Incidental Mutation 'R5529:Vrk2'
ID 433589
Institutional Source Beutler Lab
Gene Symbol Vrk2
Ensembl Gene ENSMUSG00000064090
Gene Name vaccinia related kinase 2
Synonyms 2810003O05Rik
MMRRC Submission 043087-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.235) question?
Stock # R5529 (G1)
Quality Score 225
Status Not validated
Chromosome 11
Chromosomal Location 26421398-26544006 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 26449036 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Aspartic acid to Glycine at position 186 (D186G)
Ref Sequence ENSEMBL: ENSMUSP00000105130 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000078362] [ENSMUST00000109504]
AlphaFold Q8BN21
Predicted Effect probably damaging
Transcript: ENSMUST00000078362
AA Change: D186G

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000077471
Gene: ENSMUSG00000064090
AA Change: D186G

DomainStartEndE-ValueType
Pfam:Pkinase 29 298 4.4e-18 PFAM
Pfam:Pkinase_Tyr 29 313 2e-11 PFAM
low complexity region 365 376 N/A INTRINSIC
transmembrane domain 480 502 N/A INTRINSIC
Predicted Effect probably damaging
Transcript: ENSMUST00000109504
AA Change: D186G

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000105130
Gene: ENSMUSG00000064090
AA Change: D186G

