Incidental Mutation 'R5490:Cdca2'
ID 432056
Institutional Source Beutler Lab
Gene Symbol Cdca2
Ensembl Gene ENSMUSG00000048922
Gene Name cell division cycle associated 2
Synonyms 2610311M19Rik
MMRRC Submission 043051-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.080) question?
Stock # R5490 (G1)
Quality Score 198
Status Not validated
Chromosome 14
Chromosomal Location 67913780-67953290 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 67917733 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Glutamic Acid to Glycine at position 555 (E555G)
Ref Sequence ENSEMBL: ENSMUSP00000127571 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000132705] [ENSMUST00000150006] [ENSMUST00000163100]
AlphaFold Q14B71
Predicted Effect unknown
Transcript: ENSMUST00000131179
AA Change: E109G
SMART Domains Protein: ENSMUSP00000123664
Gene: ENSMUSG00000048922
AA Change: E109G

DomainStartEndE-ValueType
low complexity region 70 83 N/A INTRINSIC
low complexity region 97 111 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000132705
SMART Domains Protein: ENSMUSP00000115633
Gene: ENSMUSG00000048922

DomainStartEndE-ValueType
Pfam:PP1_bind 378 437 4.3e-28 PFAM
low complexity region 515 528 N/A INTRINSIC
Predicted Effect possibly damaging
Transcript: ENSMUST00000150006
AA Change: E555G

PolyPhen 2 Score 0.911 (Sensitivity: 0.81; Specificity: 0.94)
SMART Domains Protein: ENSMUSP00000117847
Gene: ENSMUSG00000048922
AA Change: E555G

DomainStartEndE-ValueType
Pfam:PP1_bind 378 437 5.4e-28 PFAM
low complexity region 515 528 N/A INTRINSIC
low complexity region 542 556 N/A INTRINSIC
low complexity region 931 942 N/A INTRINSIC
Predicted Effect possibly damaging
Transcript: ENSMUST00000163100
AA Change: E555G

PolyPhen 2 Score 0.911 (Sensitivity: 0.81; Specificity: 0.94)
SMART Domains Protein: ENSMUSP00000127571
Gene: ENSMUSG00000048922
AA Change: E555G

DomainStartEndE-ValueType
Pfam:PP1_bind 379 436 4.1e-27 PFAM
low complexity region 515 528 N/A INTRINSIC
low complexity region 542 556 N/A INTRINSIC
low complexity region 931 942 N/A INTRINSIC
Coding Region Coverage
  • 1x: 98.3%
  • 3x: 97.3%
  • 10x: 95.2%
  • 20x: 90.8%
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a targeting subunit of the cell-cycle associated protein, protein phosphatase 1, with a role in targeting this protein to chromatin during anaphase. These two proteins comprise a phosphatase complex that is involved in nuclear envelope reformation and regulation of the DNA damage response. The encoded protein may also play a role in cancer progression. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2015]
Allele List at MGI

All alleles(24) : Gene trapped(24)

