Incidental Mutation 'R5368:Scara5'
ID 429496
Institutional Source Beutler Lab
Gene Symbol Scara5
Ensembl Gene ENSMUSG00000022032
Gene Name scavenger receptor class A, member 5
Synonyms 4933425F03Rik, 4932433F15Rik
MMRRC Submission 043204-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.080) question?
Stock # R5368 (G1)
Quality Score 217
Status Validated
Chromosome 14
Chromosomal Location 65903852-66002275 bp(+) (GRCm39)
Type of Mutation frame shift
DNA Base Change (assembly) CG to C at 65997111 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000022610 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000022610]
AlphaFold Q8K299
Predicted Effect probably null
Transcript: ENSMUST00000022610
SMART Domains Protein: ENSMUSP00000022610
Gene: ENSMUSG00000022032

DomainStartEndE-ValueType
transmembrane domain 60 82 N/A INTRINSIC
Pfam:Collagen 304 357 1.8e-8 PFAM
Pfam:Collagen 327 383 1.1e-8 PFAM
SR 389 489 5.5e-56 SMART
Meta Mutation Damage Score 0.9755 question?
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.6%
  • 10x: 97.3%
  • 20x: 95.3%
Validation Efficiency 97% (61/63)
MGI Phenotype PHENOTYPE: Homozygous deletion of this gene results in decreased male fertility and lymphocytic infiltration of the stroma of various tissues, particularly in the lungs. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 58 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4933402N03Rik T A 7: 130,740,925 (GRCm39) H97L possibly damaging Het
Abca9 T A 11: 110,036,372 (GRCm39) N579I probably damaging Het
Acbd3 A T 1: 180,549,660 (GRCm39) probably benign Het
Ankrd50 A T 3: 38,509,199 (GRCm39) I1056N probably damaging Het
Ceacam18 T C 7: 43,291,458 (GRCm39) V300A probably benign Het
Cfap46 C A 7: 139,207,389 (GRCm39) R1843S possibly damaging Het
D430041D05Rik A G 2: 104,078,629 (GRCm39) V1229A probably damaging Het
Dbx2 G A 15: 95,538,522 (GRCm39) S206L probably benign Het
Dnah11 A T 12: 117,918,628 (GRCm39) D1530E probably damaging Het
Ecm2 A C 13: 49,674,419 (GRCm39) T280P probably benign Het
Emc2 G A 15: 43,375,207 (GRCm39) probably null Het
Epb42 C T 2: 120,849,943 (GRCm39) V689I probably benign Het
Fam114a1 T A 5: 65,163,452 (GRCm39) M209K possibly damaging Het
Fam117a C T 11: 95,266,459 (GRCm39) S193F probably damaging Het
Foxp2 A T 6: 15,377,913 (GRCm39) probably benign Het
Frmd6 T A 12: 70,910,874 (GRCm39) C19* probably null Het
Fyb1 A G 15: 6,610,159 (GRCm39) probably null Het
Gata6 C A 18: 11,063,059 (GRCm39) H442Q possibly damaging Het
Gldc A G 19: 30,135,921 (GRCm39) S160P probably benign Het
Gm3952 A G 8: 129,472,455 (GRCm39) S1626P possibly damaging Het
Gm9762 T A 3: 78,873,742 (GRCm39) noncoding transcript Het
Gtpbp2 T C 17: 46,477,230 (GRCm39) probably benign Het
Hgd A T 16: 37,410,113 (GRCm39) T50S probably benign Het
Itpr1 C T 6: 108,364,459 (GRCm39) T22M probably damaging Het
Kif26b G A 1: 178,743,449 (GRCm39) E1182K probably damaging Het
Kirrel3 A G 9: 34,919,034 (GRCm39) E230G probably damaging Het
Leng8 A G 7: 4,142,987 (GRCm39) Y88C probably damaging Het
Lpo T C 11: 87,711,895 (GRCm39) D54G possibly damaging Het
Lypd2 G T 15: 74,604,908 (GRCm39) A29E probably benign Het
Mdn1 C T 4: 32,723,690 (GRCm39) P2542L probably damaging Het
Mical3 T C 6: 120,936,434 (GRCm39) Y1364C probably damaging Het
Mroh2b A G 15: 4,935,054 (GRCm39) N163S probably damaging Het
Mtf1 G A 4: 124,718,872 (GRCm39) C295Y probably damaging Het
Nbn T A 4: 15,969,391 (GRCm39) L212Q probably damaging Het
Obscn A T 11: 58,959,852 (GRCm39) probably null Het
Or10ag56 T A 2: 87,139,126 (GRCm39) probably null Het
Or4c110 A G 2: 88,832,435 (GRCm39) S66P probably damaging Het
Peli1 A G 11: 21,098,389 (GRCm39) T375A probably damaging Het
Picalm T C 7: 89,856,803 (GRCm39) *611Q probably null Het
Plch1 G T 3: 63,609,394 (GRCm39) Q938K possibly damaging Het
