Incidental Mutation 'R5482:Vmn2r26'
| ID |
434384 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Vmn2r26
|
| Ensembl Gene |
ENSMUSG00000096630 |
| Gene Name |
vomeronasal 2, receptor 26 |
| Synonyms |
V2r1b |
| MMRRC Submission |
043043-MU
|
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.088)
|
| Stock # |
R5482 (G1)
|
| Quality Score |
225 |
|
Status
|
Validated
|
| Chromosome |
6 |
| Chromosomal Location |
124024758-124062035 bp(+) (GRCm38) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
A to T
at 124061326 bp (GRCm38)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Glutamic Acid to Valine
at position 620
(E620V)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000032238
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000032238]
|
| AlphaFold |
Q6TAC4 |
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000032238
AA Change: E620V
PolyPhen 2
Score 0.875 (Sensitivity: 0.83; Specificity: 0.93)
|
| SMART Domains |
Protein: ENSMUSP00000032238
Gene: ENSMUSG00000096630
AA Change: E620V
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
22 |
N/A |
INTRINSIC |
|
Pfam:ANF_receptor
|
82 |
471 |
1.5e-31 |
PFAM |
|
Pfam:NCD3G
|
519 |
572 |
4.6e-25 |
PFAM |
|
Pfam:7tm_3
|
603 |
840 |
1.5e-55 |
PFAM |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000158682
|
| Meta Mutation Damage Score |
0.1795 |
| Coding Region Coverage |
- 1x: 98.9%
- 3x: 97.4%
- 10x: 94.5%
- 20x: 87.6%
|
| Validation Efficiency |
99% (68/69) |
| MGI Phenotype |
PHENOTYPE: Mice homozygous for a knock-out allele exhibit abnormal vomeronasal sensory neuron physiology and avnosmia. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 51 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 6430573F11Rik |
A |
T |
8: 36,512,049 (GRCm38) |
M269L |
probably benign |
Het |
| 9230109A22Rik |
T |
C |
15: 25,138,950 (GRCm38) |
|
noncoding transcript |
Het |
| Abca15 |
T |
C |
7: 120,369,147 (GRCm38) |
L801P |
probably damaging |
Het |
| Acap3 |
A |
G |
4: 155,900,156 (GRCm38) |
D212G |
probably benign |
Het |
| Acsl6 |
G |
A |
11: 54,327,138 (GRCm38) |
D166N |
probably damaging |
Het |
| Acy1 |
T |
C |
9: 106,434,639 (GRCm38) |
|
probably benign |
Het |
| Adgrl3 |
A |
G |
5: 81,794,513 (GRCm38) |
N1368S |
probably damaging |
Het |
| Akap5 |
T |
C |
12: 76,328,826 (GRCm38) |
I344T |
probably benign |
Het |
| Aplp1 |
A |
G |
7: 30,440,175 (GRCm38) |
F399S |
probably damaging |
Het |
| Arap3 |
A |
G |
18: 37,974,674 (GRCm38) |
S1302P |
possibly damaging |
Het |
| Bik |
T |
G |
15: 83,544,134 (GRCm38) |
V121G |
probably damaging |
Het |
| Birc6 |
A |
G |
17: 74,662,690 (GRCm38) |
T4237A |
probably damaging |
Het |
| Birc6 |
A |
T |
17: 74,641,782 (GRCm38) |
M3069L |
possibly damaging |
Het |
| Btn2a2 |
T |
C |
13: 23,486,387 (GRCm38) |
N59D |
probably benign |
Het |
| Cabyr |
A |
G |
18: 12,751,439 (GRCm38) |
S328G |
possibly damaging |
Het |
| Cfap57 |
C |
T |
4: 118,569,641 (GRCm38) |
G1067R |
probably benign |
Het |
| Cryl1 |
A |
T |
