Incidental Mutation 'R5504:Vmn2r45'
ID 430824
Institutional Source Beutler Lab
Gene Symbol Vmn2r45
Ensembl Gene ENSMUSG00000090662
Gene Name vomeronasal 2, receptor 45
Synonyms
MMRRC Submission 043065-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.073) question?
Stock # R5504 (G1)
Quality Score 225
Status Validated
Chromosome 7
Chromosomal Location 8474468-8491958 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 8486176 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Lysine to Glutamic Acid at position 371 (K371E)
Ref Sequence ENSEMBL: ENSMUSP00000129466 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000164845]
AlphaFold L7N2B5
Predicted Effect probably benign
Transcript: ENSMUST00000164845
AA Change: K371E

PolyPhen 2 Score 0.030 (Sensitivity: 0.95; Specificity: 0.82)
SMART Domains Protein: ENSMUSP00000129466
Gene: ENSMUSG00000090662
AA Change: K371E

DomainStartEndE-ValueType
signal peptide 1 18 N/A INTRINSIC
Pfam:ANF_receptor 154 469 4.5e-26 PFAM
Pfam:NCD3G 512 565 6.4e-21 PFAM
Pfam:7tm_3 598 833 2.1e-54 PFAM
Meta Mutation Damage Score 0.0898 question?
Coding Region Coverage
  • 1x: 98.3%
  • 3x: 97.3%
  • 10x: 95.2%
  • 20x: 90.6%
Validation Efficiency 99% (69/70)
Allele List at MGI
Other mutations in this stock
Total: 56 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adam34l C T 8: 44,078,319 (GRCm39) C635Y probably damaging Het
Akr1b7 A G 6: 34,396,453 (GRCm39) probably null Het
Amy2a1 T G 3: 113,325,318 (GRCm39) D92A probably benign Het
Angel2 A G 1: 190,676,083 (GRCm39) T455A probably damaging Het
Angptl2 T C 2: 33,119,050 (GRCm39) probably benign Het
Ankrd40 A G 11: 94,219,153 (GRCm39) E25G probably benign Het
Asb18 T A 1: 89,920,746 (GRCm39) D136V probably damaging Het
Asphd1 T C 7: 126,545,350 (GRCm39) I336V possibly damaging Het
Birc6 C T 17: 74,962,208 (GRCm39) P58S probably damaging Het
Bsx A T 9: 40,785,460 (GRCm39) probably benign Het
Cabin1 A G 10: 75,488,843 (GRCm39) L1965P probably benign Het
Capza3 A T 6: 139,988,165 (GRCm39) I255L probably benign Het
Ccdc185 G T 1: 182,575,192 (GRCm39) A499E probably damaging Het
Cfhr4 A T 1: 139,629,558 (GRCm39) S749T probably benign Het
Cmklr1 C G 5: 113,752,990 (GRCm39) D4H possibly damaging Het
Colgalt2 G A 1: 152,276,054 (GRCm39) V56M possibly damaging Het
Dennd1b A T 1: 139,018,246 (GRCm39) T197S probably benign Het
Dhx30 A G 9: 109,914,278 (GRCm39) Y1000H probably benign Het
Dlg2 C T 7: 92,091,865 (GRCm39) A910V probably damaging Het
Dnajb12 GC G 10: 59,728,574 (GRCm39) probably null Het
Dock5 T C 14: 68,040,535 (GRCm39) D884G probably benign Het
Fhad1 A G 4: 141,712,846 (GRCm39) S198P probably benign Het
Gabpa T C 16: 84,649,446 (GRCm39) S218P probably benign Het
Gm17654 A T 14: 43,815,494 (GRCm39) N104K unknown Het
Gm4775 T C 14: 106,338,389 (GRCm39) noncoding transcript Het
Gvin3 T A 7: 106,201,951 (GRCm39) noncoding transcript Het
Heatr1 T A 13: 12,421,500 (GRCm39) S467T possibly damaging Het
Hecw1 A G 13: 14,515,487 (GRCm39) M215T probably benign Het
Hmgn2 A T 4: 133,694,114 (GRCm39) probably benign Het
Kncn T A 4: 115,742,062 (GRCm39) I43N possibly damaging Het
Lgals3bp G T 11: 118,284,811 (GRCm39) T256N probably benign Het
