Incidental Mutation 'R5484:Zfp874b'
ID 430333
Institutional Source Beutler Lab
Gene Symbol Zfp874b
Ensembl Gene ENSMUSG00000059839
Gene Name zinc finger protein 874b
Synonyms 9630025I21Rik
MMRRC Submission 043045-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.103) question?
Stock # R5484 (G1)
Quality Score 225
Status Validated
Chromosome 13
Chromosomal Location 67619632-67632377 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) C to T at 67629373 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Valine to Isoleucine at position 52 (V52I)
Ref Sequence ENSEMBL: ENSMUSP00000153242 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000019572] [ENSMUST00000223868]
AlphaFold Q7M6X2
Predicted Effect possibly damaging
Transcript: ENSMUST00000019572
AA Change: V48I

PolyPhen 2 Score 0.535 (Sensitivity: 0.88; Specificity: 0.90)
SMART Domains Protein: ENSMUSP00000019572
Gene: ENSMUSG00000059839
AA Change: V48I

DomainStartEndE-ValueType
KRAB 5 65 4.48e-26 SMART
ZnF_C2H2 136 158 5.9e-3 SMART
ZnF_C2H2 164 186 3.16e-3 SMART
ZnF_C2H2 192 214 6.78e-3 SMART
ZnF_C2H2 220 242 2.4e-3 SMART
ZnF_C2H2 248 268 1.88e2 SMART
ZnF_C2H2 276 298 6.42e-4 SMART
ZnF_C2H2 304 326 2.12e-4 SMART
ZnF_C2H2 332 354 1.28e-3 SMART
ZnF_C2H2 360 382 8.47e-4 SMART
ZnF_C2H2 388 410 1.79e-2 SMART
ZnF_C2H2 416 438 1.47e-3 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000223711
Predicted Effect possibly damaging
Transcript: ENSMUST00000223868
AA Change: V52I

