Incidental Mutation 'R5366:Dock9'
ID 429373
Institutional Source Beutler Lab
Gene Symbol Dock9
Ensembl Gene ENSMUSG00000025558
Gene Name dedicator of cytokinesis 9
Synonyms D14Wsu89e, B230309H04Rik, Zizimin1
MMRRC Submission 042944-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R5366 (G1)
Quality Score 225
Status Validated
Chromosome 14
Chromosomal Location 121779458-122035249 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 121815615 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Cysteine to Arginine at position 1645 (C1645R)
Ref Sequence ENSEMBL: ENSMUSP00000148328 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000040700] [ENSMUST00000100299] [ENSMUST00000212181] [ENSMUST00000212376] [ENSMUST00000212416]
AlphaFold no structure available at present
Predicted Effect probably damaging
Transcript: ENSMUST00000040700
AA Change: C1654R

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000047881
Gene: ENSMUSG00000025558
AA Change: C1654R

DomainStartEndE-ValueType
Pfam:DUF3398 58 151 5.6e-36 PFAM
PH 172 280 1.38e-16 SMART
Blast:PH 297 372 4e-25 BLAST
Pfam:DOCK-C2 631 822 5.3e-51 PFAM
Pfam:DHR-2 1523 2068 2.1e-212 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000100299
AA Change: C1625R

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000097872
Gene: ENSMUSG00000025558
AA Change: C1625R

DomainStartEndE-ValueType
Pfam:DUF3398 58 153 1.5e-32 PFAM
PH 174 282 1.38e-16 SMART
Blast:PH 299 374 4e-25 BLAST
Pfam:DOCK-C2 632 825 1.3e-59 PFAM
low complexity region 1752 1763 N/A INTRINSIC
Pfam:Ded_cyto 1836 2013 2.4e-69 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000211803
Predicted Effect probably damaging
Transcript: ENSMUST00000212181
AA Change: C1655R

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
Predicted Effect
Predicted Effect noncoding transcript
Transcript: ENSMUST00000212371
Predicted Effect probably damaging
Transcript: ENSMUST00000212376
AA Change: C1645R

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
Predicted Effect noncoding transcript
Transcript: ENSMUST00000212719
Predicted Effect probably benign
Transcript: ENSMUST00000212416
Meta Mutation Damage Score 0.5333 question?
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.6%
  • 10x: 97.2%
  • 20x: 95.2%
Validation Efficiency 100% (77/77)
Allele List at MGI
Other mutations in this stock
Total: 69 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abcb5 T C 12: 118,831,665 (GRCm39) N1229S possibly damaging Het
Adgre1 G A 17: 57,709,817 (GRCm39) C158Y probably benign Het
Ahnak T A 19: 8,994,099 (GRCm39) S5128T possibly damaging Het
Ankrd36 T A 11: 5,542,841 (GRCm39) C322* probably null Het
Ano1 T A 7: 144,207,946 (GRCm39) T113S possibly damaging Het
Apeh A T 9: 107,969,005 (GRCm39) S321T probably benign Het
Atg4d T A 9: 21,179,948 (GRCm39) V273D probably damaging Het
Cacna2d4 A G 6: 119,251,279 (GRCm39) D489G probably damaging Het
