Incidental Mutation 'R5371:Vmn2r98'
ID |
428752 |
Institutional Source |
Beutler Lab
|
Gene Symbol |
Vmn2r98
|
Ensembl Gene |
ENSMUSG00000096717 |
Gene Name |
vomeronasal 2, receptor 98 |
Synonyms |
EG224552 |
Accession Numbers |
|
Essential gene? |
Probably non essential
(E-score: 0.096)
|
Stock # |
R5371 (G1)
|
Quality Score |
225 |
Status
|
Validated
|
Chromosome |
17 |
Chromosomal Location |
19273755-19301573 bp(+) (GRCm39) |
Type of Mutation |
missense |
DNA Base Change (assembly) |
G to A
at 19290015 bp (GRCm39)
|
Zygosity |
Heterozygous |
Amino Acid Change |
Cysteine to Tyrosine
at position 517
(C517Y)
|
Ref Sequence |
ENSEMBL: ENSMUSP00000131261
(fasta)
|
Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000170424]
|
AlphaFold |
E9PZ56 |
Predicted Effect |
probably damaging
Transcript: ENSMUST00000170424
AA Change: C517Y
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
SMART Domains |
Protein: ENSMUSP00000131261 Gene: ENSMUSG00000096717 AA Change: C517Y
Domain | Start | End | E-Value | Type |
signal peptide
|
1 |
19 |
N/A |
INTRINSIC |
Pfam:ANF_receptor
|
82 |
460 |
2.6e-35 |
PFAM |
Pfam:NCD3G
|
509 |
562 |
7.4e-22 |
PFAM |
Pfam:7tm_3
|
594 |
830 |
1.4e-52 |
PFAM |
low complexity region
|
844 |
856 |
N/A |
INTRINSIC |
|
Meta Mutation Damage Score |
0.6467 |
Coding Region Coverage |
- 1x: 99.2%
- 3x: 98.5%
- 10x: 97.0%
- 20x: 94.6%
|
Validation Efficiency |
96% (71/74) |
Allele List at MGI |
|
Other mutations in this stock |
Total: 59 list
Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
4930432E11Rik |
G |
T |
7: 29,261,918 (GRCm39) |
|
noncoding transcript |
Het |
Arpp21 |
G |
A |
9: 111,895,000 (GRCm39) |
P755S |
probably benign |
Het |
Aspm |
C |
T |
1: 139,398,279 (GRCm39) |
Q982* |
probably null |
Het |
Atp5f1e |
C |
T |
2: 174,304,319 (GRCm39) |
|
probably benign |
Het |
BC024139 |
A |
G |
15: 76,004,886 (GRCm39) |
*598Q |
probably null |
Het |
Bcl6 |
T |
A |
16: 23,788,736 (GRCm39) |
D544V |
possibly damaging |
Het |
Ccdc9 |
A |
T |
7: 16,014,655 (GRCm39) |
D195E |
probably damaging |
Het |
Cd38 |
A |
G |
5: 44,026,225 (GRCm39) |
N3S |
probably benign |
Het |
Cfap46 |
A |
T |
7: 139,212,097 (GRCm39) |
|
probably null |
Het |
Cmtr2 |
T |
C |
8: 110,948,044 (GRCm39) |
F118S |
probably damaging |
Het |
Cyp7a1 |
A |
G |
4: 6,268,378 (GRCm39) |
F449S |
probably damaging |
Het |
Dnah10 |
C |
T |
5: 124,820,693 (GRCm39) |
A509V |
probably benign |
Het |
Dsp |
A |
T |
13: 38,378,865 (GRCm39) |
Q1271L |
probably damaging |
Het |
Edar |
A |
C |
10: 58,443,274 (GRCm39) |
V284G |
possibly damaging |
Het |
Fdft1 |
A |
G |
14: 63,388,750 (GRCm39) |
