Incidental Mutation 'R5446:Paip2b'
ID 429070
Institutional Source Beutler Lab
Gene Symbol Paip2b
Ensembl Gene ENSMUSG00000045896
Gene Name poly(A) binding protein interacting protein 2B
MMRRC Submission 043011-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R5446 (G1)
Quality Score 225
Status Not validated
Chromosome 6
Chromosomal Location 83783040-83808723 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 83791844 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Isoleucine to Valine at position 13 (I13V)
Ref Sequence ENSEMBL: ENSMUSP00000050404 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000058383]
AlphaFold Q91W45
Predicted Effect probably benign
Transcript: ENSMUST00000058383
AA Change: I13V

PolyPhen 2 Score 0.028 (Sensitivity: 0.95; Specificity: 0.81)
SMART Domains Protein: ENSMUSP00000050404
Gene: ENSMUSG00000045896
AA Change: I13V

Pfam:PAM2 118 135 5.8e-10 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000125493
Predicted Effect noncoding transcript
Transcript: ENSMUST00000142806
Predicted Effect noncoding transcript
Transcript: ENSMUST00000145593
Coding Region Coverage
  • 1x: 99.3%
  • 3x: 98.7%
  • 10x: 97.4%
  • 20x: 95.8%
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] Most mRNAs, except for histones, contain a 3-prime poly(A) tail. Poly(A)-binding protein (PABP; see MIM 604679) enhances translation by circularizing mRNA through its interaction with the translation initiation factor EIF4G1 (MIM 600495) and the poly(A) tail. Various PABP-binding proteins regulate PABP activity, including PAIP1 (MIM 605184), a translational stimulator, and PAIP2A (MIM 605604) and PAIP2B, translational inhibitors (Derry et al., 2006 [PubMed 17381337]).[supplied by OMIM, Mar 2008]
PHENOTYPE: Mice homozygous for a knock-out allele exhibit normal reproductive system physiology. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 39 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adar A G 3: 89,647,486 (GRCm39) N155S probably damaging Het
Ak9 A G 10: 41,296,505 (GRCm39) D1417G possibly damaging Het
Ankrd52 G T 10: 128,224,430 (GRCm39) C736F probably damaging Het
Arhgap15 T A 2: 43,718,772 (GRCm39) H85Q probably benign Het
Bcat2 G A 7: 45,234,569 (GRCm39) R110H possibly damaging Het
Bscl2 A G 19: 8,823,564 (GRCm39) H4R possibly damaging Het
Cdh2 T C 18: 16,779,684 (GRCm39) I126V probably damaging Het
Cnbd2 A C 2: 156,209,581 (GRCm39) E508A possibly damaging Het
Crb2 T C 2: 37,685,461 (GRCm39) I1191T probably benign Het
Dync2h1 T C 9: 7,144,217 (GRCm39) T1075A probably benign Het
Edil3 A C 13: 89,332,957 (GRCm39) H371P possibly damaging Het
Gm5134 T C 10: 75,831,670 (GRCm39) S370P probably damaging Het
Helz T C 11: 107,523,030 (GRCm39) V737A probably damaging Het
Jade2 A G 11: 51,707,786 (GRCm39) V809A probably benign Het
Klhl23 T A 2: 69,654,582 (GRCm39) C151S probably damaging Het
Krt75 T C 15: 101,479,502 (GRCm39) D276G probably null Het
Lipm C T 19: 34,095,287 (GRCm39) A294V possibly damaging Het
Med13l A G 5: 118,880,462 (GRCm39) N1185D possibly damaging Het
Mmp27 T A 9: 7,573,516 (GRCm39) probably benign Het
Mroh2a A T 1: 88,182,687 (GRCm39) N1205I possibly damaging Het
Muc21 T A 17: 35,933,395 (GRCm39) probably benign Het
Npnt A G 3: 132,614,130 (GRCm39) L191P probably damaging Het
Or4c10b A T 2: 89,711,893 (GRCm39) H241L probably damaging Het
Pcdhac2 T A 18: 37,278,253 (GRCm39) L411Q probably damaging Het
Plekhd1 A G 12: 80,767,410 (GRCm39) N266S probably benign Het
Pnpla8 A G 12: 44,337,368 (GRCm39) T454A possibly damaging Het
Prkcg A T 7: 3,378,780 (GRCm39) Y675F probably benign Het
Pwwp2b T A 7: 138,835,066 (GRCm39) I169N probably damaging Het
Rreb1 G A 13: 38,082,473 (GRCm39) R86H possibly damaging Het
Smok3c A C 5: 138,062,895 (GRCm39) L127F probably damaging Het
St6galnac1 T A 11: 116,657,095 (GRCm39) M427L probably benign Het
Synm T C 7: 67,385,722 (GRCm39) T205A probably benign Het
Tsbp1 T C 17: 34,659,867 (GRCm39) probably null Het
Ttn A T 2: 76,641,587 (GRCm39) L5176Q possibly damaging Het
Vmn2r112 A G 17: 22,837,231 (GRCm39) Y564C probably damaging Het
Vmn2r90 A C 17: 17,932,464 (GRCm39) T124P probably damaging Het
Vpreb1a A T 16: 16,686,554 (GRCm39) V112E probably damaging Het
Zfp451 A G 1: 33,816,609 (GRCm39) L447S probably damaging Het
Zfp746 T C 6: 48,041,107 (GRCm39) T539A probably damaging Het
Other mutations in Paip2b
AlleleSourceChrCoordTypePredicted EffectPPH Score
PIT4131001:Paip2b UTSW 6 83,785,823 (GRCm39) missense probably damaging 1.00
R0635:Paip2b UTSW 6 83,786,891 (GRCm39) missense possibly damaging 0.79
R5752:Paip2b UTSW 6 83,808,252 (GRCm39) critical splice donor site probably null
R5994:Paip2b UTSW 6 83,785,867 (GRCm39) missense probably damaging 0.99
R6102:Paip2b UTSW 6 83,785,828 (GRCm39) missense possibly damaging 0.94
R6185:Paip2b UTSW 6 83,786,952 (GRCm39) missense probably benign 0.01
R7342:Paip2b UTSW 6 83,791,808 (GRCm39) missense probably damaging 0.97
R8819:Paip2b UTSW 6 83,791,738 (GRCm39) missense probably damaging 1.00
R8820:Paip2b UTSW 6 83,791,738 (GRCm39) missense probably damaging 1.00
R9634:Paip2b UTSW 6 83,787,023 (GRCm39) missense probably damaging 1.00
Z1088:Paip2b UTSW 6 83,785,864 (GRCm39) missense probably benign 0.01
Predicted Primers PCR Primer

Sequencing Primer
Posted On 2016-09-06