Incidental Mutation 'R5490:Tmem241'
ID 432063
Institutional Source Beutler Lab
Gene Symbol Tmem241
Ensembl Gene ENSMUSG00000049411
Gene Name transmembrane protein 241
Synonyms 6030446N20Rik
MMRRC Submission 043051-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R5490 (G1)
Quality Score 225
Status Not validated
Chromosome 18
Chromosomal Location 12113193-12254604 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) C to T at 12176320 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Arginine to Lysine at position 116 (R116K)
Ref Sequence ENSEMBL: ENSMUSP00000148000 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000050228] [ENSMUST00000055447] [ENSMUST00000209628] [ENSMUST00000209859] [ENSMUST00000211298]
AlphaFold Q3UME2
Predicted Effect probably benign
Transcript: ENSMUST00000050228
SMART Domains Protein: ENSMUSP00000062148
Gene: ENSMUSG00000049411

DomainStartEndE-ValueType
transmembrane domain 119 136 N/A INTRINSIC
transmembrane domain 200 217 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000055447
AA Change: R239K

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
SMART Domains Protein: ENSMUSP00000052001
Gene: ENSMUSG00000049411
AA Change: R239K

DomainStartEndE-ValueType
transmembrane domain 32 54 N/A INTRINSIC
transmembrane domain 69 91 N/A INTRINSIC
transmembrane domain 121 140 N/A INTRINSIC
transmembrane domain 150 167 N/A INTRINSIC
transmembrane domain 184 201 N/A INTRINSIC
transmembrane domain 214 236 N/A INTRINSIC
transmembrane domain 248 270 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000209628
AA Change: R116K

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
Predicted Effect probably benign
Transcript: ENSMUST00000209859
AA Change: R239K

