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|Institutional Source||Beutler Lab|
|Gene Name||galanin receptor 1|
|Is this an essential gene?||Non essential (E-score: 0.000)|
|Stock #||R5506 (G1)|
|Chromosomal Location||82392496-82406777 bp(-) (GRCm38)|
|Type of Mutation||missense|
|DNA Base Change (assembly)||T to A at 82405864 bp|
|Amino Acid Change||Tyrosine to Phenylalanine at position 96 (Y96F)|
|Ref Sequence||ENSEMBL: ENSMUSP00000066381 (fasta)|
|Gene Model||predicted gene model for transcript(s): [ENSMUST00000065224]|
|Predicted Effect||possibly damaging
AA Change: Y96F
PolyPhen 2 Score 0.949 (Sensitivity: 0.79; Specificity: 0.95)
AA Change: Y96F
|Meta Mutation Damage Score||0.1387|
|Coding Region Coverage||
|Validation Efficiency||100% (53/53)|
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The neuropeptide galanin elicits a range of biological effects by interaction with specific G-protein-coupled receptors. Galanin receptors are seven-transmembrane proteins shown to activate a variety of intracellular second-messenger pathways. GALR1 inhibits adenylyl cyclase via a G protein of the Gi/Go family. GALR1 is widely expressed in the brain and spinal cord, as well as in peripheral sites such as the small intestine and heart. [provided by RefSeq, Jul 2008]
PHENOTYPE: Homozygous mutation of this gene does not appear to result in a phenotype. [provided by MGI curators]
|Allele List at MGI|
|Other mutations in this stock||
|Other mutations in Galr1||
(F):5'- TCCCGATGGAAAAGACGCTG -3'
(R):5'- TGGAGAACTTCATTACGCTGG -3'
(F):5'- ATGGACAGCGCCCAGATG -3'
(R):5'- AGAACTTCATTACGCTGGTAGTG -3'