Cd47 T C 16: 49,716,736 (GRCm39) F256L probably damaging Het
Cd84 A T 1: 171,700,872 (GRCm39) D211V probably damaging Het
Cfap46 A G 7: 139,230,802 (GRCm39) L942P probably damaging Het
Cfh A C 1: 140,063,973 (GRCm39) C434W probably damaging Het
Chst2 T C 9: 95,287,518 (GRCm39) D276G probably damaging Het
Ctsq T C 13: 61,184,913 (GRCm39) T258A probably benign Het
Degs1 C A 1: 182,106,927 (GRCm39) D111Y probably benign Het
Dhps T A 8: 85,801,413 (GRCm39) D313E probably damaging Het
Dipk1c T A 18: 84,748,720 (GRCm39) L106Q probably damaging Het
Efcab7 A C 4: 99,761,931 (GRCm39) D407A possibly damaging Het
Eif3a G T 19: 60,767,971 (GRCm39) T189N probably benign Het
Ep300 T A 15: 81,500,301 (GRCm39) L57M probably benign Het
Exoc6b T A 6: 84,867,513 (GRCm39) I300L probably benign Het
Fzd8 T C 18: 9,213,880 (GRCm39) S321P probably damaging Het
Garre1 A T 7: 33,941,713 (GRCm39) M657K possibly damaging Het
Gm9920 T A 15: 54,975,705 (GRCm39) probably benign Het
Gucy2c A G 6: 136,697,739 (GRCm39) I668T probably damaging Het
Irgc C T 7: 24,132,851 (GRCm39) probably benign Het
Jsrp1 G T 10: 80,646,030 (GRCm39) S143* probably null Het
Kctd4 T C 14: 76,200,259 (GRCm39) Y77H probably damaging Het
Klhdc1 T A 12: 69,329,924 (GRCm39) I351N probably damaging Het
Klra17 C T 6: 129,851,858 (GRCm39) E5K possibly damaging Het
Mapk8 A T 14: 33,112,686 (GRCm39) V211E probably damaging Het
Mdn1 C T 4: 32,723,690 (GRCm39) P2542L probably damaging Het
Mrc1 T C 2: 14,326,725 (GRCm39) Y1208H probably benign Het
Mrps16 A T 14: 20,441,523 (GRCm39) S94T probably benign Het
Muc5ac A G 7: 141,361,287 (GRCm39) T1533A probably benign Het
Myh10 A T 11: 68,651,518 (GRCm39) D287V probably damaging Het
Obscn T C 11: 58,971,086 (GRCm39) T2476A probably damaging Het
Olfm2 T A 9: 20,579,708 (GRCm39) T356S probably benign Het
Or4f60 T C 2: 111,902,823 (GRCm39) Y35C possibly damaging Het
P2rx2 T A 5: 110,489,694 (GRCm39) N108I probably damaging Het
Pbx4 A T 8: 70,322,820 (GRCm39) T309S probably benign Het
Phyhip C A 14: 70,704,295 (GRCm39) H171Q probably benign Het
Pou4f3 A G 18: 42,528,819 (GRCm39) E254G probably damaging Het
Pxdn C A 12: 30,052,899 (GRCm39) H845Q probably damaging Het
Rgcc T C 14: 79,529,123 (GRCm39) T111A probably benign Het
Rptor G A 11: 119,734,539 (GRCm39) G514D probably damaging Het
Scara5 CG C 14: 65,997,111 (GRCm39) probably null Het
Sgsm1 C A 5: 113,398,905 (GRCm39) E722D possibly damaging Het
Soat1 A T 1: 156,272,181 (GRCm39) D101E probably benign Het
Spag5 T A 11: 78,211,152 (GRCm39) probably null Het
Spata31 A T 13: 65,068,273 (GRCm39) E140D probably damaging Het
Srrm2 T A 17: 24,037,678 (GRCm39) S1537T probably benign Het
Stam2 G A 2: 52,626,305 (GRCm39) probably benign Het
Tbc1d4 G T 14: 101,845,412 (GRCm39) T162K possibly damaging Het
Tmem163 A C 1: 127,428,042 (GRCm39) probably benign Het
Tmem43 T C 6: 91,455,240 (GRCm39) V72A probably benign Het
