Incidental Mutation 'R5367:Or5b106'
ID 429450
Institutional Source Beutler Lab
Gene Symbol Or5b106
Ensembl Gene ENSMUSG00000057503
Gene Name olfactory receptor family 5 subfamily B member 106
Synonyms MOR202-17, GA_x6K02T2RE5P-3473421-3472498, Olfr1459
MMRRC Submission 042945-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.089) question?
Stock # R5367 (G1)
Quality Score 225
Status Validated
Chromosome 19
Chromosomal Location 13123098-13124021 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) G to A at 13123865 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Leucine to Phenylalanine at position 53 (L53F)
Ref Sequence ENSEMBL: ENSMUSP00000150886 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000078299] [ENSMUST00000213493]
AlphaFold Q8VFV9
Predicted Effect probably damaging
Transcript: ENSMUST00000078299
AA Change: L53F

PolyPhen 2 Score 0.980 (Sensitivity: 0.75; Specificity: 0.96)
SMART Domains Protein: ENSMUSP00000077414
Gene: ENSMUSG00000057503
AA Change: L53F

DomainStartEndE-ValueType
Pfam:7tm_4 29 306 8e-50 PFAM
Pfam:7tm_1 39 288 1.5e-20 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000213493
AA Change: L53F

PolyPhen 2 Score 0.980 (Sensitivity: 0.75; Specificity: 0.96)
Predicted Effect noncoding transcript
Transcript: ENSMUST00000215405
Meta Mutation Damage Score 0.2655 question?
Coding Region Coverage
  • 1x: 99.3%
  • 3x: 98.7%
  • 10x: 97.3%
  • 20x: 95.5%
Validation Efficiency 97% (70/72)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 63 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Aadac T C 3: 59,947,057 (GRCm39) Y252H probably damaging Het
Aadat T C 8: 60,979,630 (GRCm39) I164T probably damaging Het
Adam11 A G 11: 102,664,479 (GRCm39) H389R probably benign Het
Alkbh5 G T 11: 60,429,529 (GRCm39) R94L possibly damaging Het
Ampd3 A G 7: 110,407,078 (GRCm39) K644R possibly damaging Het
Ankhd1 T A 18: 36,722,461 (GRCm39) L328H probably damaging Het
Ankrd55 G T 13: 112,455,036 (GRCm39) V45F probably damaging Het
Apol7c C A 15: 77,410,347 (GRCm39) V200F probably damaging Het
Arap1 G A 7: 101,058,337 (GRCm39) V721M probably damaging Het
Arhgef40 A G 14: 52,227,156 (GRCm39) D400G probably damaging Het
Bmp4 G T 14: 46,621,950 (GRCm39) T198K possibly damaging Het
Cblb T A 16: 52,025,016 (GRCm39) F970L probably damaging Het
Celf5 A G 10: 81,303,098 (GRCm39) S148P probably damaging Het
Ckap5 T A 2: 91,445,486 (GRCm39) C1708S possibly damaging Het
Clec2l T C 6: 38,654,459 (GRCm39) F147L possibly damaging Het
Cnksr1 T A 4: 133,957,525 (GRCm39) I465F possibly damaging Het
Coq10b A G 1: 55,092,143 (GRCm39) D37G probably benign Het
Cpq T G 15: 33,213,250 (GRCm39) Y90D possibly damaging Het
Depdc1a G A 3: 159,229,591 (GRCm39) probably null Het
Eif2ak4 T A 2: 118,266,639 (GRCm39) probably null Het
Eif3e C T 15: 43,115,700 (GRCm39) M355I probably damaging Het
Eif4e1b G A 13: 54,934,757 (GRCm39) V181M probably damaging Het
Erap1 A G 13: 74,794,680 (GRCm39) E113G probably damaging Het
Fads2 A G 19: 10,041,649 (GRCm39) L438P probably damaging Het
Fbl T A 7: 27,874,475 (GRCm39) V67E probably damaging Het
Gde1 A G 7: 118,304,629 (GRCm39) L82P probably damaging Het
Gm10226 T C 17: 21,910,884 (GRCm39) S40P possibly damaging Het
Gm10717 T G 9: 3,026,317 (GRCm39) F205C probably damaging Het
Gm1988 T A 7: 38,823,204 (GRCm39) noncoding transcript Het
Gm6728 T C 6: 136,463,502 (GRCm39) noncoding transcript Het
Grb14 C T 2: 64,747,653 (GRCm39) V369I probably benign Het
Jag1 T A 2: 136,927,014 (GRCm39) Q915L possibly damaging Het
Kdm5d G A Y: 941,645 (GRCm39) G1282D probably benign Het
Krt87 A T 15: 101,384,875 (GRCm39) L407Q probably damaging Het
Mlf1 A T 3: 67,301,296 (GRCm39) H118L probably damaging Het