Other mutations in this stock
Total: 47 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Aatf C T 11: 84,401,099 (GRCm39) G174D probably damaging Het
Abcc1 G T 16: 14,228,781 (GRCm39) G343C probably damaging Het
Asic2 T C 11: 80,780,646 (GRCm39) N370S probably benign Het
Btnl9 T C 11: 49,060,395 (GRCm39) E451G probably damaging Het
Cblb A G 16: 51,994,733 (GRCm39) H658R possibly damaging Het
Chfr A G 5: 110,300,995 (GRCm39) S299G possibly damaging Het
Eea1 A G 10: 95,861,916 (GRCm39) E741G probably benign Het
Gapvd1 T C 2: 34,583,445 (GRCm39) D1057G probably benign Het
Glyat C T 19: 12,627,645 (GRCm39) T80M probably benign Het
Gpr87 T C 3: 59,086,747 (GRCm39) S253G probably damaging Het
Hapstr1 T A 16: 8,673,721 (GRCm39) V216E probably damaging Het
Hmgxb3 A G 18: 61,296,049 (GRCm39) S320P probably damaging Het
Kcnq5 C T 1: 21,549,692 (GRCm39) G345D probably damaging Het
Kif5c T C 2: 49,648,870 (GRCm39) V938A probably benign Het
Klk14 G A 7: 43,341,501 (GRCm39) C51Y probably damaging Het
Madd G T 2: 91,000,980 (GRCm39) T467K possibly damaging Het
Mamdc4 T C 2: 25,455,890 (GRCm39) D706G probably damaging Het
Map2 A G 1: 66,452,292 (GRCm39) H476R probably damaging Het
Mgat4f A G 1: 134,317,666 (GRCm39) D146G probably damaging Het
Mpeg1 T C 19: 12,439,057 (GRCm39) S172P probably damaging Het
Nkx2-3 A T 19: 43,601,093 (GRCm39) T52S probably benign Het
Nup210 C T 6: 91,062,970 (GRCm39) V230I probably damaging Het
Or1j19 T A 2: 36,677,193 (GRCm39) Y219N probably damaging Het
Or51f2 T C 7: 102,527,100 (GRCm39) S258P probably damaging Het
Or5g9 G T 2: 85,552,666 (GRCm39) A306S probably benign Het
Pepd A G 7: 34,642,115 (GRCm39) probably null Het
Ppp1r36 T A 12: 76,484,760 (GRCm39) W238R probably damaging Het
Ppp1r36 G T 12: 76,484,761 (GRCm39) W238L possibly damaging Het
Prpf6 T G 2: 181,249,958 (GRCm39) D39E probably benign Het
Rassf5 T A 1: 131,108,932 (GRCm39) Q163L possibly damaging Het
Rbm43 T A 2: 51,815,607 (GRCm39) T205S probably benign Het
Relch T A 1: 105,647,226 (GRCm39) V672D probably damaging Het
Robo4 CGG CG 9: 37,322,786 (GRCm39) probably null Het
Sds C A 5: 120,621,715 (GRCm39) Q286K possibly damaging Het
Slc35a3 A T 3: 116,474,839 (GRCm39) C184* probably null Het
Smg1 G A 7: 117,738,659 (GRCm39) T3530I possibly damaging Het
Sspo T C 6: 48,470,214 (GRCm39) V591A probably benign Het
Stam2 T C 2: 52,610,929 (GRCm39) D31G probably damaging Het
Star A G 8: 26,299,945 (GRCm39) K96E probably damaging Het
Syne3 A G 12: 104,921,931 (GRCm39) L495P probably damaging Het
Tceanc2 A T 4: 107,022,846 (GRCm39) M47K probably benign Het
Tecpr2 T C 12: 110,881,118 (GRCm39) L85P probably damaging Het
Tmem241 C T 18: 12,176,320 (GRCm39) R116K probably benign Het
Yipf2 G A 9: 21,503,487 (GRCm39) A20V probably benign Het
Zc3h4 T A 7: 16,162,930 (GRCm39) D443E unknown Het
Zfp184 T A 13: 22,142,747 (GRCm39) V151D probably benign Het
Zhx1 T C 15: 57,916,695 (GRCm39) Y517C probably damaging Het
Other mutations in Cdca2
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01115:Cdca2 APN 14 67,952,146 (GRCm39) missense probably damaging 0.99
IGL01413:Cdca2 APN 14 67,915,343 (GRCm39) missense probably damaging 0.98
IGL01962:Cdca2 APN 14 67,943,172 (GRCm39) missense probably damaging 0.99
IGL01982:Cdca2 APN 14 67,915,168 (GRCm39) missense probably damaging 0.98
IGL02198:Cdca2 APN 14 67,932,445 (GRCm39) missense probably benign 0.00
IGL02208:Cdca2 APN 14 67,950,589 (GRCm39) missense probably damaging 0.99
IGL02883:Cdca2 APN 14 67,944,946 (GRCm39) missense probably damaging 1.00
IGL03069:Cdca2 APN 14 67,952,385 (GRCm39) splice site probably benign
F5493:Cdca2 UTSW 14 67,915,141 (GRCm39) missense probably damaging 0.99
