|Institutional Source||Beutler Lab|
|Gene Name||somatostatin receptor 4|
|Essential gene?||Possibly non essential (E-score: 0.318)|
|Stock #||R5502 (G1)|
|Chromosomal Location||148395344-148396767 bp(+) (GRCm38)|
|Type of Mutation||small insertion (1 aa in frame mutation)|
|DNA Base Change (assembly)||CGAGGAGGAGGAGGA to CGAGGAGGAGGAGGAGGA at 148395551 bp (GRCm38)|
|Amino Acid Change|
|Ref Sequence||ENSEMBL: ENSMUSP00000105588 (fasta)|
|Gene Model||predicted gene model for transcript(s): [ENSMUST00000109962]|
|AlphaFold||no structure available at present|
|Meta Mutation Damage Score||0.0846|
|Coding Region Coverage||
|Validation Efficiency||98% (84/86)|
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] Somatostatin acts at many sites to inhibit the release of many hormones and other secretory proteins. The biologic effects of somatostatin are probably mediated by a family of G protein-coupled receptors that are expressed in a tissue-specific manner. SSTR4 is a member of the superfamily of receptors having seven transmembrane segments and is expressed in highest levels in fetal and adult brain and lung. [provided by RefSeq, Jul 2008]
PHENOTYPE: Homozygote null mice have increased susceptibility to inflammation, delayed type hypersensitivity, hyperalgesia and airway hypersensitivity. [provided by MGI curators]
|Allele List at MGI|
|Other mutations in this stock||
|Other mutations in Sstr4||
(F):5'- AAGAGCTCTTCGGGCAAAGG -3'
(R):5'- AGCATGAAGAGCTCATCGG -3'
(F):5'- TTCGGGCAAAGGCACCTG -3'
(R):5'- ATGAAGAGCTCATCGGCGACG -3'