Incidental Mutation 'R5509:Mllt6'
ID 431088
Institutional Source Beutler Lab
Gene Symbol Mllt6
Ensembl Gene ENSMUSG00000038437
Gene Name myeloid/lymphoid or mixed-lineage leukemia; translocated to, 6
Synonyms Af17
MMRRC Submission 043070-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R5509 (G1)
Quality Score 225
Status Not validated
Chromosome 11
Chromosomal Location 97554240-97576289 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) G to A at 97560326 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Serine to Asparagine at position 210 (S210N)
Ref Sequence ENSEMBL: ENSMUSP00000045445 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000044730] [ENSMUST00000107586]
AlphaFold B1AR10
Predicted Effect possibly damaging
Transcript: ENSMUST00000044730
AA Change: S210N

PolyPhen 2 Score 0.828 (Sensitivity: 0.84; Specificity: 0.93)
SMART Domains Protein: ENSMUSP00000045445
Gene: ENSMUSG00000038437
AA Change: S210N

DomainStartEndE-ValueType
PHD 7 55 5.92e-7 SMART
PHD 119 178 5e-5 SMART
low complexity region 190 224 N/A INTRINSIC
low complexity region 271 284 N/A INTRINSIC
low complexity region 290 330 N/A INTRINSIC
low complexity region 358 380 N/A INTRINSIC
low complexity region 398 412 N/A INTRINSIC
low complexity region 487 498 N/A INTRINSIC
low complexity region 502 516 N/A INTRINSIC
low complexity region 520 536 N/A INTRINSIC
low complexity region 559 573 N/A INTRINSIC
low complexity region 579 601 N/A INTRINSIC
low complexity region 649 666 N/A INTRINSIC
coiled coil region 703 744 N/A INTRINSIC
low complexity region 746 756 N/A INTRINSIC
low complexity region 773 782 N/A INTRINSIC
low complexity region 802 848 N/A INTRINSIC
low complexity region 860 901 N/A INTRINSIC
coiled coil region 915 942 N/A INTRINSIC
low complexity region 995 1018 N/A INTRINSIC
low complexity region 1026 1037 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000107586
AA Change: S210N

PolyPhen 2 Score 0.007 (Sensitivity: 0.96; Specificity: 0.75)
SMART Domains Protein: ENSMUSP00000103212
Gene: ENSMUSG00000038437
AA Change: S210N