Tmprss11c G A 5: 86,429,993 (GRCm39) T24I possibly damaging Het
Trerf1 A T 17: 47,626,116 (GRCm39) noncoding transcript Het
Trim44 A G 2: 102,230,476 (GRCm39) L185P probably damaging Het
Tspyl1 A G 10: 34,158,341 (GRCm39) D22G possibly damaging Het
Ttn A T 2: 76,641,587 (GRCm39) L5176Q possibly damaging Het
Tyro3 G A 2: 119,635,312 (GRCm39) R201Q probably damaging Het
Ubxn2a T A 12: 4,930,741 (GRCm39) K206N probably benign Het
Usp17lb G T 7: 104,489,615 (GRCm39) H436Q possibly damaging Het
Vps9d1 A G 8: 123,971,853 (GRCm39) I584T possibly damaging Het
Vrk1 T A 12: 106,022,078 (GRCm39) M131K possibly damaging Het
Wdr87-ps A C 7: 29,232,964 (GRCm39) noncoding transcript Het
Zfp827 A T 8: 79,912,333 (GRCm39) K986N possibly damaging Het
Zswim4 A G 8: 84,939,419 (GRCm39) M821T probably benign Het
Other mutations in Dock9
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00236:Dock9 APN 14 121,905,880 (GRCm39) missense probably benign 0.12
IGL00817:Dock9 APN 14 121,935,703 (GRCm39) missense probably damaging 0.96
IGL00923:Dock9 APN 14 121,844,504 (GRCm39) unclassified probably benign
IGL01385:Dock9 APN 14 121,817,995 (GRCm39) missense possibly damaging 0.94
IGL01567:Dock9 APN 14 121,890,496 (GRCm39) missense probably damaging 1.00
IGL01767:Dock9 APN 14 121,860,282 (GRCm39) missense possibly damaging 0.91
IGL01811:Dock9 APN 14 121,796,440 (GRCm39) missense probably damaging 1.00
IGL02512:Dock9 APN 14 121,856,950 (GRCm39) splice site probably benign
IGL02525:Dock9 APN 14 121,877,538 (GRCm39) missense probably damaging 1.00
IGL02550:Dock9 APN 14 121,935,724 (GRCm39) start codon destroyed probably null 0.07
IGL02559:Dock9 APN 14 121,862,559 (GRCm39) splice site probably benign
IGL02666:Dock9 APN 14 121,818,111 (GRCm39) missense probably benign 0.42
IGL02674:Dock9 APN 14 121,833,023 (GRCm39) splice site probably null
IGL02795:Dock9 APN 14 121,877,390 (GRCm39) missense probably benign 0.04
IGL03074:Dock9 APN 14 121,844,682 (GRCm39) missense possibly damaging 0.95
IGL03095:Dock9 APN 14 121,876,940 (GRCm39) missense probably damaging 1.00
IGL03294:Dock9 APN 14 121,879,035 (GRCm39) splice site probably benign
R0036:Dock9 UTSW 14 121,860,265 (GRCm39) missense probably damaging 1.00
R0050:Dock9 UTSW 14 121,844,637 (GRCm39) missense probably benign 0.43
R0050:Dock9 UTSW 14 121,844,637 (GRCm39) missense probably benign 0.43
R0164:Dock9 UTSW 14 121,835,077 (GRCm39) missense probably damaging 1.00
R0164:Dock9 UTSW 14 121,835,077 (GRCm39) missense probably damaging 1.00
R0270:Dock9 UTSW 14 121,813,411 (GRCm39) missense probably benign 0.02
R0494:Dock9 UTSW 14 121,899,996 (GRCm39) missense possibly damaging 0.64
R0726:Dock9 UTSW 14 121,889,180 (GRCm39) nonsense probably null
R1029:Dock9 UTSW 14 121,837,096 (GRCm39) splice site probably null
R1214:Dock9 UTSW 14 121,823,728 (GRCm39) missense probably benign 0.02
R1231:Dock9 UTSW 14 121,813,362 (GRCm39) missense possibly damaging 0.61