14: 57,313,012 (GRCm38) |
F132I |
probably damaging |
Het |
| Dnah8 |
G |
A |
17: 30,800,547 (GRCm38) |
E3865K |
probably damaging |
Het |
| Dock3 |
G |
A |
9: 106,978,738 (GRCm38) |
R741* |
probably null |
Het |
| Fam57b |
A |
G |
7: 126,827,488 (GRCm38) |
T78A |
possibly damaging |
Het |
| Fam69a |
C |
G |
5: 107,909,663 (GRCm38) |
C343S |
probably damaging |
Het |
| Fsip2 |
C |
T |
2: 82,985,310 (GRCm38) |
L3796F |
possibly damaging |
Het |
| Gm10722 |
A |
C |
9: 3,001,041 (GRCm38) |
Y39S |
probably benign |
Het |
| Gm5535 |
C |
A |
2: 144,174,572 (GRCm38) |
|
noncoding transcript |
Het |
| Gmcl1 |
A |
T |
6: 86,718,073 (GRCm38) |
M202K |
probably damaging |
Het |
| Hecw2 |
T |
A |
1: 53,926,201 (GRCm38) |
M489L |
probably benign |
Het |
| Lrrk1 |
A |
G |
7: 66,330,670 (GRCm38) |
I254T |
probably benign |
Het |
| Lrrn3 |
G |
A |
12: 41,452,387 (GRCm38) |
L644F |
probably benign |
Het |
| Lrrn3 |
A |
C |
12: 41,452,388 (GRCm38) |
C643W |
probably damaging |
Het |
| Nr2f6 |
A |
T |
8: 71,374,538 (GRCm38) |
I373N |
probably damaging |
Het |
| Nt5dc3 |
A |
G |
10: 86,811,531 (GRCm38) |
Y130C |
probably damaging |
Het |
| Olfr1448 |
T |
C |
19: 12,919,905 (GRCm38) |
T135A |
probably damaging |
Het |
| Olfr788 |
T |
C |
10: 129,473,078 (GRCm38) |
Y129H |
probably benign |
Het |
| Otogl |
T |
A |
10: 107,821,941 (GRCm38) |
I1043F |
probably damaging |
Het |
| Padi3 |
G |
A |
4: 140,795,843 (GRCm38) |
T302I |
probably damaging |
Het |
| Pcdhgb5 |
A |
G |
18: 37,731,532 (GRCm38) |
N127D |
probably damaging |
Het |
| Pign |
A |
G |
1: 105,546,710 (GRCm38) |
F876L |
probably benign |
Het |
| Pip5k1c |
A |
G |
10: 81,293,063 (GRCm38) |
E2G |
probably damaging |
Het |
| Ppp1r18 |
G |
A |
17: 35,873,879 (GRCm38) |
E141K |
probably damaging |
Het |
| Ralbp1 |
A |
C |
17: 65,861,568 (GRCm38) |
Y247* |
probably null |
Het |
| Ripply2 |
A |
G |
9: 87,015,567 (GRCm38) |
E8G |
possibly damaging |
Het |
| Rufy3 |
TAAGCA |
TA |
5: 88,637,332 (GRCm38) |
|
probably null |
Het |
| Skint2 |
T |
G |
4: 112,625,879 (GRCm38) |
C160W |
probably damaging |
Het |
| Sun2 |
C |
T |
15: 79,737,511 (GRCm38) |
R172Q |
probably benign |
Het |
| Syna |
A |
G |
5: 134,559,174 (GRCm38) |
L307P |
possibly damaging |
Het |
| Trappc12 |
T |
C |
12: 28,691,325 (GRCm38) |
K795R |
probably damaging |
Het |
| Ttll11 |
A |
G |
2: 35,752,406 (GRCm38) |
S638P |
probably damaging |
Het |
| Usp2 |
G |
A |
9: 44,089,183 (GRCm38) |
|
probably null |
Het |
| Wdr36 |
A |
T |
18: 32,841,904 (GRCm38) |
H103L |
probably benign |
Het |
| Wnt5b |
T |
C |
6: 119,446,431 (GRCm38) |
T78A |
probably benign |
Het |
| Zc2hc1b |
C |
T |
10: 13,153,526 (GRCm38) |
R146Q |
probably damaging |
Het |
|
| Other mutations in Vmn2r26 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL01070:Vmn2r26
|
APN |
6 |
124,061,607 (GRCm38) |
missense |
probably benign |
0.00 |
|
IGL01370:Vmn2r26
|
APN |
6 |
124,061,756 (GRCm38) |
missense |
probably benign |
0.08 |
|
IGL01603:Vmn2r26
|
APN |
6 |
