Incidental Mutation 'R5433:Lamtor5'
ID 428142
Institutional Source Beutler Lab
Gene Symbol Lamtor5
Ensembl Gene ENSMUSG00000087260
Gene Name late endosomal/lysosomal adaptor, MAPK and MTOR activator 5
Synonyms 1110003H18Rik, Hbxip
MMRRC Submission 042998-MU
Accession Numbers
Essential gene? Essential (E-score: 1.000) question?
Stock # R5433 (G1)
Quality Score 225
Status Validated
Chromosome 3
Chromosomal Location 107186174-107191398 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to G at 107189323 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Cysteine to Glycine at position 120 (C120G)
Ref Sequence ENSEMBL: ENSMUSP00000129012 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000145735] [ENSMUST00000199317]
AlphaFold Q9D1L9
Predicted Effect probably benign
Transcript: ENSMUST00000145735
AA Change: C120G

PolyPhen 2 Score 0.086 (Sensitivity: 0.93; Specificity: 0.85)
SMART Domains Protein: ENSMUSP00000129012
Gene: ENSMUSG00000087260
AA Change: C120G

DomainStartEndE-ValueType
Pfam:LAMTOR5 55 142 2e-36 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000199317
AA Change: C66G

PolyPhen 2 Score 0.005 (Sensitivity: 0.97; Specificity: 0.74)
SMART Domains Protein: ENSMUSP00000143494
Gene: ENSMUSG00000087260
AA Change: C66G

DomainStartEndE-ValueType
Pfam:LAMTOR5 1 88 2.1e-37 PFAM
Meta Mutation Damage Score 0.4084 question?
Coding Region Coverage
  • 1x: 99.3%
  • 3x: 98.7%
  • 10x: 97.4%
  • 20x: 95.8%
Validation Efficiency 100% (58/58)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a protein that specifically complexes with the C-terminus of hepatitis B virus X protein (HBx). The function of this protein is to negatively regulate HBx activity and thus to alter the replication life cycle of the virus. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 53 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1700019D03Rik T C 1: 52,964,657 (GRCm39) S24G probably damaging Het
1810064F22Rik A G 9: 22,119,039 (GRCm39) noncoding transcript Het
Aacs A T 5: 125,592,078 (GRCm39) M589L probably benign Het
Adamts8 A C 9: 30,873,012 (GRCm39) H739P probably benign Het
Atp8b2 T C 3: 89,860,216 (GRCm39) probably benign Het
BC030500 A G 8: 59,366,043 (GRCm39) probably benign Het
Btnl9 T A 11: 49,066,830 (GRCm39) probably benign Het
Cd74 G T 18: 60,940,993 (GRCm39) A31S probably benign Het
Ceacam3 G A 7: 16,893,808 (GRCm39) A440T possibly damaging Het
Ces1d G A 8: 93,912,664 (GRCm39) T258I probably benign Het
Col10a1 A G 10: 34,266,735 (GRCm39) probably benign Het
Coro1b C T 19: 4,203,449 (GRCm39) A430V probably benign Het
Cyp2c65 A T 19: 39,081,928 (GRCm39) I485L probably benign Het
Dio1 A T 4: 107,163,977 (GRCm39) probably benign Het
Dmxl1 G A 18: 50,000,966 (GRCm39) probably null Het
Dynlt5 A G 4: 102,859,700 (GRCm39) E84G possibly damaging Het
Elp6 A G 9: 110,144,851 (GRCm39) Y136C probably damaging Het
Gon4l A T 3: 88,803,532 (GRCm39) Q1382L possibly damaging Het
Guca1a T C 17: 47,711,295 (GRCm39) E17G probably damaging Het
Gucy2d G A 7: 98,098,982 (GRCm39) G267E probably damaging Het
Gvin3 T A 7: 106,199,314 (GRCm39) noncoding transcript Het
Hspg2 T A 4: 137,256,105 (GRCm39) probably null Het
Il1a G T 2: 129,149,821 (GRCm39) D26E possibly damaging Het
Il22b T A 10: 118,130,789 (GRCm39) I36F probably damaging Het
Kcna1 A T 6: 126,620,075 (GRCm39) F82I probably damaging Het
Klhl18 G C 9: 110,265,195 (GRCm39) N335K possibly damaging Het
Lars1 A G 18: 42,384,363 (GRCm39) C72R possibly damaging Het
Lrrfip1 T G 1: 91,014,848 (GRCm39) probably null Het
Mapkapk3 T C 9: 107,133,491 (GRCm39) D349G probably damaging Het
Mknk2 A T 10: 80,503,059 (GRCm39) I421N probably benign Het
Myh6 A G 14: 55,191,381 (GRCm39) I820T probably benign Het
Notch2 T G 3: 98,033,450 (GRCm39) V1182G probably damaging Het
Or1af1 T G 2: 37,109,684 (GRCm39) F61C probably damaging Het
Or1e16 AGCGGTCGTAGGC AGC 11: 73,286,480 (GRCm39) probably null Het
Or2z2 C T 11: 58,346,680 (GRCm39) V32M probably damaging Het
Ppfia4 A T 1: 134,245,632 (GRCm39) S641T probably damaging Het
Prok1 T A 3: 107,146,949 (GRCm39) H6L probably benign Het
Ptprm A T 17: 67,000,468 (GRCm39) V1172E probably damaging Het
Rasal3 C T 17: 32,612,575 (GRCm39) R762Q probably benign Het
Rgs20 G T 1: 5,140,333 (GRCm39) A23E possibly damaging Het
Rprd1a T C 18: 24,640,288 (GRCm39) T163A probably benign Het
Rrm1 A T 7: 102,114,974 (GRCm39) N37I probably damaging Het
Shc4 T A 2: 125,481,350 (GRCm39) E520V probably damaging Het
Slc14a2 G T 18: 78,252,143 (GRCm39) P56Q probably damaging Het
Slc22a3 C T 17: 12,677,377 (GRCm39) G264S probably damaging Het
Svil A G 18: 5,059,294 (GRCm39) E770G probably damaging Het
Svop A G 5: 114,198,186 (GRCm39) V129A probably damaging Het
Szt2 A T 4: 118,232,663 (GRCm39) probably benign Het
Tcof1 T C 18: 60,951,105 (GRCm39) probably benign Het
Tmem30a T A 9: 79,687,930 (GRCm39) I80F probably damaging Het
Vmn2r16 G T 5: 109,511,708 (GRCm39) L638F probably damaging Het
Xkr7 T A 2: 152,896,244 (GRCm39) I366N probably damaging Het
Zer1 A G 2: 29,990,998 (GRCm39) probably benign Het
Other mutations in Lamtor5
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01552:Lamtor5 APN 3 107,186,324 (GRCm39) missense probably benign 0.03
R0419:Lamtor5 UTSW 3 107,189,227 (GRCm39) missense probably damaging 0.96
R4246:Lamtor5 UTSW 3 107,186,354 (GRCm39) missense probably benign
R7246:Lamtor5 UTSW 3 107,189,336 (GRCm39) missense probably damaging 1.00
R9277:Lamtor5 UTSW 3 107,186,404 (GRCm39) missense probably benign 0.39
Predicted Primers PCR Primer
(F):5'- TTTCTCACTAATGGACTCAGCTG -3'
(R):5'- TGGAGTGGCAAACTGATAGTTC -3'

Sequencing Primer
(F):5'- TACCAGGTGAGAGAGATCCTTTC -3'
(R):5'- CTCTGTGGTGCATTGACT -3'
Posted On 2016-09-01