Incidental Mutation 'R5440:Apol11b'
ID 428604
Institutional Source Beutler Lab
Gene Symbol Apol11b
Ensembl Gene ENSMUSG00000091694
Gene Name apolipoprotein L 11b
Synonyms A330102K04Rik
MMRRC Submission 043005-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.050) question?
Stock # R5440 (G1)
Quality Score 225
Status Not validated
Chromosome 15
Chromosomal Location 77518151-77527486 bp(-) (GRCm39)
Type of Mutation nonsense
DNA Base Change (assembly) T to A at 77519793 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Lysine to Stop codon at position 96 (K96*)
Ref Sequence ENSEMBL: ENSMUSP00000137890 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000166623] [ENSMUST00000180949] [ENSMUST00000181154] [ENSMUST00000181467]
AlphaFold E9PUZ0
Predicted Effect probably null
Transcript: ENSMUST00000166623
AA Change: K96*
SMART Domains Protein: ENSMUSP00000129476
Gene: ENSMUSG00000091694
AA Change: K96*

DomainStartEndE-ValueType
Pfam:ApoL 30 311 8.6e-78 PFAM
Predicted Effect probably null
Transcript: ENSMUST00000180949
AA Change: K96*
SMART Domains Protein: ENSMUSP00000137890
Gene: ENSMUSG00000091694
AA Change: K96*

DomainStartEndE-ValueType
Pfam:ApoL 29 323 5.1e-76 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000181154
SMART Domains Protein: ENSMUSP00000137798
Gene: ENSMUSG00000091694

DomainStartEndE-ValueType
Pfam:ApoL 29 76 5.4e-9 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000181467
SMART Domains Protein: ENSMUSP00000138009
Gene: ENSMUSG00000091694