R1535:Dock9 UTSW 14 121,783,476 (GRCm39) missense probably damaging 1.00
R1629:Dock9 UTSW 14 121,780,986 (GRCm39) missense possibly damaging 0.88
R1637:Dock9 UTSW 14 121,889,187 (GRCm39) missense possibly damaging 0.66
R1733:Dock9 UTSW 14 121,864,292 (GRCm39) missense probably benign 0.01
R1772:Dock9 UTSW 14 121,847,210 (GRCm39) missense probably benign 0.07
R1855:Dock9 UTSW 14 121,877,571 (GRCm39) missense probably damaging 1.00
R1888:Dock9 UTSW 14 121,862,617 (GRCm39) missense probably benign 0.18
R1888:Dock9 UTSW 14 121,862,617 (GRCm39) missense probably benign 0.18
R1901:Dock9 UTSW 14 121,862,565 (GRCm39) splice site probably null
R1920:Dock9 UTSW 14 121,820,792 (GRCm39) missense probably damaging 1.00
R1987:Dock9 UTSW 14 121,829,242 (GRCm39) missense probably benign 0.00
R3035:Dock9 UTSW 14 121,844,249 (GRCm39) missense possibly damaging 0.60
R3851:Dock9 UTSW 14 121,866,498 (GRCm39) splice site probably null
R4020:Dock9 UTSW 14 121,844,267 (GRCm39) missense probably benign 0.00
R4021:Dock9 UTSW 14 121,864,324 (GRCm39) missense possibly damaging 0.80
R4089:Dock9 UTSW 14 121,820,883 (GRCm39) missense probably damaging 1.00
R4258:Dock9 UTSW 14 121,818,854 (GRCm39) missense probably benign 0.00
R4423:Dock9 UTSW 14 121,799,465 (GRCm39) critical splice donor site probably null
R4561:Dock9 UTSW 14 121,796,419 (GRCm39) missense probably benign 0.01
R4604:Dock9 UTSW 14 121,905,871 (GRCm39) missense probably damaging 1.00
R4646:Dock9 UTSW 14 121,823,658 (GRCm39) missense probably damaging 1.00
R4647:Dock9 UTSW 14 121,823,658 (GRCm39) missense probably damaging 1.00
R4776:Dock9 UTSW 14 121,847,509 (GRCm39) missense possibly damaging 0.81
R4809:Dock9 UTSW 14 121,784,008 (GRCm39) missense probably benign 0.37
R4865:Dock9 UTSW 14 121,780,917 (GRCm39) makesense probably null
R4951:Dock9 UTSW 14 121,890,547 (GRCm39) missense probably benign 0.35
R5151:Dock9 UTSW 14 121,815,582 (GRCm39) missense probably damaging 1.00
R5359:Dock9 UTSW 14 121,890,472 (GRCm39) missense possibly damaging 0.69
R5502:Dock9 UTSW 14 121,847,594 (GRCm39) splice site probably null
R5579:Dock9 UTSW 14 121,837,107 (GRCm39) missense probably damaging 1.00
R5753:Dock9 UTSW 14 121,872,037 (GRCm39) missense probably benign 0.05
R5836:Dock9 UTSW 14 121,918,763 (GRCm39) missense probably damaging 1.00
R5858:Dock9 UTSW 14 121,866,204 (GRCm39) missense probably benign 0.00
R5890:Dock9 UTSW 14 121,905,820 (GRCm39) critical splice donor site probably null
R6075:Dock9 UTSW 14 121,783,385 (GRCm39) missense probably benign
R6298:Dock9 UTSW 14 121,872,006 (GRCm39) missense probably damaging 1.00
R6306:Dock9 UTSW 14 121,799,492 (GRCm39) missense probably damaging 1.00
R6321:Dock9 UTSW 14 121,783,433 (GRCm39) missense probably damaging 1.00
R6330:Dock9 UTSW 14 121,842,655 (GRCm39) start codon destroyed probably null 0.00
R6719:Dock9 UTSW 14 121,847,439 (GRCm39) missense probably damaging 1.00
