Incidental Mutation 'R5529:Daam2'
ID 433603
Institutional Source Beutler Lab
Gene Symbol Daam2
Ensembl Gene ENSMUSG00000040260
Gene Name dishevelled associated activator of morphogenesis 2
Synonyms 2310016D11Rik
MMRRC Submission 043087-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R5529 (G1)
Quality Score 169
Status Not validated
Chromosome 17
Chromosomal Location 49763050-49871371 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 49766085 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Phenylalanine to Serine at position 1041 (F1041S)
Ref Sequence ENSEMBL: ENSMUSP00000052085 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000024797] [ENSMUST00000057610] [ENSMUST00000173033] [ENSMUST00000173362] [ENSMUST00000174647]
AlphaFold Q80U19
Predicted Effect probably benign
Transcript: ENSMUST00000024797
SMART Domains Protein: ENSMUSP00000024797
Gene: ENSMUSG00000064120

DomainStartEndE-ValueType
Elp3 70 273 1.63e-8 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000057610
AA Change: F1041S

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
SMART Domains Protein: ENSMUSP00000052085
Gene: ENSMUSG00000040260
AA Change: F1041S

DomainStartEndE-ValueType
Drf_GBD 40 228 4.89e-61 SMART
Drf_FH3 231 429 1.19e-73 SMART
Blast:FH2 476 513 4e-10 BLAST
low complexity region 514 534 N/A INTRINSIC
low complexity region 539 576 N/A INTRINSIC
FH2 595 1085 7.36e-99 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000172871
SMART Domains Protein: ENSMUSP00000134449
Gene: ENSMUSG00000064120

DomainStartEndE-ValueType
Pfam:Mob_synth_C 1 86 8.6e-33 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000173033
SMART Domains Protein: ENSMUSP00000133694
Gene: ENSMUSG00000064120

DomainStartEndE-ValueType
Elp3 70 273 1.63e-8 SMART
Pfam:MoaC 493 628 6.1e-49 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000173362
SMART Domains Protein: ENSMUSP00000134265
Gene: ENSMUSG00000064120

