Incidental Mutation 'R5501:Or4c113'
ID 430594
Institutional Source Beutler Lab
Gene Symbol Or4c113
Ensembl Gene ENSMUSG00000075105
Gene Name olfactory receptor family 4 subfamily C member 113
Synonyms GA_x6K02T2Q125-50536041-50535106, Olfr1218, MOR233-12
MMRRC Submission 043062-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.072) question?
Stock # R5501 (G1)
Quality Score 225
Status Not validated
Chromosome 2
Chromosomal Location 88884833-88885768 bp(-) (GRCm39)
Type of Mutation nonsense
DNA Base Change (assembly) A to T at 88885230 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Leucine to Stop codon at position 180 (L180*)
Ref Sequence ENSEMBL: ENSMUSP00000149671 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000099798] [ENSMUST00000213609] [ENSMUST00000215048] [ENSMUST00000215054]
AlphaFold L7MU54
Predicted Effect probably null
Transcript: ENSMUST00000099798
AA Change: L180*
SMART Domains Protein: ENSMUSP00000097386
Gene: ENSMUSG00000075105
AA Change: L180*

DomainStartEndE-ValueType
Pfam:7tm_4 29 303 1.4e-45 PFAM
Pfam:7tm_1 39 286 2.2e-16 PFAM
Predicted Effect probably null
Transcript: ENSMUST00000213609
AA Change: L180*
Predicted Effect probably null
Transcript: ENSMUST00000215048
AA Change: L180*
Predicted Effect probably null
Transcript: ENSMUST00000215054
AA Change: L180*
Coding Region Coverage
  • 1x: 98.2%
  • 3x: 97.3%
  • 10x: 95.1%
  • 20x: 90.3%
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 41 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adam26a A C 8: 44,022,941 (GRCm39) L183* probably null Het
Alox12e G T 11: 70,207,055 (GRCm39) Q584K probably benign Het
Atp1a4 A G 1: 172,074,399 (GRCm39) S285P probably damaging Het
Cdt1 C T 8: 123,297,239 (GRCm39) R311W probably damaging Het
Col25a1 A G 3: 130,389,312 (GRCm39) T632A probably benign Het
Coro6 T C 11: 77,358,622 (GRCm39) F227S probably damaging Het
Diras2 C T 13: 52,661,786 (GRCm39) V174M probably benign Het
Dop1a A G 9: 86,389,783 (GRCm39) D569G probably benign Het
Dync1li2 A G 8: 105,167,104 (GRCm39) probably null Het
Dysf T C 6: 84,064,800 (GRCm39) V508A probably damaging Het
Edem1 T C 6: 108,820,061 (GRCm39) probably null Het
Eef2k A G 7: 120,488,471 (GRCm39) D452G probably benign Het
Espl1 A G 15: 102,225,565 (GRCm39) R1539G possibly damaging Het
Fat4 A G 3: 38,941,364 (GRCm39) S86G probably benign Het
Hpgd A T 8: 56,751,391 (GRCm39) D73V probably benign Het
Ltb4r1 A G 14: 56,005,539 (GRCm39) N281D probably damaging Het
Map7 T C 10: 20,151,948 (GRCm39) S638P unknown Het
Mical1 G A 10: 41,362,075 (GRCm39) A934T probably benign Het
Micu3 C A 8: 40,807,341 (GRCm39) probably null Het
Mmp24 T A 2: 155,640,056 (GRCm39) Y129N probably damaging Het
Mras A T 9: 99,293,599 (GRCm39) Y14N probably damaging Het
Msmo1 A T 8: 65,175,523 (GRCm39) I169N probably damaging Het
Mtrr G T 13: 68,727,766 (GRCm39) T60K probably damaging Het
Or5p6 G T 7: 107,631,360 (GRCm39) Y63* probably null Het
Or7g30 T A 9: 19,352,290 (GRCm39) I27N possibly damaging Het
Pam A T 1: 97,768,090 (GRCm39) C8* probably null Het
Phrf1 T G 7: 140,839,834 (GRCm39) S1169A possibly damaging Het