124,053,874 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL01651:Vmn2r26
|
APN |
6 |
124,050,673 (GRCm38) |
missense |
probably benign |
0.01 |
|
IGL02282:Vmn2r26
|
APN |
6 |
124,061,625 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL02425:Vmn2r26
|
APN |
6 |
124,061,818 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL02551:Vmn2r26
|
APN |
6 |
124,026,141 (GRCm38) |
missense |
probably benign |
0.11 |
|
IGL02690:Vmn2r26
|
APN |
6 |
124,026,132 (GRCm38) |
missense |
probably benign |
0.14 |
|
IGL03002:Vmn2r26
|
APN |
6 |
124,039,795 (GRCm38) |
missense |
possibly damaging |
0.78 |
|
IGL03270:Vmn2r26
|
APN |
6 |
124,050,819 (GRCm38) |
missense |
probably benign |
0.16 |
|
R0032:Vmn2r26
|
UTSW |
6 |
124,039,899 (GRCm38) |
missense |
possibly damaging |
0.72 |
|
R0052:Vmn2r26
|
UTSW |
6 |
124,062,033 (GRCm38) |
makesense |
probably null |
|
|
R0083:Vmn2r26
|
UTSW |
6 |
124,053,981 (GRCm38) |
splice site |
probably null |
|
|
R0682:Vmn2r26
|
UTSW |
6 |
124,061,170 (GRCm38) |
missense |
probably damaging |
0.97 |
|
R1061:Vmn2r26
|
UTSW |
6 |
124,061,644 (GRCm38) |
missense |
probably benign |
0.12 |
|
R1077:Vmn2r26
|
UTSW |
6 |
124,053,913 (GRCm38) |
missense |
probably benign |
0.00 |
|
R1263:Vmn2r26
|
UTSW |
6 |
124,050,708 (GRCm38) |
missense |
probably benign |
|
|
R1579:Vmn2r26
|
UTSW |
6 |
124,039,747 (GRCm38) |
missense |
probably benign |
0.00 |
|
R1741:Vmn2r26
|
UTSW |
6 |
124,061,472 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R1834:Vmn2r26
|
UTSW |
6 |
124,061,410 (GRCm38) |
missense |
possibly damaging |
0.54 |
|
R1838:Vmn2r26
|
UTSW |
6 |
124,024,771 (GRCm38) |
missense |
probably benign |
|
|
R1956:Vmn2r26
|
UTSW |
6 |
124,053,887 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R1996:Vmn2r26
|
UTSW |
6 |
124,061,185 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R2140:Vmn2r26
|
UTSW |
6 |
124,061,237 (GRCm38) |
missense |
probably benign |
0.01 |
|
R2327:Vmn2r26
|
UTSW |
6 |
124,039,749 (GRCm38) |
missense |
probably benign |
0.07 |
|
R2417:Vmn2r26
|
UTSW |
6 |
124,061,350 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R3930:Vmn2r26
|
UTSW |
6 |
124,025,979 (GRCm38) |
missense |
probably benign |
|
|
R4490:Vmn2r26
|
UTSW |
6 |
124,050,738 (GRCm38) |
missense |
possibly damaging |
0.47 |
|
R4629:Vmn2r26
|
UTSW |
6 |
124,061,191 (GRCm38) |
missense |
possibly damaging |
0.50 |
|
R4655:Vmn2r26
|
UTSW |
6 |
124,061,416 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R4709:Vmn2r26
|
UTSW |
6 |
124,053,965 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R4992:Vmn2r26
|
UTSW |
6 |
124,026,111 (GRCm38) |
missense |
probably benign |
0.00 |
|
R5297:Vmn2r26
|
UTSW |
6 |
124,061,873 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R5517:Vmn2r26
|
UTSW |
6 |
124,050,717 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R5737:Vmn2r26
|
UTSW |
6 |
124,039,449 (GRCm38) |
missense |
probably benign |
0.00 |
|
R5739:Vmn2r26
|
UTSW |
6 |
124,025,966 (GRCm38) |
missense |
probably benign |
0.00 |
|
