Incidental Mutation 'R5529:Zfp266'
ID 433585
Institutional Source Beutler Lab
Gene Symbol Zfp266
Ensembl Gene ENSMUSG00000060510
Gene Name zinc finger protein 266
Synonyms 5330440G10Rik, 5730601F06Rik
MMRRC Submission 043087-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.087) question?
Stock # R5529 (G1)
Quality Score 190
Status Not validated
Chromosome 9
Chromosomal Location 20406364-20432713 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 20418030 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Serine to Proline at position 7 (S7P)
Ref Sequence ENSEMBL: ENSMUSP00000134217 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000068296] [ENSMUST00000174462] [ENSMUST00000213418] [ENSMUST00000215908]
AlphaFold E9Q2S7
Predicted Effect probably damaging
Transcript: ENSMUST00000068296
AA Change: S7P

PolyPhen 2 Score 0.989 (Sensitivity: 0.72; Specificity: 0.97)
SMART Domains Protein: ENSMUSP00000066012
Gene: ENSMUSG00000060510
AA Change: S7P

DomainStartEndE-ValueType
KRAB 41 101 1.4e-27 SMART
internal_repeat_1 138 318 2.7e-16 PROSPERO
ZnF_C2H2 343 365 7.78e-3 SMART
ZnF_C2H2 371 393 1.98e-4 SMART
ZnF_C2H2 399 421 2.27e-4 SMART
ZnF_C2H2 427 449 2.47e-5 SMART
ZnF_C2H2 455 477 2.99e-4 SMART
ZnF_C2H2 483 505 1.47e-3 SMART
ZnF_C2H2 511 533 5.81e-2 SMART
ZnF_C2H2 539 561 2.79e-4 SMART
ZnF_C2H2 567 589 2.09e-3 SMART
Predicted Effect probably damaging
Transcript: ENSMUST00000174462
AA Change: S7P

PolyPhen 2 Score 0.989 (Sensitivity: 0.72; Specificity: 0.97)
SMART Domains Protein: ENSMUSP00000134217
Gene: ENSMUSG00000060510
AA Change: S7P