DomainStartEndE-ValueType
Pfam:Fer4_12 67 197 5.8e-11 PFAM
Pfam:Radical_SAM 74 199 2.5e-22 PFAM
Pfam:Fer4_14 75 180 2.5e-9 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000173430
Predicted Effect probably benign
Transcript: ENSMUST00000174647
Predicted Effect noncoding transcript
Transcript: ENSMUST00000224954
Coding Region Coverage
  • 1x: 98.7%
  • 3x: 97.5%
  • 10x: 95.7%
  • 20x: 92.5%
Validation Efficiency
MGI Phenotype PHENOTYPE: Homozygous KO in combination with homozygous Daam1 conditional KO increases the severity of the heart phenotype (abnormal ventricular morphology and pressure) of the Daam1 single KO. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 48 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abca12 T C 1: 71,304,040 (GRCm39) Y2079C probably damaging Het
Alg2 T C 4: 47,472,101 (GRCm39) R236G probably damaging Het
Alpl T A 4: 137,473,733 (GRCm39) N323I probably damaging Het
Anxa3 A G 5: 96,976,238 (GRCm39) E172G probably benign Het
Atp8a2 A G 14: 60,031,314 (GRCm39) probably null Het
Cadps T C 14: 12,454,285 (GRCm38) K1078E probably damaging Het
Ccn5 T C 2: 163,667,279 (GRCm39) probably null Het
Ces2e G T 8: 105,656,543 (GRCm39) V258L probably benign Het
Dcstamp A G 15: 39,617,932 (GRCm39) I114V probably benign Het
Ddhd2 C T 8: 26,229,587 (GRCm39) R496Q probably benign Het
Dnhd1 G A 7: 105,352,416 (GRCm39) R2523Q probably damaging Het
Eml6 T A 11: 29,714,126 (GRCm39) R1335S probably benign Het
F12 T C 13: 55,569,872 (GRCm39) N102S probably benign Het
Fbn1 G A 2: 125,215,870 (GRCm39) L712F probably benign Het
Fgf1 G T 18: 38,991,657 (GRCm39) F37L probably damaging Het
Fgf14 T A 14: 124,217,867 (GRCm39) H212L probably damaging Het
Gm10036 A T 18: 15,965,858 (GRCm39) Q3L probably benign Het
Hivep1 T C 13: 42,310,126 (GRCm39) F789L possibly damaging Het
Hspg2 C A 4: 137,279,139 (GRCm39) T3074N probably damaging Het
Katnb1 C T 8: 95,824,300 (GRCm39) R495C probably damaging Het
Kdm5b C T 1: 134,515,741 (GRCm39) H122Y probably damaging Het
Ky C T 9: 102,419,274 (GRCm39) S427L probably benign Het
Med9 T G 11: 59,851,486 (GRCm39) V105G probably benign Het
Ndufa11 T A 17: 57,028,059 (GRCm39) V43D probably damaging Het
Nlrp4b T A 7: 10,448,873 (GRCm39) C359S possibly damaging Het
Or12k8 T A 2: 36,974,921 (GRCm39) I280F possibly damaging Het
Or51e1 A T 7: 102,358,900 (GRCm39) K145* probably null Het
Paxbp1 T A 16: 90,827,401 (GRCm39) Y478F possibly damaging Het
Pole G A 5: 110,480,332 (GRCm39) E92K probably benign Het
Prom1 G T 5: 44,184,110 (GRCm39) L449M probably damaging Het
Psg28 G A 7: 18,164,373 (GRCm39) T113I probably benign Het
Reln A C 5: 22,137,713 (GRCm39) V2493G possibly damaging Het
Rp1 C T 1: 4,416,055 (GRCm39) V1686I probably benign Het
Setbp1 T C 18: 79,129,867 (GRCm39) I122V probably damaging Het
Setd5 T C 6: 113,098,529 (GRCm39) Y721H probably damaging Het
Shroom1 T C 11: 53,354,749 (GRCm39) F223S probably damaging Het
Son T A 16: 91,452,354 (GRCm39) L367Q probably damaging Het
Spred2 G T 11: 19,971,301 (GRCm39) D363Y probably damaging Het
Tbc1d8 T G 1: 39,411,836 (GRCm39) Y1000S probably benign Het
Tdp2 A T 13: 25,022,219 (GRCm39) K213* probably null Het
Tmem89 T C 9: 108,744,545 (GRCm39) I146T probably damaging Het
Vhl T C 6: 113,606,424 (GRCm39) V147A probably benign Het
Vmn2r23 C T 6: 123,690,410 (GRCm39) L429F probably benign Het
Vrk2 T C 11: 26,449,036 (GRCm39) D186G probably damaging Het
Zbtb40 A G 4: 136,710,474 (GRCm39) F1222L possibly damaging Het
Zfp266 A G 9: 20,418,030 (GRCm39) S7P probably damaging Het
Zfp472 T A 17: 33,197,407 (GRCm39) I494K possibly damaging Het
Zfp655 A G 5: 145,181,546 (GRCm39) E468G probably damaging Het
Other mutations in Daam2
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02150:Daam2 APN 17 49,797,332 (GRCm39) missense possibly damaging 0.82
IGL02373:Daam2 APN 17 49,780,408 (GRCm39) missense probably damaging 1.00