R5873:Vmn2r26
|
UTSW |
6 |
124,061,674 (GRCm38) |
missense |
probably benign |
0.01 |
|
R5907:Vmn2r26
|
UTSW |
6 |
124,039,871 (GRCm38) |
missense |
probably benign |
0.00 |
|
R6086:Vmn2r26
|
UTSW |
6 |
124,039,560 (GRCm38) |
missense |
possibly damaging |
0.48 |
|
R6134:Vmn2r26
|
UTSW |
6 |
124,061,485 (GRCm38) |
missense |
probably damaging |
0.97 |
|
R6391:Vmn2r26
|
UTSW |
6 |
124,061,389 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R6428:Vmn2r26
|
UTSW |
6 |
124,026,080 (GRCm38) |
missense |
probably benign |
0.17 |
|
R6637:Vmn2r26
|
UTSW |
6 |
124,061,691 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R6927:Vmn2r26
|
UTSW |
6 |
124,039,098 (GRCm38) |
missense |
possibly damaging |
0.93 |
|
R6953:Vmn2r26
|
UTSW |
6 |
124,039,782 (GRCm38) |
missense |
probably benign |
0.00 |
|
R7173:Vmn2r26
|
UTSW |
6 |
124,061,296 (GRCm38) |
missense |
probably benign |
0.16 |
|
R7206:Vmn2r26
|
UTSW |
6 |
124,039,768 (GRCm38) |
missense |
probably benign |
0.17 |
|
R7208:Vmn2r26
|
UTSW |
6 |
124,061,989 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R7283:Vmn2r26
|
UTSW |
6 |
124,025,955 (GRCm38) |
missense |
probably damaging |
0.97 |
|
R7506:Vmn2r26
|
UTSW |
6 |
124,039,741 (GRCm38) |
missense |
probably benign |
0.00 |
|
R7672:Vmn2r26
|
UTSW |
6 |
124,039,647 (GRCm38) |
missense |
probably benign |
0.25 |
|
R7674:Vmn2r26
|
UTSW |
6 |
124,039,362 (GRCm38) |
missense |
probably benign |
|
|
R7696:Vmn2r26
|
UTSW |
6 |
124,061,535 (GRCm38) |
missense |
possibly damaging |
0.94 |
|
R7716:Vmn2r26
|
UTSW |
6 |
124,061,745 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R7831:Vmn2r26
|
UTSW |
6 |
124,039,799 (GRCm38) |
nonsense |
probably null |
|
|
R8063:Vmn2r26
|
UTSW |
6 |
124,024,955 (GRCm38) |
missense |
probably benign |
0.00 |
|
R8331:Vmn2r26
|
UTSW |
6 |
124,061,928 (GRCm38) |
missense |
probably benign |
0.22 |
|
R8352:Vmn2r26
|
UTSW |
6 |
124,039,618 (GRCm38) |
missense |
probably benign |
0.09 |
|
R8445:Vmn2r26
|
UTSW |
6 |
124,026,036 (GRCm38) |
missense |
probably damaging |
0.97 |
|
R8452:Vmn2r26
|
UTSW |
6 |
124,039,618 (GRCm38) |
missense |
probably benign |
0.09 |
|
R8681:Vmn2r26
|
UTSW |
6 |
124,024,918 (GRCm38) |
missense |
probably benign |
0.00 |
|
R8914:Vmn2r26
|
UTSW |
6 |
124,062,024 (GRCm38) |
missense |
probably benign |
|
|
R9333:Vmn2r26
|
UTSW |
6 |
124,026,050 (GRCm38) |
missense |
probably benign |
0.13 |
|
R9351:Vmn2r26
|
UTSW |
6 |
124,039,374 (GRCm38) |
missense |
probably benign |
|
|
R9436:Vmn2r26
|
UTSW |
6 |
124,025,867 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R9515:Vmn2r26
|
UTSW |
6 |
124,061,178 (GRCm38) |
missense |
probably damaging |
1.00 |
|
RF010:Vmn2r26
|
UTSW |
6 |
124,039,489 (GRCm38) |
missense |
possibly damaging |
0.90 |
|
| Predicted Primers |
PCR Primer
(F):5'- TATCTGGAGAGTGACAAGTTGAATG -3'
(R):5'- GAAGGTCTTTGCCAAGATAGCAG -3'
Sequencing Primer
(F):5'- ATGGATCAATGTATCAAGTGTCCTG -3'
(R):5'- GTCTTTGCCAAGATAGCAGAAATGAC -3'
|
| Posted On |
2016-10-06 |
Incidental Mutation