Pkd1l2 T C 8: 117,792,569 (GRCm39) T408A probably damaging Het
Plch1 G T 3: 63,615,162 (GRCm39) Q778K probably damaging Het
Ppp1r3a A G 6: 14,719,417 (GRCm39) V499A probably benign Het
Rnd2 C T 11: 101,359,825 (GRCm39) L57F probably damaging Het
Ryr3 C A 2: 112,492,849 (GRCm39) S3736I possibly damaging Het
Serpinb13 T C 1: 106,909,915 (GRCm39) F11L possibly damaging Het
Slc45a2 C T 15: 11,027,871 (GRCm39) T480I probably damaging Het
Smcp A G 3: 92,491,731 (GRCm39) C39R unknown Het
Sox9 T A 11: 112,674,685 (GRCm39) L161Q probably damaging Het
Tanc2 T C 11: 105,805,811 (GRCm39) probably null Het
Tlr3 C T 8: 45,851,851 (GRCm39) D349N possibly damaging Het
Tmem131l G T 3: 83,833,435 (GRCm39) N809K probably damaging Het
Tyk2 T C 9: 21,032,908 (GRCm39) Y285C probably damaging Het
Usp15 T A 10: 123,011,804 (GRCm39) N98Y probably damaging Het
Other mutations in Or4c113
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01652:Or4c113 APN 2 88,884,913 (GRCm39) missense probably damaging 1.00
IGL03089:Or4c113 APN 2 88,885,357 (GRCm39) missense probably benign 0.34
IGL03387:Or4c113 APN 2 88,885,457 (GRCm39) missense probably damaging 1.00
R0350:Or4c113 UTSW 2 88,885,700 (GRCm39) missense probably benign 0.10
R0699:Or4c113 UTSW 2 88,885,636 (GRCm39) missense possibly damaging 0.67
R1609:Or4c113 UTSW 2 88,885,688 (GRCm39) missense probably benign
R1856:Or4c113 UTSW 2 88,885,203 (GRCm39) missense possibly damaging 0.95
R1972:Or4c113 UTSW 2 88,884,891 (GRCm39) missense probably benign 0.05
R2066:Or4c113 UTSW 2 88,885,243 (GRCm39) missense probably damaging 0.99
R2921:Or4c113 UTSW 2 88,884,843 (GRCm39) missense probably benign 0.04
R2923:Or4c113 UTSW 2 88,884,843 (GRCm39) missense probably benign 0.04
R4037:Or4c113 UTSW 2 88,885,032 (GRCm39) missense probably damaging 0.99
R4585:Or4c113 UTSW 2 88,885,498 (GRCm39) missense possibly damaging 0.77
R4586:Or4c113 UTSW 2 88,885,498 (GRCm39) missense possibly damaging 0.77
R5041:Or4c113 UTSW 2 88,885,265 (GRCm39) nonsense probably null
R5124:Or4c113 UTSW 2 88,885,431 (GRCm39) missense probably damaging 0.96
R5138:Or4c113 UTSW 2 88,885,291 (GRCm39) missense probably benign 0.00
R5415:Or4c113 UTSW 2 88,885,240 (GRCm39) missense probably benign 0.00
R5941:Or4c113 UTSW 2 88,884,963 (GRCm39) missense probably benign
R5991:Or4c113 UTSW 2 88,885,126 (GRCm39) missense probably benign 0.01
R6396:Or4c113 UTSW 2 88,885,641 (GRCm39) missense probably benign 0.36
R7047:Or4c113 UTSW 2 88,885,490 (GRCm39) missense probably damaging 0.98
R8038:Or4c113 UTSW 2 88,885,212 (GRCm39) missense probably damaging 1.00
R8387:Or4c113 UTSW 2 88,885,646 (GRCm39) missense probably benign
R8403:Or4c113 UTSW 2 88,884,948 (GRCm39) missense probably benign 0.00
R8794:Or4c113 UTSW 2 88,885,477 (GRCm39) missense probably benign
R8907:Or4c113 UTSW 2 88,885,542 (GRCm39) missense probably damaging 0.98
Predicted Primers PCR Primer
(F):5'- TACAACAGTAACGTGGGCTCC -3'
(R):5'- GATTGTCCTAGCAGCCATGG -3'

Sequencing Primer
(F):5'- TCGTCCTTCAGAACTGTG -3'
(R):5'- TAGCAGCCATGGCCTATGAC -3'
Posted On 2016-10-05