Incidental Mutation 'R5308:Or4k45'
ID 434459
Institutional Source Beutler Lab
Gene Symbol Or4k45
Ensembl Gene ENSMUSG00000108919
Gene Name olfactory receptor family 4 subfamily K member 45
Synonyms MOR248-10, GA_x6K02T2Q125-72616944-72616006, Olfr1295
MMRRC Submission 042891-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.131) question?
Stock # R5308 (G1)
Quality Score 225
Status Not validated
Chromosome 2
Chromosomal Location 111394849-111395787 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) C to T at 111394899 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Alanine to Threonine at position 297 (A297T)
Ref Sequence ENSEMBL: ENSMUSP00000151314 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000207283] [ENSMUST00000207786] [ENSMUST00000217772]
AlphaFold Q8VF48
Predicted Effect probably damaging
Transcript: ENSMUST00000111004
AA Change: A297T

PolyPhen 2 Score 0.988 (Sensitivity: 0.73; Specificity: 0.96)
SMART Domains Protein: ENSMUSP00000106633
Gene: ENSMUSG00000074957
AA Change: A297T

DomainStartEndE-ValueType
low complexity region 23 39 N/A INTRINSIC
Pfam:7tm_1 41 287 1.9e-27 PFAM
Pfam:7tm_4 139 280 7.1e-34 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000207283
AA Change: A297T

PolyPhen 2 Score 0.988 (Sensitivity: 0.73; Specificity: 0.96)
Predicted Effect probably damaging
Transcript: ENSMUST00000207786
AA Change: A297T

PolyPhen 2 Score 0.988 (Sensitivity: 0.73; Specificity: 0.96)
Predicted Effect noncoding transcript
Transcript: ENSMUST00000209152
Predicted Effect probably damaging
Transcript: ENSMUST00000217772
AA Change: A297T

