Incidental Mutation 'R5368:Lpo'
ID 429490
Institutional Source Beutler Lab
Gene Symbol Lpo
Ensembl Gene ENSMUSG00000009356
Gene Name lactoperoxidase
Synonyms 5830499B15Rik
MMRRC Submission 043204-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R5368 (G1)
Quality Score 225
Status Validated
Chromosome 11
Chromosomal Location 87697254-87716750 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 87711895 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Aspartic acid to Glycine at position 54 (D54G)
Ref Sequence ENSEMBL: ENSMUSP00000117763 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000103177] [ENSMUST00000136446]
AlphaFold Q5SW46
Predicted Effect probably benign
Transcript: ENSMUST00000103177
AA Change: D54G

PolyPhen 2 Score 0.297 (Sensitivity: 0.91; Specificity: 0.89)
SMART Domains Protein: ENSMUSP00000099466
Gene: ENSMUSG00000009356
AA Change: D54G

DomainStartEndE-ValueType
signal peptide 1 23 N/A INTRINSIC
Pfam:An_peroxidase 136 682 1.8e-180 PFAM
Predicted Effect possibly damaging
Transcript: ENSMUST00000136446
AA Change: D54G

PolyPhen 2 Score 0.614 (Sensitivity: 0.87; Specificity: 0.91)
SMART Domains Protein: ENSMUSP00000117763
Gene: ENSMUSG00000009356
AA Change: D54G

