Incidental Mutation 'R0481:Glp1r'
ID 43405
Institutional Source Beutler Lab
Gene Symbol Glp1r
Ensembl Gene ENSMUSG00000024027
Gene Name glucagon-like peptide 1 receptor
Synonyms GLP-1R, GLP1Rc
MMRRC Submission 038681-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R0481 (G1)
Quality Score 223
Status Validated
Chromosome 17
Chromosomal Location 31120841-31155484 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to A at 31150191 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Methionine to Lysine at position 371 (M371K)
Ref Sequence ENSEMBL: ENSMUSP00000110221 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000114574]
AlphaFold O35659
Predicted Effect probably benign
Transcript: ENSMUST00000114574
AA Change: M371K

PolyPhen 2 Score 0.026 (Sensitivity: 0.95; Specificity: 0.81)
SMART Domains Protein: ENSMUSP00000110221
Gene: ENSMUSG00000024027
AA Change: M371K

DomainStartEndE-ValueType
signal peptide 1 21 N/A INTRINSIC
HormR 58 135 9.88e-27 SMART
Pfam:7tm_2 141 398 7.4e-82 PFAM
low complexity region 440 456 N/A INTRINSIC
Meta Mutation Damage Score 0.5897 question?
Coding Region Coverage
  • 1x: 99.1%
  • 3x: 98.3%
  • 10x: 96.5%
  • 20x: 93.3%
Validation Efficiency 95% (89/94)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a 7-transmembrane protein that functions as a receptor for glucagon-like peptide 1 (GLP-1) hormone, which stimulates glucose-induced insulin secretion. This receptor, which functions at the cell surface, becomes internalized in response to GLP-1 and GLP-1 analogs, and it plays an important role in the signaling cascades leading to insulin secretion. It also displays neuroprotective effects in animal models. Polymorphisms in this gene are associated with diabetes. The protein is an important drug target for the treatment of type 2 diabetes and stroke. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Apr 2016]
PHENOTYPE: Glucose tolerance and pancreatic secretion is impaired in homozygous null mice. [provided by MGI curators]
Allele List at MGI

All alleles(1) : Targeted, knock-out(1)