V294A |
probably damaging |
Het |
Gba1 |
T |
A |
3: 89,112,778 (GRCm39) |
V140E |
probably benign |
Het |
Gm12185 |
A |
T |
11: 48,806,566 (GRCm39) |
S208R |
probably benign |
Het |
Gm21028 |
C |
A |
7: 42,227,946 (GRCm39) |
E23* |
probably null |
Het |
Gm6871 |
A |
G |
7: 41,222,992 (GRCm39) |
L32P |
probably benign |
Het |
Hhip |
C |
T |
8: 80,724,220 (GRCm39) |
V341M |
probably damaging |
Het |
Kcnq2 |
C |
A |
2: 180,776,813 (GRCm39) |
V25L |
probably damaging |
Het |
Krit1 |
C |
A |
5: 3,881,551 (GRCm39) |
H548N |
probably damaging |
Het |
Kynu |
C |
T |
2: 43,479,406 (GRCm39) |
A100V |
probably benign |
Het |
Lpp |
T |
C |
16: 24,708,554 (GRCm39) |
C295R |
probably damaging |
Het |
Mdp1 |
A |
G |
14: 55,897,806 (GRCm39) |
V9A |
probably damaging |
Het |
Mllt3 |
T |
C |
4: 87,759,093 (GRCm39) |
I318M |
possibly damaging |
Het |
Mpzl3 |
A |
G |
9: 44,966,510 (GRCm39) |
|
probably benign |
Het |
Mroh2a |
A |
G |
1: 88,186,386 (GRCm39) |
S64G |
probably benign |
Het |
Mup8 |
A |
G |
4: 60,222,423 (GRCm39) |
V16A |
probably benign |
Het |
Myh13 |
T |
A |
11: 67,235,616 (GRCm39) |
|
probably null |
Het |
Myh4 |
A |
T |
11: 67,150,150 (GRCm39) |
Q1869L |
probably damaging |
Het |
Nt5c |
G |
A |
11: 115,381,643 (GRCm39) |
|
probably null |
Het |
Olfr908 |
CACAACAACA |
CACAACA |
9: 38,427,434 (GRCm39) |
|
probably benign |
Het |
Or13c7b |
A |
T |
4: 43,821,058 (GRCm39) |
M101K |
probably damaging |
Het |
Or51h7 |
T |
A |
7: 102,591,719 (GRCm39) |
M22L |
probably benign |
Het |
Or5d43 |
C |
A |
2: 88,104,976 (GRCm39) |
C139F |
probably damaging |
Het |
Parp11 |
T |
C |
6: 127,447,755 (GRCm39) |
F30L |
probably damaging |
Het |
Pcdhgc3 |
A |
T |
18: 37,941,507 (GRCm39) |
D636V |
possibly damaging |
Het |
Ppp1cb |
T |
C |
5: 32,643,332 (GRCm39) |
F234L |
probably damaging |
Het |
Rras2 |
A |
T |
7: 113,649,572 (GRCm39) |
V164E |
probably damaging |
Het |
Rsf1 |
GCGGCGGCG |
GCGGCGGCGACGGCGGCG |
7: 97,229,120 (GRCm39) |
|
probably benign |
Het |
Scg3 |
T |
C |
9: 75,568,583 (GRCm39) |
T390A |
probably damaging |
Het |
Shh |
C |
A |
5: 28,671,688 (GRCm39) |
C25F |
probably damaging |
Het |
Slc24a1 |
T |
C |
9: 64,856,550 (GRCm39) |
K119R |
unknown |
Het |
Speg |
G |
T |
1: 75,408,037 (GRCm39) |
R3244L |
possibly damaging |
Het |
Spns1 |
A |
G |
7: 125,972,936 (GRCm39) |
|
probably benign |
Het |
Sptbn4 |
A |
C |
7: 27,059,166 (GRCm39) |
|
probably null |
Het |
Stap1 |
T |
A |
5: 86,244,375 (GRCm39) |
F214Y |
possibly damaging |
Het |
Tcerg1 |
T |
A |
18: 42,652,600 (GRCm39) |
M76K |
unknown |
Het |
Tjp1 |
A |
T |
7: 64,963,059 (GRCm39) |
Y959* |
probably null |