PolyPhen 2 Score 0.757 (Sensitivity: 0.85; Specificity: 0.92)
Predicted Effect noncoding transcript
Transcript: ENSMUST00000224308
Predicted Effect noncoding transcript
Transcript: ENSMUST00000225027
Meta Mutation Damage Score 0.1795 question?
Coding Region Coverage
  • 1x: 98.3%
  • 3x: 97.3%
  • 10x: 95.3%
  • 20x: 91.4%
Validation Efficiency 97% (76/78)
Allele List at MGI
Other mutations in this stock
Total: 71 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4921509C19Rik T C 2: 151,313,851 (GRCm39) H609R probably benign Het
Abca6 A T 11: 110,074,899 (GRCm39) V1388E probably damaging Het
Alx1 T A 10: 102,861,177 (GRCm39) D117V probably damaging Het
Ascl4 T C 10: 85,764,401 (GRCm39) L16P probably damaging Het
Atp4a G A 7: 30,420,097 (GRCm39) probably benign Het
Btnl10 G A 11: 58,814,651 (GRCm39) V444M probably damaging Het
Camkv A T 9: 107,823,345 (GRCm39) N124Y probably damaging Het
Catsperb T C 12: 101,542,175 (GRCm39) L625P probably benign Het
Ccdc171 A G 4: 83,612,199 (GRCm39) I973V probably benign Het
Celsr1 T C 15: 85,815,483 (GRCm39) D1844G probably benign Het
Chd7 G C 4: 8,828,258 (GRCm39) K1066N probably damaging Het
Cmklr1 C G 5: 113,752,990 (GRCm39) D4H possibly damaging Het
Corin T C 5: 72,515,827 (GRCm39) D409G probably benign Het
Cry1 T C 10: 84,982,588 (GRCm39) probably null Het
Cttnbp2 T A 6: 18,427,689 (GRCm39) probably benign Het
Cyrib T A 15: 63,815,056 (GRCm39) T139S probably damaging Het
Dmxl1 T A 18: 50,022,531 (GRCm39) V1623E probably damaging Het
Dnah6 G T 6: 73,069,099 (GRCm39) D2477E possibly damaging Het
Dnajb12 GC G 10: 59,728,574 (GRCm39) probably null Het
Dop1a C G 9: 86,427,341 (GRCm39) R2164G probably damaging Het
Dsp A G 13: 38,368,014 (GRCm39) T678A possibly damaging Het
Farsb A C 1: 78,452,833 (GRCm39) I51S probably damaging Het
Gm10220 T A 5: 26,322,930 (GRCm39) I161L possibly damaging Het
Gm10782 G T 13: 56,510,987 (GRCm39) noncoding transcript Het
Gm12830 A T 4: 114,702,248 (GRCm39) T137S unknown Het
Gopc A G 10: 52,234,942 (GRCm39) L67P probably damaging Het
Hmcn1 T C 1: 150,551,291 (GRCm39) I2655V probably benign Het
Hmcn2 C T 2: 31,283,066 (GRCm39) Q1981* probably null Het
Ifi209 T A 1: 173,468,640 (GRCm39) S157T probably benign Het
Ift56 T G 6: 38,366,057 (GRCm39) C124W probably benign Het
Iqcf1 A T 9: 106,379,107 (GRCm39) I74F probably damaging Het
Irf3 A T 7: 44,649,382 (GRCm39) R78W probably damaging Het
Kank4 T C 4: 98,663,022 (GRCm39) D722G probably benign Het
Loxl1 A G 9: 58,198,065 (GRCm39) V597A possibly damaging Het
Marveld1 T C 19: 42,136,272 (GRCm39) L62P probably damaging Het
Mga T G 2: 119,747,107 (GRCm39) D419E possibly damaging Het
Mroh2a A G 1: 88,186,386 (GRCm39) S64G probably benign Het
Mroh2b A G 15: 4,938,463 (GRCm39) K251E possibly damaging Het
Myh4 A G 11: 67,142,644 (GRCm39) E935G probably damaging Het
Nat8f2 C A 6: 85,844,994 (GRCm39) A123S possibly damaging Het
Niban1 A G 1: 151,593,837 (GRCm39) T841A probably benign Het
Or4d11 G A 19: 12,013,192 (GRCm39) L305F probably benign Het
Pcdha9 T A 18: 37,131,156 (GRCm39) V75E probably damaging Het
Pebp4 A T 14: 70,200,991 (GRCm39) probably null Het
Pitx1 A G 13: 55,974,166 (GRCm39) S222P probably benign Het
Plekhg3 G A 12: 76,625,174 (GRCm39) V1339M possibly damaging Het
Plekhs1 C T 19: 56,468,260 (GRCm39) S276L possibly damaging Het
Plin4 T C 17: 56,411,932 (GRCm39) T700A possibly damaging Het
Plxnb2 T C 15: 89,048,412 (GRCm39) probably null Het
Pms2 T C 5: 143,864,943 (GRCm39) I675T probably damaging Het
Polrmt A G 10: 79,577,888 (GRCm39) L268P probably damaging Het
Rtp1 A G 16: 23,248,025 (GRCm39) T33A probably benign Het
Safb2 T C 17: 56,882,346 (GRCm39) probably benign Het
Sdk1 C A 5: 142,085,941 (GRCm39) P1383Q probably damaging Het
Setdb1 A T 3: 95,244,569 (GRCm39) C758S probably damaging Het
Sh3gl2 T C 4: 85,317,160 (GRCm39) probably benign Het
Slc13a2 G A 11: 78,295,648 (GRCm39) probably benign Het
Slc35b1 T C 11: 95,278,631 (GRCm39) Y126H probably damaging Het
Strip2 C A 6: 29,917,154 (GRCm39) probably benign Het
Tbx4 A G 11: 85,805,230 (GRCm39) T440A probably damaging Het
Tcf7l2 C A 19: 55,907,940 (GRCm39) probably null Het
Tgfb1 A C 7: 25,387,574 (GRCm39) D94A probably benign Het
Tmem132b T C 5: 125,864,797 (GRCm39) C968R probably damaging Het
Tmem176b T A 6: 48,811,467 (GRCm39) M61L probably benign Het
Tmem258 A G 19: 10,184,689 (GRCm39) probably null Het
Tpr T C 1: 150,302,639 (GRCm39) L1379S probably benign Het
Vmn2r44 T C 7: 8,383,123 (GRCm39) D157G possibly damaging Het
Wfdc8 T C 2: 164,439,649 (GRCm39) I244M probably benign Het
Zfp341 T C 2: 154,466,921 (GRCm39) S97P probably benign Het
Zfp655 T C 5: 145,180,445 (GRCm39) V101A probably benign Het
Zfp788 T C 7: 41,299,277 (GRCm39) S586P probably damaging Het
Other mutations in Zfp874b
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02172:Zfp874b APN 13 67,622,135 (GRCm39) missense probably damaging 1.00
R0432:Zfp874b UTSW 13 67,629,955 (GRCm39) missense probably damaging 1.00
R0653:Zfp874b UTSW 13 67,623,052 (GRCm39) missense possibly damaging 0.69
R0727:Zfp874b UTSW 13 67,622,831 (GRCm39) missense probably damaging 1.00
R1475:Zfp874b UTSW 13 67,622,211 (GRCm39) splice site probably null
R1726:Zfp874b UTSW 13 67,622,839 (GRCm39) missense probably damaging 1.00
R6386:Zfp874b UTSW 13 67,622,962 (GRCm39) missense possibly damaging 0.70
R7029:Zfp874b UTSW 13 67,622,392 (GRCm39) missense probably damaging 0.98
R7150:Zfp874b UTSW 13 67,622,622 (GRCm39) nonsense probably null
R7726:Zfp874b UTSW 13 67,621,975 (GRCm39) missense probably benign 0.01
R7778:Zfp874b UTSW 13 67,622,093 (GRCm39) missense probably benign 0.03
R7824:Zfp874b UTSW 13 67,622,093 (GRCm39) missense probably benign 0.03
R7918:Zfp874b UTSW 13 67,622,279 (GRCm39) missense possibly damaging 0.74
R7939:Zfp874b UTSW 13 67,622,622 (GRCm39) nonsense probably null
R8053:Zfp874b UTSW 13 67,622,217 (GRCm39) missense probably damaging 0.96
R8881:Zfp874b UTSW 13 67,622,141 (GRCm39) missense probably damaging 0.99
X0028:Zfp874b UTSW 13 67,622,179 (GRCm39) missense probably damaging 0.96
Predicted Primers PCR Primer
(F):5'- CACGATAGCAAAAGACTTTAAGGC -3'
(R):5'- AGAATCTGCAGATTGTAAACCCC -3'

Sequencing Primer
(F):5'- CACAACAAATGTCTCAATGTTCATGG -3'
(R):5'- ACCCCCCACAGTATTTTAA -3'
Posted On 2016-10-05