Incidental Mutation 'R5456:Or4c10b'
ID 432743
Institutional Source Beutler Lab
Gene Symbol Or4c10b
Ensembl Gene ENSMUSG00000049057
Gene Name olfactory receptor family 4 subfamily C member 10B
Synonyms MOR232-1, Olfr1257, GA_x6K02T2Q125-51319458-51320387
MMRRC Submission 043019-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.071) question?
Stock # R5456 (G1)
Quality Score 225
Status Not validated
Chromosome 2
Chromosomal Location 89709708-89712147 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) G to A at 89711602 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Glycine to Glutamic Acid at position 144 (G144E)
Ref Sequence ENSEMBL: ENSMUSP00000107144 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000060795] [ENSMUST00000111519]
AlphaFold Q8VGP0
Predicted Effect probably damaging
Transcript: ENSMUST00000060795
AA Change: G144E

PolyPhen 2 Score 0.972 (Sensitivity: 0.77; Specificity: 0.96)
SMART Domains Protein: ENSMUSP00000056439
Gene: ENSMUSG00000049057
AA Change: G144E

DomainStartEndE-ValueType
Pfam:7tm_1 39 285 2.6e-31 PFAM
Pfam:7tm_4 137 278 8e-42 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000111519
AA Change: G144E

PolyPhen 2 Score 0.972 (Sensitivity: 0.77; Specificity: 0.96)
SMART Domains Protein: ENSMUSP00000107144
Gene: ENSMUSG00000049057
AA Change: G144E

