Incidental Mutation 'R5521:Oit3'
ID 431561
Institutional Source Beutler Lab
Gene Symbol Oit3
Ensembl Gene ENSMUSG00000009654
Gene Name oncoprotein induced transcript 3
Synonyms EF-9
MMRRC Submission 043080-MU
Accession Numbers
Essential gene? Possibly non essential (E-score: 0.378) question?
Stock # R5521 (G1)
Quality Score 144
Status Validated
Chromosome 10
Chromosomal Location 59422958-59441778 bp(-) (GRCm38)
Type of Mutation missense
DNA Base Change (assembly) G to T at 59435914 bp (GRCm38)
Zygosity Heterozygous
Amino Acid Change Alanine to Glutamic Acid at position 207 (A207E)
Ref Sequence ENSEMBL: ENSMUSP00000009798 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000009798]
AlphaFold Q8R4V5
Predicted Effect probably benign
Transcript: ENSMUST00000009798
AA Change: A207E

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
SMART Domains Protein: ENSMUSP00000009798
Gene: ENSMUSG00000009654
AA Change: A207E

DomainStartEndE-ValueType
signal peptide 1 19 N/A INTRINSIC
Blast:ZP 50 144 9e-24 BLAST
EGF 150 181 2.16e1 SMART
EGF 185 222 2.94e-3 SMART
EGF 226 263 2.35e-2 SMART
ZP 267 516 2.74e-30 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000162493
Meta Mutation Damage Score 0.0898 question?
Coding Region Coverage
  • 1x: 99.1%
  • 3x: 97.5%
  • 10x: 94.4%
  • 20x: 87.5%
Validation Efficiency 94% (72/77)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene was identified due to its downregulation in hepatocarcinomas. The encoded protein may be involved in liver development and function. [provided by RefSeq, Sep 2016]
PHENOTYPE: Mice homozygous for a knock-out allele exhibit decreased bloord uric acid, increased urine uric acid and polyuria. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 65 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abcg4 A G 9: 44,279,683 (GRCm38) probably benign Het
Abhd14a G T 9: 106,443,834 (GRCm38) D107E probably damaging Het
Acat1 T A 9: 53,583,507 (GRCm38) K362* probably null Het
Adad2 T A 8: 119,612,789 (GRCm38) S3R probably benign Het
Adcy8 C A 15: 64,815,350 (GRCm38) R435M probably damaging Het
Adgrv1 A T 13: 81,419,389 (GRCm38) S5222T probably benign Het
Ankk1 A T 9: 49,420,448 (GRCm38) M182K probably benign Het
Apba1 C T 19: 23,893,593 (GRCm38) P263L probably damaging Het
Arhgap39 G A 15: 76,765,494 (GRCm38) S26L possibly damaging Het
Ccng1 G A 11: 40,752,266 (GRCm38) T118I possibly damaging Het
Cenpe T C 3: 135,269,065 (GRCm38) S2329P probably damaging Het
Chil4 A G 3: 106,203,697 (GRCm38) Y294H possibly damaging Het
Chst8 A C 7: 34,675,245 (GRCm38) S390A probably benign Het
Dars T C 1: 128,373,973 (GRCm38) D308G probably benign Het
Dlec1 A C 9: 119,143,401 (GRCm38) Q1458P possibly damaging Het
Dvl2 G A 11: 70,006,407 (GRCm38) E312K probably damaging Het
Fchsd1 T C 18: 37,966,484 (GRCm38) H219R probably damaging Het
Foxd4 A C 19: 24,899,643 (GRCm38) C398G probably damaging Het
Gm10719 T A 9: 3,018,970 (GRCm38) F72I probably damaging Het
Gm5414 T C 15: 101,627,987 (GRCm38) I68V probably benign Het
