Incidental Mutation 'R5467:Trav13n-4'
ID 433295
Institutional Source Beutler Lab
Gene Symbol Trav13n-4
Ensembl Gene ENSMUSG00000076823
Gene Name T cell receptor alpha variable 13N-4
Synonyms Gm10907, ENSMUSG00000072517
MMRRC Submission 043028-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.072) question?
Stock # R5467 (G1)
Quality Score 225
Status Not validated
Chromosome 14
Chromosomal Location 53363836-53364102 bp(+) (GRCm38)
Type of Mutation missense
DNA Base Change (assembly) T to A at 53363846 bp (GRCm38)
Zygosity Heterozygous
Amino Acid Change Valine to Glutamic Acid at position 24 (V24E)
Ref Sequence ENSEMBL: ENSMUSP00000143372 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000103634] [ENSMUST00000196105]
AlphaFold A0A075B635
Predicted Effect probably damaging
Transcript: ENSMUST00000103634
AA Change: V4E

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
SMART Domains Protein: ENSMUSP00000100411
Gene: ENSMUSG00000076823
AA Change: V4E

DomainStartEndE-ValueType
IGv 18 89 2.89e-9 SMART
Predicted Effect probably damaging
Transcript: ENSMUST00000196105
AA Change: V24E

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
SMART Domains Protein: ENSMUSP00000143372
Gene: ENSMUSG00000076823
AA Change: V24E

DomainStartEndE-ValueType
signal peptide 1 19 N/A INTRINSIC
IGv 38 109 1.2e-11 SMART
Coding Region Coverage
  • 1x: 98.2%
  • 3x: 97.2%
  • 10x: 94.9%
  • 20x: 89.6%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 39 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Actn1 A G 12: 80,176,217 (GRCm38) M525T possibly damaging Het
Arpc5l T C 2: 39,013,739 (GRCm38) V80A possibly damaging Het
Atp7b G A 8: 22,011,554 (GRCm38) T781I probably damaging Het
Celsr3 A T 9: 108,828,637 (GRCm38) D773V probably damaging Het
Clcn6 A T 4: 148,017,636 (GRCm38) H330Q possibly damaging Het
Cwc22 ATCTCTCTCTCTCTCTCT ATCTCTCTCTCTCTCT 2: 77,929,459 (GRCm38) probably null Het
D430042O09Rik T C 7: 125,843,355 (GRCm38) F812S possibly damaging Het
Dmbt1 C A 7: 131,040,993 (GRCm38) S180R probably damaging Het
Dnase1l1 C T X: 74,277,038 (GRCm38) probably null Het
Dusp27 C A 1: 166,112,030 (GRCm38) probably null Het
Elovl7 T C 13: 108,279,622 (GRCm38) V182A probably benign Het
Eml3 G A 19: 8,937,582 (GRCm38) W601* probably null Het
Farp1 C T 14: 121,235,077 (GRCm38) P208L probably damaging Het
Fras1 A T 5: 96,780,053 (GRCm38) Y3775F probably benign Het
Gm884 G T 11: 103,603,265 (GRCm38) C655* probably null Het
Gns T C 10: 121,391,446 (GRCm38) W454R probably benign Het
Kcnh2 A T 5: 24,326,767 (GRCm38) L40* probably null Het
Kmt2d G A 15: 98,852,109 (GRCm38) probably benign Het
Mgl2 T A 11: 70,135,052 (GRCm38) I31N possibly damaging Het
Muc6 T C 7: 141,636,535 (GRCm38) T2677A possibly damaging Het
Ndst1 A G 18: 60,692,021 (GRCm38) S742P probably benign Het
Olfr108 G T 17: 37,446,082 (GRCm38) C187F probably damaging Het
Olfr1428 A C 19: 12,108,659 (GRCm38) S70A probably benign Het
Olfr1466 A T 19: 13,342,157 (GRCm38) Y133F probably damaging Het
Olfr935 T C 9: 38,994,904 (GRCm38) Y177C probably benign Het
Olfr981 G T 9: 40,022,437 (GRCm38) V15L probably benign Het
Pcdhb22 A G 18: 37,520,135 (GRCm38) D552G probably benign Het
Pikfyve T A 1: 65,252,495 (GRCm38) V1291E probably damaging Het
Ppp4r3a T C 12: 101,043,470 (GRCm38) E636G probably damaging Het
Prl5a1 A T 13: 28,150,011 (GRCm38) I166L possibly damaging Het
Rb1 T C 14: 73,211,620 (GRCm38) D690G possibly damaging Het
Sh3tc2 A G 18: 61,990,688 (GRCm38) H840R possibly damaging Het
Skida1 T C 2: 18,046,112 (GRCm38) probably benign Het
Slc31a2 A G 4: 62,292,687 (GRCm38) H19R probably damaging Het
Tnks2 A T 19: 36,881,776 (GRCm38) R314W probably damaging Het
Trak1 A G 9: 121,446,798 (GRCm38) D189G probably damaging Het
Uhrf1bp1l G T 10: 89,805,099 (GRCm38) G711W probably damaging Het
Ylpm1 T C 12: 84,996,859 (GRCm38) Y124H unknown Het
Zfp703 C T 8: 26,979,205 (GRCm38) P299L probably damaging Het
Other mutations in Trav13n-4
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00429:Trav13n-4 APN 14 53,363,831 (GRCm38) missense probably benign 0.03
IGL00562:Trav13n-4 APN 14 53,363,966 (GRCm38) missense possibly damaging 0.94
IGL00563:Trav13n-4 APN 14 53,363,966 (GRCm38) missense possibly damaging 0.94
IGL01620:Trav13n-4 APN 14 53,364,016 (GRCm38) missense probably damaging 0.99
IGL01748:Trav13n-4 APN 14 53,364,013 (GRCm38) missense probably benign 0.15
IGL02327:Trav13n-4 APN 14 53,364,110 (GRCm38) unclassified probably benign
R4197:Trav13n-4 UTSW 14 53,363,921 (GRCm38) missense probably benign
R6765:Trav13n-4 UTSW 14 53,364,100 (GRCm38) missense probably benign
R6845:Trav13n-4 UTSW 14 53,362,399 (GRCm38) missense probably damaging 1.00
R7339:Trav13n-4 UTSW 14 53,363,978 (GRCm38) missense probably benign 0.02
R8744:Trav13n-4 UTSW 14 53,363,942 (GRCm38) missense probably damaging 0.99
Predicted Primers PCR Primer
(F):5'- CCAGAGTGGTTGTACAAGCTTG -3'
(R):5'- GTTGTGGATGTCAGTCTCCCAC -3'

Sequencing Primer
(F):5'- GGTTGTACAAGCTTGCAATCC -3'
(R):5'- ACTCTGCTTTGTCCCAGAAGG -3'
Posted On 2016-10-06