DomainStartEndE-ValueType
Pfam:7tm_4 29 303 1.5e-49 PFAM
Pfam:7tm_1 39 285 3.9e-18 PFAM
Coding Region Coverage
  • 1x: 99.3%
  • 3x: 98.7%
  • 10x: 97.5%
  • 20x: 95.8%
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 36 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Acot12 A G 13: 91,889,759 (GRCm39) D37G probably damaging Het
Adcy5 T C 16: 35,118,892 (GRCm39) F1081S probably damaging Het
Apmap T A 2: 150,431,989 (GRCm39) I128L probably benign Het
Arhgap12 G A 18: 6,112,170 (GRCm39) Q65* probably null Het
Baat C T 4: 49,502,949 (GRCm39) V58I possibly damaging Het
Bco2 T C 9: 50,456,644 (GRCm39) probably null Het
Bend3 T C 10: 43,386,542 (GRCm39) Y312H probably damaging Het
Btnl2 A T 17: 34,582,295 (GRCm39) Y287F probably benign Het
Cd22 T C 7: 30,575,464 (GRCm39) I193V probably benign Het
Commd3 A G 2: 18,678,968 (GRCm39) E95G probably damaging Het
Dcbld1 A G 10: 52,190,486 (GRCm39) D215G probably damaging Het
Elfn1 A G 5: 139,958,571 (GRCm39) Y525C probably damaging Het
Fam83b T C 9: 76,399,877 (GRCm39) T409A probably benign Het
Fshr T A 17: 89,293,776 (GRCm39) I301F probably benign Het
Hemgn C T 4: 46,396,571 (GRCm39) V222M probably damaging Het
Igsf3 C T 3: 101,334,537 (GRCm39) H205Y probably benign Het
Mfsd1 T C 3: 67,497,166 (GRCm39) I147T probably benign Het
Mslnl A G 17: 25,962,133 (GRCm39) D177G probably damaging Het
Nat2 G A 8: 67,954,225 (GRCm39) V112I probably damaging Het
Or8s5 G A 15: 98,238,246 (GRCm39) A208V probably benign Het
Pabpc1l T C 2: 163,869,580 (GRCm39) S127P probably damaging Het
Poln A T 5: 34,164,786 (GRCm39) L845Q possibly damaging Het
Ppm1f T A 16: 16,741,610 (GRCm39) D361E probably damaging Het
Rapgef5 T A 12: 117,692,381 (GRCm39) probably null Het
Rarb G A 14: 16,436,843 (GRCm38) T226I probably damaging Het
Sel1l3 T C 5: 53,357,378 (GRCm39) K205E probably benign Het
Sh3glb1 T A 3: 144,415,114 (GRCm39) I75L probably benign Het
Srgap1 G A 10: 121,705,716 (GRCm39) S236L probably benign Het
Tmco3 A G 8: 13,369,815 (GRCm39) Y609C probably damaging Het
Trhde A G 10: 114,322,665 (GRCm39) V712A possibly damaging Het
Trim13 A G 14: 61,842,523 (GRCm39) D180G possibly damaging Het
Tst T C 15: 78,284,158 (GRCm39) E223G probably damaging Het
Umodl1 A G 17: 31,201,263 (GRCm39) I397M probably benign Het
Usp31 T C 7: 121,269,500 (GRCm39) D481G probably damaging Het
Vps13c T A 9: 67,834,729 (GRCm39) M1686K possibly damaging Het
Wdr83 T C 8: 85,806,837 (GRCm39) H81R probably benign Het
Other mutations in Or4c10b
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01600:Or4c10b APN 2 89,712,006 (GRCm39) missense probably benign 0.02
IGL01641:Or4c10b APN 2 89,711,952 (GRCm39) missense probably benign 0.01
IGL01668:Or4c10b APN 2 89,711,443 (GRCm39) missense probably benign 0.01
IGL01901:Or4c10b APN 2 89,711,826 (GRCm39) missense probably damaging 1.00
IGL02401:Or4c10b APN 2 89,711,797 (GRCm39) missense probably damaging 1.00
IGL02472:Or4c10b APN 2 89,711,755 (GRCm39) missense probably benign 0.44
IGL02631:Or4c10b APN 2 89,711,599 (GRCm39) missense possibly damaging 0.95
PIT4354001:Or4c10b UTSW 2 89,711,852 (GRCm39) missense probably benign 0.04
R0552:Or4c10b UTSW 2 89,711,235 (GRCm39) nonsense probably null
R0616:Or4c10b UTSW 2 89,711,935 (GRCm39) missense probably benign 0.07
R0943:Or4c10b UTSW 2 89,711,305 (GRCm39) missense probably benign 0.11
R1146:Or4c10b UTSW 2 89,711,550 (GRCm39) missense probably damaging 1.00
R1146:Or4c10b UTSW 2 89,711,550 (GRCm39) missense probably damaging 1.00
R1314:Or4c10b UTSW 2 89,711,221 (GRCm39) missense probably benign 0.35
R1641:Or4c10b UTSW 2 89,711,745 (GRCm39) missense probably benign 0.07
R1763:Or4c10b UTSW 2 89,711,473 (GRCm39) missense probably damaging 0.99
R1836:Or4c10b UTSW 2 89,711,629 (GRCm39) missense probably damaging 1.00
R2125:Or4c10b UTSW 2 89,711,982 (GRCm39) missense probably benign
R4322:Or4c10b UTSW 2 89,712,078 (GRCm39) missense probably benign 0.07
R4897:Or4c10b UTSW 2 89,711,476 (GRCm39) missense probably benign 0.39
R5446:Or4c10b UTSW 2 89,711,893 (GRCm39) missense probably damaging 1.00
R6415:Or4c10b UTSW 2 89,711,206 (GRCm39) missense probably damaging 1.00
R6905:Or4c10b UTSW 2 89,712,052 (GRCm39) missense probably benign 0.05
R7170:Or4c10b UTSW 2 89,711,397 (GRCm39) missense possibly damaging 0.70
R7170:Or4c10b UTSW 2 89,711,185 (GRCm39) missense probably benign 0.12
R7411:Or4c10b UTSW 2 89,711,605 (GRCm39) missense probably damaging 0.98
R8171:Or4c10b UTSW 2 89,711,409 (GRCm39) missense probably benign 0.05
R8490:Or4c10b UTSW 2 89,711,511 (GRCm39) missense probably damaging 1.00
R9176:Or4c10b UTSW 2 89,711,515 (GRCm39) missense probably benign 0.05
R9204:Or4c10b UTSW 2 89,711,482 (GRCm39) missense probably damaging 1.00
R9751:Or4c10b UTSW 2 89,711,956 (GRCm39) missense probably benign 0.02
Predicted Primers PCR Primer
(F):5'- TTAGCACCCCTAAACTGATAGC -3'
(R):5'- TCTTTAGGGAGCGCAGGATG -3'

Sequencing Primer
(F):5'- TCACTCTGTGAAAAGAAGACCATC -3'
(R):5'- TAGCAGACAAATAAAACCACTGTTG -3'
Posted On 2016-10-06