Incidental Mutation 'R5529:Zfp655'
ID 433574
Institutional Source Beutler Lab
Gene Symbol Zfp655
Ensembl Gene ENSMUSG00000007812
Gene Name zinc finger protein 655
Synonyms 2700038I16Rik, 9030409O18Rik
MMRRC Submission 043087-MU
Accession Numbers
Essential gene? Possibly non essential (E-score: 0.451) question?
Stock # R5529 (G1)
Quality Score 225
Status Not validated
Chromosome 5
Chromosomal Location 145168525-145184112 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 145181546 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Glutamic Acid to Glycine at position 468 (E468G)
Ref Sequence ENSEMBL: ENSMUSP00000128969 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000167316] [ENSMUST00000199322]
AlphaFold Q9CZP3
Predicted Effect probably damaging
Transcript: ENSMUST00000167316
AA Change: E468G

PolyPhen 2 Score 0.959 (Sensitivity: 0.78; Specificity: 0.95)
SMART Domains Protein: ENSMUSP00000128969
Gene: ENSMUSG00000007812
AA Change: E468G

DomainStartEndE-ValueType
ZnF_C2H2 243 265 5.29e-5 SMART
ZnF_C2H2 271 293 2.99e-4 SMART
ZnF_C2H2 299 328 1.38e2 SMART
ZnF_C2H2 334 356 6.78e-3 SMART
ZnF_C2H2 361 383 3.99e0 SMART
ZnF_C2H2 411 433 3.63e-3 SMART
ZnF_C2H2 439 461 1.01e-1 SMART
low complexity region 463 475 N/A INTRINSIC
ZnF_C2H2 495 517 6.47e1 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000199322
Coding Region Coverage
  • 1x: 98.7%
  • 3x: 97.5%
  • 10x: 95.7%
  • 20x: 92.5%
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a zinc finger protein. The zinc finger proteins are involved in DNA binding and protein-protein interactions. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 48 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abca12 T C 1: 71,304,040 (GRCm39) Y2079C probably damaging Het
Alg2 T C 4: 47,472,101 (GRCm39) R236G probably damaging Het
Alpl T A 4: 137,473,733 (GRCm39) N323I probably damaging Het
Anxa3 A G 5: 96,976,238 (GRCm39) E172G probably benign Het
Atp8a2 A G 14: 60,031,314 (GRCm39) probably null Het
Cadps T C 14: 12,454,285 (GRCm38) K1078E probably damaging Het
Ccn5 T C 2: 163,667,279 (GRCm39) probably null Het
Ces2e G T 8: 105,656,543 (GRCm39) V258L probably benign Het
Daam2 A G 17: 49,766,085 (GRCm39) F1041S probably benign Het
Dcstamp A G 15: 39,617,932 (GRCm39) I114V probably benign Het
Ddhd2 C T 8: 26,229,587 (GRCm39) R496Q probably benign Het
Dnhd1 G A 7: 105,352,416 (GRCm39) R2523Q probably damaging Het
Eml6 T A 11: 29,714,126 (GRCm39) R1335S probably benign Het
F12 T C 13: 55,569,872 (GRCm39) N102S probably benign Het
Fbn1 G A 2: 125,215,870 (GRCm39) L712F probably benign Het
Fgf1 G T 18: 38,991,657 (GRCm39) F37L probably damaging Het
Fgf14 T A 14: 124,217,867 (GRCm39) H212L probably damaging Het
Gm10036 A T 18: 15,965,858 (GRCm39) Q3L probably benign Het
Hivep1 T C 13: 42,310,126 (GRCm39) F789L possibly damaging Het
Hspg2 C A 4: 137,279,139 (GRCm39) T3074N probably damaging Het
Katnb1 C T 8: 95,824,300 (GRCm39) R495C probably damaging Het
Kdm5b C T 1: 134,515,741 (GRCm39) H122Y probably damaging Het
Ky C T 9: 102,419,274 (GRCm39) S427L probably benign Het
Med9 T G 11: 59,851,486 (GRCm39) V105G probably benign Het
Ndufa11 T A 17: 57,028,059 (GRCm39) V43D probably damaging Het
Nlrp4b T A 7: 10,448,873 (GRCm39) C359S possibly damaging Het
Or12k8 T A 2: 36,974,921 (GRCm39) I280F possibly damaging Het
Or51e1 A T 7: 102,358,900 (GRCm39) K145* probably null Het
Paxbp1 T A 16: 90,827,401 (GRCm39) Y478F possibly damaging Het
Pole G A 5: 110,480,332 (GRCm39) E92K probably benign Het
