Incidental Mutation 'R5524:Zfp563'
ID 431784
Institutional Source Beutler Lab
Gene Symbol Zfp563
Ensembl Gene ENSMUSG00000067424
Gene Name zinc finger protein 563
Synonyms zinc finger protein, Zfp413
MMRRC Submission 043082-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.059) question?
Stock # R5524 (G1)
Quality Score 225
Status Validated
Chromosome 17
Chromosomal Location 33308284-33329679 bp(+) (GRCm39)
Type of Mutation critical splice acceptor site
DNA Base Change (assembly) A to T at 33321515 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Gene Model predicted gene model for transcript(s): [ENSMUST00000131722] [ENSMUST00000140829]
AlphaFold B8JJZ9
Predicted Effect probably null
Transcript: ENSMUST00000131722
SMART Domains Protein: ENSMUSP00000118809
Gene: ENSMUSG00000067424

DomainStartEndE-ValueType
KRAB 4 61 5.45e-16 SMART
ZnF_C2H2 141 163 2.63e2 SMART
ZnF_C2H2 169 191 9.08e-4 SMART
ZnF_C2H2 197 219 9.88e-5 SMART
ZnF_C2H2 225 247 3.16e-3 SMART
ZnF_C2H2 253 275 5.81e-2 SMART
ZnF_C2H2 281 303 2.4e-3 SMART
ZnF_C2H2 309 331 1.82e-3 SMART
ZnF_C2H2 337 359 1.72e-4 SMART
ZnF_C2H2 365 387 4.54e-4 SMART
ZnF_C2H2 393 415 7.78e-3 SMART
ZnF_C2H2 421 443 3.63e-3 SMART
Predicted Effect probably null
Transcript: ENSMUST00000140829
SMART Domains Protein: ENSMUSP00000121678
Gene: ENSMUSG00000067424

DomainStartEndE-ValueType
KRAB 4 61 5.45e-16 SMART
ZnF_C2H2 141 163 2.63e2 SMART
ZnF_C2H2 169 191 9.08e-4 SMART
Pfam:zf-C2H2_4 197 209 9.4e-2 PFAM
Predicted Effect probably null
Transcript: ENSMUST00000153072
SMART Domains Protein: ENSMUSP00000119142
Gene: ENSMUSG00000067424

DomainStartEndE-ValueType
low complexity region 30 41 N/A INTRINSIC
KRAB 45 102 5.45e-16 SMART
Meta Mutation Damage Score 0.9485 question?
Coding Region Coverage
  • 1x: 98.3%
  • 3x: 97.3%
  • 10x: 95.4%
  • 20x: 91.4%
Validation Efficiency 100% (76/76)
Allele List at MGI
Other mutations in this stock
Total: 70 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1700010L04Rik T A 7: 82,503,150 (GRCm39) noncoding transcript Het
6030469F06Rik A G 12: 31,234,862 (GRCm39) noncoding transcript Het
A830031A19Rik T A 11: 24,008,776 (GRCm39) I13F unknown Het
Acsbg2 A C 17: 57,157,197 (GRCm39) L309R probably damaging Het
Adam32 A T 8: 25,412,328 (GRCm39) M76K probably damaging Het
Adamts14 C A 10: 61,066,222 (GRCm39) R297L probably damaging Het
Agbl5 G A 5: 31,051,247 (GRCm39) probably null Het
Asb14 A G 14: 26,622,408 (GRCm39) K80E possibly damaging Het
Baiap2l1 T C 5: 144,217,759 (GRCm39) T276A probably benign Het
Cacna1d G A 14: 29,764,086 (GRCm39) P2127S probably benign Het
Ces2g A G 8: 105,693,527 (GRCm39) T403A probably benign Het
Cgn A C 3: 94,687,299 (GRCm39) M1R probably null Het
Chd5 T G 4: 152,461,087 (GRCm39) S1226A probably benign Het
Col18a1 A G 10: 76,894,558 (GRCm39) V1497A probably damaging Het