IGL03046:Cdca2 UTSW 14 67,937,471 (GRCm39) intron probably benign
R0254:Cdca2 UTSW 14 67,914,627 (GRCm39) missense probably damaging 0.99
R0350:Cdca2 UTSW 14 67,950,568 (GRCm39) missense probably benign 0.02
R0368:Cdca2 UTSW 14 67,937,796 (GRCm39) missense possibly damaging 0.89
R0398:Cdca2 UTSW 14 67,935,411 (GRCm39) missense probably damaging 0.98
R0790:Cdca2 UTSW 14 67,917,740 (GRCm39) missense probably benign
R1104:Cdca2 UTSW 14 67,931,131 (GRCm39) missense probably damaging 0.99
R1474:Cdca2 UTSW 14 67,952,355 (GRCm39) intron probably benign
R1658:Cdca2 UTSW 14 67,915,148 (GRCm39) missense possibly damaging 0.93
R1782:Cdca2 UTSW 14 67,915,260 (GRCm39) missense probably benign 0.22
R2150:Cdca2 UTSW 14 67,952,258 (GRCm39) missense probably damaging 1.00
R2154:Cdca2 UTSW 14 67,914,425 (GRCm39) missense probably damaging 0.99
R2155:Cdca2 UTSW 14 67,952,287 (GRCm39) missense probably damaging 1.00
R2862:Cdca2 UTSW 14 67,935,539 (GRCm39) missense probably damaging 1.00
R3156:Cdca2 UTSW 14 67,935,612 (GRCm39) missense possibly damaging 0.91
R3840:Cdca2 UTSW 14 67,917,720 (GRCm39) nonsense probably null
R4043:Cdca2 UTSW 14 67,941,455 (GRCm39) missense probably benign 0.11
R4293:Cdca2 UTSW 14 67,952,299 (GRCm39) missense probably benign 0.06
R4679:Cdca2 UTSW 14 67,952,415 (GRCm39) missense possibly damaging 0.68
R4777:Cdca2 UTSW 14 67,950,589 (GRCm39) missense probably damaging 0.99
R4829:Cdca2 UTSW 14 67,931,202 (GRCm39) critical splice acceptor site probably null
R4843:Cdca2 UTSW 14 67,914,425 (GRCm39) missense probably damaging 1.00
R5031:Cdca2 UTSW 14 67,950,602 (GRCm39) missense probably damaging 1.00
R5181:Cdca2 UTSW 14 67,917,614 (GRCm39) missense probably damaging 0.98
R5331:Cdca2 UTSW 14 67,914,920 (GRCm39) missense possibly damaging 0.91
R5695:Cdca2 UTSW 14 67,943,078 (GRCm39) critical splice donor site probably null
R6246:Cdca2 UTSW 14 67,915,277 (GRCm39) nonsense probably null
R6866:Cdca2 UTSW 14 67,931,115 (GRCm39) missense possibly damaging 0.92
R6928:Cdca2 UTSW 14 67,943,193 (GRCm39) missense probably damaging 0.98
R6955:Cdca2 UTSW 14 67,952,453 (GRCm39) start codon destroyed probably null 0.53
R6986:Cdca2 UTSW 14 67,932,446 (GRCm39) missense probably benign 0.27
R7080:Cdca2 UTSW 14 67,935,551 (GRCm39) missense probably damaging 0.99
R7092:Cdca2 UTSW 14 67,944,800 (GRCm39) critical splice donor site probably null
R7292:Cdca2 UTSW 14 67,915,326 (GRCm39) nonsense probably null
R7308:Cdca2 UTSW 14 67,932,440 (GRCm39) missense probably benign
R7310:Cdca2 UTSW 14 67,950,673 (GRCm39) missense probably damaging 1.00
R7877:Cdca2 UTSW 14 67,914,665 (GRCm39) missense probably benign
R8012:Cdca2 UTSW 14 67,914,821 (GRCm39) missense probably benign 0.23
R8080:Cdca2 UTSW 14 67,915,004 (GRCm39) nonsense probably null
R8772:Cdca2 UTSW 14 67,935,529 (GRCm39) missense probably damaging 0.98
R9123:Cdca2 UTSW 14 67,917,762 (GRCm39) missense probably benign 0.03
R9125:Cdca2 UTSW 14 67,917,762 (GRCm39) missense probably benign 0.03
R9252:Cdca2 UTSW 14 67,914,831 (GRCm39) missense possibly damaging 0.93
R9328:Cdca2 UTSW 14 67,931,131 (GRCm39) missense probably damaging 0.99
R9406:Cdca2 UTSW 14 67,937,772 (GRCm39) missense unknown
R9667:Cdca2 UTSW 14 67,915,003 (GRCm39) missense probably benign 0.01
R9678:Cdca2 UTSW 14 67,937,778 (GRCm39) missense unknown
Z1088:Cdca2 UTSW 14 67,937,747 (GRCm39) missense probably benign 0.12
Z1177:Cdca2 UTSW 14 67,917,693 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- AAGTCCCTCCTCACAGGTTC -3'
(R):5'- AGATTACCTTTCTGGCATTTGAGC -3'

Sequencing Primer
(F):5'- ACAGGTTCCAGACTTCAACTTC -3'
(R):5'- GGCCTCAATCTATCATGGTG -3'
Posted On 2016-10-05