Incidental Mutation 'R5450:Mroh1'
ID 429302
Institutional Source Beutler Lab
Gene Symbol Mroh1
Ensembl Gene ENSMUSG00000022558
Gene Name maestro heat-like repeat family member 1
Synonyms Heatr7a, D330001F17Rik
MMRRC Submission 043015-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.076) question?
Stock # R5450 (G1)
Quality Score 225
Status Validated
Chromosome 15
Chromosomal Location 76380261-76453038 bp(+) (GRCm38)
Type of Mutation intron
DNA Base Change (assembly) C to A at 76432347 bp (GRCm38)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000154882 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000092595] [ENSMUST00000096385] [ENSMUST00000160631] [ENSMUST00000161305]
AlphaFold E0CZ22
Predicted Effect probably benign
Transcript: ENSMUST00000092595
SMART Domains Protein: ENSMUSP00000090256
Gene: ENSMUSG00000022558

DomainStartEndE-ValueType
SCOP:d1gw5a_ 4 435 4e-10 SMART
low complexity region 442 455 N/A INTRINSIC
low complexity region 594 607 N/A INTRINSIC
low complexity region 790 801 N/A INTRINSIC
low complexity region 926 937 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000096385
SMART Domains Protein: ENSMUSP00000094115
Gene: ENSMUSG00000022558

DomainStartEndE-ValueType
low complexity region 442 455 N/A INTRINSIC
low complexity region 594 607 N/A INTRINSIC
low complexity region 799 810 N/A INTRINSIC
low complexity region 935 946 N/A INTRINSIC
low complexity region 1191 1202 N/A INTRINSIC
low complexity region 1355 1367 N/A INTRINSIC
low complexity region 1488 1502 N/A INTRINSIC
Pfam:HEAT 1610 1640 2.2e-5 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000160631
SMART Domains Protein: ENSMUSP00000123806
Gene: ENSMUSG00000022558

DomainStartEndE-ValueType
low complexity region 1 14 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000160986
Predicted Effect probably benign
Transcript: ENSMUST00000161305
Predicted Effect noncoding transcript
Transcript: ENSMUST00000161683
Predicted Effect noncoding transcript
Transcript: ENSMUST00000183412
Coding Region Coverage
  • 1x: 99.3%
  • 3x: 98.6%
  • 10x: 97.2%
  • 20x: 95.2%
Validation Efficiency 97% (74/76)
Allele List at MGI
Other mutations in this stock
Total: 65 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4930505A04Rik C T 11: 30,426,349 (GRCm38) V173M probably damaging Het
AF067063 A T 13: 119,828,363 (GRCm38) V99E probably damaging Het
Arhgef4 T G 1: 34,807,324 (GRCm38) probably benign Het
Atg14 T C 14: 47,551,464 (GRCm38) N144S probably benign Het
Cacna1h A T 17: 25,383,186 (GRCm38) M1454K probably damaging Het
Catsperb A T 12: 101,446,068 (GRCm38) H138L possibly damaging Het
Ccdc129 T A 6: 55,968,811 (GRCm38) probably null Het
Cd200r2 T A 16: 44,909,571 (GRCm38) D159E probably benign Het
Cd79a G T 7: 24,899,262 (GRCm38) G79C probably damaging Het
Ceacam20 A G 7: 19,978,208 (GRCm38) H38R possibly damaging Het
Cers1 T C 8: 70,318,297 (GRCm38) L119P probably damaging Het
Ces1f C A 8: 93,265,795 (GRCm38) V343L probably benign Het
Ces3a G A 8: 105,057,918 (GRCm38) G511S possibly damaging Het
Cyfip2 A G 11: 46,284,252 (GRCm38) C98R probably benign Het
Cyp2j11 C A 4: 96,339,876 (GRCm38) V169L probably benign Het
Cyp4f17 A G 17: 32,528,886 (GRCm38) T523A probably benign Het
Ddx31 T C 2: 28,886,969 (GRCm38) S567P probably damaging Het
Dnase1l1 C T X: 74,277,038 (GRCm38) probably null Het
Dsg1b A C 18: 20,409,064 (GRCm38) H876P probably damaging Het
Edrf1 G T 7: 133,658,610 (GRCm38) M83I probably damaging Het
Eno4 T C 19: 58,960,247 (GRCm38) F393S possibly damaging Het
Eral1 C T 11: 78,078,357 (GRCm38) D106N probably benign Het
Esp18 G T 17: 39,408,179 (GRCm38) R23M probably benign Het
Fam184b C T 5: 45,539,801 (GRCm38) V674I probably benign Het
