Incidental Mutation 'R5462:Zfp267'
| ID |
433054 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Zfp267
|
| Ensembl Gene |
ENSMUSG00000033883 |
| Gene Name |
zinc finger protein 267 |
| Synonyms |
D3Ertd254e |
| MMRRC Submission |
043024-MU
|
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.136)
|
| Stock # |
R5462 (G1)
|
| Quality Score |
225 |
|
Status
|
Not validated
|
| Chromosome |
3 |
| Chromosomal Location |
36205233-36224491 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
C to T
at 36219969 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Threonine to Isoleucine
at position 664
(T664I)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000142829
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000165956]
[ENSMUST00000197653]
[ENSMUST00000205077]
|
| AlphaFold |
A0A0G2JEM5 |
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000165956
AA Change: T663I
PolyPhen 2
Score 0.953 (Sensitivity: 0.79; Specificity: 0.95)
|
| SMART Domains |
Protein: ENSMUSP00000131779
Gene: ENSMUSG00000033883
AA Change: T663I
| Domain | Start | End | E-Value | Type |
|---|
|
KRAB
|
3 |
63 |
2.91e-34 |
SMART |
|
ZnF_C2H2
|
342 |
364 |
1.08e-1 |
SMART |
|
ZnF_C2H2
|
395 |
417 |
1.56e-2 |
SMART |
|
ZnF_C2H2
|
423 |
445 |
3.11e-2 |
SMART |
|
ZnF_C2H2
|
451 |
473 |
5.9e-3 |
SMART |
|
ZnF_C2H2
|
479 |
501 |
1.82e-3 |
SMART |
|
ZnF_C2H2
|
507 |
529 |
5.21e-4 |
SMART |
|
ZnF_C2H2
|
535 |
557 |
1.84e-4 |
SMART |
|
ZnF_C2H2
|
563 |
585 |
1.95e-3 |
SMART |
|
ZnF_C2H2
|
591 |
613 |
2.05e-2 |
SMART |
|
ZnF_C2H2
|
619 |
641 |
1.6e-4 |
SMART |
|
ZnF_C2H2
|
647 |
669 |
5.21e-4 |
SMART |
|
ZnF_C2H2
|
675 |
697 |
1.69e-3 |
SMART |
|
ZnF_C2H2
|
703 |
725 |
2.61e-4 |
SMART |
|
ZnF_C2H2
|
731 |
753 |
1.12e-3 |
SMART |
|
ZnF_C2H2
|
759 |
779 |
3.85e1 |
SMART |
|
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000197653
AA Change: T664I
PolyPhen 2
Score 0.953 (Sensitivity: 0.79; Specificity: 0.95)
|
| SMART Domains |
Protein: ENSMUSP00000142829
Gene: ENSMUSG00000033883
AA Change: T664I
| Domain | Start | End | E-Value | Type |
|---|
|
KRAB
|
4 |
64 |
1.2e-36 |
SMART |
|
ZnF_C2H2
|
343 |
365 |
4.4e-4 |
SMART |
|
ZnF_C2H2
|
396 |
418 |
6.7e-5 |
SMART |
|
ZnF_C2H2
|
424 |
446 |
1.3e-4 |
SMART |
|
ZnF_C2H2
|
452 |
474 |
2.5e-5 |
SMART |
|
ZnF_C2H2
|
480 |
502 |
7.9e-6 |
SMART |
|
ZnF_C2H2
|
508 |
530 |
2.2e-6 |
SMART |
|
ZnF_C2H2
|
536 |
558 |
7.7e-7 |
SMART |
|
ZnF_C2H2
|
564 |
586 |
8e-6 |
SMART |
|
ZnF_C2H2
|
592 |
614 |
8.9e-5 |
SMART |
|
ZnF_C2H2
|
620 |
642 |
6.6e-7 |
SMART |
|
ZnF_C2H2
|
648 |
670 |
2.2e-6 |
SMART |
|
ZnF_C2H2
|
676 |
698 |
7.1e-6 |
SMART |
|
ZnF_C2H2
|
704 |
726 |
1.1e-6 |
SMART |
|
ZnF_C2H2
|
732 |
754 |
4.8e-6 |
SMART |
|
ZnF_C2H2
|
760 |
780 |
1.6e-1 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000205077
|
| Coding Region Coverage |
- 1x: 99.3%
- 3x: 98.7%
- 10x: 97.3%
- 20x: 95.5%
|
| Validation Efficiency |