DomainStartEndE-ValueType
PHD 7 55 5.92e-7 SMART
PHD 119 178 5e-5 SMART
low complexity region 190 224 N/A INTRINSIC
low complexity region 271 284 N/A INTRINSIC
low complexity region 290 330 N/A INTRINSIC
low complexity region 336 356 N/A INTRINSIC
low complexity region 388 410 N/A INTRINSIC
low complexity region 428 442 N/A INTRINSIC
low complexity region 517 528 N/A INTRINSIC
low complexity region 532 546 N/A INTRINSIC
low complexity region 550 566 N/A INTRINSIC
low complexity region 589 603 N/A INTRINSIC
low complexity region 609 631 N/A INTRINSIC
low complexity region 679 696 N/A INTRINSIC
coiled coil region 733 774 N/A INTRINSIC
low complexity region 776 786 N/A INTRINSIC
low complexity region 803 812 N/A INTRINSIC
low complexity region 832 878 N/A INTRINSIC
low complexity region 890 931 N/A INTRINSIC
coiled coil region 945 972 N/A INTRINSIC
low complexity region 1025 1048 N/A INTRINSIC
low complexity region 1056 1067 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000134158
Predicted Effect noncoding transcript
Transcript: ENSMUST00000155835
Meta Mutation Damage Score 0.1795 question?
Coding Region Coverage
  • 1x: 98.6%
  • 3x: 97.4%
  • 10x: 95.5%
  • 20x: 91.6%
Validation Efficiency
MGI Phenotype PHENOTYPE: Mice homozygous for a gene trap allele exhibit no abnormal phenotype. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 54 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abcc10 G C 17: 46,635,185 (GRCm39) Q273E probably benign Het
Acly C T 11: 100,405,805 (GRCm39) R329Q probably damaging Het
Acsm2 T C 7: 119,172,840 (GRCm39) S152P probably damaging Het
Adamtsl4 A T 3: 95,588,667 (GRCm39) I515N probably benign Het
Ank3 G A 10: 69,838,395 (GRCm39) R1566K possibly damaging Het
Atp9a T C 2: 168,481,857 (GRCm39) D879G probably damaging Het
Bmp8b G A 4: 123,008,369 (GRCm39) D112N possibly damaging Het
Camk2d T C 3: 126,633,965 (GRCm39) W496R probably damaging Het
Ccdc192 G A 18: 57,671,156 (GRCm39) probably null Het
Cflar T C 1: 58,791,551 (GRCm39) F285L probably benign Het
Cox16 T C 12: 81,519,032 (GRCm39) T176A probably benign Het
Cux1 G T 5: 136,304,171 (GRCm39) A1214D probably benign Het
Cyb5d1 C A 11: 69,284,561 (GRCm39) probably null Het
Dennd6b G A 15: 89,069,225 (GRCm39) P575S probably damaging Het
Fbxl2 A T 9: 113,814,415 (GRCm39) probably null Het
Gfpt2 T C 11: 49,717,973 (GRCm39) F483L possibly damaging Het
Glrx3 T C 7: 137,046,751 (GRCm39) C48R probably damaging Het
Invs G A 4: 48,396,337 (GRCm39) V281M probably damaging Het
Kif13a G A 13: 46,905,591 (GRCm39) A784V probably benign Het
Kmt2d T C 15: 98,737,557 (GRCm39) probably benign Het
Lmod2 A G 6: 24,603,888 (GRCm39) T288A probably damaging Het
Lrrc37a T C 11: 103,391,361 (GRCm39) K1355E probably benign Het
Magi3 A T 3: 103,922,818 (GRCm39) S1300T probably benign Het
Mdm2 A C 10: 117,526,517 (GRCm39) D307E probably damaging Het
Mroh4 T C 15: 74,478,003 (GRCm39) Y901C probably benign Het
Mtmr14 G T 6: 113,230,768 (GRCm39) probably null Het
Mug2 A T 6: 122,061,340 (GRCm39) Q1420L possibly damaging Het
Net1 T C 13: 3,934,320 (GRCm39) Q459R probably benign Het
Nle1 T C 11: 82,794,008 (GRCm39) R343G possibly damaging Het
Npat C A 9: 53,481,542 (GRCm39) N1083K probably benign Het
Nrp1 G A 8: 129,152,396 (GRCm39) G202R possibly damaging Het
Nsun4 C T 4: 115,908,974 (GRCm39) V529I possibly damaging Het
Or4b1d T A 2: 89,969,236 (GRCm39) L82F probably damaging Het
Or4z4 T A 19: 12,076,341 (GRCm39) I221F possibly damaging Het
Or5b117 A T 19: 13,431,332 (GRCm39) L183Q probably damaging Het
Or8g21 T C 9: 38,905,924 (GRCm39) D269G probably benign Het
Podxl A T 6: 31,503,548 (GRCm39) N264K probably benign Het
Ptprm C T 17: 66,996,353 (GRCm39) A1245T probably damaging Het
Rdh12 T A 12: 79,257,558 (GRCm39) probably null Het
Ryr2 T A 13: 11,760,487 (GRCm39) Y1532F probably damaging Het
Senp2 T C 16: 21,859,272 (GRCm39) F441S probably damaging Het
Snap23 C A 2: 120,425,346 (GRCm39) P111T probably benign Het
Sox2 A G 3: 34,704,938 (GRCm39) D125G probably damaging Het
Syne2 T C 12: 75,968,018 (GRCm39) W923R probably damaging Het
Tbc1d2b T C 9: 90,101,022 (GRCm39) E656G probably damaging Het
Tbcd A G 11: 121,492,838 (GRCm39) T892A probably benign Het
Tg A G 15: 66,699,142 (GRCm39) I24V probably benign Het
Trpm3 A T 19: 22,964,622 (GRCm39) K1372N probably damaging Het
Ubc A T 5: 125,464,339 (GRCm39) N329K probably benign Het