Het |
Tmprss11e |
A |
T |
5: 86,875,225 (GRCm39) |
C14S |
probably benign |
Het |
Tnfrsf14 |
T |
C |
4: 155,006,934 (GRCm39) |
|
probably null |
Het |
Tsfm |
A |
C |
10: 126,847,512 (GRCm39) |
V193G |
probably benign |
Het |
Ube2q2l |
T |
A |
6: 136,378,371 (GRCm39) |
Y153F |
probably benign |
Het |
Ush2a |
A |
T |
1: 188,175,267 (GRCm39) |
I1122L |
probably benign |
Het |
Vmn1r74 |
T |
A |
7: 11,580,984 (GRCm39) |
S95T |
probably damaging |
Het |
Vstm2b |
G |
A |
7: 40,550,702 (GRCm39) |
S99N |
possibly damaging |
Het |
Zbtb24 |
A |
G |
10: 41,327,537 (GRCm39) |
N141S |
probably benign |
Het |
Zcchc4 |
T |
G |
5: 52,942,512 (GRCm39) |
C106G |
probably benign |
Het |
|
Other mutations in Vmn2r98 |
Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
IGL00897:Vmn2r98
|
APN |
17 |
19,286,007 (GRCm39) |
splice site |
probably benign |
|
IGL01296:Vmn2r98
|
APN |
17 |
19,285,447 (GRCm39) |
missense |
probably damaging |
1.00 |
IGL01363:Vmn2r98
|
APN |
17 |
19,286,020 (GRCm39) |
missense |
probably benign |
0.01 |
IGL01618:Vmn2r98
|
APN |
17 |
19,285,521 (GRCm39) |
missense |
possibly damaging |
0.93 |
IGL01746:Vmn2r98
|
APN |
17 |
19,286,713 (GRCm39) |
missense |
probably damaging |
1.00 |
IGL01747:Vmn2r98
|
APN |
17 |
19,286,702 (GRCm39) |
missense |
probably damaging |
1.00 |
IGL01770:Vmn2r98
|
APN |
17 |
19,286,702 (GRCm39) |
missense |
probably damaging |
1.00 |
IGL01868:Vmn2r98
|
APN |
17 |
19,286,548 (GRCm39) |
missense |
probably benign |
|
IGL02123:Vmn2r98
|
APN |
17 |
19,300,941 (GRCm39) |
missense |
probably damaging |
1.00 |
IGL02323:Vmn2r98
|
APN |
17 |
19,286,113 (GRCm39) |
missense |
probably damaging |
0.99 |
IGL02543:Vmn2r98
|
APN |
17 |
19,286,083 (GRCm39) |
missense |
probably benign |
|
IGL02650:Vmn2r98
|
APN |
17 |
19,301,223 (GRCm39) |
missense |
probably benign |
0.00 |
IGL02676:Vmn2r98
|
APN |
17 |
19,285,521 (GRCm39) |
missense |
probably benign |
0.00 |
IGL02803:Vmn2r98
|
APN |
17 |
19,286,275 (GRCm39) |
missense |
probably benign |
|
IGL02807:Vmn2r98
|
APN |
17 |
19,301,283 (GRCm39) |
missense |
probably damaging |
1.00 |
IGL03307:Vmn2r98
|
APN |
17 |
19,286,242 (GRCm39) |
missense |
possibly damaging |
0.62 |
IGL03396:Vmn2r98
|
APN |
17 |
19,290,107 (GRCm39) |
missense |
possibly damaging |
0.92 |
PIT4131001:Vmn2r98
|
UTSW |
17 |
19,301,223 (GRCm39) |
missense |
probably benign |
0.00 |
R0122:Vmn2r98
|
UTSW |
17 |
19,286,662 (GRCm39) |
missense |
probably benign |
0.06 |
R0329:Vmn2r98
|
UTSW |
17 |
19,286,609 (GRCm39) |
missense |
probably benign |
0.21 |
R0330:Vmn2r98
|
UTSW |
17 |
19,286,609 (GRCm39) |
missense |
probably benign |
0.21 |