Mpi T C 9: 57,452,500 (GRCm39) D344G probably damaging Het
Myom2 G A 8: 15,178,879 (GRCm39) E1304K probably damaging Het
Npat T A 9: 53,481,564 (GRCm39) F1091I probably benign Het
Nrcam T G 12: 44,610,915 (GRCm39) probably null Het
Or2a7 T A 6: 43,151,572 (GRCm39) Y217* probably null Het
Or4c114 C T 2: 88,905,024 (GRCm39) R137Q probably benign Het
Or56a4 T C 7: 104,806,383 (GRCm39) K169E probably benign Het
Pappa2 A G 1: 158,675,615 (GRCm39) S1044P probably benign Het
Pcnx4 T C 12: 72,621,222 (GRCm39) L1014S probably damaging Het
Pear1 G A 3: 87,660,002 (GRCm39) probably benign Het
Piwil2 T A 14: 70,627,348 (GRCm39) Y797F probably benign Het
Ppp2r1b T G 9: 50,770,187 (GRCm39) L81R probably damaging Het
Pxdn C A 12: 30,052,800 (GRCm39) H812Q probably damaging Het
Rad21l A T 2: 151,510,357 (GRCm39) F33I probably damaging Het
Rgs13 A T 1: 144,015,358 (GRCm39) C120S possibly damaging Het
Rp1 G A 1: 4,420,113 (GRCm39) T333M probably damaging Het
Sema6d T A 2: 124,499,941 (GRCm39) V339E probably damaging Het
Serpina3i T A 12: 104,232,862 (GRCm39) Y256N probably damaging Het
Slc13a1 A T 6: 24,150,743 (GRCm39) M65K possibly damaging Het
Slco6d1 A G 1: 98,349,064 (GRCm39) K45R probably damaging Het
Src T C 2: 157,306,641 (GRCm39) Y215H probably damaging Het
Synj2 T C 17: 6,086,750 (GRCm39) V384A possibly damaging Het
Tmeff1 T C 4: 48,650,396 (GRCm39) S285P probably damaging Het
Vmn2r125 A G 4: 156,703,456 (GRCm39) D278G possibly damaging Het
Zfp866 A T 8: 70,218,341 (GRCm39) H426Q probably benign Het
Other mutations in Vmn2r45
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01287:Vmn2r45 APN 7 8,488,622 (GRCm39) missense probably benign 0.00
IGL01322:Vmn2r45 APN 7 8,484,332 (GRCm39) missense possibly damaging 0.49
IGL01402:Vmn2r45 APN 7 8,484,467 (GRCm39) missense probably damaging 0.98
IGL01404:Vmn2r45 APN 7 8,484,467 (GRCm39) missense probably damaging 0.98
IGL01529:Vmn2r45 APN 7 8,486,493 (GRCm39) missense probably benign
IGL01596:Vmn2r45 APN 7 8,486,272 (GRCm39) missense probably damaging 0.98
IGL01646:Vmn2r45 APN 7 8,486,337 (GRCm39) missense probably benign 0.18
IGL01819:Vmn2r45 APN 7 8,488,556 (GRCm39) missense probably benign 0.00
IGL02096:Vmn2r45 APN 7 8,484,443 (GRCm39) missense probably damaging 0.99
IGL02130:Vmn2r45 APN 7 8,486,556 (GRCm39) missense possibly damaging 0.46
IGL02409:Vmn2r45 APN 7 8,488,727 (GRCm39) missense probably benign 0.03
IGL02517:Vmn2r45 APN 7 8,486,185 (GRCm39) nonsense probably null
IGL02633:Vmn2r45 APN 7 8,488,728 (GRCm39) missense probably benign 0.01
IGL02940:Vmn2r45 APN 7 8,475,369 (GRCm39) missense probably damaging 0.99
IGL03281:Vmn2r45 APN 7 8,486,603 (GRCm39) missense probably damaging 1.00
IGL03358:Vmn2r45 APN 7 8,474,715 (GRCm39) missense probably damaging 1.00
BB004:Vmn2r45 UTSW 7 8,486,513 (GRCm39) missense probably benign
BB014:Vmn2r45 UTSW 7 8,486,513 (GRCm39) missense probably benign
R0382:Vmn2r45 UTSW 7 8,486,098 (GRCm39) missense probably benign 0.06
R0532:Vmn2r45 UTSW 7 8,474,820 (GRCm39) missense probably damaging 0.99
R0932:Vmn2r45 UTSW 7 8,478,380 (GRCm39) missense probably damaging 1.00
R1125:Vmn2r45 UTSW 7 8,488,542 (GRCm39) missense probably benign 0.00
