Incidental Mutation 'R5366:Rgcc'
ID 429371
Institutional Source Beutler Lab
Gene Symbol Rgcc
Ensembl Gene ENSMUSG00000022018
Gene Name regulator of cell cycle
Synonyms 1190002H23Rik, RGC-32
MMRRC Submission 042944-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R5366 (G1)
Quality Score 225
Status Validated
Chromosome 14
Chromosomal Location 79526190-79539075 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 79529123 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Threonine to Alanine at position 111 (T111A)
Ref Sequence ENSEMBL: ENSMUSP00000022595 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000022595]
AlphaFold Q9DBX1
Predicted Effect probably benign
Transcript: ENSMUST00000022595
AA Change: T111A

PolyPhen 2 Score 0.008 (Sensitivity: 0.96; Specificity: 0.76)
SMART Domains Protein: ENSMUSP00000022595
Gene: ENSMUSG00000022018
AA Change: T111A

DomainStartEndE-ValueType
Pfam:RGCC 1 137 7.3e-70 PFAM
Meta Mutation Damage Score 0.1095 question?
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.6%
  • 10x: 97.2%
  • 20x: 95.2%
Validation Efficiency 100% (77/77)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene is thought to regulate cell cycle progression. It is induced by p53 in response to DNA damage, or by sublytic levels of complement system proteins that result in activation of the cell cycle. The encoded protein localizes to the cytoplasm during interphase and to centrosomes during mitosis. The protein forms a complex with polo-like kinase 1. The protein also translocates to the nucleus in response to treatment with complement system proteins, and can associate with and increase the kinase activity of cell division cycle 2 protein. In different assays and cell types, overexpression of this protein has been shown to activate or suppress cell cycle progression. [provided by RefSeq, Jul 2008]
PHENOTYPE: Mice homozygous for a null allele exhibit partial prenatal lethality, abnormal vitelline vasculature morphology, and fetal growth restriction due to impaired placental angiogenesis. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 69 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abcb5 T C 12: 118,831,665 (GRCm39) N1229S possibly damaging Het
Adgre1 G A 17: 57,709,817 (GRCm39) C158Y probably benign Het
Ahnak T A 19: 8,994,099 (GRCm39) S5128T possibly damaging Het
Ankrd36 T A 11: 5,542,841 (GRCm39) C322* probably null Het
Ano1 T A 7: 144,207,946 (GRCm39) T113S possibly damaging Het
Apeh A T 9: 107,969,005 (GRCm39) S321T probably benign Het
Atg4d T A 9: 21,179,948 (GRCm39) V273D probably damaging Het
Cacna2d4 A G 6: 119,251,279 (GRCm39) D489G probably damaging Het
Cd47 T C 16: 49,716,736 (GRCm39) F256L probably damaging Het
Cd84 A T 1: 171,700,872 (GRCm39) D211V probably damaging Het
Cfap46 A G 7: 139,230,802 (GRCm39) L942P probably damaging Het
Cfh A C 1: 140,063,973 (GRCm39) C434W probably damaging Het
Chst2 T C 9: 95,287,518 (GRCm39) D276G probably damaging Het
Ctsq T C 13: 61,184,913 (GRCm39) T258A probably benign Het
Degs1 C A 1: 182,106,927 (GRCm39) D111Y probably benign Het
Dhps T A 8: 85,801,413 (GRCm39) D313E probably damaging Het
Dipk1c T A 18: 84,748,720 (GRCm39) L106Q probably damaging Het
Dock9 A G 14: 121,815,615 (GRCm39) C1645R probably damaging Het
Efcab7 A C 4: 99,761,931 (GRCm39) D407A possibly damaging Het
Eif3a G T 19: 60,767,971 (GRCm39) T189N probably benign Het
Ep300 T A 15: 81,500,301 (GRCm39) L57M probably benign Het
