Incidental Mutation 'R5529:Spred2'
ID 433588
Institutional Source Beutler Lab
Gene Symbol Spred2
Ensembl Gene ENSMUSG00000045671
Gene Name sprouty-related EVH1 domain containing 2
Synonyms Spred-2
MMRRC Submission 043087-MU
Accession Numbers
Essential gene? Possibly non essential (E-score: 0.442) question?
Stock # R5529 (G1)
Quality Score 225
Status Not validated
Chromosome 11
Chromosomal Location 19874442-19974026 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) G to T at 19971301 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Aspartic acid to Tyrosine at position 363 (D363Y)
Ref Sequence ENSEMBL: ENSMUSP00000090987 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000093298] [ENSMUST00000093299] [ENSMUST00000123036]
AlphaFold Q924S7
Predicted Effect probably damaging
Transcript: ENSMUST00000093298
AA Change: D363Y

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
SMART Domains Protein: ENSMUSP00000090987
Gene: ENSMUSG00000045671
AA Change: D363Y

DomainStartEndE-ValueType
Pfam:WH1 6 119 4.7e-13 PFAM
Pfam:Sprouty 298 403 3.8e-44 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000093299
AA Change: D390Y

PolyPhen 2 Score 0.997 (Sensitivity: 0.41; Specificity: 0.98)
SMART Domains Protein: ENSMUSP00000090988
Gene: ENSMUSG00000045671
AA Change: D390Y

DomainStartEndE-ValueType
Pfam:WH1 91 146 4.1e-10 PFAM
Pfam:Sprouty 325 430 8.6e-29 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000123036
SMART Domains Protein: ENSMUSP00000115103
Gene: ENSMUSG00000045671

