Incidental Mutation 'R5440:Cwf19l2'
ID 428587
Institutional Source Beutler Lab
Gene Symbol Cwf19l2
Ensembl Gene ENSMUSG00000025898
Gene Name CWF19 like cell cycle control factor 2
Synonyms 3230401L03Rik
MMRRC Submission 043005-MU
Accession Numbers
Essential gene? Probably essential (E-score: 0.934) question?
Stock # R5440 (G1)
Quality Score 225
Status Not validated
Chromosome 9
Chromosomal Location 3403592-3479236 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) G to A at 3475549 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Glutamic Acid to Lysine at position 829 (E829K)
Ref Sequence ENSEMBL: ENSMUSP00000027027 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000027027]
AlphaFold Q8BG79
Predicted Effect probably damaging
Transcript: ENSMUST00000027027
AA Change: E829K

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000027027
Gene: ENSMUSG00000025898
AA Change: E829K

DomainStartEndE-ValueType
low complexity region 64 114 N/A INTRINSIC
coiled coil region 165 196 N/A INTRINSIC
low complexity region 403 418 N/A INTRINSIC
coiled coil region 496 524 N/A INTRINSIC
Pfam:CwfJ_C_1 655 779 1.8e-40 PFAM
Pfam:CwfJ_C_2 788 882 4.6e-34 PFAM
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.6%
  • 10x: 97.3%
  • 20x: 95.3%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 42 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Apc G T 18: 34,354,213 (GRCm39) probably benign Het
Apol11b T A 15: 77,519,793 (GRCm39) K96* probably null Het
Arhgap35 C T 7: 16,296,849 (GRCm39) G739S probably damaging Het
Atp6v0a4 A C 6: 38,069,752 (GRCm39) F47V probably damaging Het
Bcl9 G A 3: 97,117,881 (GRCm39) P271L probably benign Het
Cd109 T C 9: 78,587,446 (GRCm39) probably null Het
Col12a1 T A 9: 79,521,645 (GRCm39) I2771F probably benign Het
Col6a1 A G 10: 76,559,288 (GRCm39) V116A probably damaging Het
Cpsf2 C G 12: 101,963,138 (GRCm39) L401V probably benign Het
D7Ertd443e G A 7: 133,951,004 (GRCm39) T223I probably damaging Het
Dtx4 G A 19: 12,469,681 (GRCm39) R149C probably damaging Het
Fam186b C T 15: 99,171,734 (GRCm39) A838T possibly damaging Het
Fzd4 G T 7: 89,057,326 (GRCm39) E458* probably null Het
Gm17669 C T 18: 67,695,526 (GRCm39) P24S possibly damaging Het
Grin2b C T 6: 135,713,304 (GRCm39) G859D probably damaging Het
Gucy2e T C 11: 69,114,472 (GRCm39) Y1019C probably damaging Het
Gzme T A 14: 56,355,910 (GRCm39) N134I possibly damaging Het
Havcr1 A T 11: 46,643,197 (GRCm39) Y39F probably damaging Het
Hint3 A T 10: 30,494,347 (GRCm39) M1K probably null Het
Hspa4l A G 3: 40,736,008 (GRCm39) K543R probably damaging Het
Ifna9 A G 4: 88,510,048 (GRCm39) probably null Het
Itgb4 C T 11: 115,874,983 (GRCm39) R447W probably benign Het
Lipo2 A G 19: 33,698,258 (GRCm39) I373T probably benign Het
Myo5c T A 9: 75,165,407 (GRCm39) I405N possibly damaging Het
Or10a49 T C 7: 108,467,833 (GRCm39) H176R probably damaging Het
P2rx1 A G 11: 72,899,329 (GRCm39) M108V probably benign Het