Other mutations in this stock
Total: 87 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abcg4 T A 9: 44,190,666 (GRCm39) N39Y probably benign Het
Adamts10 C T 17: 33,768,347 (GRCm39) Q840* probably null Het
Aff2 C T X: 68,878,248 (GRCm39) T678I probably damaging Het
Ahctf1 A G 1: 179,587,836 (GRCm39) V1418A probably benign Het
Ankrd11 G A 8: 123,626,775 (GRCm39) R136C probably damaging Het
Arf5 A G 6: 28,426,075 (GRCm39) Y154C probably damaging Het
AW551984 A G 9: 39,511,912 (GRCm39) V33A probably null Het
B4galt5 A G 2: 167,151,154 (GRCm39) L118P probably damaging Het
Bcl9l A G 9: 44,417,979 (GRCm39) I606V probably benign Het
Bdp1 A G 13: 100,177,962 (GRCm39) I1969T probably benign Het
Bicd1 A T 6: 149,413,389 (GRCm39) D260V possibly damaging Het
Cap1 A T 4: 122,756,868 (GRCm39) H272Q possibly damaging Het
Ccnk A G 12: 108,165,568 (GRCm39) probably benign Het
Cd209f A T 8: 4,155,558 (GRCm39) probably null Het
Cdk13 C A 13: 17,894,079 (GRCm39) A1123S probably damaging Het
Cdx1 C T 18: 61,153,564 (GRCm39) R158H probably damaging Het
Chd8 A G 14: 52,474,663 (GRCm39) S123P probably benign Het
Cwc22 G A 2: 77,738,455 (GRCm39) A497V probably damaging Het
Cwh43 T C 5: 73,575,370 (GRCm39) S296P probably damaging Het
Dhx38 A T 8: 110,282,848 (GRCm39) probably benign Het
Dnah5 T A 15: 28,383,745 (GRCm39) M2989K probably benign Het
Dpy19l4 A C 4: 11,272,993 (GRCm39) probably benign Het
F11r A T 1: 171,288,847 (GRCm39) H155L probably benign Het
Fcgbpl1 A T 7: 27,853,174 (GRCm39) D1487V probably damaging Het
Fitm2 A G 2: 163,311,634 (GRCm39) V193A probably benign Het
Foxk1 T A 5: 142,434,578 (GRCm39) S281T probably benign Het
Furin A G 7: 80,043,297 (GRCm39) C305R probably damaging Het
Fut8 T A 12: 77,495,334 (GRCm39) V308D probably damaging Het
Gjb3 T A 4: 127,220,125 (GRCm39) I136F probably benign Het
Glmn A T 5: 107,708,800 (GRCm39) S385T probably benign Het
Gpr179 T C 11: 97,240,544 (GRCm39) H293R probably damaging Het
H2-M11 A T 17: 36,859,846 (GRCm39) R280* probably null Het
Hadhb T A 5: 30,373,543 (GRCm39) H78Q probably damaging Het
Hectd4 A G 5: 121,433,569 (GRCm39) probably benign Het
Hexa A G 9: 59,462,693 (GRCm39) probably benign Het
Hsh2d G A 8: 72,954,304 (GRCm39) D229N probably benign Het
Hyal6 G A 6: 24,743,417 (GRCm39) C371Y probably damaging Het
Il1rap T C 16: 26,511,585 (GRCm39) Y210H probably damaging Het
Ino80 A T 2: 119,261,497 (GRCm39) H722Q probably damaging Het
Kcnt1 A G 2: 25,782,508 (GRCm39) N200S probably damaging Het
Kif27 T A 13: 58,459,078 (GRCm39) probably benign Het
Lyst T C 13: 13,852,537 (GRCm39) V2179A probably benign Het
Macf1 C A 4: 123,377,815 (GRCm39) probably null Het
Mamdc4 A G 2: 25,461,228 (GRCm39) M1T probably null Het
Mansc4 A G 6: 146,976,725 (GRCm39) I297T possibly damaging Het
Mdn1 G A 4: 32,767,182 (GRCm39) probably benign Het
Mib2 A G 4: 155,740,519 (GRCm39) probably benign Het
Mon2 A G 10: 122,849,301 (GRCm39) V1333A possibly damaging Het
Ndst2 T C 14: 20,774,536 (GRCm39) D840G possibly damaging Het
Nell2 A T 15: 95,330,563 (GRCm39) probably null Het
Or4c102 A T 2: 88,422,999 (GRCm39) I284F probably damaging Het
Or4k51 T A 2: 111,584,930 (GRCm39) M112K probably damaging Het
Or5g29 C A 2: 85,421,448 (GRCm39) A188E possibly damaging Het
Pde5a C T 3: 122,611,726 (GRCm39) probably benign Het
Phip A G 9: 82,758,769 (GRCm39) probably benign Het
Polr2b A G 5: 77,479,929 (GRCm39) I561V possibly damaging Het
Ppp4r3c2 T C X: 88,796,299 (GRCm39) S44P probably damaging Het
Prkg2 A T 5: 99,142,514 (GRCm39) probably null Het
Prl8a6 T C 13: 27,617,084 (GRCm39) D201G probably benign Het
Ptk6 G A 2: 180,844,320 (GRCm39) probably benign Het
Ptprn2 T C 12: 117,175,466 (GRCm39) probably benign Het
Rdh1 G T 10: 127,598,993 (GRCm39) R158L probably damaging Het
Rhbdl3 T C 11: 80,214,175 (GRCm39) probably benign Het
Rims4 A T 2: 163,706,040 (GRCm39) V198E probably damaging Het
Ripk1 T C 13: 34,193,733 (GRCm39) S32P probably damaging Het
Rnf13 T A 3: 57,686,872 (GRCm39) N88K probably damaging Het
Rnf13 C A 3: 57,714,474 (GRCm39) L178I probably damaging Het
Slc17a5 G T 9: 78,445,584 (GRCm39) probably null Het
Sorcs1 A G 19: 50,624,891 (GRCm39) probably benign Het
Spata31e3 T A 13: 50,401,000 (GRCm39) Q442L probably benign Het
