Incidental Mutation 'R5464:Selenbp1'
ID 433145
Institutional Source Beutler Lab
Gene Symbol Selenbp1
Ensembl Gene ENSMUSG00000068874
Gene Name selenium binding protein 1
Synonyms Lp56, Lpsb
MMRRC Submission 042850-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R5464 (G1)
Quality Score 107
Status Not validated
Chromosome 3
Chromosomal Location 94840394-94852069 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 94851727 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Methionine to Valine at position 423 (M423V)
Ref Sequence ENSEMBL: ENSMUSP00000088349 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000090839] [ENSMUST00000134202] [ENSMUST00000140757]
AlphaFold P17563
Predicted Effect probably benign
Transcript: ENSMUST00000090839
AA Change: M423V

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
SMART Domains Protein: ENSMUSP00000088349
Gene: ENSMUSG00000068874
AA Change: M423V

DomainStartEndE-ValueType
Pfam:SBP56 6 472 3.2e-225 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000134202
SMART Domains Protein: ENSMUSP00000120159
Gene: ENSMUSG00000068874

DomainStartEndE-ValueType
Pfam:SBP56 6 123 4.7e-56 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000139949
Predicted Effect probably benign
Transcript: ENSMUST00000140757
SMART Domains Protein: ENSMUSP00000118563
Gene: ENSMUSG00000068874