Gmip C T 8: 69,817,399 (GRCm38) T684I probably damaging Het
Gpr137c T C 14: 45,278,694 (GRCm38) I295T possibly damaging Het
Hivep1 T A 13: 42,158,328 (GRCm38) M1348K probably damaging Het
Igkv6-23 T C 6: 70,260,613 (GRCm38) D48G probably benign Het
Il3 G A 11: 54,267,132 (GRCm38) T40M possibly damaging Het
Ing2 T C 8: 47,669,213 (GRCm38) E100G probably damaging Het
Itpr3 C A 17: 27,107,334 (GRCm38) H1359Q probably benign Het
Lama1 T A 17: 67,780,894 (GRCm38) Y1502* probably null Het
Mamdc2 C A 19: 23,310,938 (GRCm38) G579W probably damaging Het
Mapk6 G A 9: 75,393,316 (GRCm38) probably benign Het
Mapk8ip2 C T 15: 89,458,804 (GRCm38) R616W probably damaging Het
Mc5r T A 18: 68,339,677 (GRCm38) L369H possibly damaging Het
Meis1 T C 11: 18,988,260 (GRCm38) probably benign Het
Mmp8 A G 9: 7,560,643 (GRCm38) K107R probably benign Het
Mn1 C T 5: 111,421,769 (GRCm38) H1202Y possibly damaging Het
Naip2 A G 13: 100,154,914 (GRCm38) L1172P probably damaging Het
Nek9 C T 12: 85,327,445 (GRCm38) D273N probably benign Het
Nlrp4e A T 7: 23,321,765 (GRCm38) D559V probably benign Het
Nlrp4g T C 9: 124,350,020 (GRCm38) noncoding transcript Het
Olfr1140 A G 2: 87,747,062 (GRCm38) I289V probably benign Het
Olfr298 A T 7: 86,488,631 (GRCm38) C307S probably benign Het
Olfr462 A T 11: 87,889,719 (GRCm38) M59K probably damaging Het
Olfr71 A T 4: 43,705,788 (GRCm38) M260K possibly damaging Het
Pde4c T C 8: 70,747,382 (GRCm38) probably null Het
Ppp1r26 A G 2: 28,451,426 (GRCm38) E356G probably benign Het
Pramef12 A G 4: 144,395,971 (GRCm38) M1T probably null Het
Ptges3-ps T A 6: 85,844,321 (GRCm38) noncoding transcript Het
Ptpn13 T G 5: 103,501,428 (GRCm38) F232L probably benign Het
Reps1 T C 10: 18,104,234 (GRCm38) S114P probably damaging Het
Scarf2 T A 16: 17,803,602 (GRCm38) probably null Het
Sdha A T 13: 74,350,099 (GRCm38) probably benign Het
Secisbp2l A T 2: 125,752,977 (GRCm38) V146D possibly damaging Het
Slc26a8 T A 17: 28,654,859 (GRCm38) T385S probably benign Het
Slc4a1 G A 11: 102,353,266 (GRCm38) T679M probably benign Het
Tbc1d14 T A 5: 36,520,552 (GRCm38) E353V probably damaging Het
Thap2 T A 10: 115,372,760 (GRCm38) K152* probably null Het
Thbd A T 2: 148,407,735 (GRCm38) I71N probably damaging Het
V1ra8 T A 6: 90,203,054 (GRCm38) W80R probably damaging Het
Vmn1r218 A G 13: 23,136,573 (GRCm38) Y30C probably benign Het
Vmn2r60 C A 7: 42,195,625 (GRCm38) T804K probably damaging Het
Vmn2r68 A T 7: 85,233,718 (GRCm38) D275E probably benign Het
Vps13c A G 9: 67,951,439 (GRCm38) I2724V probably benign Het
Xrcc5 C A 1: 72,346,271 (GRCm38) P507Q probably damaging Het
Zfp120 A T 2: 150,117,579 (GRCm38) Y274* probably null Het
Zfp780b C A 7: 27,974,748 (GRCm38) probably null Het
Other mutations in Oit3
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01457:Oit3 APN 10 59,425,484 (GRCm38) unclassified probably benign
IGL01665:Oit3 APN 10 59,438,909 (GRCm38) missense probably damaging 1.00
IGL01839:Oit3 APN 10 59,429,496 (GRCm38) missense probably damaging 0.98
IGL02028:Oit3 APN 10 59,438,655 (GRCm38) missense probably damaging 0.98