Fbxw13 A C 9: 109,184,157 (GRCm38) N154K probably benign Het
Gtpbp6 A G 5: 110,107,125 (GRCm38) V130A probably damaging Het
Hc T C 2: 35,013,038 (GRCm38) D1067G possibly damaging Het
Ighg1 A T 12: 113,330,506 (GRCm38) S6T unknown Het
Ikzf3 C T 11: 98,467,086 (GRCm38) R475H probably damaging Het
Kcmf1 A T 6: 72,842,930 (GRCm38) L311* probably null Het
Kmt2d C A 15: 98,855,086 (GRCm38) E184D probably damaging Het
Lrguk A T 6: 34,071,061 (GRCm38) I314F probably damaging Het
Maml2 A C 9: 13,706,467 (GRCm38) S370R probably damaging Het
Mx1 A T 16: 97,454,147 (GRCm38) Y235* probably null Het
Olfr1269 A G 2: 90,118,669 (GRCm38) *310Q probably null Het
Pamr1 T G 2: 102,639,317 (GRCm38) Y403D probably damaging Het
Panx2 A G 15: 89,068,959 (GRCm38) E551G possibly damaging Het
Patl2 A G 2: 122,125,281 (GRCm38) V258A probably benign Het
Ppm1m A G 9: 106,196,842 (GRCm38) F255L probably benign Het
Prpf40a G T 2: 53,156,926 (GRCm38) T266N possibly damaging Het
Psg18 T A 7: 18,353,425 (GRCm38) I103F probably benign Het
Rpl39-ps A G 15: 102,635,148 (GRCm38) noncoding transcript Het
Rps6kb1 A T 11: 86,532,837 (GRCm38) F106I probably damaging Het
Rsf1 CG CGACGGCGGTG 7: 97,579,908 (GRCm38) probably benign Het
Sardh G T 2: 27,239,698 (GRCm38) T245K possibly damaging Het
Shprh T G 10: 11,212,330 (GRCm38) I1619S possibly damaging Het
Skint1 G A 4: 112,025,532 (GRCm38) V258I probably benign Het
Slc27a5 T C 7: 12,994,942 (GRCm38) D331G probably benign Het
Slc29a2 A G 19: 5,029,275 (GRCm38) I309V probably benign Het
Slc30a5 C T 13: 100,821,172 (GRCm38) V130I possibly damaging Het
Slc4a3 C A 1: 75,552,656 (GRCm38) A531D probably damaging Het
Slc6a16 C T 7: 45,261,248 (GRCm38) T399I probably benign Het
Slitrk6 T A 14: 110,750,097 (GRCm38) H726L probably benign Het
Snx2 A G 18: 53,210,712 (GRCm38) K309R probably damaging Het
Speer4f2 T A 5: 17,373,219 (GRCm38) C4S possibly damaging Het
Sulf1 T C 1: 12,796,907 (GRCm38) V105A probably benign Het
Tmem8b G A 4: 43,673,992 (GRCm38) V208I probably benign Het
Vmn1r47 T C 6: 90,022,213 (GRCm38) L109P probably damaging Het
Vmn1r73 C A 7: 11,756,449 (GRCm38) Q65K possibly damaging Het
Vmn1r76 T C 7: 11,930,684 (GRCm38) Y166C probably damaging Het
Vmn2r2 T C 3: 64,126,590 (GRCm38) T504A probably benign Het
Wdr75 C A 1: 45,812,164 (GRCm38) A300E probably benign Het
Yars A G 4: 129,197,246 (GRCm38) E149G possibly damaging Het
Zbtb18 T C 1: 177,447,205 (GRCm38) F35L probably damaging Het
Zfp366 A G 13: 99,229,585 (GRCm38) Y418C probably damaging Het
Other mutations in Mroh1
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01574:Mroh1 APN 15 76,432,288 (GRCm38) missense probably benign 0.01
IGL02141:Mroh1 APN 15 76,446,599 (GRCm38) missense possibly damaging 0.47
IGL02146:Mroh1 APN 15 76,434,679 (GRCm38) splice site probably benign
IGL02205:Mroh1 APN 15 76,437,239 (GRCm38) missense possibly damaging 0.81
IGL02261:Mroh1 APN 15 76,429,160 (GRCm38) missense probably benign 0.03
IGL02818:Mroh1 APN 15 76,432,401 (GRCm38) splice site probably null
IGL02949:Mroh1 APN 15 76,408,968 (GRCm38) missense probably damaging 0.97
IGL02951:Mroh1 APN 15 76,427,636 (GRCm38) missense probably damaging 1.00
IGL03154:Mroh1 APN 15 76,452,838 (GRCm38) missense probably damaging 1.00
IGL02799:Mroh1 UTSW 15 76,392,461 (GRCm38) critical splice donor site probably null
R0068:Mroh1 UTSW 15 76,446,692 (GRCm38) splice site probably benign
R0068:Mroh1 UTSW 15 76,446,692 (GRCm38) splice site probably benign
R0076:Mroh1 UTSW 15 76,451,140 (GRCm38) missense probably benign 0.00
R0180:Mroh1 UTSW 15 76,428,250 (GRCm38) missense probably damaging 0.99
R0315:Mroh1 UTSW 15 76,427,600 (GRCm38) missense possibly damaging 0.94
R0350:Mroh1 UTSW 15 76,432,249 (GRCm38) missense probably damaging 0.98
