Incidental Mutation 'R5403:Anp32a'
ID 430114
Institutional Source Beutler Lab
Gene Symbol Anp32a
Ensembl Gene ENSMUSG00000032249
Gene Name acidic nuclear phosphoprotein 32 family member A
Synonyms pp32, Anp32
MMRRC Submission 042974-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R5403 (G1)
Quality Score 225
Status Not validated
Chromosome 9
Chromosomal Location 62248637-62286084 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to T at 62249275 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Isoleucine to Phenylalanine at position 16 (I16F)
Ref Sequence ENSEMBL: ENSMUSP00000123574 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000085519] [ENSMUST00000128636] [ENSMUST00000135395]
AlphaFold O35381
Predicted Effect probably benign
Transcript: ENSMUST00000085519
SMART Domains Protein: ENSMUSP00000082652
Gene: ENSMUSG00000032249

DomainStartEndE-ValueType
Pfam:LRR_4 64 107 5.2e-9 PFAM
Pfam:LRR_8 64 125 1.9e-9 PFAM
LRRcap 128 146 3.19e-2 SMART
coiled coil region 167 199 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000126451
Predicted Effect possibly damaging
Transcript: ENSMUST00000128636
AA Change: I16F

PolyPhen 2 Score 0.504 (Sensitivity: 0.88; Specificity: 0.90)
SMART Domains Protein: ENSMUSP00000123574
Gene: ENSMUSG00000032249
AA Change: I16F

DomainStartEndE-ValueType
Pfam:LRR_8 67 128 3.1e-10 PFAM
Pfam:LRR_4 77 111 3e-8 PFAM
Pfam:LRR_6 90 110 7.2e-6 PFAM
Pfam:LRR_7 91 107 9.5e-4 PFAM
Pfam:LRR_1 92 115 1.7e-4 PFAM
LRRcap 131 149 3.19e-2 SMART
coiled coil region 170 198 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000135395
SMART Domains Protein: ENSMUSP00000122165
Gene: ENSMUSG00000032249

DomainStartEndE-ValueType
Pfam:LRR_8 50 111 4.9e-10 PFAM
Pfam:LRR_6 73 93 9e-6 PFAM
Pfam:LRR_7 74 90 1.2e-3 PFAM
Pfam:LRR_1 75 98 2.2e-4 PFAM
LRRcap 114 132 3.19e-2 SMART
coiled coil region 153 185 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000138226
Predicted Effect noncoding transcript
Transcript: ENSMUST00000141277
Predicted Effect probably benign
Transcript: ENSMUST00000156461
SMART Domains Protein: ENSMUSP00000115293
Gene: ENSMUSG00000032249

