Mutagenetix > Incidental Mutation

Incidental Mutation 'R5446:Gm9573'

429097

Institutional Source

Beutler Lab

Gene Symbol

Gm9573

Ensembl Gene

ENSMUSG00000090588

Gene Name

predicted gene 9573

Synonyms

Muc21, epiglycanin

MMRRC Submission

043011-MU

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.098) question?

Stock #

R5446 (G1)

Quality Score

225

Status

Not validated

Chromosome

Chromosomal Location

35617923-35626637 bp(-) (GRCm38)

Type of Mutation

intron

DNA Base Change (assembly)

T to A at 35622503 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Ref Sequence

ENSEMBL: ENSMUSP00000134221 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000164502] [ENSMUST00000174521]

AlphaFold

F7C950

Predicted Effect

unknown
Transcript: ENSMUST00000164502
AA Change: T264S

SMART Domains

Protein: ENSMUSP00000130987
Gene: ENSMUSG00000090588
AA Change: T264S

Domain	Start	End	E-Value	Type
signal peptide	1	23	N/A	INTRINSIC
low complexity region	26	39	N/A	INTRINSIC
low complexity region	42	59	N/A	INTRINSIC
low complexity region	76	144	N/A	INTRINSIC
low complexity region	149	578	N/A	INTRINSIC
low complexity region	580	653	N/A	INTRINSIC
low complexity region	655	1179	N/A	INTRINSIC
low complexity region	1183	1373	N/A	INTRINSIC
low complexity region	1383	1436	N/A	INTRINSIC
low complexity region	1438	1479	N/A	INTRINSIC
Pfam:Epiglycanin_C	1518	1605	3.8e-22	PFAM

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000173759

Predicted Effect

probably benign
Transcript: ENSMUST00000174521

SMART Domains

Protein: ENSMUSP00000134221
Gene: ENSMUSG00000090509

Domain	Start	End	E-Value	Type
Pfam:SFTA2	80	117	9.2e-18	PFAM

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000174534

Coding Region Coverage

1x: 99.3%
3x: 98.7%
10x: 97.4%
20x: 95.8%

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 39 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Adar	A	G	3: 89,740,179 (GRCm38)	N155S	probably damaging	Het
Ak9	A	G	10: 41,420,509 (GRCm38)	D1417G	possibly damaging	Het
Ankrd52	G	T	10: 128,388,561 (GRCm38)	C736F	probably damaging	Het
Arhgap15	T	A	2: 43,828,760 (GRCm38)	H85Q	probably benign	Het
BC051142	T	C	17: 34,440,893 (GRCm38)		probably null	Het
Bcat2	G	A	7: 45,585,145 (GRCm38)	R110H	possibly damaging	Het
Bscl2	A	G	19: 8,846,200 (GRCm38)	H4R	possibly damaging	Het
Cdh2	T	C	18: 16,646,627 (GRCm38)	I126V	probably damaging	Het
Cnbd2	A	C	2: 156,367,661 (GRCm38)	E508A	possibly damaging	Het
Crb2	T	C	2: 37,795,449 (GRCm38)	I1191T	probably benign	Het
Dync2h1	T	C	9: 7,144,217 (GRCm38)	T1075A	probably benign	Het
Edil3	A	C	13: 89,184,838 (GRCm38)	H371P	possibly damaging	Het
Gm5134	T	C	10: 75,995,836 (GRCm38)	S370P	probably damaging	Het
Helz	T	C	11: 107,632,204 (GRCm38)	V737A	probably damaging	Het
Jade2	A	G	11: 51,816,959 (GRCm38)	V809A	probably benign	Het
Klhl23	T	A	2: 69,824,238 (GRCm38)	C151S	probably damaging	Het
Krt75	T	C	15: 101,571,067 (GRCm38)	D276G	probably null	Het
Lipm	C	T	19: 34,117,887 (GRCm38)	A294V	possibly damaging	Het
Med13l	A	G	5: 118,742,397 (GRCm38)	N1185D	possibly damaging	Het
Mmp27	T	A	9: 7,573,515 (GRCm38)		probably benign	Het
Mroh2a	A	T	1: 88,254,965 (GRCm38)	N1205I	possibly damaging	Het
Npnt	A	G	3: 132,908,369 (GRCm38)	L191P	probably damaging	Het
Olfr1257	A	T	2: 89,881,549 (GRCm38)	H241L	probably damaging	Het
Paip2b	T	C	6: 83,814,862 (GRCm38)	I13V	probably benign	Het
Pcdhac2	T	A	18: 37,145,200 (GRCm38)	L411Q	probably damaging	Het
Plekhd1	A	G	12: 80,720,636 (GRCm38)	N266S	probably benign	Het
Pnpla8	A	G	12: 44,290,585 (GRCm38)	T454A	possibly damaging	Het
Prkcg	A	T	7: 3,330,264 (GRCm38)	Y675F	probably benign	Het
Pwwp2b	T	A	7: 139,255,150 (GRCm38)	I169N	probably damaging	Het
Rreb1	G	A	13: 37,898,497 (GRCm38)	R86H	possibly damaging	Het
Smok3c	A	C	5: 138,064,633 (GRCm38)	L127F	probably damaging	Het
St6galnac1	T	A	11: 116,766,269 (GRCm38)	M427L	probably benign	Het
Synm	T	C	7: 67,735,974 (GRCm38)	T205A	probably benign	Het
Ttn	A	T	2: 76,811,243 (GRCm38)	L5176Q	possibly damaging	Het
Vmn2r112	A	G	17: 22,618,250 (GRCm38)	Y564C	probably damaging	Het
Vmn2r90	A	C	17: 17,712,202 (GRCm38)	T124P	probably damaging	Het
Vpreb1	A	T	16: 16,868,690 (GRCm38)	V112E	probably damaging	Het
Zfp451	A	G	1: 33,777,528 (GRCm38)	L447S	probably damaging	Het
Zfp746	T	C	6: 48,064,173 (GRCm38)	T539A	probably damaging	Het