R1580:Vmn2r45 UTSW 7 8,474,746 (GRCm39) missense possibly damaging 0.95
R1817:Vmn2r45 UTSW 7 8,475,372 (GRCm39) missense probably damaging 1.00
R1996:Vmn2r45 UTSW 7 8,475,024 (GRCm39) missense probably damaging 1.00
R2050:Vmn2r45 UTSW 7 8,475,021 (GRCm39) missense probably damaging 1.00
R2284:Vmn2r45 UTSW 7 8,488,765 (GRCm39) missense probably benign 0.02
R4019:Vmn2r45 UTSW 7 8,474,580 (GRCm39) nonsense probably null
R4227:Vmn2r45 UTSW 7 8,486,277 (GRCm39) missense probably damaging 0.98
R4381:Vmn2r45 UTSW 7 8,474,912 (GRCm39) nonsense probably null
R4618:Vmn2r45 UTSW 7 8,486,436 (GRCm39) missense probably benign 0.00
R4624:Vmn2r45 UTSW 7 8,484,341 (GRCm39) missense probably damaging 1.00
R4704:Vmn2r45 UTSW 7 8,486,535 (GRCm39) nonsense probably null
R4735:Vmn2r45 UTSW 7 8,486,472 (GRCm39) missense probably damaging 1.00
R4868:Vmn2r45 UTSW 7 8,484,480 (GRCm39) missense probably benign 0.06
R4983:Vmn2r45 UTSW 7 8,486,116 (GRCm39) missense probably damaging 0.99
R5246:Vmn2r45 UTSW 7 8,486,251 (GRCm39) missense probably benign 0.00
R5430:Vmn2r45 UTSW 7 8,486,333 (GRCm39) nonsense probably null
R5511:Vmn2r45 UTSW 7 8,474,832 (GRCm39) missense probably benign 0.19
R5745:Vmn2r45 UTSW 7 8,486,074 (GRCm39) missense probably benign 0.00
R5814:Vmn2r45 UTSW 7 8,474,475 (GRCm39) missense probably benign 0.00
R6223:Vmn2r45 UTSW 7 8,486,301 (GRCm39) missense probably benign
R6267:Vmn2r45 UTSW 7 8,475,207 (GRCm39) missense probably benign 0.26
R6623:Vmn2r45 UTSW 7 8,474,500 (GRCm39) missense probably benign 0.09
R6999:Vmn2r45 UTSW 7 8,486,219 (GRCm39) missense probably benign
R7242:Vmn2r45 UTSW 7 8,488,612 (GRCm39) nonsense probably null
R7491:Vmn2r45 UTSW 7 8,484,342 (GRCm39) missense probably benign 0.27
R7620:Vmn2r45 UTSW 7 8,486,222 (GRCm39) nonsense probably null
R7719:Vmn2r45 UTSW 7 8,486,460 (GRCm39) missense probably damaging 0.99
R7720:Vmn2r45 UTSW 7 8,486,460 (GRCm39) missense probably damaging 0.99
R7853:Vmn2r45 UTSW 7 8,485,987 (GRCm39) missense possibly damaging 0.90
R7873:Vmn2r45 UTSW 7 8,486,074 (GRCm39) missense probably benign 0.00
R7882:Vmn2r45 UTSW 7 8,486,409 (GRCm39) missense possibly damaging 0.82
R7927:Vmn2r45 UTSW 7 8,486,513 (GRCm39) missense probably benign
R8684:Vmn2r45 UTSW 7 8,486,511 (GRCm39) missense probably damaging 0.99
R8780:Vmn2r45 UTSW 7 8,484,371 (GRCm39) missense possibly damaging 0.94
R8811:Vmn2r45 UTSW 7 8,474,881 (GRCm39) missense probably damaging 1.00
R8893:Vmn2r45 UTSW 7 8,488,619 (GRCm39) missense probably damaging 1.00
R9043:Vmn2r45 UTSW 7 8,474,904 (GRCm39) missense possibly damaging 0.92
R9208:Vmn2r45 UTSW 7 8,486,298 (GRCm39) missense probably damaging 1.00
R9327:Vmn2r45 UTSW 7 8,474,532 (GRCm39) missense probably damaging 1.00
R9586:Vmn2r45 UTSW 7 8,486,050 (GRCm39) missense probably benign 0.01
R9599:Vmn2r45 UTSW 7 8,478,457 (GRCm39) critical splice acceptor site probably null
U24488:Vmn2r45 UTSW 7 8,475,361 (GRCm39) missense probably damaging 1.00
Z1088:Vmn2r45 UTSW 7 8,474,484 (GRCm39) missense probably benign 0.16
Predicted Primers PCR Primer
(F):5'- CTTCAAGCAGTGAGAACTGGC -3'
(R):5'- ACAATTGAATTTCCCTACCAGGAAG -3'

Sequencing Primer
(F):5'- GCAGTGAGAACTGGCTCCTTTTC -3'
(R):5'- TGAATTTCCCTACCAGGAAGACAGAC -3'
Posted On 2016-10-05