R0368:Vmn2r98
|
UTSW |
17 |
19,286,089 (GRCm39) |
nonsense |
probably null |
|
R0545:Vmn2r98
|
UTSW |
17 |
19,273,875 (GRCm39) |
missense |
probably benign |
0.15 |
R0635:Vmn2r98
|
UTSW |
17 |
19,300,759 (GRCm39) |
missense |
probably benign |
0.00 |
R0689:Vmn2r98
|
UTSW |
17 |
19,300,782 (GRCm39) |
missense |
possibly damaging |
0.83 |
R1035:Vmn2r98
|
UTSW |
17 |
19,301,011 (GRCm39) |
missense |
possibly damaging |
0.90 |
R1243:Vmn2r98
|
UTSW |
17 |
19,286,210 (GRCm39) |
missense |
possibly damaging |
0.52 |
R1421:Vmn2r98
|
UTSW |
17 |
19,285,440 (GRCm39) |
missense |
probably damaging |
1.00 |
R1629:Vmn2r98
|
UTSW |
17 |
19,287,645 (GRCm39) |
missense |
possibly damaging |
0.94 |
R1643:Vmn2r98
|
UTSW |
17 |
19,301,170 (GRCm39) |
missense |
probably damaging |
1.00 |
R1795:Vmn2r98
|
UTSW |
17 |
19,286,702 (GRCm39) |
missense |
probably damaging |
1.00 |
R1958:Vmn2r98
|
UTSW |
17 |
19,286,680 (GRCm39) |
missense |
possibly damaging |
0.70 |
R1962:Vmn2r98
|
UTSW |
17 |
19,285,595 (GRCm39) |
nonsense |
probably null |
|
R2165:Vmn2r98
|
UTSW |
17 |
19,301,553 (GRCm39) |
missense |
unknown |
|
R2238:Vmn2r98
|
UTSW |
17 |
19,286,213 (GRCm39) |
missense |
probably damaging |
1.00 |
R2252:Vmn2r98
|
UTSW |
17 |
19,300,698 (GRCm39) |
missense |
probably benign |
0.00 |
R2323:Vmn2r98
|
UTSW |
17 |
19,286,081 (GRCm39) |
missense |
probably benign |
0.18 |
R2887:Vmn2r98
|
UTSW |
17 |
19,301,439 (GRCm39) |
missense |
possibly damaging |
0.83 |
R2909:Vmn2r98
|
UTSW |
17 |
19,287,664 (GRCm39) |
missense |
probably damaging |
1.00 |
R3001:Vmn2r98
|
UTSW |
17 |
19,286,125 (GRCm39) |
missense |
probably benign |
0.01 |
R3002:Vmn2r98
|
UTSW |
17 |
19,286,125 (GRCm39) |
missense |
probably benign |
0.01 |
R3003:Vmn2r98
|
UTSW |
17 |
19,286,125 (GRCm39) |
missense |
probably benign |
0.01 |
R3788:Vmn2r98
|
UTSW |
17 |
19,300,887 (GRCm39) |
missense |
probably benign |
0.31 |
R4570:Vmn2r98
|
UTSW |
17 |
19,286,354 (GRCm39) |
missense |
probably benign |
0.11 |
R4706:Vmn2r98
|
UTSW |
17 |
19,290,007 (GRCm39) |
missense |
probably damaging |
1.00 |
R4723:Vmn2r98
|
UTSW |
17 |
19,286,602 (GRCm39) |
missense |
probably benign |
0.01 |
R5036:Vmn2r98
|
UTSW |
17 |
19,286,419 (GRCm39) |
missense |
probably benign |
0.00 |
R5072:Vmn2r98
|
UTSW |
17 |
19,286,306 (GRCm39) |
missense |
probably benign |
0.07 |
R5121:Vmn2r98
|
UTSW |
17 |
19,273,815 (GRCm39) |
missense |
probably benign |
0.13 |
R5283:Vmn2r98
|
UTSW |
17 |
19,300,981 (GRCm39) |
missense |
probably benign |
0.05 |
R5294:Vmn2r98
|
UTSW |
17 |
19,290,016 (GRCm39) |
nonsense |
probably null |
|
R5532:Vmn2r98
|
UTSW |
17 |