Vmn2r106 T A 17: 20,498,684 (GRCm39) H409L probably damaging Het
Wdfy3 T A 5: 102,009,314 (GRCm39) N2751Y possibly damaging Het
Zfp518a T A 19: 40,903,845 (GRCm39) I1258K possibly damaging Het
Zfp91 T C 19: 12,756,451 (GRCm39) E131G probably damaging Het
Zfyve26 T A 12: 79,293,295 (GRCm39) R2027W probably damaging Het
Other mutations in Mllt6
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01745:Mllt6 APN 11 97,567,754 (GRCm39) missense probably damaging 1.00
IGL01808:Mllt6 APN 11 97,563,310 (GRCm39) missense possibly damaging 0.88
IGL01967:Mllt6 APN 11 97,565,603 (GRCm39) missense probably damaging 0.98
IGL02247:Mllt6 APN 11 97,561,158 (GRCm39) missense probably benign 0.01
IGL03161:Mllt6 APN 11 97,557,977 (GRCm39) missense probably benign 0.03
R0284:Mllt6 UTSW 11 97,569,431 (GRCm39) missense probably benign 0.02
R0718:Mllt6 UTSW 11 97,567,185 (GRCm39) splice site probably benign
R0783:Mllt6 UTSW 11 97,556,571 (GRCm39) missense probably damaging 0.99
R0811:Mllt6 UTSW 11 97,569,387 (GRCm39) missense probably damaging 0.97
R0812:Mllt6 UTSW 11 97,569,387 (GRCm39) missense probably damaging 0.97
R0904:Mllt6 UTSW 11 97,555,824 (GRCm39) missense probably damaging 1.00
R0960:Mllt6 UTSW 11 97,555,772 (GRCm39) splice site probably benign
R1445:Mllt6 UTSW 11 97,563,277 (GRCm39) splice site probably benign
R1523:Mllt6 UTSW 11 97,555,849 (GRCm39) missense probably damaging 1.00
R1781:Mllt6 UTSW 11 97,563,395 (GRCm39) missense probably benign
R1952:Mllt6 UTSW 11 97,568,048 (GRCm39) missense probably damaging 0.99
R2258:Mllt6 UTSW 11 97,555,802 (GRCm39) missense probably damaging 1.00
R2259:Mllt6 UTSW 11 97,555,802 (GRCm39) missense probably damaging 1.00
R2927:Mllt6 UTSW 11 97,571,602 (GRCm39) missense probably damaging 0.98
R4866:Mllt6 UTSW 11 97,565,285 (GRCm39) missense probably damaging 1.00
R4938:Mllt6 UTSW 11 97,569,233 (GRCm39) missense probably benign
R5039:Mllt6 UTSW 11 97,560,326 (GRCm39) missense possibly damaging 0.83
R5058:Mllt6 UTSW 11 97,560,326 (GRCm39) missense possibly damaging 0.83
R5064:Mllt6 UTSW 11 97,564,775 (GRCm39) missense probably damaging 1.00
R5076:Mllt6 UTSW 11 97,560,326 (GRCm39) missense possibly damaging 0.83
R5115:Mllt6 UTSW 11 97,560,326 (GRCm39) missense possibly damaging 0.83
R5379:Mllt6 UTSW 11 97,560,326 (GRCm39) missense possibly damaging 0.83
R5510:Mllt6 UTSW 11 97,560,326 (GRCm39) missense possibly damaging 0.83
R5511:Mllt6 UTSW 11 97,560,326 (GRCm39) missense possibly damaging 0.83
R5603:Mllt6 UTSW 11 97,564,331 (GRCm39) missense probably damaging 1.00
R5816:Mllt6 UTSW 11 97,563,400 (GRCm39) missense probably damaging 0.97
R6030:Mllt6 UTSW 11 97,568,051 (GRCm39) missense probably damaging 0.99
R6030:Mllt6 UTSW 11 97,568,051 (GRCm39) missense probably damaging 0.99
R6051:Mllt6 UTSW 11 97,571,569 (GRCm39) nonsense probably null
R6180:Mllt6 UTSW 11 97,569,362 (GRCm39) missense possibly damaging 0.85
R6277:Mllt6 UTSW 11 97,564,774 (GRCm39) missense probably damaging 1.00
R6667:Mllt6 UTSW 11 97,567,760 (GRCm39) missense probably damaging 1.00
R6754:Mllt6 UTSW 11 97,565,273 (GRCm39) missense probably damaging 1.00
R6791:Mllt6 UTSW 11 97,571,428 (GRCm39) missense probably damaging 0.98
R7049:Mllt6 UTSW 11 97,564,637 (GRCm39) missense probably damaging 1.00
R7194:Mllt6 UTSW 11 97,564,394 (GRCm39) missense probably benign 0.23
R7387:Mllt6 UTSW 11 97,565,426 (GRCm39) missense probably benign 0.04
R7484:Mllt6 UTSW 11 97,563,442 (GRCm39) missense probably benign 0.18
R7685:Mllt6 UTSW 11 97,567,790 (GRCm39) missense probably damaging 0.99
R7853:Mllt6 UTSW 11 97,561,142 (GRCm39) missense probably benign
R7862:Mllt6 UTSW 11 97,556,631 (GRCm39) missense probably benign 0.03
R8004:Mllt6 UTSW 11 97,566,966 (GRCm39) missense possibly damaging 0.91
R8498:Mllt6 UTSW 11 97,567,688 (GRCm39) missense possibly damaging 0.86
R9044:Mllt6 UTSW 11 97,554,485 (GRCm39) missense probably damaging 1.00
R9297:Mllt6 UTSW 11 97,563,314 (GRCm39) missense probably damaging 0.96
R9457:Mllt6 UTSW 11 97,556,586 (GRCm39) missense probably benign 0.12
R9557:Mllt6 UTSW 11 97,564,310 (GRCm39) missense probably benign 0.04
Z1177:Mllt6 UTSW 11 97,567,251 (GRCm39) missense possibly damaging 0.73
Predicted Primers PCR Primer
(F):5'- AGCTTTAGGATAGCTAGGCTGAG -3'
(R):5'- CTCTGGAAAGAAGCCCATGAG -3'

Sequencing Primer
(F):5'- CGGAGTGTCATGGCAGAC -3'
(R):5'- CATGAGAGAGCGGGTCTTCAC -3'
Posted On 2016-10-05