Other mutations in Gm9573

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
BB009:Gm9573	UTSW	17	35,622,633 (GRCm38)	intron	probably benign
FR4304:Gm9573	UTSW	17	35,622,121 (GRCm38)	intron	probably benign
R0334:Gm9573	UTSW	17	35,622,722 (GRCm38)	intron	probably benign
R0946:Gm9573	UTSW	17	35,618,213 (GRCm38)	missense	probably benign	0.32
R1117:Gm9573	UTSW	17	35,620,028 (GRCm38)	intron	probably benign
R1345:Gm9573	UTSW	17	35,621,597 (GRCm38)	intron	probably benign
R1697:Gm9573	UTSW	17	35,620,648 (GRCm38)	intron	probably benign
R1750:Gm9573	UTSW	17	35,621,048 (GRCm38)	intron	probably benign
R1756:Gm9573	UTSW	17	35,619,239 (GRCm38)	intron	probably benign
R1946:Gm9573	UTSW	17	35,622,524 (GRCm38)	intron	probably benign
R1978:Gm9573	UTSW	17	35,622,965 (GRCm38)	intron	probably benign
R1991:Gm9573	UTSW	17	35,618,708 (GRCm38)	missense	probably benign	0.32
R1992:Gm9573	UTSW	17	35,618,708 (GRCm38)	missense	probably benign	0.32
R2063:Gm9573	UTSW	17	35,621,405 (GRCm38)	intron	probably benign
R2356:Gm9573	UTSW	17	35,621,671 (GRCm38)	intron	probably benign
R2866:Gm9573	UTSW	17	35,619,707 (GRCm38)	intron	probably benign
R3826:Gm9573	UTSW	17	35,621,612 (GRCm38)	intron	probably benign
R4020:Gm9573	UTSW	17	35,620,061 (GRCm38)	intron	probably benign
R4474:Gm9573	UTSW	17	35,620,604 (GRCm38)	intron	probably benign
R4677:Gm9573	UTSW	17	35,619,707 (GRCm38)	intron	probably benign
R4786:Gm9573	UTSW	17	35,619,329 (GRCm38)	intron	probably benign
R5071:Gm9573	UTSW	17	35,620,552 (GRCm38)	intron	probably benign
R5173:Gm9573	UTSW	17	35,620,741 (GRCm38)	intron	probably benign
R5283:Gm9573	UTSW	17	35,621,332 (GRCm38)	intron	probably benign
R5542:Gm9573	UTSW	17	35,622,503 (GRCm38)	intron	probably benign
R5716:Gm9573	UTSW	17	35,620,783 (GRCm38)	intron	probably benign
R5913:Gm9573	UTSW	17	35,623,231 (GRCm38)	intron	probably benign
R6011:Gm9573	UTSW	17	35,622,182 (GRCm38)	intron	probably benign
R6198:Gm9573	UTSW	17	35,620,916 (GRCm38)	intron	probably benign
R6394:Gm9573	UTSW	17	35,620,166 (GRCm38)	intron	probably benign
R6786:Gm9573	UTSW	17	35,623,165 (GRCm38)	intron	probably benign
R6940:Gm9573	UTSW	17	35,623,226 (GRCm38)	intron	probably benign
R7082:Gm9573	UTSW	17	35,621,201 (GRCm38)	missense	unknown
R7103:Gm9573	UTSW	17	35,621,540 (GRCm38)	missense	unknown
R7110:Gm9573	UTSW	17	35,622,618 (GRCm38)	intron	probably benign
R7139:Gm9573	UTSW	17	35,622,633 (GRCm38)	intron	probably benign
R7165:Gm9573	UTSW	17	35,621,978 (GRCm38)	missense	unknown
