|Institutional Source||Beutler Lab|
|Gene Name||proviral integration site 3|
|Synonyms||KID-1/kinase induced by depolarization, Kid1|
|Is this an essential gene?||Non essential (E-score: 0.000)|
|Stock #||R5486 (G1)|
|Chromosomal Location||88862186-88865726 bp(+) (GRCm38)|
|Type of Mutation||missense|
|DNA Base Change (assembly)||T to C at 88863222 bp|
|Amino Acid Change||Valine to Alanine at position 97 (V97A)|
|Ref Sequence||ENSEMBL: ENSMUSP00000044603 (fasta)|
|Gene Model||predicted gene model for transcript(s): [ENSMUST00000042818]|
|Predicted Effect||possibly damaging
AA Change: V97A
PolyPhen 2 Score 0.713 (Sensitivity: 0.86; Specificity: 0.92)
AA Change: V97A
|Predicted Effect||noncoding transcript
|Coding Region Coverage||
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene belongs to the Ser/Thr protein kinase family, and PIM subfamily. This gene is overexpressed in hematological and epithelial tumors and is associated with MYC coexpression. It plays a role in the regulation of signal transduction cascades, contributing to both cell proliferation and survival, and provides a selective advantage in tumorigenesis. [provided by RefSeq, Jun 2012]
PHENOTYPE: Homozygous null mice are healthy and fertile and do not display any gross abnormalities. [provided by MGI curators]
|Allele List at MGI|
|Other mutations in this stock||
|Other mutations in Pim3||
(F):5'- CTGTGAAGCACGTGGTGAAG -3'
(R):5'- CAGTGTAGACCGTGTCCTTGAG -3'
(F):5'- CACGTGGTGAAGGAGCG -3'
(R):5'- AGCCGAAGTCGATGAGCTTC -3'