Srpk1 G A 17: 28,809,218 (GRCm39) probably benign Het
Stk10 A G 11: 32,564,708 (GRCm39) K840E probably damaging Het
Suco A G 1: 161,689,882 (GRCm39) probably benign Het
T2 G A 17: 8,636,007 (GRCm39) probably null Het
Tbc1d5 A G 17: 51,226,079 (GRCm39) S255P probably damaging Het
Tenm1 T C X: 41,625,058 (GRCm39) Y2254C probably damaging Het
Tex9 T A 9: 72,385,678 (GRCm39) K11* probably null Het
Tlr4 A G 4: 66,746,153 (GRCm39) I29V probably benign Het
Tmem255a A T X: 37,288,523 (GRCm39) V278D probably damaging Het
Trpc3 T C 3: 36,678,566 (GRCm39) I840V probably benign Het
Trpm3 G A 19: 22,878,435 (GRCm39) R622Q possibly damaging Het
Vmn1r214 T A 13: 23,219,464 (GRCm39) Y319* probably null Het
Vmn1r53 A T 6: 90,200,700 (GRCm39) V208E probably damaging Het
Vmn2r89 T C 14: 51,693,577 (GRCm39) F309S probably damaging Het
Xirp2 T A 2: 67,340,253 (GRCm39) F831L possibly damaging Het
Yes1 G T 5: 32,797,749 (GRCm39) E23* probably null Het
Zfp292 A T 4: 34,810,059 (GRCm39) M995K probably benign Het
Other mutations in Glp1r
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00158:Glp1r APN 17 31,120,891 (GRCm39) missense possibly damaging 0.96
IGL00516:Glp1r APN 17 31,144,532 (GRCm39) missense probably damaging 1.00
IGL00653:Glp1r APN 17 31,149,734 (GRCm39) missense probably damaging 1.00
IGL00917:Glp1r APN 17 31,138,443 (GRCm39) splice site probably benign
IGL02005:Glp1r APN 17 31,143,585 (GRCm39) missense probably benign 0.03
IGL02411:Glp1r APN 17 31,143,485 (GRCm39) missense probably damaging 1.00
IGL02889:Glp1r APN 17 31,150,118 (GRCm39) splice site probably benign
IGL02928:Glp1r APN 17 31,137,911 (GRCm39) missense probably benign 0.00
N/A:Glp1r UTSW 17 31,150,257 (GRCm39) missense probably damaging 0.98
R0135:Glp1r UTSW 17 31,143,551 (GRCm39) missense probably benign 0.00
R0395:Glp1r UTSW 17 31,155,312 (GRCm39) missense probably benign 0.34
R0602:Glp1r UTSW 17 31,128,201 (GRCm39) missense probably benign 0.12
R0841:Glp1r UTSW 17 31,138,406 (GRCm39) missense probably benign 0.01
R1145:Glp1r UTSW 17 31,138,406 (GRCm39) missense probably benign 0.01
R1145:Glp1r UTSW 17 31,138,406 (GRCm39) missense probably benign 0.01
R1232:Glp1r UTSW 17 31,137,905 (GRCm39) missense probably benign
R1804:Glp1r UTSW 17 31,149,687 (GRCm39) splice site probably null
R1846:Glp1r UTSW 17 31,148,909 (GRCm39) critical splice acceptor site probably null
R1982:Glp1r UTSW 17 31,144,601 (GRCm39) nonsense probably null
R1990:Glp1r UTSW 17 31,149,722 (GRCm39) missense possibly damaging 0.53
R2091:Glp1r UTSW 17 31,144,523 (GRCm39) missense probably damaging 0.97
R3432:Glp1r UTSW 17 31,143,531 (GRCm39) missense probably damaging 1.00
R4456:Glp1r UTSW 17 31,137,949 (GRCm39) nonsense probably null
R4488:Glp1r UTSW 17 31,137,905 (GRCm39) missense probably benign
R4610:Glp1r UTSW 17 31,150,221 (GRCm39) missense probably benign 0.03
R4884:Glp1r UTSW 17 31,155,240 (GRCm39) missense probably damaging 1.00
R5055:Glp1r UTSW 17 31,137,861 (GRCm39) missense probably benign
R6358:Glp1r UTSW 17 31,151,618 (GRCm39) missense probably benign 0.07
R6359:Glp1r UTSW 17 31,148,946 (GRCm39) missense probably damaging 1.00
R6490:Glp1r UTSW 17 31,143,546 (GRCm39) missense probably damaging 0.98
R6698:Glp1r UTSW 17 31,155,375 (GRCm39) missense probably damaging 1.00
R7063:Glp1r UTSW 17 31,144,532 (GRCm39) missense probably damaging 1.00
R7165:Glp1r UTSW 17 31,128,297 (GRCm39) missense probably benign 0.23
R7293:Glp1r UTSW 17 31,143,599 (GRCm39) missense probably benign 0.00
R7646:Glp1r UTSW 17 31,155,257 (GRCm39) missense probably benign 0.38
R7655:Glp1r UTSW 17 31,149,572 (GRCm39) critical splice donor site probably null
R7656:Glp1r UTSW 17 31,149,572 (GRCm39) critical splice donor site probably null
R7686:Glp1r UTSW 17 31,144,633 (GRCm39) missense probably damaging 1.00
R8531:Glp1r UTSW 17 31,143,531 (GRCm39) missense probably damaging 1.00
R9050:Glp1r UTSW 17 31,137,892 (GRCm39) missense probably damaging 1.00
X0064:Glp1r UTSW 17 31,138,437 (GRCm39) critical splice donor site probably null
Predicted Primers PCR Primer
(F):5'- ACTCTATTCTTAGCAGCCCCTGGAC -3'
(R):5'- TGCATCAATTGCCTGGCAGGAC -3'

Sequencing Primer
(F):5'- AAGCGTGTTCATGACTCAGC -3'
(R):5'- TATGTCCAAATACCTGGGGACAC -3'
Posted On 2013-05-23