DomainStartEndE-ValueType
KRAB 41 101 1.4e-27 SMART
internal_repeat_1 138 318 2.7e-16 PROSPERO
ZnF_C2H2 343 365 7.78e-3 SMART
ZnF_C2H2 371 393 1.98e-4 SMART
ZnF_C2H2 399 421 2.27e-4 SMART
ZnF_C2H2 427 449 2.47e-5 SMART
ZnF_C2H2 455 477 2.99e-4 SMART
ZnF_C2H2 483 505 1.47e-3 SMART
ZnF_C2H2 511 533 5.81e-2 SMART
ZnF_C2H2 539 561 2.79e-4 SMART
ZnF_C2H2 567 589 2.09e-3 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000180846
Predicted Effect unknown
Transcript: ENSMUST00000213418
AA Change: S7P
Predicted Effect probably benign
Transcript: ENSMUST00000215908
Predicted Effect noncoding transcript
Transcript: ENSMUST00000217488
Coding Region Coverage
  • 1x: 98.7%
  • 3x: 97.5%
  • 10x: 95.7%
  • 20x: 92.5%
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a protein containing many tandem zinc-finger motifs. Zinc fingers are protein or nucleic acid-binding domains, and may be involved in a variety of functions, including regulation of transcription. This gene is located in a cluster of similar genes encoding zinc finger proteins on chromosome 19. Alternative splicing results in multiple transcript variants for this gene. [provided by RefSeq, Sep 2012]
Allele List at MGI
Other mutations in this stock
Total: 48 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abca12 T C 1: 71,304,040 (GRCm39) Y2079C probably damaging Het
Alg2 T C 4: 47,472,101 (GRCm39) R236G probably damaging Het
Alpl T A 4: 137,473,733 (GRCm39) N323I probably damaging Het
Anxa3 A G 5: 96,976,238 (GRCm39) E172G probably benign Het
Atp8a2 A G 14: 60,031,314 (GRCm39) probably null Het
Cadps T C 14: 12,454,285 (GRCm38) K1078E probably damaging Het
Ccn5 T C 2: 163,667,279 (GRCm39) probably null Het
Ces2e G T 8: 105,656,543 (GRCm39) V258L probably benign Het
Daam2 A G 17: 49,766,085 (GRCm39) F1041S probably benign Het
Dcstamp A G 15: 39,617,932 (GRCm39) I114V probably benign Het
Ddhd2 C T 8: 26,229,587 (GRCm39) R496Q probably benign Het
Dnhd1 G A 7: 105,352,416 (GRCm39) R2523Q probably damaging Het
Eml6 T A 11: 29,714,126 (GRCm39) R1335S probably benign Het
F12 T C 13: 55,569,872 (GRCm39) N102S probably benign Het
Fbn1 G A 2: 125,215,870 (GRCm39) L712F probably benign Het
Fgf1 G T 18: 38,991,657 (GRCm39) F37L probably damaging Het
Fgf14 T A 14: 124,217,867 (GRCm39) H212L probably damaging Het
Gm10036 A T 18: 15,965,858 (GRCm39) Q3L probably benign Het
Hivep1 T C 13: 42,310,126 (GRCm39) F789L possibly damaging Het
Hspg2 C A 4: 137,279,139 (GRCm39) T3074N probably damaging Het
Katnb1 C T 8: 95,824,300 (GRCm39) R495C probably damaging Het
Kdm5b C T 1: 134,515,741 (GRCm39) H122Y probably damaging Het
Ky C T 9: 102,419,274 (GRCm39) S427L probably benign Het
Med9 T G 11: 59,851,486 (GRCm39) V105G probably benign Het
Ndufa11 T A 17: 57,028,059 (GRCm39) V43D probably damaging Het
Nlrp4b T A 7: 10,448,873 (GRCm39) C359S possibly damaging Het
Or12k8 T A 2: 36,974,921 (GRCm39) I280F possibly damaging Het
Or51e1 A T 7: 102,358,900 (GRCm39) K145* probably null Het
Paxbp1 T A 16: 90,827,401 (GRCm39) Y478F possibly damaging Het
Pole G A 5: 110,480,332 (GRCm39) E92K probably benign Het
Prom1 G T 5: 44,184,110 (GRCm39) L449M probably damaging Het
Psg28 G A 7: 18,164,373 (GRCm39) T113I probably benign Het
Reln A C 5: 22,137,713 (GRCm39) V2493G possibly damaging Het
Rp1 C T 1: 4,416,055 (GRCm39) V1686I probably benign Het
Setbp1 T C 18: 79,129,867 (GRCm39) I122V probably damaging Het
Setd5 T C 6: 113,098,529 (GRCm39) Y721H probably damaging Het
Shroom1 T C 11: 53,354,749 (GRCm39) F223S probably damaging Het
Son T A 16: 91,452,354 (GRCm39) L367Q probably damaging Het
Spred2 G T 11: 19,971,301 (GRCm39) D363Y probably damaging Het
Tbc1d8 T G 1: 39,411,836 (GRCm39) Y1000S probably benign Het
Tdp2 A T 13: 25,022,219 (GRCm39) K213* probably null Het
Tmem89 T C 9: 108,744,545 (GRCm39) I146T probably damaging Het
Vhl T C 6: 113,606,424 (GRCm39) V147A probably benign Het
Vmn2r23 C T 6: 123,690,410 (GRCm39) L429F probably benign Het
Vrk2 T C 11: 26,449,036 (GRCm39) D186G probably damaging Het
Zbtb40 A G 4: 136,710,474 (GRCm39) F1222L possibly damaging Het
Zfp472 T A 17: 33,197,407 (GRCm39) I494K possibly damaging Het
Zfp655 A G 5: 145,181,546 (GRCm39) E468G probably damaging Het
Other mutations in Zfp266
AlleleSourceChrCoordTypePredicted EffectPPH Score
PIT4453001:Zfp266 UTSW 9 20,417,299 (GRCm39) missense probably benign
R0744:Zfp266 UTSW 9 20,411,095 (GRCm39) missense probably damaging 1.00
R0836:Zfp266 UTSW 9 20,411,095 (GRCm39) missense probably damaging 1.00
R2180:Zfp266 UTSW 9 20,410,975 (GRCm39) missense probably damaging 1.00
R2422:Zfp266 UTSW 9 20,410,558 (GRCm39) missense possibly damaging 0.89
R3085:Zfp266 UTSW 9 20,412,240 (GRCm39) missense probably damaging 0.99
R3791:Zfp266 UTSW 9 20,410,777 (GRCm39) missense probably damaging 0.99
R3972:Zfp266 UTSW 9 20,411,446 (GRCm39) missense probably damaging 1.00
R5378:Zfp266 UTSW 9 20,410,659 (GRCm39) missense probably damaging 1.00
R5788:Zfp266 UTSW 9 20,417,332 (GRCm39) missense probably damaging 0.98
R6476:Zfp266 UTSW 9 20,410,577 (GRCm39) missense probably damaging 1.00
R6901:Zfp266 UTSW 9 20,410,895 (GRCm39) nonsense probably null
R7326:Zfp266 UTSW 9 20,413,391 (GRCm39) missense probably benign 0.03
R7417:Zfp266 UTSW 9 20,412,232 (GRCm39) missense probably benign
R7783:Zfp266 UTSW 9 20,411,626 (GRCm39) missense probably benign 0.04
R7917:Zfp266 UTSW 9 20,416,423 (GRCm39) missense probably benign 0.00
R7947:Zfp266 UTSW 9 20,410,548 (GRCm39) missense probably benign 0.00
R8174:Zfp266 UTSW 9 20,418,110 (GRCm39) start gained probably benign
R8194:Zfp266 UTSW 9 20,411,610 (GRCm39) missense probably benign 0.05
R8776:Zfp266 UTSW 9 20,411,509 (GRCm39) missense probably benign 0.03
R8776-TAIL:Zfp266 UTSW 9 20,411,509 (GRCm39) missense probably benign 0.03
R8872:Zfp266 UTSW 9 20,411,275 (GRCm39) missense probably benign 0.22
R9096:Zfp266 UTSW 9 20,416,440 (GRCm39) missense probably damaging 1.00
R9220:Zfp266 UTSW 9 20,413,337 (GRCm39) nonsense probably null
R9284:Zfp266 UTSW 9 20,411,300 (GRCm39) nonsense probably null
R9502:Zfp266 UTSW 9 20,413,413 (GRCm39) nonsense probably null
R9547:Zfp266 UTSW 9 20,411,746 (GRCm39) missense probably benign 0.40
R9550:Zfp266 UTSW 9 20,410,482 (GRCm39) missense probably damaging 1.00
R9752:Zfp266 UTSW 9 20,411,496 (GRCm39) missense probably benign 0.15
Predicted Primers PCR Primer
(F):5'- TCGCAAGCATACATCCTGGG -3'
(R):5'- TTATCTGCAGAGAGTGAGCACTAC -3'

Sequencing Primer
(F):5'- GCATACATCCTGGGACCCTAAATC -3'
(R):5'- AGAGTGAGCACTACTGTGTGATG -3'
Posted On 2016-10-06