Incidental Mutation 'R5536:Zfp932'
| ID |
434820 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Zfp932
|
| Ensembl Gene |
ENSMUSG00000066613 |
| Gene Name |
zinc finger protein 932 |
| Synonyms |
2310001H12Rik |
| MMRRC Submission |
043094-MU
|
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.078)
|
| Stock # |
R5536 (G1)
|
| Quality Score |
210 |
|
Status
|
Not validated
|
| Chromosome |
5 |
| Chromosomal Location |
110144387-110158277 bp(+) (GRCm39) |
| Type of Mutation |
nonsense |
| DNA Base Change (assembly) |
T to A
at 110157713 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Cysteine to Stop codon
at position 470
(C470*)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000140446
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000099484]
[ENSMUST00000112536]
[ENSMUST00000112540]
[ENSMUST00000125213]
[ENSMUST00000143639]
[ENSMUST00000187241]
|
| AlphaFold |
E9QAG8 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000099484
|
| SMART Domains |
Protein: ENSMUSP00000097083
Gene: ENSMUSG00000066613
| Domain | Start | End | E-Value | Type |
|---|
|
KRAB
|
5 |
61 |
1.74e-14 |
SMART |
|
| Predicted Effect |
probably null
Transcript: ENSMUST00000112536
AA Change: C437*
|
| SMART Domains |
Protein: ENSMUSP00000108155
Gene: ENSMUSG00000066613
AA Change: C437*
| Domain | Start | End | E-Value | Type |
|---|
|
Blast:KRAB
|
1 |
31 |
5e-12 |
BLAST |
|
ZnF_C2H2
|
71 |
93 |
1.1e-2 |
SMART |
|
ZnF_C2H2
|
99 |
121 |
5.21e-4 |
SMART |
|
ZnF_C2H2
|
127 |
149 |
3.39e-3 |
SMART |
|
ZnF_C2H2
|
155 |
177 |
1.76e-1 |
SMART |
|
ZnF_C2H2
|
183 |
205 |
1.3e-4 |
SMART |
|
ZnF_C2H2
|
211 |
233 |
1.1e-2 |
SMART |
|
ZnF_C2H2
|
239 |
261 |
2.27e-4 |
SMART |
|
ZnF_C2H2
|
267 |
289 |
1.84e-4 |
SMART |
|
ZnF_C2H2
|
295 |
317 |
5.21e-4 |
SMART |
|
ZnF_C2H2
|
323 |
345 |
9.73e-4 |
SMART |
|
ZnF_C2H2
|
351 |
373 |
1.58e-3 |
SMART |
|
ZnF_C2H2
|
379 |
401 |
1.58e-3 |
SMART |
|
ZnF_C2H2
|
407 |
429 |
5.14e-3 |
SMART |
|
ZnF_C2H2
|
435 |
457 |
2.61e-4 |
SMART |
|
ZnF_C2H2
|
463 |
485 |
2.43e-4 |
SMART |
|
| Predicted Effect |
probably null
Transcript: ENSMUST00000112540
AA Change: C470*
|
| SMART Domains |
Protein: ENSMUSP00000108159
Gene: ENSMUSG00000066613
AA Change: C470*
| Domain | Start | End | E-Value | Type |
|---|
|
KRAB
|
5 |
61 |
1.74e-14 |
SMART |
|
ZnF_C2H2
|
104 |
126 |
1.1e-2 |
SMART |
|
ZnF_C2H2
|
132 |
154 |
5.21e-4 |
SMART |
|
ZnF_C2H2
|
160 |
182 |
3.39e-3 |
SMART |
|
ZnF_C2H2
|
188 |
210 |
1.76e-1 |
SMART |
|
ZnF_C2H2
|
216 |
238 |
1.3e-4 |
SMART |
|
ZnF_C2H2
|
244 |
266 |
1.1e-2 |
SMART |
|
ZnF_C2H2
|
272 |
294 |
2.27e-4 |
SMART |
|
ZnF_C2H2
|
300 |
322 |
1.84e-4 |
SMART |
|
ZnF_C2H2
|
328 |
350 |
5.21e-4 |
SMART |
|
ZnF_C2H2
|
356 |
378 |
9.73e-4 |
SMART |
|
ZnF_C2H2
|
384 |
406 |
1.58e-3 |
SMART |
|
ZnF_C2H2
|
412 |
434 |
1.58e-3 |
SMART |
|
ZnF_C2H2
|
440 |
462 |
5.14e-3 |
SMART |
|
ZnF_C2H2
