Incidental Mutation 'R5368:Or4c110'
ID 429458
Institutional Source Beutler Lab
Gene Symbol Or4c110
Ensembl Gene ENSMUSG00000100016
Gene Name olfactory receptor family 4 subfamily C member 110
Synonyms MOR233-13, Olfr1215, GA_x6K02T2Q125-50482823-50481885
MMRRC Submission 043204-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.072) question?
Stock # R5368 (G1)
Quality Score 225
Status Validated
Chromosome 2
Chromosomal Location 88831692-88832634 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 88832435 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Serine to Proline at position 66 (S66P)
Ref Sequence ENSEMBL: ENSMUSP00000150030 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000188399] [ENSMUST00000214809] [ENSMUST00000216271]
AlphaFold A3KGY3
Predicted Effect probably damaging
Transcript: ENSMUST00000188399
AA Change: S66P

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000141134
Gene: ENSMUSG00000100016
AA Change: S66P

DomainStartEndE-ValueType
low complexity region 24 34 N/A INTRINSIC
Pfam:7tm_1 39 286 1.9e-25 PFAM
Pfam:7tm_4 138 283 1.7e-38 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000214809
AA Change: S66P

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
Predicted Effect probably damaging
Transcript: ENSMUST00000216271
AA Change: S66P

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
Meta Mutation Damage Score 0.2078 question?
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.6%
  • 10x: 97.3%
  • 20x: 95.3%
Validation Efficiency 97% (61/63)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 58 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4933402N03Rik T A 7: 130,740,925 (GRCm39) H97L possibly damaging Het
Abca9 T A 11: 110,036,372 (GRCm39) N579I probably damaging Het
Acbd3 A T 1: 180,549,660 (GRCm39) probably benign Het
Ankrd50 A T 3: 38,509,199 (GRCm39) I1056N probably damaging Het
Ceacam18 T C 7: 43,291,458 (GRCm39) V300A probably benign Het
Cfap46 C A 7: 139,207,389 (GRCm39) R1843S possibly damaging Het
D430041D05Rik A G 2: 104,078,629 (GRCm39) V1229A probably damaging Het
Dbx2 G A 15: 95,538,522 (GRCm39) S206L probably benign Het
Dnah11 A T 12: 117,918,628 (GRCm39) D1530E probably damaging Het
Ecm2 A C 13: 49,674,419 (GRCm39) T280P probably benign Het
Emc2 G A 15: 43,375,207 (GRCm39) probably null Het
Epb42 C T 2: 120,849,943 (GRCm39) V689I probably benign Het
Fam114a1 T A 5: 65,163,452 (GRCm39) M209K possibly damaging Het
Fam117a C T 11: 95,266,459 (GRCm39) S193F probably damaging Het
Foxp2 A T 6: 15,377,913 (GRCm39) probably benign Het
Frmd6 T A 12: 70,910,874 (GRCm39) C19* probably null Het
Fyb1 A G 15: 6,610,159 (GRCm39) probably null Het
Gata6 C A 18: 11,063,059 (GRCm39) H442Q possibly damaging Het
Gldc A G 19: 30,135,921 (GRCm39) S160P probably benign Het
Gm3952 A G 8: 129,472,455 (GRCm39) S1626P possibly damaging Het
Gm9762 T A 3: 78,873,742 (GRCm39) noncoding transcript Het
Gtpbp2 T C 17: 46,477,230 (GRCm39) probably benign Het
Hgd A T 16: 37,410,113 (GRCm39) T50S probably benign Het
Itpr1 C T 6: 108,364,459 (GRCm39) T22M probably damaging Het
Kif26b G A 1: 178,743,449 (GRCm39) E1182K probably damaging Het
Kirrel3 A G 9: 34,919,034 (GRCm39) E230G probably damaging Het
Leng8 A G 7: 4,142,987 (GRCm39) Y88C probably damaging Het
Lpo T C 11: 87,711,895 (GRCm39) D54G possibly damaging Het
Lypd2 G T 15: 74,604,908 (GRCm39) A29E probably benign Het
Mdn1 C T 4: 32,723,690 (GRCm39) P2542L probably damaging Het