DomainStartEndE-ValueType
Pfam:LRR_9 5 138 8e-13 PFAM
Pfam:LRR_4 60 104 9.7e-10 PFAM
Pfam:LRR_8 60 121 8.6e-10 PFAM
Pfam:LRR_4 84 129 2.8e-9 PFAM
Pfam:LRR_1 85 106 1.4e-3 PFAM
Meta Mutation Damage Score 0.1795 question?
Coding Region Coverage
  • 1x: 99.4%
  • 3x: 98.7%
  • 10x: 97.4%
  • 20x: 95.7%
Validation Efficiency
MGI Phenotype PHENOTYPE: Homozygous mutant mice are viable, fertile, behaviorally normal, and show no defects of the central nervous system. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 52 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Acsbg3 G T 17: 57,183,221 (GRCm39) probably benign Het
Adamts6 A G 13: 104,489,323 (GRCm39) D392G possibly damaging Het
Adcy8 C T 15: 64,588,001 (GRCm39) V929I probably benign Het
Alkbh8 A G 9: 3,385,318 (GRCm39) K537E probably benign Het
Asb18 T C 1: 89,942,110 (GRCm39) T64A probably benign Het
Bpifb4 A T 2: 153,785,912 (GRCm39) I17F probably damaging Het
Brd7 G T 8: 89,084,169 (GRCm39) Q148K probably damaging Het
Brinp1 A G 4: 68,711,201 (GRCm39) W336R probably benign Het
Ccdc88b T A 19: 6,835,108 (GRCm39) T38S unknown Het
Cd46 C T 1: 194,744,719 (GRCm39) V340I possibly damaging Het
Cdr2 G A 7: 120,557,968 (GRCm39) Q186* probably null Het
Ces1e T G 8: 93,935,240 (GRCm39) D404A probably benign Het
Chd3 A T 11: 69,239,895 (GRCm39) probably null Het
Cmtm1 CGGCACGTACTGAAGGTCGCTGACTGGATGGTGTGGCACGTACTGAAGGTCGCTGACTGGATGGTGTGGCACGTACTGAAGGTCGCTGACTGGATGGT CGGCACGTACTGAAGGTCGCTGACTGGATGGTGTGGCACGTACTGAAGGTCGCTGACTGGATGGT 8: 105,036,102 (GRCm39) probably benign Het
Cntnap3 G A 13: 64,909,792 (GRCm39) T771I possibly damaging Het
Cops8 C T 1: 90,534,342 (GRCm39) probably benign Het
Csmd2 C T 4: 128,380,677 (GRCm39) R2078C probably benign Het
Ddx50 A G 10: 62,482,809 (GRCm39) S87P probably benign Het
Dennd2b A G 7: 109,156,112 (GRCm39) S213P probably damaging Het
Dlg2 A G 7: 92,080,210 (GRCm39) T598A probably damaging Het
Dnah8 G A 17: 30,967,542 (GRCm39) D2585N probably benign Het
Epha6 A T 16: 59,595,933 (GRCm39) D919E probably damaging Het
Fndc9 C T 11: 46,128,541 (GRCm39) S20L probably benign Het
Gpx6 A G 13: 21,501,813 (GRCm39) E145G probably damaging Het
Hc A G 2: 34,947,446 (GRCm39) Y23H probably damaging Het
Insyn2b A T 11: 34,353,058 (GRCm39) T367S probably benign Het
Jmy G T 13: 93,577,904 (GRCm39) Q755K probably benign Het
Krtap4-7 A T 11: 99,534,540 (GRCm39) S108T unknown Het
Mgat5b T G 11: 116,839,483 (GRCm39) I333S probably benign Het
Mrtfb A G 16: 13,218,877 (GRCm39) T519A probably damaging Het
Naip6 G A 13: 100,436,585 (GRCm39) A646V probably benign Het
Opn4 T C 14: 34,314,894 (GRCm39) T460A probably benign Het
Or6b2 A T 1: 92,408,019 (GRCm39) V108E possibly damaging Het
Or8g22 G T 9: 38,957,999 (GRCm39) P239T probably damaging Het
Otogl T A 10: 107,644,617 (GRCm39) M1210L probably benign Het
Pheta1 A G 5: 121,990,794 (GRCm39) E52G possibly damaging Het
Phf24 A T 4: 42,933,831 (GRCm39) probably null Het
Ppargc1a G A 5: 51,620,167 (GRCm39) probably benign Het
Ptprd G A 4: 75,872,405 (GRCm39) R1355* probably null Het
Rad50 A G 11: 53,586,108 (GRCm39) probably null Het
Robo4 CGG CG 9: 37,322,786 (GRCm39) probably null Het
Rsf1 GCG GCGACGGCGACG 7: 97,229,114 (GRCm39) probably benign Het
Tbcd C A 11: 121,451,569 (GRCm39) N546K probably damaging Het
Tenm4 A G 7: 96,538,034 (GRCm39) D1832G probably damaging Het
Tfap2e T C 4: 126,628,439 (GRCm39) I172M probably benign Het
Tnip2 A G 5: 34,671,108 (GRCm39) L45P probably damaging Het
Ttc3 T C 16: 94,260,703 (GRCm39) V1396A probably benign Het
Ube2o A T 11: 116,439,633 (GRCm39) I179N possibly damaging Het
Usp17le T C 7: 104,418,441 (GRCm39) I234V probably damaging Het
Zfp106 T C 2: 120,365,262 (GRCm39) T382A probably benign Het
Zfp607a A G 7: 27,578,744 (GRCm39) K605E possibly damaging Het
Zmynd10 T A 9: 107,427,785 (GRCm39) L363H possibly damaging Het
Other mutations in Anp32a
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00655:Anp32a APN 9 62,278,994 (GRCm39) splice site probably benign
IGL01799:Anp32a APN 9 62,279,092 (GRCm39) missense probably benign 0.06
IGL02066:Anp32a APN 9 62,284,615 (GRCm39) unclassified probably benign
IGL02536:Anp32a APN 9 62,279,110 (GRCm39) missense probably damaging 0.98
R1608:Anp32a UTSW 9 62,279,375 (GRCm39) missense probably damaging 0.99
R2149:Anp32a UTSW 9 62,279,084 (GRCm39) missense probably benign 0.19
R5287:Anp32a UTSW 9 62,249,275 (GRCm39) missense possibly damaging 0.50
R5381:Anp32a UTSW 9 62,279,459 (GRCm39) missense probably damaging 0.97
R5427:Anp32a UTSW 9 62,284,598 (GRCm39) unclassified probably benign
R6856:Anp32a UTSW 9 62,279,397 (GRCm39) missense possibly damaging 0.95
R6906:Anp32a UTSW 9 62,284,851 (GRCm39) unclassified probably benign
R7949:Anp32a UTSW 9 62,280,948 (GRCm39) missense unknown
R8134:Anp32a UTSW 9 62,284,863 (GRCm39) missense unknown
R9501:Anp32a UTSW 9 62,282,019 (GRCm39) missense unknown
Predicted Primers PCR Primer
(F):5'- CCTTGGTGTGTGACTGACTACC -3'
(R):5'- TTAAACTCGAGCCATCTCCC -3'

Sequencing Primer
(F):5'- ACTGACTACCTGTGCGTGTGC -3'
(R):5'- CAACTCCGCAGCAGTCG -3'
Posted On 2016-09-06