R0399:Mroh1 UTSW 15 76,452,099 (GRCm38) missense probably benign 0.44
R0835:Mroh1 UTSW 15 76,451,883 (GRCm38) missense probably damaging 0.96
R0893:Mroh1 UTSW 15 76,408,938 (GRCm38) missense possibly damaging 0.62
R1109:Mroh1 UTSW 15 76,446,509 (GRCm38) splice site probably benign
R1527:Mroh1 UTSW 15 76,452,263 (GRCm38) missense probably benign 0.03
R1595:Mroh1 UTSW 15 76,433,530 (GRCm38) splice site probably benign
R1900:Mroh1 UTSW 15 76,433,385 (GRCm38) missense probably benign 0.00
R1901:Mroh1 UTSW 15 76,436,049 (GRCm38) missense probably benign
R2223:Mroh1 UTSW 15 76,408,045 (GRCm38) critical splice donor site probably null
R2415:Mroh1 UTSW 15 76,421,211 (GRCm38) missense probably damaging 0.99
R3113:Mroh1 UTSW 15 76,408,536 (GRCm38) splice site probably benign
R3437:Mroh1 UTSW 15 76,433,608 (GRCm38) missense possibly damaging 0.92
R3618:Mroh1 UTSW 15 76,452,346 (GRCm38) missense possibly damaging 0.55
R3833:Mroh1 UTSW 15 76,401,619 (GRCm38) missense probably benign 0.08
R4073:Mroh1 UTSW 15 76,407,985 (GRCm38) missense probably benign 0.13
R4156:Mroh1 UTSW 15 76,402,126 (GRCm38) splice site probably null
R4276:Mroh1 UTSW 15 76,393,851 (GRCm38) missense probably damaging 1.00
R4745:Mroh1 UTSW 15 76,408,530 (GRCm38) critical splice donor site probably null
R5574:Mroh1 UTSW 15 76,433,931 (GRCm38) missense probably benign
R5673:Mroh1 UTSW 15 76,430,181 (GRCm38) missense probably damaging 1.00
R5970:Mroh1 UTSW 15 76,451,491 (GRCm38) missense probably benign 0.24
R5993:Mroh1 UTSW 15 76,446,680 (GRCm38) missense probably damaging 0.99
R6008:Mroh1 UTSW 15 76,451,357 (GRCm38) missense possibly damaging 0.50
R6082:Mroh1 UTSW 15 76,430,223 (GRCm38) missense probably benign 0.06
R6302:Mroh1 UTSW 15 76,436,119 (GRCm38) critical splice donor site probably null
R7030:Mroh1 UTSW 15 76,437,317 (GRCm38) missense probably benign 0.01
R7098:Mroh1 UTSW 15 76,408,457 (GRCm38) nonsense probably null
R7334:Mroh1 UTSW 15 76,427,638 (GRCm38) missense probably benign 0.00
R7337:Mroh1 UTSW 15 76,451,476 (GRCm38) missense probably benign 0.00
R7352:Mroh1 UTSW 15 76,451,474 (GRCm38) missense probably benign 0.06
R7446:Mroh1 UTSW 15 76,452,272 (GRCm38) missense possibly damaging 0.93
R7453:Mroh1 UTSW 15 76,433,545 (GRCm38) missense probably damaging 1.00
R7669:Mroh1 UTSW 15 76,451,848 (GRCm38) missense possibly damaging 0.88
R7753:Mroh1 UTSW 15 76,433,275 (GRCm38) missense possibly damaging 0.62
R7860:Mroh1 UTSW 15 76,447,332 (GRCm38) missense probably benign 0.00
R7990:Mroh1 UTSW 15 76,452,275 (GRCm38) missense probably damaging 1.00
R8140:Mroh1 UTSW 15 76,433,873 (GRCm38) missense probably benign 0.00
R8325:Mroh1 UTSW 15 76,432,215 (GRCm38) frame shift probably null
R8334:Mroh1 UTSW 15 76,446,556 (GRCm38) missense probably benign
R8529:Mroh1 UTSW 15 76,427,632 (GRCm38) missense probably benign 0.00
R8544:Mroh1 UTSW 15 76,443,358 (GRCm38) nonsense probably null
R8688:Mroh1 UTSW 15 76,428,350 (GRCm38) missense probably benign 0.00
R8769:Mroh1 UTSW 15 76,412,926 (GRCm38) missense probably benign 0.00
R8782:Mroh1 UTSW 15 76,414,296 (GRCm38) missense possibly damaging 0.74
R8887:Mroh1 UTSW 15 76,447,274 (GRCm38) missense probably benign 0.43
R8934:Mroh1 UTSW 15 76,450,186 (GRCm38) missense probably benign 0.03
R9254:Mroh1 UTSW 15 76,408,015 (GRCm38) missense probably benign 0.16
R9400:Mroh1 UTSW 15 76,451,893 (GRCm38) missense possibly damaging 0.93
R9443:Mroh1 UTSW 15 76,434,764 (GRCm38) missense probably damaging 1.00
Z1177:Mroh1 UTSW 15 76,423,761 (GRCm38) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- ACTCTCTACCTCAGGATCGAAGC -3'
(R):5'- GAGCTGTACTCCACCACACTTC -3'

Sequencing Primer
(F):5'- CTCAGGATCGAAGCGAGCAC -3'
(R):5'- TTCCCCAGGACCACCATGG -3'
Posted On 2016-09-06