Mical3 T C 6: 120,936,434 (GRCm39) Y1364C probably damaging Het
Mroh2b A G 15: 4,935,054 (GRCm39) N163S probably damaging Het
Mtf1 G A 4: 124,718,872 (GRCm39) C295Y probably damaging Het
Nbn T A 4: 15,969,391 (GRCm39) L212Q probably damaging Het
Obscn A T 11: 58,959,852 (GRCm39) probably null Het
Or10ag56 T A 2: 87,139,126 (GRCm39) probably null Het
Peli1 A G 11: 21,098,389 (GRCm39) T375A probably damaging Het
Picalm T C 7: 89,856,803 (GRCm39) *611Q probably null Het
Plch1 G T 3: 63,609,394 (GRCm39) Q938K possibly damaging Het
Plxnb2 A G 15: 89,043,796 (GRCm39) V1352A possibly damaging Het
Pmepa1 G A 2: 173,070,115 (GRCm39) R147W probably damaging Het
Prdm16 T G 4: 154,429,848 (GRCm39) K373Q probably damaging Het
Qki T G 17: 10,457,964 (GRCm39) E135A probably damaging Het
Rad50 T C 11: 53,575,073 (GRCm39) K556E probably benign Het
Scara5 CG C 14: 65,997,111 (GRCm39) probably null Het
Sin3a T A 9: 57,018,084 (GRCm39) D834E possibly damaging Het
Smg8 G A 11: 86,971,086 (GRCm39) S895L probably benign Het
Sorl1 T C 9: 41,890,686 (GRCm39) I1944M probably benign Het
Stam2 G A 2: 52,626,305 (GRCm39) probably benign Het
Tmprss7 A T 16: 45,481,252 (GRCm39) W645R probably damaging Het
Tns1 T C 1: 73,980,176 (GRCm39) M1111V probably benign Het
Ttn A C 2: 76,608,726 (GRCm39) D17763E probably damaging Het
Ttn A T 2: 76,641,587 (GRCm39) L5176Q possibly damaging Het
Ubr4 G A 4: 139,124,839 (GRCm39) probably benign Het
Usp31 T C 7: 121,260,588 (GRCm39) H637R probably damaging Het
Vps50 A C 6: 3,567,739 (GRCm39) E545A possibly damaging Het
Wdfy3 G T 5: 102,020,724 (GRCm39) L2527M probably damaging Het
Wfdc2 T C 2: 164,405,354 (GRCm39) V85A possibly damaging Het
Other mutations in Or4c110
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00226:Or4c110 APN 2 88,831,683 (GRCm39) utr 3 prime probably benign
IGL02395:Or4c110 APN 2 88,832,507 (GRCm39) missense probably benign 0.00
IGL02399:Or4c110 APN 2 88,832,507 (GRCm39) missense probably benign 0.00
IGL02409:Or4c110 APN 2 88,832,254 (GRCm39) missense possibly damaging 0.75
IGL02421:Or4c110 APN 2 88,831,688 (GRCm39) splice site probably null
IGL03036:Or4c110 APN 2 88,832,459 (GRCm39) missense possibly damaging 0.94
R2036:Or4c110 UTSW 2 88,831,976 (GRCm39) missense probably damaging 0.97
R2199:Or4c110 UTSW 2 88,831,894 (GRCm39) missense probably damaging 0.98
R3930:Or4c110 UTSW 2 88,832,377 (GRCm39) missense probably benign 0.32
R4990:Or4c110 UTSW 2 88,831,816 (GRCm39) missense probably damaging 0.97
R5199:Or4c110 UTSW 2 88,832,107 (GRCm39) missense possibly damaging 0.70
R5396:Or4c110 UTSW 2 88,832,540 (GRCm39) missense probably benign 0.15
R6881:Or4c110 UTSW 2 88,832,281 (GRCm39) missense probably damaging 1.00
R7195:Or4c110 UTSW 2 88,832,075 (GRCm39) missense
R7425:Or4c110 UTSW 2 88,832,544 (GRCm39) missense
R7804:Or4c110 UTSW 2 88,831,855 (GRCm39) missense unknown
R7976:Or4c110 UTSW 2 88,831,973 (GRCm39) missense probably damaging 0.97
R8094:Or4c110 UTSW 2 88,832,712 (GRCm39) start gained probably benign
R8716:Or4c110 UTSW 2 88,832,060 (GRCm39) missense
R8737:Or4c110 UTSW 2 88,832,351 (GRCm39) nonsense probably null
R9485:Or4c110 UTSW 2 88,831,709 (GRCm39) missense unknown
R9721:Or4c110 UTSW 2 88,832,060 (GRCm39) missense
Z1088:Or4c110 UTSW 2 88,832,182 (GRCm39) missense possibly damaging 0.94
Predicted Primers PCR Primer
(F):5'- CACAGAGCCTCCTGTTCATAATTG -3'
(R):5'- CCAAACCATTGTAACTGAGTTCG -3'

Sequencing Primer
(F):5'- GGCTTACAAATGGCTACATACCGG -3'
(R):5'- GTACTCCTGGGACTTTCACAAAAC -3'
Posted On 2016-09-06