PolyPhen 2 Score 0.988 (Sensitivity: 0.73; Specificity: 0.96)
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 97.7%
  • 10x: 95.4%
  • 20x: 91.2%
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 65 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1700006A11Rik C G 3: 124,199,999 (GRCm39) G531A probably damaging Het
4921504E06Rik T C 2: 19,528,892 (GRCm39) D163G probably damaging Het
Abcd4 C T 12: 84,650,067 (GRCm39) probably null Het
Alg9 T C 9: 50,734,011 (GRCm39) S570P possibly damaging Het
Angptl3 C A 4: 98,922,723 (GRCm39) H255N probably benign Het
Ank3 G A 10: 69,838,395 (GRCm39) R1566K possibly damaging Het
Cdc37 A T 9: 21,052,060 (GRCm39) D326E probably benign Het
Cdk13 T C 13: 17,946,898 (GRCm39) K6R probably damaging Het
Ces1b T C 8: 93,793,645 (GRCm39) K315E probably benign Het
Cfap61 G A 2: 145,951,908 (GRCm39) G190S probably damaging Het
Cimap3 T C 3: 105,908,419 (GRCm39) T107A probably benign Het
Ckap4 T C 10: 84,364,238 (GRCm39) E275G probably benign Het
Cplane1 G A 15: 8,290,174 (GRCm39) probably null Het
Csf3r A G 4: 125,929,137 (GRCm39) D349G probably benign Het
Cyp2d37-ps T C 15: 82,574,012 (GRCm39) noncoding transcript Het
Dmbt1 T A 7: 130,642,751 (GRCm39) C190S probably damaging Het
Dnah11 A G 12: 118,049,415 (GRCm39) F1670L possibly damaging Het
Dnah5 A T 15: 28,229,797 (GRCm39) I144F possibly damaging Het
Eno2 C A 6: 124,744,056 (GRCm39) V84L probably damaging Het
Ercc4 G T 16: 12,948,028 (GRCm39) R325L probably damaging Het
Fcgr2b T G 1: 170,793,279 (GRCm39) Q250P probably benign Het
Garin5a T C 7: 44,149,606 (GRCm39) V109A probably damaging Het
Garre1 T A 7: 33,945,180 (GRCm39) K355* probably null Het
Gcfc2 T C 6: 81,920,524 (GRCm39) probably null Het
Glb1l2 C T 9: 26,676,055 (GRCm39) G509D probably damaging Het
Gm11595 G A 11: 99,663,381 (GRCm39) R100C unknown Het
Grn A G 11: 102,327,018 (GRCm39) N160D possibly damaging Het
Hexd T A 11: 121,113,095 (GRCm39) V510D probably damaging Het
Igfbp1 G A 11: 7,149,919 (GRCm39) probably null Het
Itga11 T A 9: 62,663,051 (GRCm39) M589K probably benign Het
Itpr1 A T 6: 108,333,472 (GRCm39) S51C probably damaging Het
Klra3 T C 6: 130,311,270 (GRCm39) probably null Het
Mad2l1 T C 6: 66,514,675 (GRCm39) probably null Het
Matn3 CGGGGCTCGGGGGC CGGGGC 12: 9,002,308 (GRCm39) probably null Het
Myo9a T A 9: 59,771,244 (GRCm39) Y939N probably damaging Het
Nxpe3 C T 16: 55,686,834 (GRCm39) S58N probably benign Het
Or1j16 T A 2: 36,530,706 (GRCm39) Y218* probably null Het
Or3a1c T A 11: 74,046,397 (GRCm39) M139K probably damaging Het
Or4c103 T C 2: 88,513,749 (GRCm39) E109G probably benign Het
Paics T C 5: 77,104,479 (GRCm39) S35P probably damaging Het
Pcnt A C 10: 76,192,159 (GRCm39) Y2717* probably null Het
Plekho2 T A 9: 65,465,957 (GRCm39) N144Y probably damaging Het
Plscr5 T C 9: 92,080,565 (GRCm39) F17S possibly damaging Het
Prrc2a C T 17: 35,380,023 (GRCm39) R192H unknown Het
Rbm27 T A 18: 42,460,275 (GRCm39) M735K probably damaging Het
Rfc1 T A 5: 65,436,804 (GRCm39) K625N probably damaging Het
Ric8b T A 10: 84,783,611 (GRCm39) F156L probably benign Het
Romo1 C A 2: 155,986,473 (GRCm39) A32E possibly damaging Het
Rpl26 T A 11: 68,795,284 (GRCm39) Y135N probably damaging Het
Sacs T C 14: 61,429,849 (GRCm39) V636A probably benign Het
Scyl2 A T 10: 89,477,869 (GRCm39) I710N probably benign Het
Sh3bp5 C A 14: 31,099,452 (GRCm39) R265L probably benign Het
Slc4a1 T A 11: 102,249,903 (GRCm39) I154F probably damaging Het
Snx11 A G 11: 96,661,535 (GRCm39) S157P probably damaging Het
Snx18 G A 13: 113,753,383 (GRCm39) Q517* probably null Het
Stard4 G T 18: 33,336,678 (GRCm39) N212K probably damaging Het
Strn3 A G 12: 51,676,168 (GRCm39) Y454H probably damaging Het
Stx17 A T 4: 48,182,851 (GRCm39) probably benign Het
Tas2r121 G A 6: 132,677,480 (GRCm39) T164I possibly damaging Het
Tbc1d8 T C 1: 39,428,490 (GRCm39) Y485C probably damaging Het
Tmem45b T C 9: 31,340,380 (GRCm39) M8V probably damaging Het
Usp28 T C 9: 48,948,501 (GRCm39) F844L probably damaging Het
Usp32 T A 11: 84,908,544 (GRCm39) N1054I probably benign Het
Xpa T A 4: 46,185,659 (GRCm39) E106D probably benign Het
Zfp85 C T 13: 67,896,974 (GRCm39) C366Y probably damaging Het
Other mutations in Or4k45
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02110:Or4k45 APN 2 111,395,252 (GRCm39) missense probably damaging 1.00
IGL02426:Or4k45 APN 2 111,394,883 (GRCm39) missense probably benign
IGL02638:Or4k45 APN 2 111,395,249 (GRCm39) missense probably damaging 1.00
IGL02743:Or4k45 APN 2 111,394,888 (GRCm39) missense possibly damaging 0.95
IGL03161:Or4k45 APN 2 111,395,676 (GRCm39) missense possibly damaging 0.78
G1patch:Or4k45 UTSW 2 111,395,252 (GRCm39) missense probably damaging 1.00
PIT4377001:Or4k45 UTSW 2 111,395,556 (GRCm39) missense probably damaging 0.98
R0448:Or4k45 UTSW 2 111,395,559 (GRCm39) missense probably benign 0.42
R1634:Or4k45 UTSW 2 111,395,691 (GRCm39) missense probably benign 0.00
R2065:Or4k45 UTSW 2 111,395,057 (GRCm39) missense probably damaging 0.99
R5534:Or4k45 UTSW 2 111,395,349 (GRCm39) missense probably benign 0.00
R5990:Or4k45 UTSW 2 111,395,019 (GRCm39) missense probably damaging 0.99
R6725:Or4k45 UTSW 2 111,395,252 (GRCm39) missense probably damaging 1.00
R7492:Or4k45 UTSW 2 111,395,166 (GRCm39) missense probably benign 0.00
R8116:Or4k45 UTSW 2 111,395,783 (GRCm39) missense probably benign 0.01
R8400:Or4k45 UTSW 2 111,395,747 (GRCm39) missense probably damaging 1.00
R8493:Or4k45 UTSW 2 111,395,324 (GRCm39) missense probably damaging 1.00
R9636:Or4k45 UTSW 2 111,395,786 (GRCm39) start codon destroyed probably null 1.00
R9736:Or4k45 UTSW 2 111,395,626 (GRCm39) missense probably benign 0.03
Predicted Primers PCR Primer
(F):5'- CATAGAAGCATAGTTTGATGGCATGTG -3'
(R):5'- ACTTGCAGTGCCCACATCAC -3'

Sequencing Primer
(F):5'- TGATGGCATGTGGAAATATTACTC -3'
(R):5'- AGTGCCCACATCACTGTAGTG -3'
Posted On 2016-10-06