroprotection. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 61 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4931429L15Rik C T 9: 46,220,624 (GRCm39) probably null Het
Abca13 T A 11: 9,143,533 (GRCm39) probably null Het
Akap13 A T 7: 75,259,991 (GRCm39) T69S probably benign Het
Arl1 T A 10: 88,572,966 (GRCm39) C80S probably damaging Het
Bltp2 T A 11: 78,162,916 (GRCm39) L926* probably null Het
Brsk1 A G 7: 4,712,003 (GRCm39) T618A possibly damaging Het
Cep295 T C 9: 15,235,533 (GRCm39) H1982R probably damaging Het
Ces5a A T 8: 94,226,059 (GRCm39) S559T unknown Het
Clcf1 A G 19: 4,272,213 (GRCm39) N90S possibly damaging Het
Clec16a G A 16: 10,549,543 (GRCm39) C872Y probably damaging Het
Cobll1 A T 2: 64,933,701 (GRCm39) D430E possibly damaging Het
Cyp1a2 T A 9: 57,589,794 (GRCm39) I7F probably benign Het
Cyp2b23 G A 7: 26,380,848 (GRCm39) R126* probably null Het
Daam2 A G 17: 49,787,782 (GRCm39) W444R possibly damaging Het
Dcbld2 T A 16: 58,275,621 (GRCm39) C446S probably damaging Het
Dnase1l1 C T X: 73,320,644 (GRCm39) probably null Het
Eif2d T C 1: 131,086,035 (GRCm39) *177R probably null Het
Fkbp15 G A 4: 62,246,114 (GRCm39) A438V probably damaging Het
Gjb5 G A 4: 127,249,652 (GRCm39) A164V probably benign Het
Grin1 A T 2: 25,188,285 (GRCm39) probably null Het
Hey2 T A 10: 30,710,019 (GRCm39) T245S probably benign Het
Ifi206 T C 1: 173,308,797 (GRCm39) T400A probably benign Het
Itga7 G A 10: 128,779,902 (GRCm39) E480K probably null Het
Itpr1 T C 6: 108,470,755 (GRCm39) Y2227H possibly damaging Het
Krt8 T C 15: 101,912,337 (GRCm39) D113G probably damaging Het
Lgr6 C T 1: 134,921,748 (GRCm39) A199T probably damaging Het
Lins1 A G 7: 66,357,843 (GRCm39) probably benign Het
Lmf1 A T 17: 25,881,610 (GRCm39) D553V possibly damaging Het
Lnpep A G 17: 17,786,992 (GRCm39) S536P probably damaging Het
Lrp1b A T 2: 40,620,716 (GRCm39) C3587* probably null Het
Macf1 A T 4: 123,290,917 (GRCm39) D3435E possibly damaging Het
Mmp1b T C 9: 7,384,897 (GRCm39) I251V possibly damaging Het
Myg1 A T 15: 102,245,397 (GRCm39) N206I probably damaging Het
Myl12a T G 17: 71,301,694 (GRCm39) R144S probably benign Het
Myo5a T A 9: 75,055,179 (GRCm39) I454K probably damaging Het
Nwd2 A G 5: 63,965,051 (GRCm39) D1545G probably benign Het
Ogdhl T G 14: 32,061,181 (GRCm39) D457E probably damaging Het
Or5ac20 T A 16: 59,104,704 (GRCm39) D52V probably damaging Het
Or9s18 A C 13: 65,300,588 (GRCm39) L183F probably damaging Het
Paf1 A G 7: 28,095,095 (GRCm39) I112V possibly damaging Het
Pate7 T A 9: 35,689,407 (GRCm39) probably null Het
Pcdhga4 C T 18: 37,819,798 (GRCm39) P449L probably damaging Het
Pla2g6 A T 15: 79,183,342 (GRCm39) I495N possibly damaging Het
Ptgs1 A G 2: 36,127,234 (GRCm39) Y40C probably damaging Het