|
468 |
490 |
2.61e-4 |
SMART |
|
ZnF_C2H2
|
496 |
518 |
2.43e-4 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000125213
|
| SMART Domains |
Protein: ENSMUSP00000119843
Gene: ENSMUSG00000066613
| Domain | Start | End | E-Value | Type |
|---|
|
Blast:KRAB
|
1 |
34 |
2e-14 |
BLAST |
|
ZnF_C2H2
|
71 |
93 |
1.1e-2 |
SMART |
|
ZnF_C2H2
|
99 |
121 |
5.21e-4 |
SMART |
|
ZnF_C2H2
|
127 |
149 |
3.39e-3 |
SMART |
|
ZnF_C2H2
|
155 |
177 |
1.76e-1 |
SMART |
|
Pfam:zf-C2H2_6
|
182 |
191 |
7.3e-1 |
PFAM |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000143639
|
| SMART Domains |
Protein: ENSMUSP00000121749
Gene: ENSMUSG00000066613
| Domain | Start | End | E-Value | Type |
|---|
|
KRAB
|
4 |
60 |
1.74e-14 |
SMART |
|
ZnF_C2H2
|
103 |
125 |
1.1e-2 |
SMART |
|
ZnF_C2H2
|
131 |
153 |
5.21e-4 |
SMART |
|
ZnF_C2H2
|
159 |
181 |
3.39e-3 |
SMART |
|
ZnF_C2H2
|
187 |
209 |
1.76e-1 |
SMART |
|
| Predicted Effect |
probably null
Transcript: ENSMUST00000187241
AA Change: C470*
|
| SMART Domains |
Protein: ENSMUSP00000140446
Gene: ENSMUSG00000066613
AA Change: C470*
| Domain | Start | End | E-Value | Type |
|---|
|
KRAB
|
5 |
61 |
7.1e-17 |
SMART |
|
ZnF_C2H2
|
104 |
126 |
4.8e-5 |
SMART |
|
ZnF_C2H2
|
132 |
154 |
2.2e-6 |
SMART |
|
ZnF_C2H2
|
160 |
182 |
1.5e-5 |
SMART |
|
ZnF_C2H2
|
188 |
210 |
7.2e-4 |
SMART |
|
ZnF_C2H2
|
216 |
238 |
5.4e-7 |
SMART |
|
ZnF_C2H2
|
244 |
266 |
4.5e-5 |
SMART |
|
ZnF_C2H2
|
272 |
294 |
9.2e-7 |
SMART |
|
ZnF_C2H2
|
300 |
322 |
7.5e-7 |
SMART |
|
ZnF_C2H2
|
328 |
350 |
2.1e-6 |
SMART |
|
ZnF_C2H2
|
356 |
378 |
4e-6 |
SMART |
|
ZnF_C2H2
|
384 |
406 |
6.5e-6 |
SMART |
|
ZnF_C2H2
|
412 |
434 |
6.9e-6 |
SMART |
|
ZnF_C2H2
|
440 |
462 |
2.1e-5 |
SMART |
|
ZnF_C2H2
|
468 |
490 |
1.1e-6 |
SMART |
|
ZnF_C2H2
|
496 |
518 |
1.1e-6 |
SMART |
|
| Coding Region Coverage |
- 1x: 99.9%
- 3x: 99.6%
- 10x: 98.3%
- 20x: 95.0%
|
| Validation Efficiency |
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 47 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 1110002E22Rik |
G |
T |
3: 137,772,149 (GRCm39) |
G446V |
possibly damaging |
Het |
| Aadac |
T |
G |
3: 59,946,984 (GRCm39) |
N227K |
probably benign |
Het |
| Acap1 |
C |
T |
11: 69,780,133 (GRCm39) |
G74R |
probably benign |
Het |
| Adrm1 |
A |
G |
2: 179,813,981 (GRCm39) |
|
probably benign |
Het |
| Appl1 |
G |
C |
14: 26,645,737 (GRCm39) |
S691* |
probably null |
Het |
| Atp2a2 |
T |
C |
5: 122,595,245 (GRCm39) |
D1035G |
probably benign |
Het |
| AW551984 |
A |
G |
9: 39,504,169 (GRCm39) |
I599T |
probably benign |
Het |
| Col23a1 |
C |
A |
11: 51,458,776 (GRCm39) |
D304E |
probably damaging |
Het |
| Csmd1 |
T |
C |
8: 16,338,674 (GRCm39) |
R478G |
probably damaging |
Het |
| Dnah7a |
T |
C |
1: 53,464,412 (GRCm39) |
N3660D |
probably benign |
Het |
| Drosha |
T |
A |
15: 12,929,797 (GRCm39) |
Y1331N |
possibly damaging |
Het |
