Incidental Mutation 'R5474:Or8g51'
ID 433976
Institutional Source Beutler Lab
Gene Symbol Or8g51
Ensembl Gene ENSMUSG00000056961
Gene Name olfactory receptor family 8 subfamily G member 51
Synonyms GA_x6K02T2PVTD-32400678-32399743, Olfr919, MOR171-23
MMRRC Submission 043035-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.072) question?
Stock # R5474 (G1)
Quality Score 225
Status Not validated
Chromosome 9
Chromosomal Location 38608725-38609672 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to A at 38609609 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Threonine to Serine at position 18 (T18S)
Ref Sequence ENSEMBL: ENSMUSP00000150303 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000071425] [ENSMUST00000215612] [ENSMUST00000217508]
AlphaFold Q8VF78
Predicted Effect probably benign
Transcript: ENSMUST00000071425
AA Change: T22S

PolyPhen 2 Score 0.354 (Sensitivity: 0.90; Specificity: 0.89)
SMART Domains Protein: ENSMUSP00000071372
Gene: ENSMUSG00000056961
AA Change: T22S

DomainStartEndE-ValueType
Pfam:7tm_4 35 312 9.8e-50 PFAM
Pfam:7tm_1 45 294 9e-21 PFAM
Predicted Effect possibly damaging
Transcript: ENSMUST00000215612
AA Change: T18S

PolyPhen 2 Score 0.686 (Sensitivity: 0.86; Specificity: 0.92)
Predicted Effect possibly damaging
Transcript: ENSMUST00000217508
AA Change: T18S