Ptprn2 A T 12: 117,148,267 (GRCm39) I676F probably damaging Het
Rev3l T C 10: 39,700,927 (GRCm39) L1808P possibly damaging Het
Sall2 A G 14: 52,550,586 (GRCm39) S868P probably damaging Het
Shoc1 A T 4: 59,049,017 (GRCm39) M1116K probably benign Het
Slc47a2 A G 11: 61,198,412 (GRCm39) F428L probably benign Het
Slco1a7 C T 6: 141,681,826 (GRCm39) probably null Het
Slco3a1 A T 7: 73,934,363 (GRCm39) F603Y possibly damaging Het
Smyd2 A T 1: 189,642,090 (GRCm39) C65* probably null Het
Ssu72 T C 4: 155,800,007 (GRCm39) F57L probably damaging Het
Tanc2 A G 11: 105,813,709 (GRCm39) T1718A probably benign Het
Tnks G C 8: 35,432,720 (GRCm39) P34A unknown Het
Top3a G A 11: 60,653,348 (GRCm39) T42I probably damaging Het
Trank1 T C 9: 111,220,369 (GRCm39) S2369P probably damaging Het
Ttn A T 2: 76,641,587 (GRCm39) L5176Q possibly damaging Het
Ubqln1 T C 13: 58,330,997 (GRCm39) Q410R probably damaging Het
Vmn2r11 A G 5: 109,207,224 (GRCm39) I32T possibly damaging Het
Xcr1 A G 9: 123,685,375 (GRCm39) F129S probably benign Het
Other mutations in Grm3
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00495:Grm3 APN 5 9,562,290 (GRCm39) missense probably benign
IGL01393:Grm3 APN 5 9,639,856 (GRCm39) missense probably benign 0.00
IGL01398:Grm3 APN 5 9,535,762 (GRCm39) unclassified probably benign
IGL01825:Grm3 APN 5 9,561,600 (GRCm39) missense probably damaging 1.00
IGL01966:Grm3 APN 5 9,561,486 (GRCm39) missense probably damaging 0.98
IGL02367:Grm3 APN 5 9,561,660 (GRCm39) missense probably damaging 1.00
IGL02526:Grm3 APN 5 9,639,847 (GRCm39) missense probably damaging 1.00
IGL02972:Grm3 APN 5 9,562,410 (GRCm39) missense probably damaging 1.00
IGL03356:Grm3 APN 5 9,562,206 (GRCm39) missense possibly damaging 0.89
BB002:Grm3 UTSW 5 9,639,880 (GRCm39) missense probably benign 0.09
BB012:Grm3 UTSW 5 9,639,880 (GRCm39) missense probably benign 0.09
R0032:Grm3 UTSW 5 9,561,452 (GRCm39) splice site probably null
R0032:Grm3 UTSW 5 9,561,452 (GRCm39) splice site probably null
R0389:Grm3 UTSW 5 9,554,794 (GRCm39) missense probably damaging 1.00
R0455:Grm3 UTSW 5 9,562,477 (GRCm39) missense probably benign
R0538:Grm3 UTSW 5 9,562,446 (GRCm39) missense possibly damaging 0.95
R0553:Grm3 UTSW 5 9,620,048 (GRCm39) missense probably benign 0.16
R1124:Grm3 UTSW 5 9,620,297 (GRCm39) missense probably benign
R1163:Grm3 UTSW 5 9,620,738 (GRCm39) missense probably benign 0.34
R1440:Grm3 UTSW 5 9,639,958 (GRCm39) missense probably benign
R1635:Grm3 UTSW 5 9,561,520 (GRCm39) missense probably damaging 1.00
R1734:Grm3 UTSW 5 9,639,742 (GRCm39) missense probably benign 0.00
R1895:Grm3 UTSW 5 9,562,123 (GRCm39) missense probably damaging 1.00
R1926:Grm3 UTSW 5 9,554,881 (GRCm39) missense probably damaging 0.98