| E2f6 |
T |
G |
12: 16,874,685 (GRCm39) |
S256A |
probably benign |
Het |
| Evc |
A |
G |
5: 37,483,927 (GRCm39) |
|
probably benign |
Het |
| Fsip2 |
A |
T |
2: 82,817,403 (GRCm39) |
I4379F |
probably benign |
Het |
| Galnt2 |
T |
C |
8: 125,050,412 (GRCm39) |
C91R |
probably damaging |
Het |
| Gm3095 |
G |
T |
14: 15,170,371 (GRCm39) |
M73I |
probably benign |
Het |
| Gpr179 |
T |
A |
11: 97,234,641 (GRCm39) |
Q480L |
probably damaging |
Het |
| Gucy2g |
T |
A |
19: 55,226,359 (GRCm39) |
I186F |
probably benign |
Het |
| Hmcn1 |
T |
A |
1: 150,631,042 (GRCm39) |
I919F |
probably benign |
Het |
| Kdm3a |
A |
C |
6: 71,588,920 (GRCm39) |
V363G |
probably benign |
Het |
| Kmt2d |
G |
A |
15: 98,749,990 (GRCm39) |
|
probably benign |
Het |
| Lama5 |
C |
T |
2: 179,831,142 (GRCm39) |
R1839H |
probably damaging |
Het |
| Lpo |
T |
C |
11: 87,707,389 (GRCm39) |
D208G |
probably damaging |
Het |
| Lpp |
A |
G |
16: 24,663,956 (GRCm39) |
D411G |
possibly damaging |
Het |
| Marco |
T |
C |
1: 120,432,464 (GRCm39) |
S8G |
possibly damaging |
Het |
| Mthfr |
T |
C |
4: 148,128,940 (GRCm39) |
F171S |
probably damaging |
Het |
| Nlrx1 |
A |
T |
9: 44,175,183 (GRCm39) |
S198T |
probably damaging |
Het |
| Nol10 |
C |
A |
12: 17,466,138 (GRCm39) |
S511* |
probably null |
Het |
| Nup153 |
T |
C |
13: 46,836,485 (GRCm39) |
T1375A |
probably benign |
Het |
| Obscn |
A |
G |
11: 58,998,697 (GRCm39) |
S1367P |
probably damaging |
Het |
| Or4x6 |
A |
G |
2: 89,949,183 (GRCm39) |
V253A |
probably benign |
Het |
| Pcdha7 |
G |
A |
18: 37,108,303 (GRCm39) |
V443M |
probably damaging |
Het |
| Plekha1 |
G |
T |
7: 130,511,331 (GRCm39) |
R305I |
probably damaging |
Het |
| Psmb2 |
T |
A |
4: 126,578,002 (GRCm39) |
I60N |
probably damaging |
Het |
| Rad17 |
C |
A |
13: 100,767,612 (GRCm39) |
G330C |
probably damaging |
Het |
| Slc5a6 |
A |
G |
5: 31,200,446 (GRCm39) |
S80P |
probably damaging |
Het |
| Srgap2 |
T |
A |
1: 131,228,128 (GRCm39) |
|
probably null |
Het |
| Taf8 |
C |
A |
17: 47,805,407 (GRCm39) |
R164L |
possibly damaging |
Het |
| Tmem87a |
C |
A |
2: 120,227,911 (GRCm39) |
D79Y |
probably damaging |
Het |
| Tmtc4 |
G |
A |
14: 123,170,291 (GRCm39) |
R574W |
probably benign |
Het |
| Tprn |
G |
A |
2: 25,153,369 (GRCm39) |
A224T |
probably benign |
Het |
| Usf3 |
A |
G |
16: 44,037,733 (GRCm39) |
T738A |
probably benign |
Het |
| Vmn2r54 |
A |
C |
7: 12,366,343 (GRCm39) |
V197G |
probably benign |
Het |
| Zbtb40 |
G |
T |
4: 136,714,642 (GRCm39) |
P1049Q |
probably damaging |
Het |
| Zfp551 |
A |
T |
7: 12,149,488 (GRCm39) |
S640R |
possibly damaging |
Het |
| Zkscan8 |
T |
C |
13: 21,710,838 (GRCm39) |
I91V |
probably damaging |
Het |
| Zmat4 |
T |
C |
8: 24,238,508 (GRCm39) |
V30A |
probably damaging |
Het |
|
| Other mutations in Zfp932 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
R0153:Zfp932
|
UTSW |