Cpd A T 11: 76,688,727 (GRCm39) Y848* probably null Het
Cyp2a12 T C 7: 26,730,656 (GRCm39) V207A probably benign Het
Cyth1 G A 11: 118,073,593 (GRCm39) R247W probably benign Het
Derl3 T C 10: 75,730,324 (GRCm39) V129A possibly damaging Het
Ehmt2 C T 17: 35,118,067 (GRCm39) R40* probably null Het
Eml1 A T 12: 108,487,635 (GRCm39) I518L probably damaging Het
Eri1 A G 8: 35,945,763 (GRCm39) V174A probably benign Het
Fgd3 T A 13: 49,431,053 (GRCm39) I435F probably damaging Het
Foxd1 T G 13: 98,492,412 (GRCm39) S429A unknown Het
Ftcd T A 10: 76,425,165 (GRCm39) probably benign Het
Gm5478 G T 15: 101,553,102 (GRCm39) N323K probably benign Het
Gnpda1 G T 18: 38,468,161 (GRCm39) P45Q probably damaging Het
Kif20a G T 18: 34,763,678 (GRCm39) probably null Het
Klrb1 T C 6: 128,689,296 (GRCm39) probably null Het
Lcorl C A 5: 45,932,864 (GRCm39) probably null Het
Lcorl T A 5: 45,932,865 (GRCm39) probably null Het
Lrp1b T A 2: 41,000,900 (GRCm39) K2108M probably damaging Het
Lyst C T 13: 13,921,364 (GRCm39) P3437S probably benign Het
Macrod2 A T 2: 142,159,863 (GRCm39) M349L possibly damaging Het
Marchf7 T C 2: 60,075,647 (GRCm39) probably benign Het
Mcm9 A T 10: 53,424,786 (GRCm39) C601* probably null Het
Muc19 G T 15: 91,778,587 (GRCm39) noncoding transcript Het
Mycbp2 T C 14: 103,532,673 (GRCm39) D427G probably damaging Het
Nap1l5 C A 6: 58,883,763 (GRCm39) V64L possibly damaging Het
Ncam2 C T 16: 81,231,766 (GRCm39) R77* probably null Het
Npas3 T C 12: 54,115,721 (GRCm39) V863A possibly damaging Het
Nr2c2 T A 6: 92,116,746 (GRCm39) probably null Het
Oosp3 T C 19: 11,682,794 (GRCm39) F56S possibly damaging Het
Or1a1b A T 11: 74,097,409 (GRCm39) L211Q probably damaging Het
Or5k17 C T 16: 58,746,172 (GRCm39) C254Y probably benign Het
Or8g20 C T 9: 39,396,283 (GRCm39) V89M probably damaging Het
Plgrkt G A 19: 29,327,850 (GRCm39) P78S probably damaging Het
Prss36 G A 7: 127,533,637 (GRCm39) Q56* probably null Het
Ptprz1 A G 6: 22,986,317 (GRCm39) probably null Het
Qsox2 A T 2: 26,107,699 (GRCm39) F265I probably damaging Het
R3hcc1l G T 19: 42,552,307 (GRCm39) E435* probably null Het
Shbg T C 11: 69,507,588 (GRCm39) D163G probably benign Het
Skint7 T A 4: 111,837,546 (GRCm39) L108H probably damaging Het
Smtnl1 T A 2: 84,649,238 (GRCm39) E5D probably benign Het
Spock1 C T 13: 57,704,608 (GRCm39) G120D probably damaging Het
Stk11ip G T 1: 75,508,971 (GRCm39) C700F probably damaging Het
Sult4a1 C T 15: 83,974,159 (GRCm39) probably null Het
Syngap1 A G 17: 27,176,126 (GRCm39) H138R probably damaging Het
Tdrd7 A G 4: 46,034,301 (GRCm39) K1016E probably benign Het
Tmem167b T C 3: 108,467,569 (GRCm39) K26E possibly damaging Het
Tnfaip3 A G 10: 18,883,943 (GRCm39) S146P probably damaging Het
Ttn C T 2: 76,607,060 (GRCm39) V16242I possibly damaging Het
