Incidental Mutation 'R5524:Lcorl'
ID 431740
Institutional Source Beutler Lab
Gene Symbol Lcorl
Ensembl Gene ENSMUSG00000015882
Gene Name ligand dependent nuclear receptor corepressor-like
Synonyms A830039H10Rik, Mlr1
MMRRC Submission 043082-MU
Accession Numbers
Essential gene? Possibly non essential (E-score: 0.305) question?
Stock # R5524 (G1)
Quality Score 225
Status Validated
Chromosome 5
Chromosomal Location 45854523-46014957 bp(-) (GRCm39)
Type of Mutation critical splice acceptor site
DNA Base Change (assembly) T to A at 45932865 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000140503 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000016026] [ENSMUST00000016026] [ENSMUST00000045586] [ENSMUST00000045586] [ENSMUST00000087164] [ENSMUST00000087164] [ENSMUST00000121573] [ENSMUST00000121573] [ENSMUST00000186633] [ENSMUST00000189859] [ENSMUST00000189859] [ENSMUST00000190036] [ENSMUST00000190036]
AlphaFold Q3U285
Predicted Effect probably null
Transcript: ENSMUST00000016026
SMART Domains Protein: ENSMUSP00000016026
Gene: ENSMUSG00000015882

DomainStartEndE-ValueType
low complexity region 234 253 N/A INTRINSIC
Pfam:HTH_psq 276 313 5.1e-9 PFAM
Pfam:HTH_psq 525 570 1.9e-19 PFAM
Predicted Effect probably null
Transcript: ENSMUST00000016026
SMART Domains Protein: ENSMUSP00000016026
Gene: ENSMUSG00000015882

DomainStartEndE-ValueType
low complexity region 234 253 N/A INTRINSIC
Pfam:HTH_psq 276 313 5.1e-9 PFAM
Pfam:HTH_psq 525 570 1.9e-19 PFAM
Predicted Effect probably null
Transcript: ENSMUST00000045586
SMART Domains Protein: ENSMUSP00000042677
Gene: ENSMUSG00000015882

DomainStartEndE-ValueType
low complexity region 234 253 N/A INTRINSIC
Predicted Effect probably null
Transcript: ENSMUST00000045586
SMART Domains Protein: ENSMUSP00000042677
Gene: ENSMUSG00000015882

DomainStartEndE-ValueType
low complexity region 234 253 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000067997
Predicted Effect probably null
Transcript: ENSMUST00000087164
SMART Domains Protein: ENSMUSP00000084408
Gene: ENSMUSG00000015882

DomainStartEndE-ValueType
low complexity region 151 170 N/A INTRINSIC
Pfam:HTH_psq 193 230 3.4e-7 PFAM
Pfam:HTH_psq 442 487 9.4e-18 PFAM
Predicted Effect probably null
Transcript: ENSMUST00000087164
SMART Domains Protein: ENSMUSP00000084408
Gene: ENSMUSG00000015882

DomainStartEndE-ValueType
low complexity region 151 170 N/A INTRINSIC
Pfam:HTH_psq 193 230 3.4e-7 PFAM
Pfam:HTH_psq 442 487 9.4e-18 PFAM
Predicted Effect probably null
Transcript: ENSMUST00000121573
SMART Domains Protein: ENSMUSP00000112416
Gene: ENSMUSG00000015882

DomainStartEndE-ValueType
low complexity region 151 170 N/A INTRINSIC
Predicted Effect probably null
Transcript: ENSMUST00000121573
SMART Domains Protein: ENSMUSP00000112416
Gene: ENSMUSG00000015882

DomainStartEndE-ValueType
low complexity region 151 170 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000156295
Predicted Effect probably benign
Transcript: ENSMUST00000186633
Predicted Effect probably benign
Transcript: ENSMUST00000187615
Predicted Effect probably null
Transcript: ENSMUST00000189859
SMART Domains Protein: ENSMUSP00000139996
Gene: ENSMUSG00000015882

DomainStartEndE-ValueType
Blast:ZnF_C2H2 16 38 1e-5 BLAST
Predicted Effect probably null
Transcript: ENSMUST00000189859
SMART Domains Protein: ENSMUSP00000139996
Gene: ENSMUSG00000015882