R1940:Grm3 UTSW 5 9,561,682 (GRCm39) missense probably damaging 1.00
R1946:Grm3 UTSW 5 9,562,123 (GRCm39) missense probably damaging 1.00
R2004:Grm3 UTSW 5 9,639,793 (GRCm39) missense possibly damaging 0.57
R2005:Grm3 UTSW 5 9,639,793 (GRCm39) missense possibly damaging 0.57
R2006:Grm3 UTSW 5 9,639,793 (GRCm39) missense possibly damaging 0.57
R3116:Grm3 UTSW 5 9,620,752 (GRCm39) missense probably damaging 1.00
R4083:Grm3 UTSW 5 9,562,054 (GRCm39) missense probably benign
R4537:Grm3 UTSW 5 9,562,083 (GRCm39) missense probably benign 0.02
R4855:Grm3 UTSW 5 9,620,047 (GRCm39) missense probably damaging 0.98
R5060:Grm3 UTSW 5 9,620,167 (GRCm39) missense probably damaging 0.99
R5093:Grm3 UTSW 5 9,639,766 (GRCm39) missense probably benign 0.01
R5525:Grm3 UTSW 5 9,554,872 (GRCm39) missense probably damaging 1.00
R5642:Grm3 UTSW 5 9,620,536 (GRCm39) missense probably benign 0.21
R5804:Grm3 UTSW 5 9,620,155 (GRCm39) missense probably benign 0.33
R5915:Grm3 UTSW 5 9,561,927 (GRCm39) missense probably damaging 1.00
R5966:Grm3 UTSW 5 9,561,930 (GRCm39) missense probably damaging 0.98
R6151:Grm3 UTSW 5 9,561,556 (GRCm39) missense probably damaging 1.00
R6419:Grm3 UTSW 5 9,620,201 (GRCm39) missense probably damaging 1.00
R7267:Grm3 UTSW 5 9,639,581 (GRCm39) missense probably benign 0.00
R7555:Grm3 UTSW 5 9,620,000 (GRCm39) missense probably benign 0.00
R7657:Grm3 UTSW 5 9,561,452 (GRCm39) splice site probably null
R7925:Grm3 UTSW 5 9,639,880 (GRCm39) missense probably benign 0.09
R8032:Grm3 UTSW 5 9,562,272 (GRCm39) missense probably benign 0.11
R8227:Grm3 UTSW 5 9,620,242 (GRCm39) missense possibly damaging 0.65
R8462:Grm3 UTSW 5 9,562,365 (GRCm39) missense probably benign
R8500:Grm3 UTSW 5 9,561,726 (GRCm39) missense probably benign 0.21
R8696:Grm3 UTSW 5 9,562,311 (GRCm39) missense probably damaging 1.00
R8807:Grm3 UTSW 5 9,561,499 (GRCm39) missense probably damaging 1.00
R8828:Grm3 UTSW 5 9,554,725 (GRCm39) missense probably benign 0.00
R8876:Grm3 UTSW 5 9,561,580 (GRCm39) missense probably damaging 1.00
R8896:Grm3 UTSW 5 9,562,483 (GRCm39) missense possibly damaging 0.91
R9035:Grm3 UTSW 5 9,620,464 (GRCm39) missense probably damaging 0.99
R9779:Grm3 UTSW 5 9,561,656 (GRCm39) missense possibly damaging 0.74
X0020:Grm3 UTSW 5 9,562,195 (GRCm39) missense probably damaging 1.00
X0025:Grm3 UTSW 5 9,535,790 (GRCm39) missense probably damaging 1.00
X0026:Grm3 UTSW 5 9,562,238 (GRCm39) nonsense probably null
Z1088:Grm3 UTSW 5 9,620,183 (GRCm39) missense probably damaging 0.97
Predicted Primers PCR Primer
(F):5'- CATCACAGAGCTTGGTGGTG -3'
(R):5'- TCACGAGAGTTGATCGCTG -3'

Sequencing Primer
(F):5'- ATGCGCCATGGCATACACTG -3'
(R):5'- AGAGTTGATCGCTGCAGCC -3'
Posted On 2016-09-01