R7200:Gm9573	UTSW	17	35,622,633 (GRCm38)	intron	probably benign
R7204:Gm9573	UTSW	17	35,621,213 (GRCm38)	intron	probably benign
R7289:Gm9573	UTSW	17	35,618,869 (GRCm38)	missense	unknown
R7290:Gm9573	UTSW	17	35,618,869 (GRCm38)	missense	unknown
R7295:Gm9573	UTSW	17	35,618,869 (GRCm38)	missense	unknown
R7319:Gm9573	UTSW	17	35,622,043 (GRCm38)	intron	probably benign
R7462:Gm9573	UTSW	17	35,620,676 (GRCm38)	missense	unknown
R7529:Gm9573	UTSW	17	35,619,231 (GRCm38)	missense	unknown
R7718:Gm9573	UTSW	17	35,622,836 (GRCm38)	missense	unknown
R7762:Gm9573	UTSW	17	35,622,085 (GRCm38)	missense	unknown
R7788:Gm9573	UTSW	17	35,618,906 (GRCm38)	missense	unknown
R7798:Gm9573	UTSW	17	35,621,254 (GRCm38)	missense	unknown
R7831:Gm9573	UTSW	17	35,618,759 (GRCm38)	missense	unknown
R7896:Gm9573	UTSW	17	35,620,025 (GRCm38)	missense	unknown
R7899:Gm9573	UTSW	17	35,620,601 (GRCm38)	intron	probably benign
R7932:Gm9573	UTSW	17	35,622,633 (GRCm38)	intron	probably benign
R8025:Gm9573	UTSW	17	35,620,987 (GRCm38)	intron	probably benign
R8077:Gm9573	UTSW	17	35,619,736 (GRCm38)	intron	probably benign
R8090:Gm9573	UTSW	17	35,621,725 (GRCm38)	missense	unknown
R8169:Gm9573	UTSW	17	35,621,180 (GRCm38)	missense	unknown
R8184:Gm9573	UTSW	17	35,622,830 (GRCm38)	missense	unknown
R8209:Gm9573	UTSW	17	35,619,707 (GRCm38)	intron	probably benign
R8226:Gm9573	UTSW	17	35,619,707 (GRCm38)	intron	probably benign
R8464:Gm9573	UTSW	17	35,622,206 (GRCm38)	intron	probably benign
R8670:Gm9573	UTSW	17	35,621,648 (GRCm38)	missense	unknown
R8783:Gm9573	UTSW	17	35,619,983 (GRCm38)	missense	unknown
R8856:Gm9573	UTSW	17	35,620,973 (GRCm38)	missense	unknown
R9155:Gm9573	UTSW	17	35,621,239 (GRCm38)	missense	unknown
R9214:Gm9573	UTSW	17	35,620,946 (GRCm38)	missense	unknown
R9353:Gm9573	UTSW	17	35,619,653 (GRCm38)	missense	unknown
R9618:Gm9573	UTSW	17	35,622,043 (GRCm38)	intron	probably benign
R9621:Gm9573	UTSW	17	35,621,828 (GRCm38)	missense	unknown
R9679:Gm9573	UTSW	17	35,619,599 (GRCm38)	missense	unknown
RF025:Gm9573	UTSW	17	35,622,879 (GRCm38)	intron	probably benign
Z1176:Gm9573	UTSW	17	35,621,245 (GRCm38)	missense	unknown
Z1177:Gm9573	UTSW	17	35,621,059 (GRCm38)	missense	unknown
Z1177:Gm9573	UTSW	17	35,620,925 (GRCm38)	missense	unknown

Predicted Primers

PCR Primer
(F):5'- TGAGGCAGTGCTGGATTCAG -3'
(R):5'- TGCCTCAGGATCTACACCTACC -3'

Sequencing Primer
(F):5'- CTGGATTCAGTGGTGGGCAG -3'
(R):5'- ATCCAGCACTGCCTCAGG -3'

Posted On

2016-09-06