Vmn2r-ps3 T A 3: 63,960,870 (GRCm39) noncoding transcript Het
Vps13c T C 9: 67,864,838 (GRCm39) F3049S probably damaging Het
Vstm2l T C 2: 157,777,355 (GRCm39) W78R probably damaging Het
Wbp1l C A 19: 46,642,695 (GRCm39) A216D possibly damaging Het
Zer1 C G 2: 29,994,866 (GRCm39) V510L probably damaging Het
Zfp28 A T 7: 6,397,850 (GRCm39) probably null Het
Zfp352 C A 4: 90,113,341 (GRCm39) P494T possibly damaging Het
Zfp353-ps A G 8: 42,535,600 (GRCm39) noncoding transcript Het
Zim1 T C 7: 6,680,320 (GRCm39) N448D probably benign Het
Other mutations in Zfp563
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01629:Zfp563 APN 17 33,323,600 (GRCm39) missense probably damaging 1.00
IGL01981:Zfp563 APN 17 33,324,383 (GRCm39) missense probably benign 0.16
IGL02407:Zfp563 APN 17 33,323,795 (GRCm39) missense probably benign 0.00
IGL02662:Zfp563 APN 17 33,321,253 (GRCm39) missense probably damaging 1.00
IGL03220:Zfp563 APN 17 33,323,661 (GRCm39) missense probably benign 0.44
R0241:Zfp563 UTSW 17 33,323,659 (GRCm39) missense possibly damaging 0.61
R0241:Zfp563 UTSW 17 33,323,659 (GRCm39) missense possibly damaging 0.61
R0537:Zfp563 UTSW 17 33,323,659 (GRCm39) missense possibly damaging 0.61
R0552:Zfp563 UTSW 17 33,323,659 (GRCm39) missense possibly damaging 0.61
R1544:Zfp563 UTSW 17 33,324,187 (GRCm39) missense probably benign 0.01
R3763:Zfp563 UTSW 17 33,323,902 (GRCm39) nonsense probably null
R3979:Zfp563 UTSW 17 33,324,701 (GRCm39) missense probably benign 0.03
R4938:Zfp563 UTSW 17 33,324,683 (GRCm39) missense probably damaging 1.00
R5280:Zfp563 UTSW 17 33,323,812 (GRCm39) missense probably damaging 0.99
R5383:Zfp563 UTSW 17 33,323,681 (GRCm39) missense probably benign
R5485:Zfp563 UTSW 17 33,308,540 (GRCm39) unclassified probably benign
R5567:Zfp563 UTSW 17 33,308,431 (GRCm39) unclassified probably benign
R5736:Zfp563 UTSW 17 33,323,960 (GRCm39) missense possibly damaging 0.91
R5758:Zfp563 UTSW 17 33,323,894 (GRCm39) missense probably damaging 1.00
R6034:Zfp563 UTSW 17 33,323,935 (GRCm39) missense probably damaging 0.96
R6034:Zfp563 UTSW 17 33,323,935 (GRCm39) missense probably damaging 0.96
R6532:Zfp563 UTSW 17 33,324,672 (GRCm39) missense probably benign 0.21
R9241:Zfp563 UTSW 17 33,321,520 (GRCm39) missense probably benign 0.10
R9360:Zfp563 UTSW 17 33,324,428 (GRCm39) missense probably benign 0.38
R9410:Zfp563 UTSW 17 33,321,320 (GRCm39) missense probably damaging 1.00
R9453:Zfp563 UTSW 17 33,308,565 (GRCm39) missense
RF007:Zfp563 UTSW 17 33,323,999 (GRCm39) missense probably benign
X0023:Zfp563 UTSW 17 33,324,695 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- GAACTGCTTGGAGAAGGTATCT -3'
(R):5'- AGAAGATCAACTGTATCATCTTGTTAG -3'

Sequencing Primer
(F):5'- GGATTTACTGGATCCTTCCCAGAAG -3'
(R):5'- GAATGTCTGTGCAACACCTG -3'
Posted On 2016-10-05