Exoc6b T A 6: 84,867,513 (GRCm39) I300L probably benign Het
Fzd8 T C 18: 9,213,880 (GRCm39) S321P probably damaging Het
Garre1 A T 7: 33,941,713 (GRCm39) M657K possibly damaging Het
Gm9920 T A 15: 54,975,705 (GRCm39) probably benign Het
Gucy2c A G 6: 136,697,739 (GRCm39) I668T probably damaging Het
Irgc C T 7: 24,132,851 (GRCm39) probably benign Het
Jsrp1 G T 10: 80,646,030 (GRCm39) S143* probably null Het
Kctd4 T C 14: 76,200,259 (GRCm39) Y77H probably damaging Het
Klhdc1 T A 12: 69,329,924 (GRCm39) I351N probably damaging Het
Klra17 C T 6: 129,851,858 (GRCm39) E5K possibly damaging Het
Mapk8 A T 14: 33,112,686 (GRCm39) V211E probably damaging Het
Mdn1 C T 4: 32,723,690 (GRCm39) P2542L probably damaging Het
Mrc1 T C 2: 14,326,725 (GRCm39) Y1208H probably benign Het
Mrps16 A T 14: 20,441,523 (GRCm39) S94T probably benign Het
Muc5ac A G 7: 141,361,287 (GRCm39) T1533A probably benign Het
Myh10 A T 11: 68,651,518 (GRCm39) D287V probably damaging Het
Obscn T C 11: 58,971,086 (GRCm39) T2476A probably damaging Het
Olfm2 T A 9: 20,579,708 (GRCm39) T356S probably benign Het
Or4f60 T C 2: 111,902,823 (GRCm39) Y35C possibly damaging Het
P2rx2 T A 5: 110,489,694 (GRCm39) N108I probably damaging Het
Pbx4 A T 8: 70,322,820 (GRCm39) T309S probably benign Het
Phyhip C A 14: 70,704,295 (GRCm39) H171Q probably benign Het
Pou4f3 A G 18: 42,528,819 (GRCm39) E254G probably damaging Het
Pxdn C A 12: 30,052,899 (GRCm39) H845Q probably damaging Het
Rptor G A 11: 119,734,539 (GRCm39) G514D probably damaging Het
Scara5 CG C 14: 65,997,111 (GRCm39) probably null Het
Sgsm1 C A 5: 113,398,905 (GRCm39) E722D possibly damaging Het
Soat1 A T 1: 156,272,181 (GRCm39) D101E probably benign Het
Spag5 T A 11: 78,211,152 (GRCm39) probably null Het
Spata31 A T 13: 65,068,273 (GRCm39) E140D probably damaging Het
Srrm2 T A 17: 24,037,678 (GRCm39) S1537T probably benign Het
Stam2 G A 2: 52,626,305 (GRCm39) probably benign Het
Tbc1d4 G T 14: 101,845,412 (GRCm39) T162K possibly damaging Het
Tmem163 A C 1: 127,428,042 (GRCm39) probably benign Het
Tmem43 T C 6: 91,455,240 (GRCm39) V72A probably benign Het
Tmprss11c G A 5: 86,429,993 (GRCm39) T24I possibly damaging Het
Trerf1 A T 17: 47,626,116 (GRCm39) noncoding transcript Het
Trim44 A G 2: 102,230,476 (GRCm39) L185P probably damaging Het
Tspyl1 A G 10: 34,158,341 (GRCm39) D22G possibly damaging Het
Ttn A T 2: 76,641,587 (GRCm39) L5176Q possibly damaging Het
Tyro3 G A 2: 119,635,312 (GRCm39) R201Q probably damaging Het
Ubxn2a T A 12: 4,930,741 (GRCm39) K206N probably benign Het
Usp17lb G T 7: 104,489,615 (GRCm39) H436Q possibly damaging Het
Vps9d1 A G 8: 123,971,853 (GRCm39) I584T possibly damaging Het
Vrk1 T A 12: 106,022,078 (GRCm39) M131K possibly damaging Het
Wdr87-ps A C 7: 29,232,964 (GRCm39) noncoding transcript Het
Zfp827 A T 8: 79,912,333 (GRCm39) K986N possibly damaging Het
Zswim4 A G 8: 84,939,419 (GRCm39) M821T probably benign Het
Other mutations in Rgcc
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01521:Rgcc APN 14 79,538,185 (GRCm39) missense probably damaging 1.00
R4180:Rgcc UTSW 14 79,538,155 (GRCm39) missense probably benign 0.05
R4996:Rgcc UTSW 14 79,527,716 (GRCm39) missense possibly damaging 0.85
Predicted Primers PCR Primer
(F):5'- TGTTGCTTTGAGTCATGTCCAC -3'
(R):5'- TTCTGTAGACAGGCTGGCAAG -3'

Sequencing Primer
(F):5'- GTCATGTCCACTTTtaaatataga -3'
(R):5'- ACAGGCTGGCAAGTGTGTG -3'
Posted On 2016-09-06