Pcsk2 T A 2: 143,388,463 (GRCm39) V18E probably benign Het
Pigr A T 1: 130,777,359 (GRCm39) probably null Het
Pkp1 A T 1: 135,810,230 (GRCm39) C447S probably benign Het
Prom1 T A 5: 44,215,988 (GRCm39) I96F probably benign Het
Prpf4b T C 13: 35,068,076 (GRCm39) probably benign Het
Ropn1 C A 16: 34,491,542 (GRCm39) D102E probably benign Het
Slc35e2 C T 4: 155,694,483 (GRCm39) P10L probably benign Het
Sphk1 T G 11: 116,425,714 (GRCm39) V17G possibly damaging Het
Syngr1 A G 15: 79,982,219 (GRCm39) N2S probably benign Het
Syt9 T G 7: 107,101,330 (GRCm39) S359A possibly damaging Het
Terb1 T C 8: 105,215,131 (GRCm39) I282V probably damaging Het
Ttn T A 2: 76,585,168 (GRCm39) I22042F probably damaging Het
Ttn A T 2: 76,739,600 (GRCm39) D3646E probably benign Het
Ube2d1 A G 10: 71,091,682 (GRCm39) W141R probably damaging Het
Vmn2r41 T A 7: 8,141,362 (GRCm39) I701F probably damaging Het
Zfp770 T C 2: 114,026,596 (GRCm39) D491G probably benign Het
Other mutations in Cwf19l2
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00227:Cwf19l2 APN 9 3,409,990 (GRCm39) missense probably benign 0.01
IGL00573:Cwf19l2 APN 9 3,450,161 (GRCm39) splice site probably benign
IGL00757:Cwf19l2 APN 9 3,460,054 (GRCm39) missense probably damaging 1.00
IGL00803:Cwf19l2 APN 9 3,430,810 (GRCm39) missense probably benign 0.41
IGL01916:Cwf19l2 APN 9 3,477,869 (GRCm39) missense possibly damaging 0.82
IGL02315:Cwf19l2 APN 9 3,410,030 (GRCm39) missense probably damaging 1.00
IGL02419:Cwf19l2 APN 9 3,418,777 (GRCm39) critical splice donor site probably null
IGL02427:Cwf19l2 APN 9 3,456,817 (GRCm39) missense probably benign 0.00
IGL03026:Cwf19l2 APN 9 3,428,777 (GRCm39) missense probably benign 0.28
IGL03028:Cwf19l2 APN 9 3,430,622 (GRCm39) missense probably benign 0.26
IGL03199:Cwf19l2 APN 9 3,477,830 (GRCm39) missense probably damaging 1.00
R0015:Cwf19l2 UTSW 9 3,454,666 (GRCm39) missense probably benign 0.00
R0015:Cwf19l2 UTSW 9 3,454,666 (GRCm39) missense probably benign 0.00
R0532:Cwf19l2 UTSW 9 3,431,057 (GRCm39) missense probably benign 0.38
R0724:Cwf19l2 UTSW 9 3,421,377 (GRCm39) critical splice donor site probably null
R0924:Cwf19l2 UTSW 9 3,441,047 (GRCm39) splice site probably benign
R0947:Cwf19l2 UTSW 9 3,421,286 (GRCm39) missense probably benign 0.16
R1210:Cwf19l2 UTSW 9 3,430,810 (GRCm39) missense probably benign 0.00
R1393:Cwf19l2 UTSW 9 3,456,818 (GRCm39) missense probably benign 0.01
R1541:Cwf19l2 UTSW 9 3,456,760 (GRCm39) missense probably damaging 1.00
R1594:Cwf19l2 UTSW 9 3,430,973 (GRCm39) missense probably benign
R1870:Cwf19l2 UTSW 9 3,458,802 (GRCm39) missense possibly damaging 0.56
R1950:Cwf19l2 UTSW 9 3,418,674 (GRCm39) missense probably benign
R1996:Cwf19l2 UTSW 9 3,417,947 (GRCm39) missense probably benign 0.01
R2005:Cwf19l2 UTSW 9 3,430,720 (GRCm39) missense possibly damaging 0.92
R2246:Cwf19l2 UTSW 9 3,430,661 (GRCm39) missense probably benign 0.16