R6784:Dock9 UTSW 14 121,780,926 (GRCm39) missense probably damaging 1.00
R6826:Dock9 UTSW 14 121,860,330 (GRCm39) missense probably damaging 1.00
R6830:Dock9 UTSW 14 121,860,330 (GRCm39) missense probably damaging 1.00
R6838:Dock9 UTSW 14 121,784,008 (GRCm39) missense possibly damaging 0.71
R6868:Dock9 UTSW 14 121,823,676 (GRCm39) missense probably benign 0.37
R6919:Dock9 UTSW 14 121,880,564 (GRCm39) missense probably benign 0.42
R6989:Dock9 UTSW 14 121,864,791 (GRCm39) missense probably damaging 1.00
R7539:Dock9 UTSW 14 121,818,848 (GRCm39) missense probably damaging 1.00
R7645:Dock9 UTSW 14 121,835,075 (GRCm39) missense probably benign 0.44
R7875:Dock9 UTSW 14 121,863,396 (GRCm39) nonsense probably null
R7900:Dock9 UTSW 14 121,783,491 (GRCm39) missense possibly damaging 0.84
R8040:Dock9 UTSW 14 121,889,206 (GRCm39) missense probably benign 0.06
R8420:Dock9 UTSW 14 121,783,454 (GRCm39) missense probably damaging 1.00
R8511:Dock9 UTSW 14 121,918,847 (GRCm39) missense probably damaging 1.00
R8511:Dock9 UTSW 14 121,864,801 (GRCm39) missense probably benign 0.40
R8514:Dock9 UTSW 14 121,896,199 (GRCm39) missense probably benign 0.25
R8691:Dock9 UTSW 14 121,877,517 (GRCm39) missense possibly damaging 0.49
R8804:Dock9 UTSW 14 121,842,595 (GRCm39) missense probably damaging 0.98
R8894:Dock9 UTSW 14 121,860,373 (GRCm39) missense probably benign 0.10
R8900:Dock9 UTSW 14 121,817,940 (GRCm39) missense probably damaging 1.00
R9069:Dock9 UTSW 14 121,866,324 (GRCm39) missense probably damaging 0.98
R9218:Dock9 UTSW 14 121,905,871 (GRCm39) missense probably damaging 1.00
R9233:Dock9 UTSW 14 121,820,781 (GRCm39) missense probably benign 0.09
R9236:Dock9 UTSW 14 121,876,970 (GRCm39) missense probably damaging 1.00
R9285:Dock9 UTSW 14 121,833,012 (GRCm39) missense probably benign
R9451:Dock9 UTSW 14 121,787,601 (GRCm39) splice site probably benign
R9461:Dock9 UTSW 14 121,842,601 (GRCm39) missense probably benign 0.05
R9484:Dock9 UTSW 14 121,818,844 (GRCm39) missense probably damaging 1.00
R9517:Dock9 UTSW 14 121,829,236 (GRCm39) missense probably benign 0.07
R9542:Dock9 UTSW 14 121,864,775 (GRCm39) missense probably damaging 1.00
R9694:Dock9 UTSW 14 121,818,791 (GRCm39) missense probably damaging 1.00
R9701:Dock9 UTSW 14 121,876,983 (GRCm39) missense probably benign 0.01
R9703:Dock9 UTSW 14 121,781,989 (GRCm39) makesense probably null
R9726:Dock9 UTSW 14 121,835,149 (GRCm39) missense possibly damaging 0.61
R9741:Dock9 UTSW 14 121,877,516 (GRCm39) missense probably damaging 1.00
Z1088:Dock9 UTSW 14 121,792,687 (GRCm39) missense probably damaging 1.00
Z1176:Dock9 UTSW 14 121,889,194 (GRCm39) missense probably benign
Predicted Primers PCR Primer
(F):5'- TACGAAGCTAGGACGACATGC -3'
(R):5'- CTTTTGCGCTAAGATACAGCAG -3'

Sequencing Primer
(F):5'- CCATAACACGGGTGCTTTTG -3'
(R):5'- CGCTAAGATACAGCAGTTGTAAATAG -3'
Posted On 2016-09-06