Incidental Mutation 'R5486:Pim3'
ID 430386
Institutional Source Beutler Lab
Gene Symbol Pim3
Ensembl Gene ENSMUSG00000035828
Gene Name proviral integration site 3
Synonyms Kid1, KID-1/kinase induced by depolarization
MMRRC Submission 043047-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R5486 (G1)
Quality Score 108
Status Not validated
Chromosome 15
Chromosomal Location 88746397-88749929 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 88747425 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Valine to Alanine at position 97 (V97A)
Ref Sequence ENSEMBL: ENSMUSP00000044603 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000042818]
AlphaFold P58750
Predicted Effect possibly damaging
Transcript: ENSMUST00000042818
AA Change: V97A

PolyPhen 2 Score 0.713 (Sensitivity: 0.86; Specificity: 0.92)
SMART Domains Protein: ENSMUSP00000044603
Gene: ENSMUSG00000035828
AA Change: V97A

DomainStartEndE-ValueType
S_TKc 40 293 9.25e-69 SMART
low complexity region 312 325 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000229969
Coding Region Coverage
  • 1x: 98.2%
  • 3x: 97.2%
  • 10x: 95.1%
  • 20x: 90.4%
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene belongs to the Ser/Thr protein kinase family, and PIM subfamily. This gene is overexpressed in hematological and epithelial tumors and is associated with MYC coexpression. It plays a role in the regulation of signal transduction cascades, contributing to both cell proliferation and survival, and provides a selective advantage in tumorigenesis. [provided by RefSeq, Jun 2012]
PHENOTYPE: Homozygous null mice are healthy and fertile and do not display any gross abnormalities. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 43 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
A930009A15Rik G T 10: 115,415,810 (GRCm39) probably benign Het
Acad8 A T 9: 26,910,791 (GRCm39) M1K probably null Het
Adam12 C A 7: 133,509,401 (GRCm39) R786S possibly damaging Het
Add3 G A 19: 53,232,818 (GRCm39) V604I probably benign Het
Alpk2 A T 18: 65,427,425 (GRCm39) probably null Het
Ano3 T C 2: 110,576,215 (GRCm39) D102G probably damaging Het
Bdp1 T C 13: 100,235,018 (GRCm39) Y192C probably damaging Het
Bod1l A T 5: 41,964,524 (GRCm39) D2693E possibly damaging Het
Ccdc7a T C 8: 129,711,884 (GRCm39) N284D probably damaging Het
Clic6 A G 16: 92,326,740 (GRCm39) probably null Het
Cln5 T C 14: 103,313,630 (GRCm39) I294T probably damaging Het
Cmklr1 C G 5: 113,752,990 (GRCm39) D4H possibly damaging Het
Cyp2d9 T A 15: 82,336,779 (GRCm39) W43R probably damaging Het
Dnajb12 GC G 10: 59,728,574 (GRCm39) probably null Het
Erlec1 A T 11: 30,885,047 (GRCm39) H413Q probably damaging Het
Fam168a T A 7: 100,483,376 (GRCm39) M203K probably damaging Het
Fat2 A T 11: 55,144,507 (GRCm39) S4122R probably benign Het
Fgd4 A T 16: 16,292,901 (GRCm39) L272Q probably damaging Het
Hpcal4 A G 4: 123,084,557 (GRCm39) K162R probably benign Het
Iars1 T A 13: 49,863,049 (GRCm39) probably null Het
Lbr A G 1: 181,646,403 (GRCm39) probably null Het
Lrp2 T C 2: 69,267,809 (GRCm39) I4259V probably benign Het
Mcm3 C T 1: 20,885,118 (GRCm39) G189S probably damaging Het
Nr1d2 A G 14: 18,206,860 (GRCm38) V137A possibly damaging Het
Or52d1 C A 7: 103,755,705 (GRCm39) T73N probably damaging Het
Or52n3 T A 7: 104,530,168 (GRCm39) C85S probably benign Het
Or7g33 A G 9: 19,448,590 (GRCm39) V212A probably benign Het
Piwil2 T C 14: 70,638,880 (GRCm39) N479S probably benign Het
Pld3 C A 7: 27,233,156 (GRCm39) W365L probably damaging Het
Plk3 C A 4: 116,987,600 (GRCm39) E412* probably null Het
Psmd1 A G 1: 86,064,772 (GRCm39) I935V possibly damaging Het
Sh2b2 A G 5: 136,260,944 (GRCm39) S91P probably benign Het
Skor2 A G 18: 76,946,395 (GRCm39) N39S unknown Het
Slc22a22 A G 15: 57,126,847 (GRCm39) V55A probably damaging Het
Smg7 A G 1: 152,721,927 (GRCm39) S595P probably damaging Het
Snrnp200 C T 2: 127,074,986 (GRCm39) P1520S possibly damaging Het
Taar7a T A 10: 23,868,356 (GRCm39) T342S probably benign Het
Tecpr2 A T 12: 110,899,449 (GRCm39) I606F probably benign Het
Tex19.2 A T 11: 121,008,304 (GRCm39) M48K probably benign Het
Thoc1 A G 18: 9,992,204 (GRCm39) T511A probably benign Het
Trpc2 GTGTCCTA GTGTCCTATGTCCTA 7: 101,744,420 (GRCm39) probably null Het
Ubr5 C A 15: 38,008,983 (GRCm39) A1077S probably benign Het
Wdr95 A T 5: 149,519,795 (GRCm39) R571* probably null Het
Other mutations in Pim3
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02363:Pim3 APN 15 88,747,116 (GRCm39) missense probably benign 0.34
IGL02423:Pim3 APN 15 88,747,734 (GRCm39) missense probably benign 0.23
R2219:Pim3 UTSW 15 88,747,115 (GRCm39) missense possibly damaging 0.92
R2264:Pim3 UTSW 15 88,748,793 (GRCm39) missense probably damaging 1.00
R5086:Pim3 UTSW 15 88,748,606 (GRCm39) missense probably damaging 1.00
R5245:Pim3 UTSW 15 88,747,404 (GRCm39) missense possibly damaging 0.88
R6759:Pim3 UTSW 15 88,747,296 (GRCm39) critical splice donor site probably null
Z1177:Pim3 UTSW 15 88,748,644 (GRCm39) missense possibly damaging 0.92
Predicted Primers PCR Primer
(F):5'- CTGTGAAGCACGTGGTGAAG -3'
(R):5'- CAGTGTAGACCGTGTCCTTGAG -3'

Sequencing Primer
(F):5'- CACGTGGTGAAGGAGCG -3'
(R):5'- AGCCGAAGTCGATGAGCTTC -3'
Posted On 2016-10-05