DomainStartEndE-ValueType
Blast:ZnF_C2H2 16 38 1e-5 BLAST
Predicted Effect probably null
Transcript: ENSMUST00000190036
Predicted Effect probably null
Transcript: ENSMUST00000190036
Predicted Effect noncoding transcript
Transcript: ENSMUST00000200385
Meta Mutation Damage Score 0.9477 question?
Coding Region Coverage
  • 1x: 98.3%
  • 3x: 97.3%
  • 10x: 95.4%
  • 20x: 91.4%
Validation Efficiency 100% (76/76)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a transcription factor that appears to function in spermatogenesis. Polymorphisms in this gene are associated with measures of skeletal frame size and adult height. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2009]
Allele List at MGI
Other mutations in this stock
Total: 69 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1700010L04Rik T A 7: 82,503,150 (GRCm39) noncoding transcript Het
6030469F06Rik A G 12: 31,234,862 (GRCm39) noncoding transcript Het
A830031A19Rik T A 11: 24,008,776 (GRCm39) I13F unknown Het
Acsbg2 A C 17: 57,157,197 (GRCm39) L309R probably damaging Het
Adam32 A T 8: 25,412,328 (GRCm39) M76K probably damaging Het
Adamts14 C A 10: 61,066,222 (GRCm39) R297L probably damaging Het
Agbl5 G A 5: 31,051,247 (GRCm39) probably null Het
Asb14 A G 14: 26,622,408 (GRCm39) K80E possibly damaging Het
Baiap2l1 T C 5: 144,217,759 (GRCm39) T276A probably benign Het
Cacna1d G A 14: 29,764,086 (GRCm39) P2127S probably benign Het
Ces2g A G 8: 105,693,527 (GRCm39) T403A probably benign Het
Cgn A C 3: 94,687,299 (GRCm39) M1R probably null Het
Chd5 T G 4: 152,461,087 (GRCm39) S1226A probably benign Het
Col18a1 A G 10: 76,894,558 (GRCm39) V1497A probably damaging Het
Cpd A T 11: 76,688,727 (GRCm39) Y848* probably null Het
Cyp2a12 T C 7: 26,730,656 (GRCm39) V207A probably benign Het
Cyth1 G A 11: 118,073,593 (GRCm39) R247W probably benign Het
Derl3 T C 10: 75,730,324 (GRCm39) V129A possibly damaging Het
Ehmt2 C T 17: 35,118,067 (GRCm39) R40* probably null Het
Eml1 A T 12: 108,487,635 (GRCm39) I518L probably damaging Het
Eri1 A G 8: 35,945,763 (GRCm39) V174A probably benign Het
Fgd3 T A 13: 49,431,053 (GRCm39) I435F probably damaging Het
Foxd1 T G 13: 98,492,412 (GRCm39) S429A unknown Het
Ftcd T A 10: 76,425,165 (GRCm39) probably benign Het
Gm5478 G T 15: 101,553,102 (GRCm39) N323K probably benign Het
Gnpda1 G T 18: 38,468,161 (GRCm39) P45Q probably damaging Het
Kif20a G T 18: 34,763,678 (GRCm39) probably null Het
Klrb1 T C 6: 128,689,296 (GRCm39) probably null Het
Lrp1b T A 2: 41,000,900 (GRCm39) K2108M probably damaging Het
Lyst C T 13: 13,921,364 (GRCm39) P3437S probably benign Het
Macrod2 A T 2: 142,159,863 (GRCm39) M349L possibly damaging Het
Marchf7 T C 2: 60,075,647 (GRCm39) probably benign Het
Mcm9 A T 10: 53,424,786 (GRCm39) C601* probably null Het
Muc19 G T 15: 91,778,587 (GRCm39) noncoding transcript Het
Mycbp2 T C 14: 103,532,673 (GRCm39) D427G probably damaging Het
Nap1l5 C A 6: 58,883,763 (GRCm39) V64L possibly damaging Het
Ncam2 C T 16: 81,231,766 (GRCm39) R77* probably null Het
Npas3 T C 12: 54,115,721 (GRCm39) V863A possibly damaging Het
Nr2c2 T A 6: 92,116,746 (GRCm39) probably null Het
Oosp3 T C 19: 11,682,794 (GRCm39) F56S possibly damaging Het
Or1a1b A T 11: 74,097,409 (GRCm39) L211Q probably damaging Het
Or5k17 C T 16: 58,746,172 (GRCm39) C254Y probably benign Het
Or8g20 C T 9: 39,396,283 (GRCm39) V89M probably damaging Het
Plgrkt G A 19: 29,327,850 (GRCm39) P78S probably damaging Het
Prss36 G A 7: 127,533,637 (GRCm39) Q56* probably null Het
Ptprz1 A G 6: 22,986,317 (GRCm39) probably null Het
Qsox2 A T 2: 26,107,699 (GRCm39) F265I probably damaging Het
R3hcc1l G T 19: 42,552,307 (GRCm39) E435* probably null Het
Shbg T C 11: 69,507,588 (GRCm39) D163G probably benign Het
Skint7 T A 4: 111,837,546 (GRCm39) L108H probably damaging Het