5 |
110,154,834 (GRCm39) |
missense |
probably benign |
0.27 |
|
R0268:Zfp932
|
UTSW |
5 |
110,156,929 (GRCm39) |
missense |
probably benign |
0.24 |
|
R1673:Zfp932
|
UTSW |
5 |
110,156,854 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1797:Zfp932
|
UTSW |
5 |
110,144,489 (GRCm39) |
start gained |
probably benign |
|
|
R1893:Zfp932
|
UTSW |
5 |
110,157,069 (GRCm39) |
missense |
possibly damaging |
0.71 |
|
R1942:Zfp932
|
UTSW |
5 |
110,154,853 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2073:Zfp932
|
UTSW |
5 |
110,157,684 (GRCm39) |
missense |
possibly damaging |
0.60 |
|
R2076:Zfp932
|
UTSW |
5 |
110,157,334 (GRCm39) |
missense |
probably benign |
0.01 |
|
R2329:Zfp932
|
UTSW |
5 |
110,157,406 (GRCm39) |
missense |
probably benign |
0.01 |
|
R3944:Zfp932
|
UTSW |
5 |
110,157,820 (GRCm39) |
missense |
probably benign |
0.37 |
|
R4551:Zfp932
|
UTSW |
5 |
110,157,505 (GRCm39) |
missense |
probably benign |
0.03 |
|
R4679:Zfp932
|
UTSW |
5 |
110,157,760 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4692:Zfp932
|
UTSW |
5 |
110,157,052 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5116:Zfp932
|
UTSW |
5 |
110,157,242 (GRCm39) |
missense |
probably benign |
0.05 |
|
R5260:Zfp932
|
UTSW |
5 |
110,157,501 (GRCm39) |
nonsense |
probably null |
|
|
R6351:Zfp932
|
UTSW |
5 |
110,157,209 (GRCm39) |
nonsense |
probably null |
|
|
R6786:Zfp932
|
UTSW |
5 |
110,157,606 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R6843:Zfp932
|
UTSW |
5 |
110,156,581 (GRCm39) |
missense |
probably benign |
0.02 |
|
R7437:Zfp932
|
UTSW |
5 |
110,157,880 (GRCm39) |
missense |
probably benign |
0.10 |
|
R7496:Zfp932
|
UTSW |
5 |
110,156,694 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R7704:Zfp932
|
UTSW |
5 |
110,157,630 (GRCm39) |
missense |
probably benign |
0.09 |
|
R8224:Zfp932
|
UTSW |
5 |
110,144,480 (GRCm39) |
start gained |
probably benign |
|
|
R8317:Zfp932
|
UTSW |
5 |
110,156,922 (GRCm39) |
nonsense |
probably null |
|
|
R8765:Zfp932
|
UTSW |
5 |
110,154,827 (GRCm39) |
missense |
probably benign |
0.01 |
|
R8967:Zfp932
|
UTSW |
5 |
110,156,883 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9083:Zfp932
|
UTSW |
5 |
110,157,100 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9142:Zfp932
|
UTSW |
5 |
110,157,520 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9511:Zfp932
|
UTSW |
5 |
110,155,177 (GRCm39) |
missense |
possibly damaging |
0.46 |
|
R9533:Zfp932
|
UTSW |
5 |
110,157,787 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9640:Zfp932
|
UTSW |
5 |
110,157,064 (GRCm39) |
missense |
probably benign |
0.00 |
|
| Predicted Primers |
PCR Primer
(F):5'- TGGAGAGAAGCCTTACAAGTGTGA -3'
(R):5'- CACTTGTCATGGGCCAAGTATATTT -3'
Sequencing Primer
(F):5'- GAAGCCTTACAAGTGTGATCAATG -3'
(R):5'- GGGCCAAGTATATTTAGTCCACC -3'
|
| Posted On |
2016-10-24 |
Incidental Mutation