19,287,645 (GRCm39) |
missense |
possibly damaging |
0.94 |
R5598:Vmn2r98
|
UTSW |
17 |
19,301,161 (GRCm39) |
missense |
probably benign |
0.37 |
R5800:Vmn2r98
|
UTSW |
17 |
19,286,260 (GRCm39) |
missense |
probably benign |
0.17 |
R6089:Vmn2r98
|
UTSW |
17 |
19,286,336 (GRCm39) |
missense |
probably benign |
0.29 |
R6155:Vmn2r98
|
UTSW |
17 |
19,286,143 (GRCm39) |
missense |
possibly damaging |
0.87 |
R6853:Vmn2r98
|
UTSW |
17 |
19,286,063 (GRCm39) |
missense |
probably benign |
0.00 |
R6920:Vmn2r98
|
UTSW |
17 |
19,285,510 (GRCm39) |
missense |
probably damaging |
0.98 |
R7012:Vmn2r98
|
UTSW |
17 |
19,286,530 (GRCm39) |
missense |
probably benign |
0.06 |
R7042:Vmn2r98
|
UTSW |
17 |
19,301,184 (GRCm39) |
missense |
probably benign |
|
R7068:Vmn2r98
|
UTSW |
17 |
19,285,575 (GRCm39) |
missense |
probably benign |
|
R7607:Vmn2r98
|
UTSW |
17 |
19,287,570 (GRCm39) |
missense |
possibly damaging |
0.95 |
R7763:Vmn2r98
|
UTSW |
17 |
19,300,797 (GRCm39) |
missense |
probably benign |
0.00 |
R7771:Vmn2r98
|
UTSW |
17 |
19,287,460 (GRCm39) |
splice site |
probably null |
|
R7915:Vmn2r98
|
UTSW |
17 |
19,287,493 (GRCm39) |
missense |
probably benign |
0.10 |
R8028:Vmn2r98
|
UTSW |
17 |
19,273,912 (GRCm39) |
missense |
probably benign |
0.00 |
R8205:Vmn2r98
|
UTSW |
17 |
19,301,425 (GRCm39) |
missense |
probably damaging |
0.99 |
R8241:Vmn2r98
|
UTSW |
17 |
19,301,031 (GRCm39) |
missense |
probably damaging |
0.99 |
R8906:Vmn2r98
|
UTSW |
17 |
19,286,532 (GRCm39) |
missense |
probably benign |
|
R8952:Vmn2r98
|
UTSW |
17 |
19,285,531 (GRCm39) |
missense |
possibly damaging |
0.76 |
R9147:Vmn2r98
|
UTSW |
17 |
19,286,383 (GRCm39) |
missense |
probably benign |
0.04 |
R9148:Vmn2r98
|
UTSW |
17 |
19,286,383 (GRCm39) |
missense |
probably benign |
0.04 |
R9187:Vmn2r98
|
UTSW |
17 |
19,301,481 (GRCm39) |
missense |
probably damaging |
1.00 |
R9344:Vmn2r98
|
UTSW |
17 |
19,286,777 (GRCm39) |
missense |
probably benign |
0.14 |
R9467:Vmn2r98
|
UTSW |
17 |
19,287,517 (GRCm39) |
missense |
probably benign |
0.01 |
R9487:Vmn2r98
|
UTSW |
17 |
19,301,496 (GRCm39) |
missense |
possibly damaging |
0.78 |
R9753:Vmn2r98
|
UTSW |
17 |
19,285,665 (GRCm39) |
missense |
probably benign |
0.27 |
Z1177:Vmn2r98
|
UTSW |
17 |
19,287,685 (GRCm39) |
nonsense |
probably null |
|
Z1177:Vmn2r98
|
UTSW |
17 |
19,285,398 (GRCm39) |
critical splice acceptor site |
probably null |
|
|
Predicted Primers |
PCR Primer
(F):5'- GGTATATCAACTAATGGCTTCCCC -3'
(R):5'- GGCTGTTTTGAACTAATTAAAGGGG -3'
Sequencing Primer
(F):5'- TGGCTTCCCCAATGGATCCAG -3'
(R):5'- TTTGAACTAATTAAAGGGGATGGTG -3'
|
Posted On |
2016-09-06 |