DomainStartEndE-ValueType
Pfam:SBP56 6 123 4.7e-56 PFAM
Coding Region Coverage
  • 1x: 99.3%
  • 3x: 98.6%
  • 10x: 97.2%
  • 20x: 95.2%
Validation Efficiency
MGI Phenotype PHENOTYPE: Mice homozygous for a knock-out allele exhibit sex-specific changes in organ weights. Mice homozygous for a different allele lack methanethiol oxidase activity and exhibit an increase in dimethylsulfide and dimethyl-sulfone serum levels. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 49 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4930562C15Rik G A 16: 4,682,227 (GRCm39) G180E probably damaging Het
Acsl1 T A 8: 46,958,775 (GRCm39) D95E probably benign Het
Acyp2 C T 11: 30,456,354 (GRCm39) E98K possibly damaging Het
Adamts16 T A 13: 70,909,868 (GRCm39) H895L probably benign Het
Alox12e T C 11: 70,208,505 (GRCm39) Y483C probably damaging Het
Atp13a2 T A 4: 140,733,381 (GRCm39) F952I probably damaging Het
Crot T G 5: 9,033,690 (GRCm39) probably null Het
Dnaja1 T A 4: 40,724,133 (GRCm39) M98K probably benign Het
Eps8 C T 6: 137,504,473 (GRCm39) G87R probably damaging Het
Flg2 C A 3: 93,109,277 (GRCm39) T435K possibly damaging Het
Gpatch4 T C 3: 87,962,062 (GRCm39) probably null Het
Heatr1 T A 13: 12,448,524 (GRCm39) M1795K probably benign Het
Ift52 T C 2: 162,871,735 (GRCm39) V189A probably benign Het
Kif21a T A 15: 90,878,058 (GRCm39) D250V probably damaging Het
Lrrc66 T C 5: 73,765,622 (GRCm39) T474A probably benign Het
Mcub T C 3: 129,709,365 (GRCm39) E316G probably benign Het
Mettl15 C T 2: 109,021,967 (GRCm39) V113I probably benign Het
Mroh8 T A 2: 157,063,150 (GRCm39) I824F probably damaging Het
Mrpl19 A G 6: 81,938,992 (GRCm39) M270T probably damaging Het
Naa12 C T 18: 80,255,138 (GRCm39) A144V probably damaging Het
Or10d4 A T 9: 39,581,066 (GRCm39) T238S probably damaging Het
Or4ac1-ps1 T C 2: 88,370,599 (GRCm39) Y58C probably null Het
Or51a25 A G 7: 102,373,124 (GRCm39) V191A possibly damaging Het
Or51a39 T C 7: 102,362,889 (GRCm39) T244A probably benign Het
Or51a43 C A 7: 103,717,674 (GRCm39) R188L possibly damaging Het
Or51f5 A G 7: 102,424,640 (GRCm39) K303R probably benign Het
Or52a24 T A 7: 103,381,396 (GRCm39) W88R probably damaging Het
Or5ak23 AAGTCTGGAGTC AAGTC 2: 85,245,057 (GRCm39) probably null Het
Or6x1 T C 9: 40,099,080 (GRCm39) I223T probably damaging Het
Pacs1 T C 19: 5,197,235 (GRCm39) M430V probably benign Het
Piezo2 A G 18: 63,278,176 (GRCm39) S243P probably damaging Het
Ppp1r36 A T 12: 76,474,852 (GRCm39) probably null Het
Prdm16 T A 4: 154,430,601 (GRCm39) probably null Het
Prss36 A T 7: 127,533,405 (GRCm39) W97R probably damaging Het
Psmg4 A T 13: 34,362,047 (GRCm39) I112F probably damaging Het
Ptpru C T 4: 131,499,868 (GRCm39) G1259R probably damaging Het
Rsph4a T C 10: 33,785,337 (GRCm39) I416T possibly damaging Het
Scn2a C T 2: 65,532,100 (GRCm39) R571C probably damaging Het
Serpina3i G A 12: 104,234,751 (GRCm39) A361T possibly damaging Het
Serpinb3c A T 1: 107,199,434 (GRCm39) D362E probably damaging Het
Sf3a3 T C 4: 124,622,033 (GRCm39) probably null Het
Sgcg A G 14: 61,474,304 (GRCm39) V113A possibly damaging Het
Slc3a2 T C 19: 8,691,008 (GRCm39) K74R probably damaging Het
Smco1 T A 16: 32,092,694 (GRCm39) W122R probably damaging Het
Snx19 A G 9: 30,339,269 (GRCm39) K136E possibly damaging Het
Trim32 A G 4: 65,532,625 (GRCm39) N394S probably damaging Het
Uqcrb T C 13: 67,048,889 (GRCm39) D87G probably damaging Het
Wipf3 T C 6: 54,462,308 (GRCm39) S173P possibly damaging Het
Zfp473 T C 7: 44,382,062 (GRCm39) E756G probably damaging Het
Other mutations in Selenbp1
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01970:Selenbp1 APN 3 94,844,313 (GRCm39) missense probably benign 0.24
IGL03281:Selenbp1 APN 3 94,844,621 (GRCm39) nonsense probably null
PIT4131001:Selenbp1 UTSW 3 94,844,607 (GRCm39) missense probably damaging 0.99
R0415:Selenbp1 UTSW 3 94,844,224 (GRCm39) missense possibly damaging 0.61
R1132:Selenbp1 UTSW 3 94,844,644 (GRCm39) missense probably benign 0.02
R1421:Selenbp1 UTSW 3 94,851,183 (GRCm39) missense probably benign
R1522:Selenbp1 UTSW 3 94,844,669 (GRCm39) missense probably damaging 1.00
R1676:Selenbp1 UTSW 3 94,851,854 (GRCm39) missense probably damaging 1.00
R1701:Selenbp1 UTSW 3 94,844,701 (GRCm39) missense probably damaging 1.00
R2152:Selenbp1 UTSW 3 94,851,441 (GRCm39) missense probably damaging 1.00
R3033:Selenbp1 UTSW 3 94,845,351 (GRCm39) missense probably benign 0.22
R4363:Selenbp1 UTSW 3 94,850,060 (GRCm39) splice site probably null
R4631:Selenbp1 UTSW 3 94,851,879 (GRCm39) makesense probably null
R4798:Selenbp1 UTSW 3 94,851,211 (GRCm39) missense probably benign 0.27
R4935:Selenbp1 UTSW 3 94,845,269 (GRCm39) missense probably benign 0.10
R6253:Selenbp1 UTSW 3 94,851,157 (GRCm39) missense possibly damaging 0.95
R6314:Selenbp1 UTSW 3 94,844,576 (GRCm39) missense probably damaging 1.00
R7199:Selenbp1 UTSW 3 94,851,745 (GRCm39) missense possibly damaging 0.79
R7330:Selenbp1 UTSW 3 94,847,021 (GRCm39) missense probably benign
R7637:Selenbp1 UTSW 3 94,844,659 (GRCm39) nonsense probably null
R7658:Selenbp1 UTSW 3 94,851,413 (GRCm39) missense probably benign 0.03
R8739:Selenbp1 UTSW 3 94,844,601 (GRCm39) missense probably damaging 0.99
R8803:Selenbp1 UTSW 3 94,851,821 (GRCm39) missense possibly damaging 0.88
R8987:Selenbp1 UTSW 3 94,847,425 (GRCm39) missense probably benign 0.10
R9145:Selenbp1 UTSW 3 94,851,414 (GRCm39) missense probably benign 0.38
R9209:Selenbp1 UTSW 3 94,847,079 (GRCm39) missense probably benign 0.08
R9747:Selenbp1 UTSW 3 94,844,648 (GRCm39) missense probably damaging 0.99
Predicted Primers
Posted On 2016-10-06