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 31 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 4930562C15Rik |
G |
A |
16: 4,682,227 (GRCm39) |
G180E |
probably damaging |
Het |
| 4933412E24Rik |
A |
G |
15: 59,886,917 (GRCm39) |
F508L |
probably benign |
Het |
| Acyp2 |
C |
T |
11: 30,456,354 (GRCm39) |
E98K |
possibly damaging |
Het |
| Amz1 |
A |
G |
5: 140,733,976 (GRCm39) |
Y184C |
probably damaging |
Het |
| Calm3 |
A |
T |
7: 16,651,619 (GRCm39) |
D23E |
possibly damaging |
Het |
| Cep112 |
T |
A |
11: 108,409,570 (GRCm39) |
N479K |
probably damaging |
Het |
| Cfap251 |
T |
C |
5: 123,436,695 (GRCm39) |
|
probably null |
Het |
| Csmd1 |
A |
C |
8: 16,011,486 (GRCm39) |
N2522K |
probably benign |
Het |
| Dhx30 |
A |
G |
9: 109,930,042 (GRCm39) |
L18P |
probably damaging |
Het |
| E2f2 |
A |
T |
4: 135,900,224 (GRCm39) |
T45S |
probably benign |
Het |
| Grk3 |
T |
C |
5: 113,117,074 (GRCm39) |
Y67C |
probably damaging |
Het |
| Htt |
T |
A |
5: 35,042,851 (GRCm39) |
C2290* |
probably null |
Het |
| Igsf10 |
T |
C |
3: 59,233,175 (GRCm39) |
T1853A |
probably damaging |
Het |
| Kmt2d |
G |
A |
15: 98,749,990 (GRCm39) |
|
probably benign |
Het |
| Mast2 |
A |
G |
4: 116,164,655 (GRCm39) |
L1587P |
probably damaging |
Het |
| Mdn1 |
A |
G |
4: 32,720,897 (GRCm39) |
N2337D |
probably benign |
Het |
| Mettl3 |
T |
C |
14: 52,537,336 (GRCm39) |
Q182R |
probably damaging |
Het |
| Mterf1b |
A |
G |
5: 4,246,541 (GRCm39) |
S61G |
probably benign |
Het |
| Mycbp2 |
T |
C |
14: 103,437,562 (GRCm39) |
Y2100C |
probably damaging |
Het |
| Nt5m |
T |
A |
11: 59,765,385 (GRCm39) |
W138R |
probably damaging |
Het |
| Or5g29 |
A |
G |
2: 85,421,640 (GRCm39) |
Y252C |
probably damaging |
Het |
| Prex1 |
A |
G |
2: 166,486,728 (GRCm39) |
Y114H |
probably benign |
Het |
| Rasa2 |
A |
T |
9: 96,453,971 (GRCm39) |
S322T |
probably damaging |
Het |
| Sis |
A |
T |
3: 72,857,171 (GRCm39) |
D373E |
probably damaging |
Het |
| Snx29 |
A |
T |
16: 11,328,876 (GRCm39) |
M552L |
possibly damaging |
Het |
| Sptbn1 |
G |
T |
11: 30,050,520 (GRCm39) |
F2356L |
possibly damaging |
Het |
| Tbc1d10c |
G |
T |
19: 4,238,052 (GRCm39) |
Q241K |
probably benign |
Het |
| Vmn1r222 |
A |
G |
13: 23,417,045 (GRCm39) |
I56T |
probably benign |
Het |
| Vmn2r111 |
T |
C |
17: 22,767,238 (GRCm39) |
Y753C |
probably damaging |
Het |
| Vmn2r37 |
A |
G |
7: 9,220,973 (GRCm39) |
W297R |
probably damaging |
Het |
| Zbtb47 |
G |
T |
9: 121,596,729 (GRCm39) |
R695L |
probably damaging |
Het |
|
| Other mutations in Zfp267 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL01524:Zfp267
|
APN |
3 |
36,218,729 (GRCm39) |
missense |
possibly damaging |
0.86 |
|
IGL02089:Zfp267
|
APN |
3 |
36,218,877 (GRCm39) |
missense |
possibly damaging |
0.53 |
|
IGL02162:Zfp267
|
APN |
3 |
36,218,210 (GRCm39) |
missense |
probably benign |
0.18 |
|
R0243:Zfp267
|
UTSW |
3 |
36,219,303 (GRCm39) |
missense |
possibly damaging |
0.47 |
|
R0512:Zfp267
|
UTSW |
3 |