PolyPhen 2 Score 0.686 (Sensitivity: 0.86; Specificity: 0.92)
Coding Region Coverage
  • 1x: 98.2%
  • 3x: 97.2%
  • 10x: 95.0%
  • 20x: 90.1%
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 41 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abcb5 C T 12: 118,904,425 (GRCm39) G122S probably null Het
Ankmy1 T C 1: 92,812,926 (GRCm39) D461G possibly damaging Het
Ascc3 T C 10: 50,725,634 (GRCm39) I2119T probably benign Het
Bud13 G C 9: 46,199,251 (GRCm39) R204T probably damaging Het
Clec4a4 T C 6: 122,989,706 (GRCm39) S116P probably damaging Het
Cnga1 T C 5: 72,762,536 (GRCm39) Y326C probably damaging Het
Cngb1 A T 8: 95,978,597 (GRCm39) I588N probably damaging Het
Cspg5 A T 9: 110,080,076 (GRCm39) I334F probably damaging Het
Cyp2c29 G A 19: 39,313,436 (GRCm39) A350T probably damaging Het
D5Ertd579e G T 5: 36,772,601 (GRCm39) S598Y probably damaging Het
Dgkq A G 5: 108,797,009 (GRCm39) probably null Het
Dnah2 C T 11: 69,349,746 (GRCm39) R2399Q probably benign Het
Dock4 T C 12: 40,795,730 (GRCm39) I849T probably benign Het
Drd4 T C 7: 140,873,641 (GRCm39) W98R probably damaging Het
Duox1 A T 2: 122,177,106 (GRCm39) Q1511L probably benign Het
Gtdc1 A T 2: 44,646,379 (GRCm39) L83Q probably damaging Het
H2-T3 G A 17: 36,500,999 (GRCm39) P6S probably damaging Het
H6pd A G 4: 150,080,546 (GRCm39) C92R probably damaging Het
Ide A G 19: 37,249,583 (GRCm39) V923A unknown Het
Kcnc4 A T 3: 107,355,207 (GRCm39) S414T possibly damaging Het
Krt14 A T 11: 100,095,571 (GRCm39) M278K probably damaging Het
Lrit1 T A 14: 36,783,943 (GRCm39) S424T probably benign Het
Muc4 G A 16: 32,581,635 (GRCm39) S2500N unknown Het
Ncs1 A T 2: 31,170,796 (GRCm39) N70Y probably damaging Het
Nemf C A 12: 69,363,109 (GRCm39) R923L probably benign Het
Nrros T C 16: 31,963,170 (GRCm39) I246M probably benign Het
Or5w13 G A 2: 87,523,401 (GRCm39) S275F probably damaging Het
Or6a2 T A 7: 106,600,296 (GRCm39) Y257F probably damaging Het
Polb A G 8: 23,120,386 (GRCm39) Y296H probably benign Het
Prrc2a A T 17: 35,378,189 (GRCm39) F440L unknown Het
Prrc2c T C 1: 162,537,213 (GRCm39) probably benign Het
Ptprk C T 10: 28,372,926 (GRCm39) R726* probably null Het
Rnpc3 A T 3: 113,409,158 (GRCm39) L247* probably null Het
Scfd2 C T 5: 74,692,025 (GRCm39) V86I probably benign Het
Sec14l5 A G 16: 4,996,382 (GRCm39) T443A possibly damaging Het
Slc22a29 A G 19: 8,195,221 (GRCm39) V138A probably damaging Het
Usp15 T C 10: 122,963,950 (GRCm39) D524G probably damaging Het
Vav3 A G 3: 109,571,737 (GRCm39) T220A probably benign Het
Vmn2r17 G A 5: 109,582,150 (GRCm39) S513N probably damaging Het
Zfp84 C T 7: 29,476,514 (GRCm39) S402L probably damaging Het
Zfta A T 19: 7,397,524 (GRCm39) R24W probably damaging Het
Other mutations in Or8g51
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01510:Or8g51 APN 9 38,609,201 (GRCm39) missense probably benign 0.00
IGL02515:Or8g51 APN 9 38,609,087 (GRCm39) missense probably benign 0.39
IGL02745:Or8g51 APN 9 38,609,494 (GRCm39) missense probably damaging 0.99
H8562:Or8g51 UTSW 9 38,609,206 (GRCm39) missense probably damaging 1.00
R1960:Or8g51 UTSW 9 38,609,500 (GRCm39) missense probably benign 0.28
R1973:Or8g51 UTSW 9 38,609,164 (GRCm39) missense probably damaging 0.96
R3119:Or8g51 UTSW 9 38,608,955 (GRCm39) nonsense probably null
R4543:Or8g51 UTSW 9 38,608,841 (GRCm39) missense possibly damaging 0.93
R4752:Or8g51 UTSW 9 38,609,266 (GRCm39) missense probably damaging 0.99
R5532:Or8g51 UTSW 9 38,608,943 (GRCm39) missense probably damaging 1.00
R5635:Or8g51 UTSW 9 38,609,455 (GRCm39) missense possibly damaging 0.64
R5940:Or8g51 UTSW 9 38,609,007 (GRCm39) nonsense probably null
R6820:Or8g51 UTSW 9 38,608,771 (GRCm39) missense possibly damaging 0.88
R7164:Or8g51 UTSW 9 38,609,515 (GRCm39) missense possibly damaging 0.95
R7337:Or8g51 UTSW 9 38,609,161 (GRCm39) missense probably benign 0.12
R7806:Or8g51 UTSW 9 38,609,567 (GRCm39) missense probably benign 0.39
R8287:Or8g51 UTSW 9 38,609,633 (GRCm39) missense probably benign 0.06
R9120:Or8g51 UTSW 9 38,608,735 (GRCm39) missense probably benign 0.01
Z1176:Or8g51 UTSW 9 38,609,224 (GRCm39) missense possibly damaging 0.76
Predicted Primers PCR Primer
(F):5'- AGGAGATGACATTCTTCTTTGCC -3'
(R):5'- GTTAACAAATATGAAGAGCTGCTGG -3'

Sequencing Primer
(F):5'- AGTTCACCAACATCTTCGGGG -3'
(R):5'- GCTGCTGGAAAGAGGAAATACC -3'
Posted On 2016-10-06