DomainStartEndE-ValueType
Pfam:WH1 120 175 1.5e-10 PFAM
Coding Region Coverage
  • 1x: 98.7%
  • 3x: 97.5%
  • 10x: 95.7%
  • 20x: 92.5%
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] SPRED2 is a member of the Sprouty (see SPRY1; MIM 602465)/SPRED family of proteins that regulate growth factor-induced activation of the MAP kinase cascade (see MAPK1; MIM 176948) (Nonami et al., 2004 [PubMed 15465815]).[supplied by OMIM, Mar 2008]
PHENOTYPE: Homozygous null mice are fertile and display increased hematopoietic cell formation in culture. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 48 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abca12 T C 1: 71,304,040 (GRCm39) Y2079C probably damaging Het
Alg2 T C 4: 47,472,101 (GRCm39) R236G probably damaging Het
Alpl T A 4: 137,473,733 (GRCm39) N323I probably damaging Het
Anxa3 A G 5: 96,976,238 (GRCm39) E172G probably benign Het
Atp8a2 A G 14: 60,031,314 (GRCm39) probably null Het
Cadps T C 14: 12,454,285 (GRCm38) K1078E probably damaging Het
Ccn5 T C 2: 163,667,279 (GRCm39) probably null Het
Ces2e G T 8: 105,656,543 (GRCm39) V258L probably benign Het
Daam2 A G 17: 49,766,085 (GRCm39) F1041S probably benign Het
Dcstamp A G 15: 39,617,932 (GRCm39) I114V probably benign Het
Ddhd2 C T 8: 26,229,587 (GRCm39) R496Q probably benign Het
Dnhd1 G A 7: 105,352,416 (GRCm39) R2523Q probably damaging Het
Eml6 T A 11: 29,714,126 (GRCm39) R1335S probably benign Het
F12 T C 13: 55,569,872 (GRCm39) N102S probably benign Het
Fbn1 G A 2: 125,215,870 (GRCm39) L712F probably benign Het
Fgf1 G T 18: 38,991,657 (GRCm39) F37L probably damaging Het
Fgf14 T A 14: 124,217,867 (GRCm39) H212L probably damaging Het
Gm10036 A T 18: 15,965,858 (GRCm39) Q3L probably benign Het
Hivep1 T C 13: 42,310,126 (GRCm39) F789L possibly damaging Het
Hspg2 C A 4: 137,279,139 (GRCm39) T3074N probably damaging Het
Katnb1 C T 8: 95,824,300 (GRCm39) R495C probably damaging Het
Kdm5b C T 1: 134,515,741 (GRCm39) H122Y probably damaging Het
Ky C T 9: 102,419,274 (GRCm39) S427L probably benign Het
Med9 T G 11: 59,851,486 (GRCm39) V105G probably benign Het
Ndufa11 T A 17: 57,028,059 (GRCm39) V43D probably damaging Het
Nlrp4b T A 7: 10,448,873 (GRCm39) C359S possibly damaging Het
Or12k8 T A 2: 36,974,921 (GRCm39) I280F possibly damaging Het
Or51e1 A T 7: 102,358,900 (GRCm39) K145* probably null Het
Paxbp1 T A 16: 90,827,401 (GRCm39) Y478F possibly damaging Het
Pole G A 5: 110,480,332 (GRCm39) E92K probably benign Het
Prom1 G T 5: 44,184,110 (GRCm39) L449M probably damaging Het
Psg28 G A 7: 18,164,373 (GRCm39) T113I probably benign Het
Reln A C 5: 22,137,713 (GRCm39) V2493G possibly damaging Het
Rp1 C T 1: 4,416,055 (GRCm39) V1686I probably benign Het
Setbp1 T C 18: 79,129,867 (GRCm39) I122V probably damaging Het
Setd5 T C 6: 113,098,529 (GRCm39) Y721H probably damaging Het
Shroom1 T C 11: 53,354,749 (GRCm39) F223S probably damaging Het
Son T A 16: 91,452,354 (GRCm39) L367Q probably damaging Het
Tbc1d8 T G 1: 39,411,836 (GRCm39) Y1000S probably benign Het
Tdp2 A T 13: 25,022,219 (GRCm39) K213* probably null Het
Tmem89 T C 9: 108,744,545 (GRCm39) I146T probably damaging Het
Vhl T C 6: 113,606,424 (GRCm39) V147A probably benign Het
Vmn2r23 C T 6: 123,690,410 (GRCm39) L429F probably benign Het
Vrk2 T C 11: 26,449,036 (GRCm39) D186G probably damaging Het
Zbtb40 A G 4: 136,710,474 (GRCm39) F1222L possibly damaging Het
Zfp266 A G 9: 20,418,030 (GRCm39) S7P probably damaging Het
Zfp472 T A 17: 33,197,407 (GRCm39) I494K possibly damaging Het
Zfp655 A G 5: 145,181,546 (GRCm39) E468G probably damaging Het
Other mutations in Spred2
AlleleSourceChrCoordTypePredicted EffectPPH Score
R0512:Spred2 UTSW 11 19,958,485 (GRCm39) splice site probably benign
R0944:Spred2 UTSW 11 19,951,104 (GRCm39) splice site probably benign
R1467:Spred2 UTSW 11 19,968,109 (GRCm39) missense probably benign 0.00
R1467:Spred2 UTSW 11 19,968,109 (GRCm39) missense probably benign 0.00
R2156:Spred2 UTSW 11 19,971,241 (GRCm39) missense probably damaging 1.00
R2915:Spred2 UTSW 11 19,948,215 (GRCm39) missense probably damaging 1.00
R3433:Spred2 UTSW 11 19,948,277 (GRCm39) nonsense probably null
R4839:Spred2 UTSW 11 19,948,233 (GRCm39) missense possibly damaging 0.53
R5100:Spred2 UTSW 11 19,971,291 (GRCm39) nonsense probably null
R5353:Spred2 UTSW 11 19,968,155 (GRCm39) missense possibly damaging 0.82
R5709:Spred2 UTSW 11 19,971,415 (GRCm39) missense probably damaging 1.00
R6978:Spred2 UTSW 11 19,948,254 (GRCm39) missense possibly damaging 0.73
R7345:Spred2 UTSW 11 19,874,958 (GRCm39) critical splice donor site probably null
R8073:Spred2 UTSW 11 19,958,422 (GRCm39) missense probably benign 0.45
R8847:Spred2 UTSW 11 19,951,064 (GRCm39) missense probably benign 0.03
R8888:Spred2 UTSW 11 19,951,019 (GRCm39) missense probably benign 0.11
R8895:Spred2 UTSW 11 19,951,019 (GRCm39) missense probably benign 0.11
X0025:Spred2 UTSW 11 19,948,234 (GRCm39) missense probably benign 0.01
Predicted Primers PCR Primer
(F):5'- TGTGATCAAGACACAGCCG -3'
(R):5'- AAGAGACAAGTTGCCCGTGG -3'

Sequencing Primer
(F):5'- GTACTGCAGGGATATGTTTAATCACG -3'
(R):5'- TGGCCGTGGATGGAGAAGC -3'
Posted On 2016-10-06