Prom1 G T 5: 44,184,110 (GRCm39) L449M probably damaging Het
Psg28 G A 7: 18,164,373 (GRCm39) T113I probably benign Het
Reln A C 5: 22,137,713 (GRCm39) V2493G possibly damaging Het
Rp1 C T 1: 4,416,055 (GRCm39) V1686I probably benign Het
Setbp1 T C 18: 79,129,867 (GRCm39) I122V probably damaging Het
Setd5 T C 6: 113,098,529 (GRCm39) Y721H probably damaging Het
Shroom1 T C 11: 53,354,749 (GRCm39) F223S probably damaging Het
Son T A 16: 91,452,354 (GRCm39) L367Q probably damaging Het
Spred2 G T 11: 19,971,301 (GRCm39) D363Y probably damaging Het
Tbc1d8 T G 1: 39,411,836 (GRCm39) Y1000S probably benign Het
Tdp2 A T 13: 25,022,219 (GRCm39) K213* probably null Het
Tmem89 T C 9: 108,744,545 (GRCm39) I146T probably damaging Het
Vhl T C 6: 113,606,424 (GRCm39) V147A probably benign Het
Vmn2r23 C T 6: 123,690,410 (GRCm39) L429F probably benign Het
Vrk2 T C 11: 26,449,036 (GRCm39) D186G probably damaging Het
Zbtb40 A G 4: 136,710,474 (GRCm39) F1222L possibly damaging Het
Zfp266 A G 9: 20,418,030 (GRCm39) S7P probably damaging Het
Zfp472 T A 17: 33,197,407 (GRCm39) I494K possibly damaging Het
Other mutations in Zfp655
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00639:Zfp655 APN 5 145,180,955 (GRCm39) missense probably damaging 1.00
IGL01679:Zfp655 APN 5 145,180,637 (GRCm39) missense probably damaging 0.96
IGL02379:Zfp655 APN 5 145,180,765 (GRCm39) missense probably benign 0.13
IGL02647:Zfp655 APN 5 145,179,816 (GRCm39) missense probably benign
R0104:Zfp655 UTSW 5 145,180,825 (GRCm39) missense probably damaging 1.00
R0104:Zfp655 UTSW 5 145,180,825 (GRCm39) missense probably damaging 1.00
R0270:Zfp655 UTSW 5 145,181,267 (GRCm39) missense probably damaging 1.00
R0608:Zfp655 UTSW 5 145,180,867 (GRCm39) missense possibly damaging 0.57
R1528:Zfp655 UTSW 5 145,181,411 (GRCm39) missense probably damaging 0.98
R2076:Zfp655 UTSW 5 145,181,410 (GRCm39) missense possibly damaging 0.89
R2119:Zfp655 UTSW 5 145,181,594 (GRCm39) missense probably damaging 0.98
R2375:Zfp655 UTSW 5 145,181,206 (GRCm39) missense probably benign 0.10
R2403:Zfp655 UTSW 5 145,181,356 (GRCm39) missense probably benign 0.00
R4032:Zfp655 UTSW 5 145,180,858 (GRCm39) missense possibly damaging 0.50
R4532:Zfp655 UTSW 5 145,181,507 (GRCm39) missense probably benign 0.06
R4880:Zfp655 UTSW 5 145,181,168 (GRCm39) missense probably damaging 0.99
R5484:Zfp655 UTSW 5 145,180,445 (GRCm39) missense probably benign 0.01
R6193:Zfp655 UTSW 5 145,181,586 (GRCm39) missense probably benign 0.03
R6195:Zfp655 UTSW 5 145,180,572 (GRCm39) missense possibly damaging 0.52
R7050:Zfp655 UTSW 5 145,181,545 (GRCm39) missense probably benign 0.12
R7471:Zfp655 UTSW 5 145,181,542 (GRCm39) missense possibly damaging 0.80
R7612:Zfp655 UTSW 5 145,173,999 (GRCm39) missense unknown
R7626:Zfp655 UTSW 5 145,173,917 (GRCm39) missense probably damaging 1.00
R7989:Zfp655 UTSW 5 145,181,380 (GRCm39) missense probably damaging 1.00
R8557:Zfp655 UTSW 5 145,180,835 (GRCm39) missense probably benign 0.37
R8805:Zfp655 UTSW 5 145,181,290 (GRCm39) missense probably damaging 1.00
R9602:Zfp655 UTSW 5 145,181,473 (GRCm39) missense probably benign 0.00
R9664:Zfp655 UTSW 5 145,180,442 (GRCm39) missense probably damaging 1.00
Z1176:Zfp655 UTSW 5 145,180,813 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- ATGATGAATGTGGGCTGGCC -3'
(R):5'- GAACTTGACTAAATGTCTCCCCAAG -3'

Sequencing Primer
(F):5'- TGGGCTGGCCTATGTTAAACAAC -3'
(R):5'- CCAAGTTCACTGCATTCATAAGG -3'
Posted On 2016-10-06