Plxnb2 A G 15: 89,043,796 (GRCm39) V1352A possibly damaging Het
Pmepa1 G A 2: 173,070,115 (GRCm39) R147W probably damaging Het
Prdm16 T G 4: 154,429,848 (GRCm39) K373Q probably damaging Het
Qki T G 17: 10,457,964 (GRCm39) E135A probably damaging Het
Rad50 T C 11: 53,575,073 (GRCm39) K556E probably benign Het
Sin3a T A 9: 57,018,084 (GRCm39) D834E possibly damaging Het
Smg8 G A 11: 86,971,086 (GRCm39) S895L probably benign Het
Sorl1 T C 9: 41,890,686 (GRCm39) I1944M probably benign Het
Stam2 G A 2: 52,626,305 (GRCm39) probably benign Het
Tmprss7 A T 16: 45,481,252 (GRCm39) W645R probably damaging Het
Tns1 T C 1: 73,980,176 (GRCm39) M1111V probably benign Het
Ttn A C 2: 76,608,726 (GRCm39) D17763E probably damaging Het
Ttn A T 2: 76,641,587 (GRCm39) L5176Q possibly damaging Het
Ubr4 G A 4: 139,124,839 (GRCm39) probably benign Het
Usp31 T C 7: 121,260,588 (GRCm39) H637R probably damaging Het
Vps50 A C 6: 3,567,739 (GRCm39) E545A possibly damaging Het
Wdfy3 G T 5: 102,020,724 (GRCm39) L2527M probably damaging Het
Wfdc2 T C 2: 164,405,354 (GRCm39) V85A possibly damaging Het
Other mutations in Scara5
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00402:Scara5 APN 14 65,975,864 (GRCm39) splice site probably benign
IGL00772:Scara5 APN 14 65,908,011 (GRCm39) utr 5 prime probably benign
IGL01768:Scara5 APN 14 65,927,224 (GRCm39) nonsense probably null
IGL02081:Scara5 APN 14 65,968,104 (GRCm39) missense possibly damaging 0.96
IGL02280:Scara5 APN 14 65,968,227 (GRCm39) missense probably benign
IGL02795:Scara5 APN 14 65,968,129 (GRCm39) missense possibly damaging 0.72
IGL02887:Scara5 APN 14 66,000,278 (GRCm39) missense unknown
R0040:Scara5 UTSW 14 66,000,166 (GRCm39) splice site probably benign
R0605:Scara5 UTSW 14 65,997,097 (GRCm39) missense possibly damaging 0.85
R0735:Scara5 UTSW 14 65,968,468 (GRCm39) missense possibly damaging 0.85
R0925:Scara5 UTSW 14 66,000,167 (GRCm39) critical splice acceptor site probably benign
R1575:Scara5 UTSW 14 65,968,314 (GRCm39) missense probably benign 0.18
R1746:Scara5 UTSW 14 65,968,539 (GRCm39) missense probably benign
R1968:Scara5 UTSW 14 65,927,249 (GRCm39) missense possibly damaging 0.73
R4455:Scara5 UTSW 14 66,000,196 (GRCm39) missense probably benign 0.01
R4547:Scara5 UTSW 14 65,908,023 (GRCm39) missense possibly damaging 0.72
R4779:Scara5 UTSW 14 65,968,198 (GRCm39) missense probably benign 0.03
R5218:Scara5 UTSW 14 65,997,111 (GRCm39) frame shift probably null
R5316:Scara5 UTSW 14 65,927,264 (GRCm39) missense possibly damaging 0.73
R5331:Scara5 UTSW 14 65,997,111 (GRCm39) frame shift probably null
R5332:Scara5 UTSW 14 65,997,111 (GRCm39) frame shift probably null
R5366:Scara5 UTSW 14 65,997,111 (GRCm39) frame shift probably null
R5367:Scara5 UTSW 14 65,997,111 (GRCm39) frame shift probably null
R5369:Scara5 UTSW 14 65,997,111 (GRCm39) frame shift probably null
R5417:Scara5 UTSW 14 65,997,111 (GRCm39) frame shift probably null
R5418:Scara5 UTSW 14 65,997,111 (GRCm39) frame shift probably null
R5420:Scara5 UTSW 14 65,997,111 (GRCm39) frame shift probably null
R5447:Scara5 UTSW 14 65,997,111 (GRCm39) frame shift probably null
R5473:Scara5 UTSW 14 65,977,788 (GRCm39) missense possibly damaging 0.84
R5580:Scara5 UTSW 14 65,968,528 (GRCm39) missense probably benign 0.02
R7734:Scara5 UTSW 14 65,968,600 (GRCm39) missense possibly damaging 0.85
R7995:Scara5 UTSW 14 65,997,057 (GRCm39) missense possibly damaging 0.53
R8090:Scara5 UTSW 14 65,979,586 (GRCm39) nonsense probably null
R8308:Scara5 UTSW 14 65,927,234 (GRCm39) missense probably damaging 0.97
R9036:Scara5 UTSW 14 66,000,197 (GRCm39) missense probably benign 0.24
Predicted Primers PCR Primer
(F):5'- ACGACACAAGGTAGCCTCATG -3'
(R):5'- CACATGAAGGTGACGCAGAC -3'

Sequencing Primer
(F):5'- CACAAGGTAGCCTCATGGTTTTAGC -3'
(R):5'- CAGGCCTAGCATCCATGGTTTTC -3'
Posted On 2016-09-06