Smtnl1 T A 2: 84,649,238 (GRCm39) E5D probably benign Het
Spock1 C T 13: 57,704,608 (GRCm39) G120D probably damaging Het
Stk11ip G T 1: 75,508,971 (GRCm39) C700F probably damaging Het
Sult4a1 C T 15: 83,974,159 (GRCm39) probably null Het
Syngap1 A G 17: 27,176,126 (GRCm39) H138R probably damaging Het
Tdrd7 A G 4: 46,034,301 (GRCm39) K1016E probably benign Het
Tmem167b T C 3: 108,467,569 (GRCm39) K26E possibly damaging Het
Tnfaip3 A G 10: 18,883,943 (GRCm39) S146P probably damaging Het
Ttn C T 2: 76,607,060 (GRCm39) V16242I possibly damaging Het
Vmn2r-ps3 T A 3: 63,960,870 (GRCm39) noncoding transcript Het
Vps13c T C 9: 67,864,838 (GRCm39) F3049S probably damaging Het
Vstm2l T C 2: 157,777,355 (GRCm39) W78R probably damaging Het
Wbp1l C A 19: 46,642,695 (GRCm39) A216D possibly damaging Het
Zer1 C G 2: 29,994,866 (GRCm39) V510L probably damaging Het
Zfp28 A T 7: 6,397,850 (GRCm39) probably null Het
Zfp352 C A 4: 90,113,341 (GRCm39) P494T possibly damaging Het
Zfp353-ps A G 8: 42,535,600 (GRCm39) noncoding transcript Het
Zfp563 A T 17: 33,321,515 (GRCm39) probably null Het
Zim1 T C 7: 6,680,320 (GRCm39) N448D probably benign Het
Other mutations in Lcorl
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00780:Lcorl APN 5 45,904,637 (GRCm39) missense probably damaging 1.00
IGL01611:Lcorl APN 5 45,904,434 (GRCm39) missense probably damaging 1.00
IGL03014:Lcorl UTSW 5 45,931,371 (GRCm39) intron probably benign
R0070:Lcorl UTSW 5 45,891,043 (GRCm39) missense probably damaging 1.00
R0070:Lcorl UTSW 5 45,891,043 (GRCm39) missense probably damaging 1.00
R0499:Lcorl UTSW 5 45,891,711 (GRCm39) missense probably benign 0.00
R1518:Lcorl UTSW 5 45,891,543 (GRCm39) missense possibly damaging 0.94
R1817:Lcorl UTSW 5 45,952,688 (GRCm39) missense probably damaging 1.00
R1977:Lcorl UTSW 5 45,932,762 (GRCm39) missense probably null 0.16
R2171:Lcorl UTSW 5 45,904,493 (GRCm39) missense probably damaging 0.99
R3737:Lcorl UTSW 5 45,891,383 (GRCm39) missense possibly damaging 0.95
R3738:Lcorl UTSW 5 45,891,383 (GRCm39) missense possibly damaging 0.95
R3739:Lcorl UTSW 5 45,891,383 (GRCm39) missense possibly damaging 0.95
R3825:Lcorl UTSW 5 45,932,729 (GRCm39) splice site probably benign
R4035:Lcorl UTSW 5 45,891,383 (GRCm39) missense possibly damaging 0.95
R4199:Lcorl UTSW 5 45,891,130 (GRCm39) missense possibly damaging 0.83
R4583:Lcorl UTSW 5 45,890,931 (GRCm39) nonsense probably null
R4647:Lcorl UTSW 5 45,890,931 (GRCm39) nonsense probably null
R4803:Lcorl UTSW 5 45,904,623 (GRCm39) unclassified probably null
R5524:Lcorl UTSW 5 45,932,864 (GRCm39) critical splice acceptor site probably null
R5526:Lcorl UTSW 5 45,891,069 (GRCm39) missense probably benign
R5533:Lcorl UTSW 5 45,891,219 (GRCm39) missense possibly damaging 0.47
R5772:Lcorl UTSW 5 45,952,709 (GRCm39) splice site probably null
R5927:Lcorl UTSW 5 45,882,766 (GRCm39) intron probably benign
R6175:Lcorl UTSW 5 45,933,832 (GRCm39) missense probably damaging 1.00
R6734:Lcorl UTSW 5 45,890,839 (GRCm39) missense probably damaging 0.98
R6864:Lcorl UTSW 5 45,904,546 (GRCm39) missense probably damaging 1.00
R7078:Lcorl UTSW 5 45,904,566 (GRCm39) missense probably damaging 1.00
R7396:Lcorl UTSW 5 46,014,801 (GRCm39) splice site probably null
R7624:Lcorl UTSW 5 45,859,307 (GRCm39) missense probably benign
R9008:Lcorl UTSW 5 45,931,516 (GRCm39) intron probably benign
R9354:Lcorl UTSW 5 45,890,968 (GRCm39) nonsense probably null
R9497:Lcorl UTSW 5 45,891,339 (GRCm39) missense probably benign
X0023:Lcorl UTSW 5 45,891,354 (GRCm39) missense probably damaging 0.98
Predicted Primers PCR Primer
(F):5'- AGCTGACACTCTTATTGGCTC -3'
(R):5'- GCATAAACTTTTCGGCAGTGC -3'

Sequencing Primer
(F):5'- GACACTCTTATTGGCTCTAGTAAGAC -3'
(R):5'- TTGGGATTTTATGAAAGGCA -3'
Posted On 2016-10-05