R2420:Cwf19l2 UTSW 9 3,411,341 (GRCm39) missense possibly damaging 0.80
R3051:Cwf19l2 UTSW 9 3,410,006 (GRCm39) missense probably benign 0.05
R3738:Cwf19l2 UTSW 9 3,456,803 (GRCm39) missense probably benign 0.01
R3915:Cwf19l2 UTSW 9 3,456,776 (GRCm39) missense probably damaging 1.00
R4034:Cwf19l2 UTSW 9 3,456,803 (GRCm39) missense probably benign 0.01
R4035:Cwf19l2 UTSW 9 3,456,803 (GRCm39) missense probably benign 0.01
R4323:Cwf19l2 UTSW 9 3,430,452 (GRCm39) missense probably damaging 0.99
R4328:Cwf19l2 UTSW 9 3,458,878 (GRCm39) missense probably damaging 1.00
R4329:Cwf19l2 UTSW 9 3,458,878 (GRCm39) missense probably damaging 1.00
R4692:Cwf19l2 UTSW 9 3,428,709 (GRCm39) missense probably damaging 1.00
R4775:Cwf19l2 UTSW 9 3,430,973 (GRCm39) missense probably benign
R4779:Cwf19l2 UTSW 9 3,410,035 (GRCm39) missense possibly damaging 0.95
R4822:Cwf19l2 UTSW 9 3,458,839 (GRCm39) missense probably damaging 1.00
R4833:Cwf19l2 UTSW 9 3,430,783 (GRCm39) missense probably benign 0.28
R5110:Cwf19l2 UTSW 9 3,450,012 (GRCm39) critical splice acceptor site probably null
R5120:Cwf19l2 UTSW 9 3,418,761 (GRCm39) nonsense probably null
R5164:Cwf19l2 UTSW 9 3,475,511 (GRCm39) missense probably damaging 1.00
R5567:Cwf19l2 UTSW 9 3,456,831 (GRCm39) missense probably damaging 1.00
R5594:Cwf19l2 UTSW 9 3,418,773 (GRCm39) missense probably benign 0.42
R5960:Cwf19l2 UTSW 9 3,411,404 (GRCm39) missense probably benign 0.43
R6222:Cwf19l2 UTSW 9 3,454,569 (GRCm39) nonsense probably null
R6259:Cwf19l2 UTSW 9 3,458,879 (GRCm39) missense probably damaging 1.00
R6688:Cwf19l2 UTSW 9 3,450,015 (GRCm39) missense probably benign 0.00
R6983:Cwf19l2 UTSW 9 3,477,817 (GRCm39) missense probably damaging 1.00
R7063:Cwf19l2 UTSW 9 3,430,532 (GRCm39) missense probably benign 0.03
R7506:Cwf19l2 UTSW 9 3,456,775 (GRCm39) missense probably damaging 1.00
R7733:Cwf19l2 UTSW 9 3,450,066 (GRCm39) missense probably benign 0.19
R7846:Cwf19l2 UTSW 9 3,477,889 (GRCm39) missense probably damaging 1.00
R7900:Cwf19l2 UTSW 9 3,460,107 (GRCm39) missense probably damaging 1.00
R8510:Cwf19l2 UTSW 9 3,454,732 (GRCm39) missense possibly damaging 0.89
R8709:Cwf19l2 UTSW 9 3,430,723 (GRCm39) missense probably benign 0.26
R8900:Cwf19l2 UTSW 9 3,447,245 (GRCm39) missense probably benign 0.01
R9031:Cwf19l2 UTSW 9 3,417,942 (GRCm39) missense probably benign 0.00
R9373:Cwf19l2 UTSW 9 3,454,718 (GRCm39) missense probably damaging 0.99
R9701:Cwf19l2 UTSW 9 3,430,454 (GRCm39) missense probably damaging 1.00
T0722:Cwf19l2 UTSW 9 3,456,755 (GRCm39) missense probably benign 0.00
X0003:Cwf19l2 UTSW 9 3,456,755 (GRCm39) missense probably benign 0.00
X0020:Cwf19l2 UTSW 9 3,418,662 (GRCm39) missense probably damaging 1.00
Z1177:Cwf19l2 UTSW 9 3,428,782 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- ACTTGATGAAGGTCTGGCTG -3'
(R):5'- CAGTTACTGAGCACACTGCC -3'

Sequencing Primer
(F):5'- GGCTGTCAGAATGAATTATGTTCC -3'
(R):5'- CTGAGCACACTGCCAAAAATGTTTG -3'
Posted On 2016-09-01