36,220,262 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R0722:Zfp267
|
UTSW |
3 |
36,219,218 (GRCm39) |
missense |
probably benign |
0.35 |
|
R0762:Zfp267
|
UTSW |
3 |
36,220,016 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R0792:Zfp267
|
UTSW |
3 |
36,218,711 (GRCm39) |
missense |
probably benign |
0.01 |
|
R0894:Zfp267
|
UTSW |
3 |
36,218,935 (GRCm39) |
nonsense |
probably null |
|
|
R1731:Zfp267
|
UTSW |
3 |
36,218,620 (GRCm39) |
missense |
probably benign |
0.18 |
|
R2098:Zfp267
|
UTSW |
3 |
36,220,289 (GRCm39) |
missense |
probably benign |
|
|
R2099:Zfp267
|
UTSW |
3 |
36,218,361 (GRCm39) |
missense |
possibly damaging |
0.86 |
|
R3709:Zfp267
|
UTSW |
3 |
36,213,725 (GRCm39) |
missense |
possibly damaging |
0.71 |
|
R3808:Zfp267
|
UTSW |
3 |
36,219,792 (GRCm39) |
splice site |
probably null |
|
|
R4035:Zfp267
|
UTSW |
3 |
36,218,989 (GRCm39) |
missense |
possibly damaging |
0.53 |
|
R4288:Zfp267
|
UTSW |
3 |
36,213,747 (GRCm39) |
missense |
possibly damaging |
0.71 |
|
R4289:Zfp267
|
UTSW |
3 |
36,213,747 (GRCm39) |
missense |
possibly damaging |
0.71 |
|
R4959:Zfp267
|
UTSW |
3 |
36,218,285 (GRCm39) |
missense |
possibly damaging |
0.91 |
|
R4973:Zfp267
|
UTSW |
3 |
36,218,285 (GRCm39) |
missense |
possibly damaging |
0.91 |
|
R5102:Zfp267
|
UTSW |
3 |
36,216,814 (GRCm39) |
missense |
possibly damaging |
0.73 |
|
R5548:Zfp267
|
UTSW |
3 |
36,219,640 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
R5782:Zfp267
|
UTSW |
3 |
36,219,128 (GRCm39) |
missense |
possibly damaging |
0.73 |
|
R6153:Zfp267
|
UTSW |
3 |
36,219,303 (GRCm39) |
missense |
possibly damaging |
0.47 |
|
R6225:Zfp267
|
UTSW |
3 |
36,220,352 (GRCm39) |
missense |
probably benign |
0.18 |
|
R6602:Zfp267
|
UTSW |
3 |
36,219,004 (GRCm39) |
missense |
possibly damaging |
0.86 |
|
R6785:Zfp267
|
UTSW |
3 |
36,219,601 (GRCm39) |
nonsense |
probably null |
|
|
R7513:Zfp267
|
UTSW |
3 |
36,218,792 (GRCm39) |
missense |
possibly damaging |
0.53 |
|
R7846:Zfp267
|
UTSW |
3 |
36,219,738 (GRCm39) |
missense |
probably benign |
0.43 |
|
R8120:Zfp267
|
UTSW |
3 |
36,218,640 (GRCm39) |
missense |
possibly damaging |
0.96 |
|
R8265:Zfp267
|
UTSW |
3 |
36,213,677 (GRCm39) |
start gained |
probably benign |
|
|
R8415:Zfp267
|
UTSW |
3 |
36,219,182 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R8826:Zfp267
|
UTSW |
3 |
36,218,255 (GRCm39) |
missense |
possibly damaging |
0.86 |
|
R9026:Zfp267
|
UTSW |
3 |
36,219,066 (GRCm39) |
missense |
possibly damaging |
0.96 |
|
R9159:Zfp267
|
UTSW |
3 |
36,219,902 (GRCm39) |
missense |
possibly damaging |
0.47 |
|
R9786:Zfp267
|
UTSW |
3 |
36,219,853 (GRCm39) |
nonsense |
probably null |
|
|
X0021:Zfp267
|
UTSW |
3 |
36,218,340 (GRCm39) |
missense |
possibly damaging |
0.72 |
|
| Predicted Primers |
PCR Primer
(F):5'- GGCAAAGCCTTTAACCGTG -3'
(R):5'- GGAACTGGATTTAAAGGCGCC -3'
Sequencing Primer
(F):5'- GCAAAGCCTTTAACCGTGTATTTTTC -3'
(R):5'- ACCTCTGGGTAAAAGCCTTG -3'
|
| Posted On |
2016-10-06 |
Incidental Mutation