DomainStartEndE-ValueType
signal peptide 1 23 N/A INTRINSIC
PDB:4OEK|A 116 145 4e-7 PDB
SCOP:g1cxp.1 130 145 1e-4 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000157004
Meta Mutation Damage Score 0.1795 question?
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.6%
  • 10x: 97.3%
  • 20x: 95.3%
Validation Efficiency 97% (61/63)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the peroxidase family of proteins. The encoded preproprotein is proteolytically processed to generate the mature enzyme. Following its secretion from salivary, mammary, and other mucosal glands, this enzyme catalyzes the generation of the antimicrobial substance hypothiocyanous acid. This gene is present in a gene cluster on chromosome 17. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed. [provided by RefSeq, Jan 2016]
Allele List at MGI
Other mutations in this stock
Total: 58 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4933402N03Rik T A 7: 130,740,925 (GRCm39) H97L possibly damaging Het
Abca9 T A 11: 110,036,372 (GRCm39) N579I probably damaging Het
Acbd3 A T 1: 180,549,660 (GRCm39) probably benign Het
Ankrd50 A T 3: 38,509,199 (GRCm39) I1056N probably damaging Het
Ceacam18 T C 7: 43,291,458 (GRCm39) V300A probably benign Het
Cfap46 C A 7: 139,207,389 (GRCm39) R1843S possibly damaging Het
D430041D05Rik A G 2: 104,078,629 (GRCm39) V1229A probably damaging Het
Dbx2 G A 15: 95,538,522 (GRCm39) S206L probably benign Het
Dnah11 A T 12: 117,918,628 (GRCm39) D1530E probably damaging Het
Ecm2 A C 13: 49,674,419 (GRCm39) T280P probably benign Het
Emc2 G A 15: 43,375,207 (GRCm39) probably null Het
Epb42 C T 2: 120,849,943 (GRCm39) V689I probably benign Het
Fam114a1 T A 5: 65,163,452 (GRCm39) M209K possibly damaging Het
Fam117a C T 11: 95,266,459 (GRCm39) S193F probably damaging Het
Foxp2 A T 6: 15,377,913 (GRCm39) probably benign Het
Frmd6 T A 12: 70,910,874 (GRCm39) C19* probably null Het
Fyb1 A G 15: 6,610,159 (GRCm39) probably null Het
Gata6 C A 18: 11,063,059 (GRCm39) H442Q possibly damaging Het
Gldc A G 19: 30,135,921 (GRCm39) S160P probably benign Het
Gm3952 A G 8: 129,472,455 (GRCm39) S1626P possibly damaging Het
Gm9762 T A 3: 78,873,742 (GRCm39) noncoding transcript Het
Gtpbp2 T C 17: 46,477,230 (GRCm39) probably benign Het
Hgd A T 16: 37,410,113 (GRCm39) T50S probably benign Het
Itpr1 C T 6: 108,364,459 (GRCm39) T22M probably damaging Het
Kif26b G A 1: 178,743,449 (GRCm39) E1182K probably damaging Het
Kirrel3 A G 9: 34,919,034 (GRCm39) E230G probably damaging Het
Leng8 A G 7: 4,142,987 (GRCm39) Y88C probably damaging Het
Lypd2 G T 15: 74,604,908 (GRCm39) A29E probably benign Het
Mdn1 C T 4: 32,723,690 (GRCm39) P2542L probably damaging Het
Mical3 T C 6: 120,936,434 (GRCm39) Y1364C probably damaging Het
Mroh2b A G 15: 4,935,054 (GRCm39) N163S probably damaging Het
Mtf1 G A 4: 124,718,872 (GRCm39) C295Y probably damaging Het
Nbn T A 4: 15,969,391 (GRCm39) L212Q probably damaging Het
Obscn A T 11: 58,959,852 (GRCm39) probably null Het
Or10ag56 T A 2: 87,139,126 (GRCm39) probably null Het
Or4c110 A G 2: 88,832,435 (GRCm39) S66P probably damaging Het
Peli1 A G 11: 21,098,389 (GRCm39) T375A probably damaging Het
Picalm T C 7: 89,856,803 (GRCm39) *611Q probably null Het
Plch1 G T 3: 63,609,394 (GRCm39) Q938K possibly damaging Het
Plxnb2 A G 15: 89,043,796 (GRCm39) V1352A possibly damaging Het
Pmepa1 G A 2: 173,070,115 (GRCm39) R147W probably damaging Het
Prdm16 T G 4: 154,429,848 (GRCm39) K373Q probably damaging Het
Qki T G 17: 10,457,964 (GRCm39) E135A probably damaging Het
Rad50 T C 11: 53,575,073 (GRCm39) K556E probably benign Het
Scara5 CG C 14: 65,997,111 (GRCm39) probably null Het
Sin3a T A 9: 57,018,084 (GRCm39) D834E possibly damaging Het
Smg8 G A 11: 86,971,086 (GRCm39) S895L probably benign Het
Sorl1 T C 9: 41,890,686 (GRCm39) I1944M probably benign Het
Stam2 G A 2: 52,626,305 (GRCm39) probably benign Het
Tmprss7 A T 16: 45,481,252 (GRCm39) W645R probably damaging Het
Tns1 T C 1: 73,980,176 (GRCm39) M1111V probably benign Het
Ttn A C 2: 76,608,726 (GRCm39) D17763E probably damaging Het
Ttn A T 2: 76,641,587 (GRCm39) L5176Q possibly damaging Het
Ubr4 G A 4: 139,124,839 (GRCm39) probably benign Het
Usp31 T C 7: 121,260,588 (GRCm39) H637R probably damaging Het
Vps50 A C 6: 3,567,739 (GRCm39) E545A possibly damaging Het
Wdfy3 G T 5: 102,020,724 (GRCm39) L2527M probably damaging Het
Wfdc2 T C 2: 164,405,354 (GRCm39) V85A possibly damaging Het
Other mutations in Lpo
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01483:Lpo APN 11 87,711,964 (GRCm39) missense probably benign 0.43
IGL01833:Lpo APN 11 87,698,159 (GRCm39) missense possibly damaging 0.81
IGL02413:Lpo APN 11 87,697,732 (GRCm39) missense possibly damaging 0.87
IGL02706:Lpo APN 11 87,708,599 (GRCm39) missense probably benign 0.02
IGL02865:Lpo APN 11 87,697,803 (GRCm39) missense possibly damaging 0.80
IGL02939:Lpo APN 11 87,706,004 (GRCm39) missense possibly damaging 0.85
R1072:Lpo UTSW 11 87,709,260 (GRCm39) missense probably damaging 1.00
R1169:Lpo UTSW 11 87,708,143 (GRCm39) missense possibly damaging 0.58
R1667:Lpo UTSW 11 87,698,067 (GRCm39) unclassified probably benign
R1719:Lpo UTSW 11 87,700,018 (GRCm39) splice site probably null
R2133:Lpo UTSW 11 87,711,956 (GRCm39) missense probably benign 0.17
R2871:Lpo UTSW 11 87,707,350 (GRCm39) missense possibly damaging 0.51
R2871:Lpo UTSW 11 87,707,350 (GRCm39) missense possibly damaging 0.51
R4382:Lpo UTSW 11 87,713,027 (GRCm39) missense probably benign 0.14
R4657:Lpo UTSW 11 87,705,173 (GRCm39) missense probably damaging 1.00
R4936:Lpo UTSW 11 87,701,166 (GRCm39) missense probably benign 0.02
R4969:Lpo UTSW 11 87,697,751 (GRCm39) missense probably benign 0.09
R5536:Lpo UTSW 11 87,707,389 (GRCm39) missense probably damaging 1.00
R6246:Lpo UTSW 11 87,713,058 (GRCm39) missense unknown
R6556:Lpo UTSW 11 87,708,589 (GRCm39) nonsense probably null
R6817:Lpo UTSW 11 87,700,067 (GRCm39) missense probably benign
R7024:Lpo UTSW 11 87,707,269 (GRCm39) missense probably damaging 1.00
R7203:Lpo UTSW 11 87,700,077 (GRCm39) missense possibly damaging 0.75
R7206:Lpo UTSW 11 87,698,249 (GRCm39) missense probably damaging 1.00
R8355:Lpo UTSW 11 87,705,114 (GRCm39) missense probably damaging 1.00
R8455:Lpo UTSW 11 87,705,114 (GRCm39) missense probably damaging 1.00
R8693:Lpo UTSW 11 87,700,066 (GRCm39) missense probably benign 0.04
R8848:Lpo UTSW 11 87,708,603 (GRCm39) missense probably benign 0.00
R8891:Lpo UTSW 11 87,697,848 (GRCm39) missense probably benign 0.08
R8989:Lpo UTSW 11 87,708,660 (GRCm39) missense probably benign 0.00
RF010:Lpo UTSW 11 87,711,928 (GRCm39) missense probably benign 0.00
Predicted Primers PCR Primer
(F):5'- GAGGCATCTTAGAAGCTGGG -3'
(R):5'- TTGAACCCCTATGAGCTAATGG -3'

Sequencing Primer
(F):5'- CTTAGAAGCTGGGATTTTTAGAACTG -3'
(R):5'- TAATGGCTGCCGGGGTC -3'
Posted On 2016-09-06