DomainStartEndE-ValueType
Pfam:ApoL 1 144 2.3e-15 PFAM
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.6%
  • 10x: 97.3%
  • 20x: 95.3%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 42 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Apc G T 18: 34,354,213 (GRCm39) probably benign Het
Arhgap35 C T 7: 16,296,849 (GRCm39) G739S probably damaging Het
Atp6v0a4 A C 6: 38,069,752 (GRCm39) F47V probably damaging Het
Bcl9 G A 3: 97,117,881 (GRCm39) P271L probably benign Het
Cd109 T C 9: 78,587,446 (GRCm39) probably null Het
Col12a1 T A 9: 79,521,645 (GRCm39) I2771F probably benign Het
Col6a1 A G 10: 76,559,288 (GRCm39) V116A probably damaging Het
Cpsf2 C G 12: 101,963,138 (GRCm39) L401V probably benign Het
Cwf19l2 G A 9: 3,475,549 (GRCm39) E829K probably damaging Het
D7Ertd443e G A 7: 133,951,004 (GRCm39) T223I probably damaging Het
Dtx4 G A 19: 12,469,681 (GRCm39) R149C probably damaging Het
Fam186b C T 15: 99,171,734 (GRCm39) A838T possibly damaging Het
Fzd4 G T 7: 89,057,326 (GRCm39) E458* probably null Het
Gm17669 C T 18: 67,695,526 (GRCm39) P24S possibly damaging Het
Grin2b C T 6: 135,713,304 (GRCm39) G859D probably damaging Het
Gucy2e T C 11: 69,114,472 (GRCm39) Y1019C probably damaging Het
Gzme T A 14: 56,355,910 (GRCm39) N134I possibly damaging Het
Havcr1 A T 11: 46,643,197 (GRCm39) Y39F probably damaging Het
Hint3 A T 10: 30,494,347 (GRCm39) M1K probably null Het
Hspa4l A G 3: 40,736,008 (GRCm39) K543R probably damaging Het
Ifna9 A G 4: 88,510,048 (GRCm39) probably null Het
Itgb4 C T 11: 115,874,983 (GRCm39) R447W probably benign Het
Lipo2 A G 19: 33,698,258 (GRCm39) I373T probably benign Het
Myo5c T A 9: 75,165,407 (GRCm39) I405N possibly damaging Het
Or10a49 T C 7: 108,467,833 (GRCm39) H176R probably damaging Het
P2rx1 A G 11: 72,899,329 (GRCm39) M108V probably benign Het
Pcsk2 T A 2: 143,388,463 (GRCm39) V18E probably benign Het
Pigr A T 1: 130,777,359 (GRCm39) probably null Het
Pkp1 A T 1: 135,810,230 (GRCm39) C447S probably benign Het
Prom1 T A 5: 44,215,988 (GRCm39) I96F probably benign Het
Prpf4b T C 13: 35,068,076 (GRCm39) probably benign Het
Ropn1 C A 16: 34,491,542 (GRCm39) D102E probably benign Het
Slc35e2 C T 4: 155,694,483 (GRCm39) P10L probably benign Het
Sphk1 T G 11: 116,425,714 (GRCm39) V17G possibly damaging Het
Syngr1 A G 15: 79,982,219 (GRCm39) N2S probably benign Het
Syt9 T G 7: 107,101,330 (GRCm39) S359A possibly damaging Het
Terb1 T C 8: 105,215,131 (GRCm39) I282V probably damaging Het
Ttn T A 2: 76,585,168 (GRCm39) I22042F probably damaging Het
Ttn A T 2: 76,739,600 (GRCm39) D3646E probably benign Het
Ube2d1 A G 10: 71,091,682 (GRCm39) W141R probably damaging Het
Vmn2r41 T A 7: 8,141,362 (GRCm39) I701F probably damaging Het
Zfp770 T C 2: 114,026,596 (GRCm39) D491G probably benign Het
Other mutations in Apol11b
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01294:Apol11b APN 15 77,522,219 (GRCm39) missense probably damaging 0.99
IGL01295:Apol11b APN 15 77,522,219 (GRCm39) missense probably damaging 0.99
IGL01398:Apol11b APN 15 77,522,219 (GRCm39) missense probably damaging 0.99
IGL01399:Apol11b APN 15 77,522,219 (GRCm39) missense probably damaging 0.99
IGL01400:Apol11b APN 15 77,522,219 (GRCm39) missense probably damaging 0.99
IGL01402:Apol11b APN 15 77,522,219 (GRCm39) missense probably damaging 0.99
R1815:Apol11b UTSW 15 77,519,772 (GRCm39) missense probably damaging 1.00
R2327:Apol11b UTSW 15 77,522,153 (GRCm39) missense probably damaging 0.97
R3917:Apol11b UTSW 15 77,519,504 (GRCm39) missense probably benign 0.03
R4424:Apol11b UTSW 15 77,522,133 (GRCm39) critical splice donor site probably null
R4766:Apol11b UTSW 15 77,519,133 (GRCm39) missense probably benign 0.00
R4804:Apol11b UTSW 15 77,519,466 (GRCm39) missense probably damaging 1.00
R5600:Apol11b UTSW 15 77,519,288 (GRCm39) missense probably damaging 0.97
R5866:Apol11b UTSW 15 77,524,747 (GRCm39) missense probably null 0.97
R5997:Apol11b UTSW 15 77,519,697 (GRCm39) missense probably benign 0.01
R6213:Apol11b UTSW 15 77,522,200 (GRCm39) missense possibly damaging 0.82
R6249:Apol11b UTSW 15 77,519,537 (GRCm39) missense probably benign 0.00
R6364:Apol11b UTSW 15 77,522,258 (GRCm39) missense possibly damaging 0.46
R6984:Apol11b UTSW 15 77,519,546 (GRCm39) missense probably benign 0.01
R8064:Apol11b UTSW 15 77,519,417 (GRCm39) missense not run
R9081:Apol11b UTSW 15 77,524,771 (GRCm39) missense possibly damaging 0.91
R9082:Apol11b UTSW 15 77,524,771 (GRCm39) missense possibly damaging 0.91
R9105:Apol11b UTSW 15 77,524,771 (GRCm39) missense possibly damaging 0.91
R9569:Apol11b UTSW 15 77,524,771 (GRCm39) missense possibly damaging 0.91
R9570:Apol11b UTSW 15 77,524,771 (GRCm39) missense possibly damaging 0.91
R9571:Apol11b UTSW 15 77,524,771 (GRCm39) missense possibly damaging 0.91
R9573:Apol11b UTSW 15 77,524,771 (GRCm39) missense possibly damaging 0.91
R9790:Apol11b UTSW 15 77,519,475 (GRCm39) missense probably benign 0.17
R9791:Apol11b UTSW 15 77,519,475 (GRCm39) missense probably benign 0.17
Z1088:Apol11b UTSW 15 77,522,207 (GRCm39) missense probably benign 0.17
Z1176:Apol11b UTSW 15 77,522,207 (GRCm39) missense probably benign 0.17
Z1177:Apol11b UTSW 15 77,522,207 (GRCm39) missense probably benign 0.17
Predicted Primers PCR Primer
(F):5'- ATGCTGAGAGTGCCAGACTG -3'
(R):5'- GGATCGTGGACATCTAGGATG -3'

Sequencing Primer
(F):5'- AGACTGGCCCCTGCTGTAAC -3'
(R):5'- GTAGAATGGAAAACTTTGGATCTCTG -3'
Posted On 2016-09-01