IGL02626:Daam2 APN 17 49,797,282 (GRCm39) missense possibly damaging 0.46
IGL02793:Daam2 APN 17 49,771,056 (GRCm39) missense probably damaging 1.00
IGL02861:Daam2 APN 17 49,776,455 (GRCm39) missense probably damaging 1.00
IGL02875:Daam2 APN 17 49,771,056 (GRCm39) missense probably damaging 1.00
IGL03370:Daam2 APN 17 49,793,529 (GRCm39) missense probably benign 0.19
R0145:Daam2 UTSW 17 49,787,806 (GRCm39) missense probably benign
R0310:Daam2 UTSW 17 49,770,952 (GRCm39) critical splice donor site probably null
R0362:Daam2 UTSW 17 49,787,813 (GRCm39) splice site probably null
R0423:Daam2 UTSW 17 49,776,449 (GRCm39) nonsense probably null
R0883:Daam2 UTSW 17 49,805,911 (GRCm39) utr 5 prime probably benign
R0928:Daam2 UTSW 17 49,795,255 (GRCm39) missense probably benign 0.30
R1444:Daam2 UTSW 17 49,787,779 (GRCm39) missense possibly damaging 0.89
R1559:Daam2 UTSW 17 49,803,148 (GRCm39) splice site probably benign
R1733:Daam2 UTSW 17 49,797,231 (GRCm39) missense possibly damaging 0.60
R1919:Daam2 UTSW 17 49,792,485 (GRCm39) missense probably benign 0.00
R1930:Daam2 UTSW 17 49,769,241 (GRCm39) splice site probably null
R1968:Daam2 UTSW 17 49,790,088 (GRCm39) missense probably damaging 1.00
R2520:Daam2 UTSW 17 49,787,785 (GRCm39) nonsense probably null
R3004:Daam2 UTSW 17 49,767,682 (GRCm39) missense probably damaging 0.98
R3726:Daam2 UTSW 17 49,776,766 (GRCm39) missense probably damaging 1.00
R3854:Daam2 UTSW 17 49,765,624 (GRCm39) missense probably benign
R4833:Daam2 UTSW 17 49,797,173 (GRCm39) missense possibly damaging 0.91
R4878:Daam2 UTSW 17 49,767,738 (GRCm39) missense probably damaging 1.00
R5015:Daam2 UTSW 17 49,783,550 (GRCm39) missense probably damaging 1.00
R5106:Daam2 UTSW 17 49,783,489 (GRCm39) missense probably damaging 1.00
R5184:Daam2 UTSW 17 49,801,419 (GRCm39) missense possibly damaging 0.50
R5419:Daam2 UTSW 17 49,787,782 (GRCm39) missense possibly damaging 0.95
R5974:Daam2 UTSW 17 49,771,501 (GRCm39) missense probably damaging 1.00
R5979:Daam2 UTSW 17 49,766,232 (GRCm39) missense possibly damaging 0.47
R6032:Daam2 UTSW 17 49,793,525 (GRCm39) missense probably damaging 1.00
R6032:Daam2 UTSW 17 49,793,525 (GRCm39) missense probably damaging 1.00
R6050:Daam2 UTSW 17 49,793,530 (GRCm39) missense possibly damaging 0.78
R6180:Daam2 UTSW 17 49,776,694 (GRCm39) missense probably damaging 0.99
R6225:Daam2 UTSW 17 49,801,467 (GRCm39) missense probably damaging 0.98
R6385:Daam2 UTSW 17 49,770,964 (GRCm39) missense probably damaging 1.00
R6426:Daam2 UTSW 17 49,776,404 (GRCm39) missense probably damaging 1.00
R6427:Daam2 UTSW 17 49,776,404 (GRCm39) missense probably damaging 1.00
R6428:Daam2 UTSW 17 49,776,404 (GRCm39) missense probably damaging 1.00
R6539:Daam2 UTSW 17 49,776,739 (GRCm39) missense probably damaging 1.00
R7090:Daam2 UTSW 17 49,789,973 (GRCm39) missense probably damaging 0.99
R7108:Daam2 UTSW 17 49,767,702 (GRCm39) missense probably damaging 1.00
R7487:Daam2 UTSW 17 49,793,510 (GRCm39) missense probably benign 0.03
R7599:Daam2 UTSW 17 49,787,755 (GRCm39) nonsense probably null
R7763:Daam2 UTSW 17 49,797,050 (GRCm39) missense probably benign 0.04
R8039:Daam2 UTSW 17 49,771,566 (GRCm39) missense probably damaging 1.00
R8700:Daam2 UTSW 17 49,803,180 (GRCm39) missense probably damaging 1.00
R9000:Daam2 UTSW 17 49,769,197 (GRCm39) missense probably damaging 1.00
R9286:Daam2 UTSW 17 49,786,922 (GRCm39) missense possibly damaging 0.63
R9508:Daam2 UTSW 17 49,765,618 (GRCm39) missense probably damaging 1.00
R9621:Daam2 UTSW 17 49,780,332 (GRCm39) missense probably damaging 1.00
V1662:Daam2 UTSW 17 49,771,629 (GRCm39) missense possibly damaging 0.85
Z1177:Daam2 UTSW 17 49,796,044 (GRCm39) missense probably damaging 1.00
Z1177:Daam2 UTSW 17 49,771,648 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- CTGGGCATACTTCCTGACAG -3'
(R):5'- CATGTCTTTCACAGTTTGCCAAG -3'

Sequencing Primer
(F):5'- GCATACTTCCTGACAGGGACC -3'
(R):5'- AGGCACTGACACATTTCGG -3'
Posted On 2016-10-06