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
Predicted Effect probably benign
Transcript: ENSMUST00000211298
Coding Region Coverage
  • 1x: 98.3%
  • 3x: 97.3%
  • 10x: 95.2%
  • 20x: 90.8%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 47 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Aatf C T 11: 84,401,099 (GRCm39) G174D probably damaging Het
Abcc1 G T 16: 14,228,781 (GRCm39) G343C probably damaging Het
Asic2 T C 11: 80,780,646 (GRCm39) N370S probably benign Het
Btnl9 T C 11: 49,060,395 (GRCm39) E451G probably damaging Het
Cblb A G 16: 51,994,733 (GRCm39) H658R possibly damaging Het
Cdca2 T C 14: 67,917,733 (GRCm39) E555G possibly damaging Het
Chfr A G 5: 110,300,995 (GRCm39) S299G possibly damaging Het
Eea1 A G 10: 95,861,916 (GRCm39) E741G probably benign Het
Gapvd1 T C 2: 34,583,445 (GRCm39) D1057G probably benign Het
Glyat C T 19: 12,627,645 (GRCm39) T80M probably benign Het
Gpr87 T C 3: 59,086,747 (GRCm39) S253G probably damaging Het
Hapstr1 T A 16: 8,673,721 (GRCm39) V216E probably damaging Het
Hmgxb3 A G 18: 61,296,049 (GRCm39) S320P probably damaging Het
Kcnq5 C T 1: 21,549,692 (GRCm39) G345D probably damaging Het
Kif5c T C 2: 49,648,870 (GRCm39) V938A probably benign Het
Klk14 G A 7: 43,341,501 (GRCm39) C51Y probably damaging Het
Madd G T 2: 91,000,980 (GRCm39) T467K possibly damaging Het
Mamdc4 T C 2: 25,455,890 (GRCm39) D706G probably damaging Het
Map2 A G 1: 66,452,292 (GRCm39) H476R probably damaging Het
Mgat4f A G 1: 134,317,666 (GRCm39) D146G probably damaging Het
Mpeg1 T C 19: 12,439,057 (GRCm39) S172P probably damaging Het
Nkx2-3 A T 19: 43,601,093 (GRCm39) T52S probably benign Het
Nup210 C T 6: 91,062,970 (GRCm39) V230I probably damaging Het
Or1j19 T A 2: 36,677,193 (GRCm39) Y219N probably damaging Het
Or51f2 T C 7: 102,527,100 (GRCm39) S258P probably damaging Het
Or5g9 G T 2: 85,552,666 (GRCm39) A306S probably benign Het
Pepd A G 7: 34,642,115 (GRCm39) probably null Het
Ppp1r36 T A 12: 76,484,760 (GRCm39) W238R probably damaging Het
Ppp1r36 G T 12: 76,484,761 (GRCm39) W238L possibly damaging Het
Prpf6 T G 2: 181,249,958 (GRCm39) D39E probably benign Het
Rassf5 T A 1: 131,108,932 (GRCm39) Q163L possibly damaging Het
Rbm43 T A 2: 51,815,607 (GRCm39) T205S probably benign Het
Relch T A 1: 105,647,226 (GRCm39) V672D probably damaging Het
Robo4 CGG CG 9: 37,322,786 (GRCm39) probably null Het
Sds C A 5: 120,621,715 (GRCm39) Q286K possibly damaging Het
Slc35a3 A T 3: 116,474,839 (GRCm39) C184* probably null Het
Smg1 G A 7: 117,738,659 (GRCm39) T3530I possibly damaging Het
Sspo T C 6: 48,470,214 (GRCm39) V591A probably benign Het
Stam2 T C 2: 52,610,929 (GRCm39) D31G probably damaging Het
Star A G 8: 26,299,945 (GRCm39) K96E probably damaging Het
Syne3 A G 12: 104,921,931 (GRCm39) L495P probably damaging Het
Tceanc2 A T 4: 107,022,846 (GRCm39) M47K probably benign Het
Tecpr2 T C 12: 110,881,118 (GRCm39) L85P probably damaging Het
Yipf2 G A 9: 21,503,487 (GRCm39) A20V probably benign Het
Zc3h4 T A 7: 16,162,930 (GRCm39) D443E unknown Het
Zfp184 T A 13: 22,142,747 (GRCm39) V151D probably benign Het
Zhx1 T C 15: 57,916,695 (GRCm39) Y517C probably damaging Het
Other mutations in Tmem241
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02256:Tmem241 APN 18 12,246,489 (GRCm39) missense probably damaging 1.00
R0106:Tmem241 UTSW 18 12,239,066 (GRCm39) intron probably benign
R1203:Tmem241 UTSW 18 12,217,035 (GRCm39) splice site probably benign
R1218:Tmem241 UTSW 18 12,197,271 (GRCm39) missense probably damaging 1.00
R1304:Tmem241 UTSW 18 12,203,135 (GRCm39) critical splice donor site probably null
R1416:Tmem241 UTSW 18 12,126,631 (GRCm39) missense probably benign 0.00
R1430:Tmem241 UTSW 18 12,126,651 (GRCm39) missense probably benign 0.01
R1539:Tmem241 UTSW 18 12,176,297 (GRCm39) missense possibly damaging 0.92
R1729:Tmem241 UTSW 18 12,201,369 (GRCm39) missense probably damaging 0.99
R1775:Tmem241 UTSW 18 12,251,469 (GRCm39) missense probably damaging 1.00
R3813:Tmem241 UTSW 18 12,200,167 (GRCm39) splice site probably benign
R4352:Tmem241 UTSW 18 12,246,496 (GRCm39) missense probably benign 0.35
R4903:Tmem241 UTSW 18 12,237,176 (GRCm39) missense probably damaging 1.00
R4966:Tmem241 UTSW 18 12,237,176 (GRCm39) missense probably damaging 1.00
R5704:Tmem241 UTSW 18 12,197,263 (GRCm39) missense probably damaging 1.00
R6943:Tmem241 UTSW 18 12,180,641 (GRCm39) missense possibly damaging 0.92
R7037:Tmem241 UTSW 18 12,246,463 (GRCm39) missense probably benign 0.02
R7209:Tmem241 UTSW 18 12,237,229 (GRCm39) missense probably damaging 0.97
R8698:Tmem241 UTSW 18 12,197,288 (GRCm39) missense possibly damaging 0.93
R9562:Tmem241 UTSW 18 12,176,356 (GRCm39) nonsense probably null
RF013:Tmem241 UTSW 18 12,116,618 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- ATGAATGGCCAGGCATGTG -3'
(R):5'- TGAGAGTGATGGCATCTGC -3'

Sequencing Primer
(F):5'- GGATGCTGAGGTAGACTTTG -3'
(R):5'- ATCTGCCTGTAATCGCGG -3'
Posted On 2016-10-05