PIT4585001:Oit3 UTSW 10 59,431,013 (GRCm38) missense possibly damaging 0.54
R0567:Oit3 UTSW 10 59,435,978 (GRCm38) missense probably damaging 0.99
R0781:Oit3 UTSW 10 59,428,194 (GRCm38) missense probably damaging 1.00
R1110:Oit3 UTSW 10 59,428,194 (GRCm38) missense probably damaging 1.00
R1563:Oit3 UTSW 10 59,428,074 (GRCm38) missense probably damaging 1.00
R1623:Oit3 UTSW 10 59,428,239 (GRCm38) missense probably damaging 0.99
R1693:Oit3 UTSW 10 59,425,417 (GRCm38) missense probably damaging 1.00
R1754:Oit3 UTSW 10 59,427,940 (GRCm38) splice site probably null
R1853:Oit3 UTSW 10 59,441,622 (GRCm38) critical splice donor site probably null
R2070:Oit3 UTSW 10 59,431,013 (GRCm38) missense probably benign 0.03
R2211:Oit3 UTSW 10 59,428,070 (GRCm38) missense probably damaging 1.00
R2516:Oit3 UTSW 10 59,441,685 (GRCm38) start gained probably benign
R2516:Oit3 UTSW 10 59,428,345 (GRCm38) missense probably damaging 1.00
R3103:Oit3 UTSW 10 59,438,891 (GRCm38) missense probably damaging 0.98
R4414:Oit3 UTSW 10 59,428,103 (GRCm38) missense probably damaging 1.00
R4415:Oit3 UTSW 10 59,428,103 (GRCm38) missense probably damaging 1.00
R4416:Oit3 UTSW 10 59,428,103 (GRCm38) missense probably damaging 1.00
R4417:Oit3 UTSW 10 59,428,103 (GRCm38) missense probably damaging 1.00
R4584:Oit3 UTSW 10 59,425,462 (GRCm38) missense probably damaging 1.00
R4734:Oit3 UTSW 10 59,424,082 (GRCm38) missense probably damaging 0.99
R4748:Oit3 UTSW 10 59,424,082 (GRCm38) missense probably damaging 0.99
R4749:Oit3 UTSW 10 59,424,082 (GRCm38) missense probably damaging 0.99
R5070:Oit3 UTSW 10 59,424,027 (GRCm38) missense probably damaging 1.00
R6326:Oit3 UTSW 10 59,428,239 (GRCm38) missense probably damaging 1.00
R6490:Oit3 UTSW 10 59,438,552 (GRCm38) missense possibly damaging 0.92
R6526:Oit3 UTSW 10 59,429,640 (GRCm38) missense probably damaging 1.00
R6766:Oit3 UTSW 10 59,438,712 (GRCm38) missense probably damaging 0.99
R6921:Oit3 UTSW 10 59,435,945 (GRCm38) missense probably damaging 0.99
R7129:Oit3 UTSW 10 59,428,344 (GRCm38) missense probably damaging 0.99
R7440:Oit3 UTSW 10 59,429,570 (GRCm38) missense probably damaging 0.99
R7495:Oit3 UTSW 10 59,423,943 (GRCm38) missense possibly damaging 0.74
R7512:Oit3 UTSW 10 59,438,894 (GRCm38) missense probably damaging 1.00
R7866:Oit3 UTSW 10 59,424,030 (GRCm38) missense probably benign 0.03
R8312:Oit3 UTSW 10 59,438,810 (GRCm38) missense probably benign 0.01
R8321:Oit3 UTSW 10 59,428,160 (GRCm38) missense probably benign 0.00
R8919:Oit3 UTSW 10 59,441,646 (GRCm38) missense unknown
R9131:Oit3 UTSW 10 59,435,929 (GRCm38) missense probably benign 0.01
R9457:Oit3 UTSW 10 59,441,683 (GRCm38) start codon destroyed unknown
R9478:Oit3 UTSW 10 59,438,642 (GRCm38) missense probably damaging 0.99
R9502:Oit3 UTSW 10 59,428,351 (GRCm38) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- CTGTCCACAGCTTAAGCACC -3'
(R):5'- CGCTGGCTCATACACGATAG -3'

Sequencing Primer
(F):5'- GGTGCCCTGTAGCCATTTC -3'
(R):5'- TAGGGCATCTGGGAAGACAC -3'
Posted On 2016-10-05