Mmp10 G T 9: 7,505,603 (GRCm39) C289F probably damaging Het
Mroh2a A T 1: 88,182,687 (GRCm39) N1205I possibly damaging Het
Myo9a T A 9: 59,807,732 (GRCm39) S2029T probably damaging Het
Nap1l4 A C 7: 143,088,035 (GRCm39) S174R probably damaging Het
Nos3 A G 5: 24,576,942 (GRCm39) T490A probably benign Het
Or12d2 T A 17: 37,625,147 (GRCm39) I43F probably damaging Het
Or4k35 T A 2: 111,100,235 (GRCm39) Q159L possibly damaging Het
Or5a1 A G 19: 12,097,800 (GRCm39) V80A possibly damaging Het
Or5g23 A T 2: 85,438,718 (GRCm39) C179S probably damaging Het
Pdlim7 G C 13: 55,653,975 (GRCm39) T214S probably benign Het
Piezo2 T C 18: 63,197,802 (GRCm39) E1578G probably damaging Het
Ptcd1 T A 5: 145,084,715 (GRCm39) probably benign Het
Sart3 C T 5: 113,897,277 (GRCm39) probably null Het
Scara5 CG C 14: 65,997,111 (GRCm39) probably null Het
Scrn2 A G 11: 96,923,953 (GRCm39) D279G possibly damaging Het
Sh2d3c A G 2: 32,635,914 (GRCm39) D94G probably damaging Het
Slc12a4 A T 8: 106,678,266 (GRCm39) V309E probably damaging Het
Slc1a6 A G 10: 78,623,637 (GRCm39) E12G probably damaging Het
Smarcal1 T C 1: 72,635,135 (GRCm39) probably null Het
Smr3a T C 5: 88,155,897 (GRCm39) probably benign Het
Stox2 A G 8: 47,656,260 (GRCm39) I72T probably damaging Het
Tmem234 G T 4: 129,494,500 (GRCm39) probably benign Het
Tmem35b A G 4: 127,018,266 (GRCm39) Q20R possibly damaging Het
Tom1l2 G A 11: 60,132,634 (GRCm39) H430Y probably benign Het
Tpo T C 12: 30,153,289 (GRCm39) Y355C probably damaging Het
Tulp2 A G 7: 45,166,075 (GRCm39) N122S possibly damaging Het
Washc2 T A 6: 116,236,111 (GRCm39) L1194H probably damaging Het
Xbp1 T C 11: 5,471,910 (GRCm39) V12A probably benign Het
Other mutations in Or5b106
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01371:Or5b106 APN 19 13,123,192 (GRCm39) missense possibly damaging 0.82
IGL01618:Or5b106 APN 19 13,123,614 (GRCm39) missense probably benign 0.00
IGL01800:Or5b106 APN 19 13,123,993 (GRCm39) missense probably damaging 1.00
IGL02224:Or5b106 APN 19 13,123,120 (GRCm39) missense probably damaging 1.00
BB009:Or5b106 UTSW 19 13,123,345 (GRCm39) missense probably benign 0.10
BB019:Or5b106 UTSW 19 13,123,345 (GRCm39) missense probably benign 0.10
PIT4651001:Or5b106 UTSW 19 13,123,991 (GRCm39) missense probably benign 0.02
R0617:Or5b106 UTSW 19 13,123,727 (GRCm39) missense probably benign 0.28
R2041:Or5b106 UTSW 19 13,124,041 (GRCm39) start gained probably benign
R2878:Or5b106 UTSW 19 13,123,771 (GRCm39) missense probably benign 0.38
R3742:Or5b106 UTSW 19 13,123,258 (GRCm39) missense probably damaging 0.98
R4905:Or5b106 UTSW 19 13,123,541 (GRCm39) missense probably benign 0.07
R4914:Or5b106 UTSW 19 13,123,355 (GRCm39) missense possibly damaging 0.64
R4915:Or5b106 UTSW 19 13,123,355 (GRCm39) missense possibly damaging 0.64
R4916:Or5b106 UTSW 19 13,123,355 (GRCm39) missense possibly damaging 0.64
R4917:Or5b106 UTSW 19 13,123,355 (GRCm39) missense possibly damaging 0.64
R4918:Or5b106 UTSW 19 13,123,355 (GRCm39) missense possibly damaging 0.64
R6242:Or5b106 UTSW 19 13,123,450 (GRCm39) missense probably benign 0.05
R6632:Or5b106 UTSW 19 13,123,552 (GRCm39) missense probably benign 0.02
R6893:Or5b106 UTSW 19 13,123,106 (GRCm39) missense probably benign 0.00
R7932:Or5b106 UTSW 19 13,123,345 (GRCm39) missense probably benign 0.10
R9572:Or5b106 UTSW 19 13,123,928 (GRCm39) missense possibly damaging 0.78
R9730:Or5b106 UTSW 19 13,123,747 (GRCm39) missense possibly damaging 0.80
Predicted Primers PCR Primer
(F):5'- GCTGCATAGCGATCATAGGC -3'
(R):5'- TAAGGCCTTCTGTTGATTAACTGAC -3'

Sequencing Primer
(F):5'- TGCATAGCGATCATAGGCCATGG -3'
(R):5'- CTGACATCATTAATGGAGAACAGAAC -3'
Posted On 2016-09-06