DomainStartEndE-ValueType
Pfam:Pkinase 29 302 2.8e-22 PFAM
Pfam:Pkinase_Tyr 29 313 1.3e-11 PFAM
low complexity region 365 376 N/A INTRINSIC
transmembrane domain 480 502 N/A INTRINSIC
Coding Region Coverage
  • 1x: 98.7%
  • 3x: 97.5%
  • 10x: 95.7%
  • 20x: 92.5%
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the vaccinia-related kinase (VRK) family of serine/threonine protein kinases. The encoded protein acts as an effector of signaling pathways that regulate apoptosis and tumor cell growth. Variants in this gene have been associated with schizophrenia. Alternative splicing results in multiple transcript variants that differ in their subcellular localization and biological activity. [provided by RefSeq, Jan 2014]
Allele List at MGI
Other mutations in this stock
Total: 48 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abca12 T C 1: 71,304,040 (GRCm39) Y2079C probably damaging Het
Alg2 T C 4: 47,472,101 (GRCm39) R236G probably damaging Het
Alpl T A 4: 137,473,733 (GRCm39) N323I probably damaging Het
Anxa3 A G 5: 96,976,238 (GRCm39) E172G probably benign Het
Atp8a2 A G 14: 60,031,314 (GRCm39) probably null Het
Cadps T C 14: 12,454,285 (GRCm38) K1078E probably damaging Het
Ccn5 T C 2: 163,667,279 (GRCm39) probably null Het
Ces2e G T 8: 105,656,543 (GRCm39) V258L probably benign Het
Daam2 A G 17: 49,766,085 (GRCm39) F1041S probably benign Het
Dcstamp A G 15: 39,617,932 (GRCm39) I114V probably benign Het
Ddhd2 C T 8: 26,229,587 (GRCm39) R496Q probably benign Het
Dnhd1 G A 7: 105,352,416 (GRCm39) R2523Q probably damaging Het
Eml6 T A 11: 29,714,126 (GRCm39) R1335S probably benign Het
F12 T C 13: 55,569,872 (GRCm39) N102S probably benign Het
Fbn1 G A 2: 125,215,870 (GRCm39) L712F probably benign Het
Fgf1 G T 18: 38,991,657 (GRCm39) F37L probably damaging Het
Fgf14 T A 14: 124,217,867 (GRCm39) H212L probably damaging Het
Gm10036 A T 18: 15,965,858 (GRCm39) Q3L probably benign Het
Hivep1 T C 13: 42,310,126 (GRCm39) F789L possibly damaging Het
Hspg2 C A 4: 137,279,139 (GRCm39) T3074N probably damaging Het
Katnb1 C T 8: 95,824,300 (GRCm39) R495C probably damaging Het
Kdm5b C T 1: 134,515,741 (GRCm39) H122Y probably damaging Het
Ky C T 9: 102,419,274 (GRCm39) S427L probably benign Het
Med9 T G 11: 59,851,486 (GRCm39) V105G probably benign Het
Ndufa11 T A 17: 57,028,059 (GRCm39) V43D probably damaging Het
Nlrp4b T A 7: 10,448,873 (GRCm39) C359S possibly damaging Het
Or12k8 T A 2: 36,974,921 (GRCm39) I280F possibly damaging Het
Or51e1 A T 7: 102,358,900 (GRCm39) K145* probably null Het
Paxbp1 T A 16: 90,827,401 (GRCm39) Y478F possibly damaging Het
Pole G A 5: 110,480,332 (GRCm39) E92K probably benign Het
Prom1 G T 5: 44,184,110 (GRCm39) L449M probably damaging Het
Psg28 G A 7: 18,164,373 (GRCm39) T113I probably benign Het
Reln A C 5: 22,137,713 (GRCm39) V2493G possibly damaging Het
Rp1 C T 1: 4,416,055 (GRCm39) V1686I probably benign Het
Setbp1 T C 18: 79,129,867 (GRCm39) I122V probably damaging Het
Setd5 T C 6: 113,098,529 (GRCm39) Y721H probably damaging Het
Shroom1 T C 11: 53,354,749 (GRCm39) F223S probably damaging Het
Son T A 16: 91,452,354 (GRCm39) L367Q probably damaging Het
Spred2 G T 11: 19,971,301 (GRCm39) D363Y probably damaging Het
Tbc1d8 T G 1: 39,411,836 (GRCm39) Y1000S probably benign Het
Tdp2 A T 13: 25,022,219 (GRCm39) K213* probably null Het
Tmem89 T C 9: 108,744,545 (GRCm39) I146T probably damaging Het
Vhl T C 6: 113,606,424 (GRCm39) V147A probably benign Het
Vmn2r23 C T 6: 123,690,410 (GRCm39) L429F probably benign Het
Zbtb40 A G 4: 136,710,474 (GRCm39) F1222L possibly damaging Het
Zfp266 A G 9: 20,418,030 (GRCm39) S7P probably damaging Het
Zfp472 T A 17: 33,197,407 (GRCm39) I494K possibly damaging Het
Zfp655 A G 5: 145,181,546 (GRCm39) E468G probably damaging Het
Other mutations in Vrk2
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01865:Vrk2 APN 11 26,485,560 (GRCm39) missense possibly damaging 0.73
IGL02011:Vrk2 APN 11 26,421,717 (GRCm39) missense probably benign 0.10
IGL02185:Vrk2 APN 11 26,485,638 (GRCm39) nonsense probably null
IGL02257:Vrk2 APN 11 26,484,266 (GRCm39) missense probably damaging 1.00
IGL02424:Vrk2 APN 11 26,426,564 (GRCm39) missense probably benign 0.00
macromacro UTSW 11 26,499,325 (GRCm39) missense probably damaging 1.00
R0127:Vrk2 UTSW 11 26,484,313 (GRCm39) splice site probably benign
R0184:Vrk2 UTSW 11 26,500,046 (GRCm39) missense probably damaging 0.98
R0670:Vrk2 UTSW 11 26,436,959 (GRCm39) critical splice donor site probably null
R0751:Vrk2 UTSW 11 26,433,331 (GRCm39) splice site probably benign
R0766:Vrk2 UTSW 11 26,485,522 (GRCm39) splice site probably benign
R1103:Vrk2 UTSW 11 26,499,325 (GRCm39) missense probably damaging 1.00
R1184:Vrk2 UTSW 11 26,433,331 (GRCm39) splice site probably benign
R1312:Vrk2 UTSW 11 26,485,522 (GRCm39) splice site probably benign
R2041:Vrk2 UTSW 11 26,497,914 (GRCm39) missense probably benign 0.01
R2857:Vrk2 UTSW 11 26,433,324 (GRCm39) missense possibly damaging 0.54
R2859:Vrk2 UTSW 11 26,433,324 (GRCm39) missense possibly damaging 0.54
R3615:Vrk2 UTSW 11 26,439,866 (GRCm39) missense possibly damaging 0.90
R3616:Vrk2 UTSW 11 26,439,866 (GRCm39) missense possibly damaging 0.90
R4163:Vrk2 UTSW 11 26,497,915 (GRCm39) missense probably benign 0.00
R4651:Vrk2 UTSW 11 26,439,803 (GRCm39) missense probably damaging 0.98
R4652:Vrk2 UTSW 11 26,439,803 (GRCm39) missense probably damaging 0.98
R4662:Vrk2 UTSW 11 26,421,611 (GRCm39) missense possibly damaging 0.95
R5262:Vrk2 UTSW 11 26,541,697 (GRCm39) missense possibly damaging 0.94
R5458:Vrk2 UTSW 11 26,448,919 (GRCm39) missense probably damaging 0.99
R5840:Vrk2 UTSW 11 26,484,314 (GRCm39) splice site probably benign
R5892:Vrk2 UTSW 11 26,484,372 (GRCm39) intron probably benign
R6054:Vrk2 UTSW 11 26,436,975 (GRCm39) missense probably benign 0.20
R6923:Vrk2 UTSW 11 26,439,893 (GRCm39) missense probably damaging 1.00
R6952:Vrk2 UTSW 11 26,485,597 (GRCm39) missense probably damaging 0.97
R7841:Vrk2 UTSW 11 26,421,457 (GRCm39) missense probably damaging 1.00
R8165:Vrk2 UTSW 11 26,485,575 (GRCm39) missense probably benign 0.21
R9074:Vrk2 UTSW 11 26,543,917 (GRCm39) intron probably benign
R9583:Vrk2 UTSW 11 26,433,157 (GRCm39) critical splice donor site probably null
Predicted Primers PCR Primer
(F):5'- TCTCAGGTAACAGCTTCAACAC -3'
(R):5'- TGAAGAGTTGACCTAAGTCTGAAG -3'

Sequencing Primer
(F):5'- ACACTCTCAATTTAAACATCCTCCTG -3'
(R):5'- ACTTGCAGAAGGTGACTCTC -3'
Posted On 2016-10-06